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| 1 | Optimal Predictive Control for Path Following of a Full Drive-by-Wire Vehicle at Varying Speeds显示文摘The current research of the global chassis control problem for the full drive-by-wire vehicle focuses on the control allocation(CA) of the four-wheel-distributed traction/braking/steering systems. However, the path following performance and the handling stability of the vehicle can be enhanced a step further by automatically adjusting the vehicle speed to the optimal value. The optimal solution for the combined longitudinal and lateral motion control(MC)problem is given. First, a new variable step-size spatial transformation method is proposed and utilized in the prediction model to derive the dynamics of the vehicle with respect to the road, such that the tracking errors can be explicitly obtained over the prediction horizon at varying speeds. Second, a nonlinear model predictive control(NMPC) algorithm is introduced to handle the nonlinear coupling between any two directions of the vehicular planar motion and computes the sequence of the optimal motion states for following the desired path. Third, a hierarchical control structure is proposed to separate the motion controller into a NMPC based path planner and a terminal sliding mode control(TSMC) based path follower. As revealed through off-line simulations, the hierarchical methodology brings nearly 1700% improvement in computational efficiency without loss of control performance. Finally, the control algorithm is verified through a hardware in-the-loop simulation system. Double-lanechange(DLC) test results show that by using the optimal predictive controller, the root-mean-square(RMS) values of the lateral deviations and the orientation errors can be reduced by 41% and 30%, respectively, comparing to those by the optimal preview acceleration(OPA) driver model with the non-preview speed-tracking method. Additionally,the average vehicle speed is increased by 0.26 km/h with the peak sideslip angle suppressed to 1.9°. This research proposes a novel motion controller, which provides the full drive-by-wire vehicle with better lane-keeping and collision-avoidance capabilities during autonomous driving. | Pan SONG Bolin GAO Shugang XIE Rui FANG | 2017 | Chinese Journal of Mechanical Engineering2017，30，3： | 4 |
| 2 | Bitter receptor TAS2R138 facilitates lipid droplet degradation in neutrophils during Pseudomonas aeruginosa infection显示文摘Bitter receptors function primarily in sensing taste,but may also have other functions,such as detecting pathogenic organisms due to their agile response to foreign objects.The mouse taste receptor type-2 member 138(TAS2R138)is a member of the G-protein-coupled bitter receptor family,which is not only found in the tongue and nasal cavity,but also widely distributed in other organs,such as the respiratory tract,gut,and lungs.Despite its diverse functions,the role of TAS2R138 in host defense against bacterial infection is largely unknown.Here,we show that TAS2R138 facilitates the degradation of lipid droplets(LDs)in neutrophils during Pseudomonas aeruginosa infection through competitive binding with PPARG(peroxisome proliferator-activated receptor gamma)antagonist:A/-(3-oxododecanoyl)-L-homoserine lactone(AHL-12),which coincidently is a virulence-bound signal produced by this bacterium(P.aeruginosa).The released PPARG then migrates from nuclei to the cytoplasm to accelerate the degradation of LDs by binding PLIN2(perilipin-2).Subsequently,the TAS2R138-AHL-12 complex targets LDs to augment their degradation,and thereby facilitating the clearance of AHL-12 in neutrophils to maintain homeostasis in the local environment.These findings reveal a crucial role for TAS2R138 in neutrophil-mediated host immunity against P.aeruginosa infection. | Qinqin Pu Kai Guo Ping Lin Zhihan Wang Shugang Qin Pan Gao Colin Combs Nadeem Khan Zhenwei Xia Min Wu | 2021 | Signal Transduction and Targeted Therapy2021，6，7： | 2 |
| 3 | Interaction among inflammasome,autophagy and non-coding RNAs:new horizons for drug显示文摘Autophagy and inflammasomes are shown to interact in various situations including infectious disease,cancer,diabetes and neurodegeneration.Since multiple layers of molecular regulators contribute to the interplay between autophagy and inflammasome activation,the detail of such interplay remains largely unknown.Non-coding RNAs(ncRNAs),which have been implicated in regulating an expanding list of cellular processes including immune defense against pathogens and inflammatory response in cancer and metabolic diseases,may join in the crosstalk between inflammasomes and autophagy in physiological or disease conditions.In this review,we summarize the latest research on the interlink among ncRNAs,inflammasomes and autophagy and discuss the emerging role of these three in multiple signaling transduction pathways involved in clinical conditions.By analyzing these intriguing interconnections,we hope to unveil the mechanism inter-regulating these multiple processes and ultimately discover potential drug targets for some refractory diseases. | Qinqin Pu Ping Lin Zhihan Wang Pan Gao Shugang Qin Luqing Cui Min Wu | 2019 | Precision Clinical Medicine2019，2，3： | 1 |
| 4 | Experimental investigation on the seepage law of pres-sure-relieved gas under the influence of mining 显示文摘 | LI Shugang XIAO Peng PAN Hongyu | 2012 | SafetyScience2012，50，： | 1 |
| 5 | Experimental investigation on the seepage law of pressure-relieved gas under the influence of mining显示文摘 | Shugang Li Peng Xiao Hongyu Pan Haifei Lin Lianhua Cheng | 2011 | Safety Science2011，，4： | 1 |
| 6 | Metal-organic frameworks derived low-crystalline NiCo_(2)S_(4)/Co_(3)S_(4) nanocages with dual heterogeneous interfaces for high-performance supercapacitors显示文摘Nickel cobalt bimetallic heterogeneous sulfides are attractive battery-type materials for electrochemical energy storage.However,the precise synthesis of electrode materials that integrate highly efficient ions/electrons diffusion with abundant charge transfer channels has always been challenging.Herein,an effective and concise controllable hydrothermal approach is reported for tuning the crystalline and integrated structures of MOF-derived bimetallic sulfides to accelerate the charge transfer kinetics,and thus enabling rich Faradaic redox reaction.The as-obtained low-crystalline heterogeneous NiCo_(2)S_(4)/Co_(3)S_(4)nanocages exhibit a high specific capacity(1023 C/g at 1 A/g),remarkable rate performance(560 C/g at 10A/g),and outstanding cycling stability(89.6%retention after 5000 cycles).Furthermore,hybrid supercapacitors fabricated with NiCo_(2)S_(4)/Co_(3)S_(4)and nitrogen-doped reduced graphene oxide display an outstanding energy density of 40.8 Wh/kg at a power density of 806.3 W/kg,with an excellent capacity retention of 88.3%after 10000 charge-discharge cycles. | Zixin Jia Youning Wang Jiaqi Chen Zhijie Cao Shugang Pan Yan Zhou Jingwen Sun Junwu Zhu Xin Wang Yongsheng Fu | 2023 | Chinese Chemical Letters2023，34，1： | 1 |
| 7 | Loose Sand Cemented by Microbial Cementitious Material:Composition,Microstructure and Mechanical Properties显示文摘Through the influence of the dosage of culture solution and calcium source on hardness and compressive strength of samples,the formulation of microbial cementitious materials was optimized and defined.The influence of temperature on composition,microstructure and mechanical properties of loose sand cemented by microbial cementitious material was compared and analyzed systematically.With the increase of temperature,the performance of loose sand was improved remarkably.Calcite with cementitious properties could be induced at higher temperatures,but not at lower temperatures.When the temperature was 30℃,loose sand cemented by microbial cementitious material had more calcite and more dense structure.Moreover,hardness and compressive strength were also superior.The wind tunnel test showed that the wind erosion resistance was improved obviously and the mass loss was lower at high temperature.Engineering properties of loose sand cemented by microbial cementitious material was measured integrally.Through comparative analysis,engineering properties of loose sand were basically unchanged,and there was no negative effect on the later period use of sand. | 詹其伟 WANG Shugang LIU Baoya PAN Zhihong YU Xiaoniu QIAN Chunxiang | 2021 | Journal of Wuhan University of Technology(Materials Science)2021，36，5： | 0 |
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