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| 1 | The effects of air temperature and precipitation on the net primary productivity in China during the early 21st century显示文摘Research on how terrestrial ecosystems respond to climate change can reveal the complex interactions between vegetation and climate,net primary productivity (NPP),an important vegetation parameter and ecological indicator,fluctuates within any given ecological environment or regional carbon budget.In this study, spatial interpolation was used to generate a spatial dataset, with 1-km spatial resolution,with meteorological data from 736 observation stations across China.An improved CASA model was used to simulate NPP over the period of 2001-2013 by taking into account land-cover change in every year during the same period.We propose the grid- based spatial patterns and dynamics of annual NPP,annual average temperature,and annual total precipitation based on the model.We also used the model to demonstrate the spatial correlation between NPP,temperature,and pre- cipitation in the study area with special focus on the impact of climate change in the early 21st century.Results showed that the spatial pattern of NPP over all of China is characterized by higher values in the southeast and lower values in the northwest.The spatial pattern of temperature indicates substantial latitudinal differences across the country,and the spatial pattem of precipitation shows a ribbon of decline from the southeast coast to the northwest inland.Most areas show an upward trend in NPP. Temperatures appear to decrease across the country during the global warming hiatus (1998-2008),and are accom- panied by an increase in precipitation over most regions.The correlation between NPP and annual average temperature is weak.Alternatively,NPP and annual total precipitation are positively correlated in northern and central China at a coefficient above 0.64(p <0.01)yet negatively correlated in the eastem parts of the Qinghai- Tibet Plateau and Sichuan Basin.Results can provide useful information for improving parameters for calibra- tion of the terrestrial ecosystem process model. | Qianfeng WANG Jingyu ZENG Song LENG Bingxiong FAN Jia TANG Cong JIANGs Yi HUANG Qing ZHANG Yanping QU Wnlin WANG Wei SHUI | 2018 | Frontiers of Earth Science2018，12，4： | 6 |
| 2 | Mutation analyses of integrated HBV genome in hepatitis B patients显示文摘Little has been learnt in the last 30 years about detection of HBV genome as well as its mutation analysis between hepatitis B fathers (HBF) and their children. In this study, we used nest polymerase chain reaction (PCR), fluorescence in situ hybridization (FISH), and DNA sequencing analysis, to examine the integrated HBV genome in paraffin-embedded testis tissues, which were taken as samples from HBF, and in peripheral blood mononuclear cells (PBMC) from 74 cases of HBFs and their children who were born after their fathers’ HBV infection (caHBF). We found that HBV DNA existed in testis tissues, mainly in the basilar parts of the seminiferous tubules, and also in PBMC of HBF. It was also documented that there were point mutations of poly-loci, insertions and deletions of nucleotides in integrated HBV genomes, and the types of gene mutations in the HBFs were similar to those in caHBF. This study addresses the major types of gene mutations in integrated HBV genome in human patients and also presents reliable evidence of possible genetic transmission of hepatitis B. | Peilin Wang Xiuhai Wang Shuying Cong Hongming Ma Xuecheng Zhang | 2008 | Journal of Genetics and Genomics2008，35，2： | 6 |
| 3 | Microwave ablation of primary breast cancer inhibits metastatic progression in model mice via activation of natural killer cells显示文摘Surgery is essential for controlling the symptoms and complications of stage IV breast cancer.However,locoregional treatment of primary tumors often results in distant progression,including lung metastasis,the most common type of visceral metastasis.As a minimally invasive thermal therapy,microwave ablation(MWA)has been attempted in the treatment of breast cancer,but the innate immune response after MWA has not yet been reported.Using two murine models of stage IV breast cancer,we found that MWA of primary breast cancer inhibited the progression of lung metastasis and improved survival.NK cells were activated after MWA of the primary tumor and exhibited enhanced cytotoxic functions,and the cytotoxic pathways of NK cells were activated.Depletion experiments showed that NK cells but not CD4+or CD8+T cells played a pivotal role in prolonging survival.Then,we found that compared with surgery or control treatment,MWA of the primary tumor induced completely different NK-cell-related cytokine profiles.Macrophages were activated after MWA of the primary tumor and produced IL-15 that activated NK cells to inhibit the progression of metastasis.In addition,MWA of human breast cancer stimulated an autologous NK-cell response.These results demonstrate that MWA of the primary tumor in metastatic breast cancer inhibits metastatic progression via the macrophage/IL-15/NK-cell axis.MWA of the primary tumor may be a promising treatment strategy for de novo stage IV breast cancer,although further substantiation is essential for clinical testing. | Muxin Yu Hong Pan Nan Che Li Li Cong Wang Yue Wang Ge Ma Mengjia Qian Jiawei Liu Mingjie Zheng Hui Xie Lijun Ling Yi Zhao Xiaoxiang Guan Qiang Ding Wenbin Zhou Shui Wang | 2021 | Cellular & Molecular Immunology2021，18，9： | 5 |
| 4 | Rnf20 deficiency in adipocyte impairs adipose tissue development and thermogenesis显示文摘RNF20,an E3 ligase critical for monoubiquitination of histone H2B at lysine 120(H2Bub),has been implicated in the regulation of various cellar processes;however,its physiological roles in adipocytes remain poorly characterized.Here,we report that the adipocyte-specific knockout of Rnf20(ASKO)in mice led to progressive fat toss,organomegaly and hyperinsulinemia.Despite signs of hyperinsulinemia,normal insulin sensitivity and improved glucose tolerance were observed in the young and aged CD-fed ASKO mice.In addition,high-fat diet-fed ASKO mice developed severe liver steatosis.Moreover,we observed that the ASKO mice were extremely sensitive to a cold environment due to decreased expression levels of brown adipose tissue(BAT)selective genes,including uncoupling protein 1(l/cpf),and impaired mitochondrial functions.Significantly decreased levels of peroxisome proliterator-activated receptor gamma(Ppary)were observed in the gonadal white adipose tissues(gWAT)from the ASKO mice,suggesting that Rnf20 regulates adipogenesis,at least in part,through Ppary.Rosiglitazone-treated ASKO mice exhibited increased fat mass compared to that of the non-treated ASKO mice.Collectively,our results illustrate the critical role of RNF20 in control of white and brown adipose tissue development and physiological function. | Xiaojuan Liang Cong Tao Jianfei Pan Lilan Zhang Lulu Liu Ying Zhao Yiping Fan Chunwei Cao Jiali Liu Jin Zhang Sin Man Lam Guanghou Shui Wanzhu Jin Wei Li Jianguo Zhao Kui Li Yanfang Wang | 2021 | Protein & Cell2021，12，6： | 1 |
| 5 | Experimental investigation on the invert stability of operating railway tunnels with different drainage systems using 3D printing technology显示文摘In recent years, the invert anomalies of operating railway tunnels in water-rich areas occur frequently,which greatly affect the transportation capacity of the railway lines. Tunnel drainage system is a crucial factor to ensure the invert stability by regulating the external water pressure(EWP). By means of a threedimensional(3D) printing model, this paper experimentally investigates the deformation behavior of the invert for the tunnels with the traditional drainage system(TDS) widely used in China and its optimized drainage system(ODS) with bottom drainage function. Six test groups with a total of 110 test conditions were designed to consider the design factors and environmental factors in engineering practice,including layout of the drainage system, blockage of the drainage system and groundwater level fluctuation. It was found that there are significant differences in the water discharge, EWP and invert stability for the tunnels with the two drainage systems. Even with a dense arrangement of the external blind tubes, TDS was still difficult to eliminate the excessive EWP below the invert, which is the main cause for the invert instability. Blockage of drainage system further increased the invert uplift and aggravated the track irregularity, especially when the blockage degree is more than 50%. However, ODS can prevent these invert anomalies by reasonably controlling the EWP at tunnel bottom. Even when the groundwater level reached 60 m and the blind tubes were fully blocked, the invert stability can still be maintained and the railway track experienced a settlement of only 1.8 mm. Meanwhile, the on-site monitoring under several rainstorms further showed that the average EWP of the invert was controlled within 84 k Pa, while the maximum settlement of the track slab was only 0.92 mm, which also was in good agreement with the results of model test. | Linyi Li Junsheng Yang Jinyang Fu Shuying Wang Cong Zhang Maolong Xiang | 2022 | Journal of Rock Mechanics and Geotechnical Engineering2022，14，5： | 1 |
| 6 | Differential gene expression of the key signalling pathway in para‐carcinoma, carcinoma and relapse human pancreatic cancer显示文摘 | Zheng‐Yan Chang Ran Sun Yu‐Shui Ma Da Fu Xiao‐Long Lai Yu‐Sheng Li Xing‐Hong Wang Xiao‐Ping Zhang Zhong‐Wei Lv Xian‐Ling Cong Wen‐Ping Li | 2014 | Cell Biochem Funct2014，，3： | 1 |
| 7 | Analysis and validation of diagnostic biomarkers and immune cell infiltration characteristics in pediatric sepsis by integrating bioinformatics and machine learning显示文摘Background Pediatric sepsis is a complicated condition characterized by life-threatening organ failure resulting from a dysregulated host response to infection in children.It is associated with high rates of morbidity and mortality,and rapid detection and administration of antimicrobials have been emphasized.The objective of this study was to evaluate the diagnostic biomarkers of pediatric sepsis and the function of immune cell infiltration in the development of this illness.Methods Three gene expression datasets were available from the Gene Expression Omnibus collection.First,the differentially expressed genes(DEGs)were found with the use of the R program,and then gene set enrichment analysis was carried out.Subsequently,the DEGs were combined with the major module genes chosen using the weighted gene co-expression network.The hub genes were identified by the use of three machine-learning algorithms:random forest,support vector machine-recursive feature elimination,and least absolute shrinkage and selection operator.The receiver operating characteristic curve and nomogram model were used to verify the discrimination and efficacy of the hub genes.In addition,the inflammatory and immune status of pediatric sepsis was assessed using cell-type identification by estimating relative subsets of RNA transcripts(CIBERSORT).The relationship between the diagnostic markers and infiltrating immune cells was further studied.Results Overall,after overlapping key module genes and DEGs,we detected 402 overlapping genes.As pediatric sepsis diagnostic indicators,CYSTM1(AUC=0.988),MMP8(AUC=0.973),and CD177(AUC=0.986)were investigated and demonstrated statistically significant differences(P<0.05)and diagnostic efficacy in the validation set.As indicated by the immune cell infiltration analysis,multiple immune cells may be involved in the development of pediatric sepsis.Additionally,all diagnostic characteristics may correlate with immune cells to varying degrees.Conclusions The candidate hub genes(CD177,CYSTM1,and MMP8)were identified,and the nomogram was constructed for pediatric sepsis diagnosis.Our study could provide potential peripheral blood diagnostic candidate genes for pediatric sepsis patients. | Wen‑Yuan Zhang Zhong‑Hua Chen Xiao‑Xia An Hui Li Hua‑Lin Zhang Shui‑Jing Wu Yu‑Qian Guo Kai Zhang Cong‑Li Zeng Xiang‑Ming Fang | 2023 | World Journal of Pediatrics2023，19，11： | 0 |
| 8 | Threats and Avoidance Measures of Frost Damage of‘Shushanggan’Apricot in the Ili River Valley显示文摘[Objectives]To explore the threat factors of frost damage to‘Shushanggan’Apricot in the Ili River Valley,and to provide measures for avoiding frost damage.[Methods]Based on the meteorological data of the Ili River Valley counties and cities during the 12 years from 2010 to 2021 and using the critical low temperature of‘Shushanggan’Apricot as the main factor,we comprehensively analyzed the threats of low temperature in winter in January and late frost in April in spring in the Ili River Valley.[Results]During the 12 years,there were 4 years of low temperature below the critical(-26—-28℃)of‘Shushanggan’Apricot in the Ili River Valley counties and cities in January,accounting for 33.3%,and a total of 59 d.The frequency of occurrence was:Nilka County>Qapqal County>Yining City>Gongliu County>Huocheng County>Khorgos City>Yining County>Tekes County>Xinyuan County.In April,there were 9 years with a low temperature below the critical temperature(-0.6℃)flowering and fruit setting of‘Shushanggan’Apricot,accounting for 75%,and a total of 134 d.The frequency of occurrence was:Nilka County>Tekes County>Gongliu County>Yining County>Huocheng County>Khorgos City>Xinyuan County>Yining City>Qapqal County.The low temperature threats of‘Shushanggan’Apricot suitable cultivation areas were ranked as follows:Nilka County>Gongliu County>Tekes County>Qapqal County>Huocheng County>Yining City>Yining County>Khorgos City>Xinyuan County.Combined with the observation and survey of frost damage on the spot,we comprehensively analyzed and evaluated the cultivation area of‘Shushanggan’Apricot in the Ili River Valley:three counties(Nilka County,Gongliu County,and Tekes County)in the eastern region,except Xinyuan County,suffered frequent late frost damage,are suitable areas for the cultivation of‘Shushanggan’Apricot;three counties and two cities in the western region(Qapqal County,Huocheng County,Yining City,Yining County,Khorgos City)and Xinyuan County in the eastern region are suitable areas for‘Shushanggan’Apricot.The inversion zone at an altitude of 820-1100 in the valley is the superior area for‘Shushanggan’Apricot.[Conclusions]We explored the suitable areas in the origin area of‘Shushanggan’Apricot,and came up with measures to avoid frost damage,to provide a reference for the development of‘Shushanggan’Apricot. | Guizhi CONG Shuying CHEN Yuping MA Jin WANG You SHI | 2021 | Asian Agricultural Research2021，13，5： | 0 |
| 9 | Exploring the abundance and influencing factors of antimicrobial resistance genes in manure plasmidome from swine farms显示文摘Plasmids play a critical role in the dissemination of antimicrobial resistance genes(ARGs),however,a systematical understanding of ARGs originated from plasmids in swine production is currently lacking.Herein,quantitative polymerase chain reaction was applied to determine the prevalence of ten ARGs and the class1 integron gene intI1 of plasmid source in swinemanure from 44 farms in Sichuan,Hubei and Hebei provinces,China.All assayed ARGs were observed in plasmid DNA samples,and the average absolute abundance of aac(6’)-Ib-cr,blaNDM,blaCTX-M,optrA,ermB,floR,mcr-1,qnrS,tetM,sul1 and intI1 were 7.09,2.90,4.67,6.62,7.55,7.14,4.08,4.85,7.16,7.11 and 8.07 of 10 log copies/gram,respectively.IntI1 showed a high correlation(r>0.8,P<0.01)with the abundance of aac(6’)-Ib-cr and sul1 in swine manure.Moreover,the farm scale(i.e.,herd population)and geographical location were not found to be critical factors influencing the absolute abundance of ARGs of plasmid DNA in swine farms.However,the concentrations of florfenicol,Cu,Zn,Fe,total phosphorus(TP)and total potassium(TK)demonstrated a significant correlation with the abundance of several ARGs.Particularly,Cu and Zn had high correlations with optrA and blaCTX-M,respectively.Our results demonstrated that antibiotics,heavy metals and environmental nutrients are likely jointly contributing to the long-term persistence of ARGs in swine production.This study provides insights into the abundance and influencing factors of ARGs from swine manure,which is of significance for assessing and reducing the public health risks in livestock production. | Zunfang Tu Junrui Shui Jinxin Liu Hongmei Tuo Haoyu Zhang Cong Lin Jingyi Feng Yuxuan Feng Wen Su Anyun Zhang | 2023 | Journal of Environmental Sciences2023，，2： | 0 |
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