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| 1 | Comparison of Travel Mode Choice Between Taxi and Subway Regarding Traveling Convenience显示文摘In this study, we investigate travel mode choice behavior between taxi and subway with an emphasis on the influence of traveling convenience. In the first stage, we examine the Origin-Destination(OD) points of Beijing taxi trips and compare these locations with the respective nearest subway station. Statistics reveal several interesting conclusions. First, for approximately 24.89% of all trips, no convenient subway connections exist between the OD pairs. As such, a taxi becomes the only viable choice. Second, for 80.23% of the remaining 75.11%of trips(equivalent to 60.26% of all trips), access distance from either the origin or the destination to the nearest subway station is greater than 500 meters. This phenomenon indicates that walking distance plays an important role in travel mode choice. In the second stage, we examine groups of taxi trips with similar travel distances and travel times to reveal common features. We establish a preference rule in terms of travel distance and travel time.This determines whether an individual driver will take a taxi or the subway, using a pairwise comparison-based preference regression model. Tests indicate that more than 95% of taxi trips can be correctly predicted by this preference rule. This conclusion reveals that traveling convenience dominates the travel model choice between taxi and subway. All these findings shed light on the factors that influence travel mode choice behavior. | Li Li Shuofeng Wang Meng Li Jiyuan Tan | 2018 | Tsinghua Science and Technology2018，23，2： | 2 |
| 2 | Combustion and emissions characteristics of a hybrid hydrogen-gas- oline 显示文摘 | Changwei Ji Shuofeng Wang 13o Zhang | 2010 | 35(1 engine under various loads and lean conditions International Journal of Hydrogen Energy2010，1，： | 1 |
| 3 | Effect of hydrogen addition on the idle performance of a spark ignited gasoline engine at stoichiometric condition 显示文摘 | Ji Changwei Wang Shuofeng | 2009 | International Journal of Hydrogen Energy2009，34，8： | 1 |
| 4 | Combustion analysisand emissions characteristics of a hydrogen-blended methanol engineat various spark timings 显示文摘 | ZHANG Bo JI Chang^vei WANG Shuofeng | 2015 | international Journal of HydrogenEnergy2015，40，： | 1 |
| 5 | Emissions performance of a hybrid hydrogen–gasoline engine-powered passenger car under the New European Driving Cycle显示文摘 | Changwei Ji Shuofeng Wang Bo Zhang Xiaolong Liu | 2013 | Fuel2013，，： | 1 |
| 6 | Performance of a hybrid hydrogen–gasoline engine under various operating conditions显示文摘 | Changwei Ji Shuofeng Wang Bo Zhang | 2011 | Applied Energy2011，，： | 1 |
| 7 | Development and validation of a laminar flame speed correlation for the CFD simulation of hydrogen-enriched gasoline engines显示文摘 | Changwei Ji Xiaolong Liu Shuofeng Wang Binbin Gao Jinxin Yang | 2012 | International Journal of Hydrogen Energy2012，，： | 1 |
| 8 | Effect of hydrogen addition on combustion and emissions performance of a spark-ignited ethanol engine at idle and stoichiometric conditions显示文摘 | Shuofeng Wang Changwei Ji Bo Zhang | 2010 | International Journal of Hydrogen Energy2010，，17： | 1 |
| 9 | P21-activated kinase 1 (PAK1)-mediated cytoskeleton rearrangement promotes SARS-CoV-2 entry and ACE2 autophagic degradation显示文摘Severe acute respiratory syndrome coronavirus 2(SARS-CoV-2),the causative agent of coronavirus disease 2019(COVID-19),has had a significant impact on healthcare systems and economies worldwide.The continuous emergence of new viral strains presents a major challenge in the development of effective antiviral agents.Strategies that possess broad-spectrum antiviral activities are desirable to control SARS-CoV-2 infection.ACE2,an angiotensin-containing enzyme that prevents the overactivation of the renin angiotensin system,is the receptor for SARS-CoV-2.ACE2 interacts with the spike protein and facilitates viral attachment and entry into host cells.Yet,SARS-CoV-2 infection also promotes ACE2 degradation.Whether restoring ACE2 surface expression has an impact on SARS-CoV-2 infection is yet to be determined.Here,we show that the ACE2-spike complex is endocytosed and degraded via autophagy in a manner that depends on clathrin-mediated endocytosis and PAK1-mediated cytoskeleton rearrangement.In contrast,free cellular spike protein is selectively cleaved into S1 and s2 subunits in a lysosomal-dependent manner.Importantly,we show that the pan-PAK inhibitor FRAX-486 restores ACE2 surface expression and suppresses infection by different SARS-CoV-2 strains.FRAX-486-treated Syrian hamsters exhibit significantly decreased lung viral load and alleviated pulmonary inflammation compared with untreated hamsters.In summary,our findings have identified novel pathways regulating viral entry,as well as therapeutic targets and candidate compounds for controlling the emerging strains of SARS-CoV-2 infection. | Ming Liu Bingtai Lu Yue Li Shuofeng Yuan Zhen Zhuang Guangyu Li Dong Wang Liuheyi Ma Jianheng Zhu Jinglu Zhao Chris Chung-Sing Chan Vincent Kwok-Man Poon Kenn Ka-Heng Chik Zhiyao Zhao Huifang Xian Jingxian Zhao Jincun Zhao Jasper Fuk-Woo Chan Yuxia Zhang | 2023 | Signal Transduction and Targeted Therapy2023，8，11： | 0 |
| 10 | Intranasal administration of a single dose of a candidate live attenuated vaccine derived from an NSP16-deficient SARS-CoV-2 strain confers sterilizing immunity in animals显示文摘Live attenuated vaccines might elicit mucosal and sterilizing immunity against SARS-CoV-2 that the existing mRNA,adenoviral vector and inactivated vaccines fail to induce.Here,we describe a candidate live attenuated vaccine strain of SARS-CoV-2 in which the NSP16 gene,which encodes 2′-O-methyltransferase,is catalytically disrupted by a point mutation.This virus,designated d16,was severely attenuated in hamsters and transgenic mice,causing only asymptomatic and nonpathogenic infection.A single dose of d16 administered intranasally resulted in sterilizing immunity in both the upper and lower respiratory tracts of hamsters,thus preventing viral spread in a contact-based transmission model.It also robustly stimulated humoral and cell-mediated immune responses,thus conferring full protection against lethal challenge with SARS-CoV-2 in a transgenic mouse model.The neutralizing antibodies elicited by d16 effectively cross-reacted with several SARS-CoV-2 variants.Secretory immunoglobulin A was detected in the blood and nasal wash of vaccinated mice.Our work provides proof-of-principle evidence for harnessing NSP16-deficient SARS-CoV-2 for the development of live attenuated vaccines and paves the way for further preclinical studies of d16 as a prototypic vaccine strain,to which new features might be introduced to improve safety,transmissibility,immunogenicity and efficacy. | Zi-Wei Ye Chon Phin Ong Kaiming Tang Yilan Fan Cuiting Luo Runhong Zhou Peng Luo Yun Cheng Victor Sebastien Gray Pui Wang Hin Chu Jasper Fuk-Woo Chan Kelvin Kai-Wang To Honglin Chen Zhiwei Chen Kwok-Yung Yuen Guang Sheng Ling Shuofeng Yuan Dong-Yan Jin | 2022 | Cellular & Molecular Immunology2022，19，5： | 0 |
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