|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Cdx2 expression and its promoter methylation during metaplasia-dysplasia-carcinoma sequence in Barrett's esophagus显示文摘AIM:To examine how the expression of caudal type homebox transcription factor 2(Cdx2) is regulated in the development of malignancy in Barrett's esophagus.METHODS:Cdx2,mucin(MUC) series(MUC2,MUC5AC and MUC6),p53 and E-cadherin expression in Barrett's esophagus and adenocarcinoma specimens were examined by immunostaining.Isolated clusters of cells from(1) MUC2 and Cdx2-positive intestinal metaplastic mucosa;(2) MUC5AC and MUC6-positive,and MUC2 and Cdx2-negative high-grade dysplasia(HD),or intramucosal adenocarcinoma(IMC);and(3) MUC5AC,MUC6 and Cdx2-positive poorly-differentiated invasive adenocarcinoma(PDA) were analyzed by methylationspecific polymerase chain reaction using sets of primers for detecting methylation status of the Cdx2 gene.RESULTS:Most of the non-neoplastic Barrett's esophageal mucosa showing intestinal-type metaplasia with or without low-grade dysplasia was positive for E-cadherin,MUC series and Cdx2,but negative for p53.A portion of the low-grade to HD was positive for E-cadherin,MUC5AC,MUC6 and p53,but negative for MUC2 and Cdx2.The definite IMC area was strongly positive for MUC5AC,MUC6 and p53,but negative for MUC2 and Cdx2.Methylation of the Cdx2 promoter was not observed in intestinal metaplasia,while hypermethylation of part of its promoter was observed in hot dipped and IMC.Hypermethylation of a large fraction of the Cdx2 promoter was observed in PDA.CONCLUSION:Cdx2 expression is restored irrespective of the methylation status of its promoter.Apparent positive immunohistochemical results can be a molecular mark for gene silencing memory. | Kenji Makita Riko Kitazawa Shuho Semba Koto Fujiishi Miku Nakagawa Ryuma Haraguchi Sohei Kitazawa | 2013 | World Journal of Gastroenterology2013，19，4： | 5 |
| 2 | Significance of AKT phosphorylation on tumor growth and vascular endothelial growth factor expression in human gastric carcinoma显示文摘 | Iwao K Shuho S Yoshiko M | 2006 | Pathobiology2006，73，： | 1 |
| 3 | Reduced Expression of cyclin-dependent kinase inhibitor p27kipl associated with advanced stage and invasiveness of gastric carcinomas 显示文摘 | Wataru Y Yasusei K Shuho S | 1997 | Jpn J Cancer Res1997，88，7： | 1 |
| 4 | Phosphorylation of AKT/PKB is required for suppression of cancer cell apoptosis and tumor progression in human eolorectal carcinoma显示文摘 | Nanawin IT Shuho SE Masafumi IT | 2002 | Cancer2002，94，12： | 1 |
| 5 | Phosphorylation of Akt/PKB is required for suppression of cancer cell apoptosis and tumor progression in human colorectal carcinoma显示文摘 | Nanami I Shuho S Masafumi I | | 0，，12： | 1 |
| 6 | Significance of AKT phosphorylation on tumor growth and vascular endothelial growth factor expression in human gastric carcinoma显示文摘 | Iwan K Shuho S Yoshiko M | 2006 | Pathobiology2006，73，5： | 1 |
| 7 | Cdx2 tran- scription factor regulates claudin - 3 and clandin - 4 expression during in- testinal differentiation of gastric carcinoma 显示文摘 | Shinya Satake Shuho Semba Yoshiko Matsuda | 2008 | Pathol Int2008，58，3： | 1 |
| 8 | Laser welding system for various3-D welding-development of coaxial laser welding heads显示文摘 | Shuho T Takashi I Masao W | 2005 | Technical Review2005，42，2： | 1 |
| 9 | Phosphorylation of AKT/PKB is required for suppression of cancer cell apoptosis and tumor progression in human colorectal carcinoma显示文摘 | Nanaw IT Shuho SE Masafumi IT | 2002 | Cancer2002，94，12： | 1 |
| 10 | Role of the WWOX gene, encompassing fragile region FRA16D, in suppression of pancreatic carcinoma cells显示文摘 | Shunji Nakayama Shuho Semba Naoko Maeda | 2008 | Cancer Sci2008，99，7： | 1 |
| 11 | Expression of PRL-3 phosphatase in human gastric carcinomas:close correlation with invasion and metastasis显示文摘 | Upik Anderiani Miskad Shuho Semba Hirotaka Kato | 2004 | Pathobiolgy2004，71，4： | 1 |
| 12 | Reduced expression of cyclin-dependent kinase inhibitor p27 associated with advanced stage and invasiveness of gastric carcinomas 显示文摘 | Watam Yasuiw Yasusei Kudo Shuho Semba | 1997 | JPn J cancer Res1997，88，： | 1 |
| 13 | Biological similarities and differences between pancreatic intraepithelial neoplasias and intraductal papillary mucinous neoplasms显示文摘 | Toshiyuki Moriya Wataru Kimura MD Shuho Semba Fumiaki Sakurai Ichiro Hirai Jinfeng Ma Akira Fuse Kunihiko Maeda Mitsunori Yamakawa | 2005 | International Journal of Gastrointestinal Cancer2005，，2： | 1 |
| 14 | High expression of PRL-3 promotes cancer cell motility and liver metastasis in human colorectal cancer: a predictive molecular marker of metachronous liver and lung metastases显示文摘 | Hirotaka K Shuho S Hiroshi Y | 2004 | Clin Cancer Res2004，10，21： | 1 |
| 15 | Cdx2 transcription factor regulates claudin-3 and claudin-4 expression during intestinal differentiation of gastric carcinoma 显示文摘 | Shinya S Shuho S Yoshiko M | 2008 | Pathol Int2008，58，3： | 1 |
| 16 | Failure analysis and life prediction of a set of extra high pressure and heat exchangers containing defects显示文摘 | DAI Shuho | 1997 | International Journal of Pressure Vessels and Piping1997，70，3： | 1 |
| 17 | Frequent nuclear accumulation of β-catenin in pituitary adenoma显示文摘 | Shuho Semba Shuang-Yin Han Hidetoshi Ikeda | 2001 | American Cancer Society2001，91，： | 1 |
| 18 | Pbosphorylation of Akt/PKB is required for suppression of cancer cell Apoptosis and Tumor progression in human coloroctal carcinoma显示文摘 | Shuho SE Masafumi IT | 2002 | Cancer2002，94，12： | 1 |
| 19 | Laser Welding System for Various 3-D Welding-Development of Coaxial laser welding heads 显示文摘 | Shuho T Takashi I Masao W | 2005 | Technical Review2005，42，2： | 1 |
| 20 | Removal of perfluflrooctanoate from surface water by polyaluminium chloride coagulation 显示文摘 | DENG Shuho QIU Zhou YU Gang | 2011 | Water Research2011，45，4： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员