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| 1 | Scaffolding protein Gab1 regulates myeloid dendritic cell migration in allergic asthma显示文摘气喘是在多重基因、环境的因素之中包含复杂相互影响的普通过敏混乱。最近的研究作为一个新奇气喘危险性因素识别了人的 GAB1 的基因变体。然而,在肺的 Gab1 的功能仍然保持大部分未经勘探。在这研究,我们首先在尖锐恶化期间从气喘的病人在外部血 mononuclear 房间观察了 Gab1 水平的举起与康复相比。有在 myeloid 的有选择地破坏的 Gab1 的老鼠树枝状的房间(mDCs ) 更加在气喘的试验性的模型稀释了过敏发炎。进一步的调查在 Gab1 缺乏的 mDCs 的调停 CCL19 的移植揭示了突出的减小到排干淋巴节点和驾驶 Th2 的适应激活的随后的缺陷。机械学地, Gab1 是在气喘的回答期间调整 mDC 移植的 CCL19/CCR7 chemokine 轴的一个必要部件。一起,这些调查结果在肺为 Gab1 的角色提供第一条证据,给我们气喘的致病的更深的理解。 | Yun Zhang Yun Xu Shuwan Liu Xiaohong Guo Dong Cen Jiaqi Xu Heyuan Li Kaijun Li Chunlai Zeng Linrong LU Yiting Zhou Huahao Shen Hongqiang Cheng Xue Zhang Yuehai Ke | 2016 | Cell Research2016，26，11： | 3 |
| 2 | Ets-2 Regulates Cell Apoptosis via the Akt Pathway, through the Regulation of Urothelial Cancer Associatedl, a Long Non-Coding RNA, in Bladder Cancer Cells显示文摘 | Wenjing Wu Shuwan Zhang Xu Li | 2013 | PLOS ONE2013，8，9： | 1 |
| 3 | Upregulation of long non-coding RNA urothelial carcinoma associated1 by CCAAT/enhancer binding protein α contributes to bladder cancer cell growthand reduced apoptosis显示文摘 | Mei Xue Xu Li Wenjing Wu Shuwan Zhang Shouzhen Wu Zhengkun Li Wei Chen | 2014 | Oncology Reports2014，，5： | 1 |
| 4 | Modulation of fatty acid synthase by ATR checkpoint kinase Rad3显示文摘Fatty acid synthase (FAS) is the key enzyme for de novo fatty acid synthesis and exists widely from bacteria to mammalian cells (Schweizer and Hofmann, 2004). It is involved in membrane organization, metabolism regulation, energy storage, and many other processes (Maier et al., 2010). The ataxia telangiectasia-mutated and Rad3-related kinase (ATR) is a master regulator of DNA damage response (DDR) and is highly conserved. ATR is activated by DNA double-strand breaks and various types of DNA replication stresses (Cortez et al., 2001). Recent researches have reported that FAS seems closely related to genome stability (Wu et al., 2016). It has been proved that palmitic acid, the product of FAS, can inhibit ATR phosphorylation and kinase activity in mouse fibroblast (Zeng et al., 2008). These studies suggest that there is a crosstalk between fatty acid metabolism and DDR pathway, but the mechanism remains unknown. | Shuwan Qiu Sheng Liu Zannati Ferdous Zaoti Xuejuan Wang and Gang Cai | 2019 | Journal of Molecular Cell Biology2019，11，12： | 1 |
| 5 | Surface gly- cosylation of polyacrylonitrile ultrafiltration membrane to improve its anti-fouling performance显示文摘 | Dai Zhengwei Ling Shuwan Xu Zhikang | 2008 | J Membr Sci2008，325，： | 1 |
| 6 | MICROSTRUCTURES AND OPTICAL PROPERTIES OF Te_(81)Ge_(15)Sb_4 THIN FILMS USED FOR PHASE CHANGE RECORDING MATERIALS显示文摘MICROSTRUCTURESANDOPTICALPROPERTIESOFTe_(81)Ge_(15)Sb_4THINFILMSUSEDFORPHASECHANGERECORDINGMATERIALS￥Song,Lianpeng;Huang,Shuwa?.. | Song, Lianpeng Huang, Shuwan | 1995 | 中国有色金属学会会刊:英文版1995，5，3： | 0 |
| 7 | On the horizon:Hedgehog signaling to heal broken bones显示文摘Uncovering the molecular pathways that drive skeletal repair has been an ongoing challenge. Initial efforts have relied on in vitro assays to identify the key signaling pathways that drive cartilage and bone differentiation. While these assays can provide some clues, assessing specific pathways in animal models is critical. Furthermore, definitive proof that a pathway is required for skeletal repair is best provided using genetic tests. Stimulating the Hh(Hedgehog) pathway can promote cartilage and bone differentiation in cell culture assays. In addition, the application of HH protein or various pathway agonists in vivo has a positive influence on bone healing. Until recently, however, genetic proof that the Hh pathway is involved in bone repair has been lacking. Here, we consider both in vitro and in vivo studies that examine the role of Hh in repair and discuss some of the challenges inherent in their interpretation. We also identify needed areas of study considering a new appreciation for the role of cartilage during repair, the variety of cell types that may have differing roles in repair, and the recent availability of powerful lineage tracing techniques. We are optimistic that emerging genetic tools will make it possible to precisely define when and in which cells promoting Hh signaling can best promote skeletal repair, and thus, the clinical potential for targeting the Hh pathway can be realized. | Stephanie T.Kuwahara Shuwan Liu Andrew Chareunsouk Maxwell Serowoky Francesca V.Mariani | 2022 | Bone Research2022，10，1： | 0 |
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