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| 1 | Randomised controlled trial comparing modified Sano's and narrow band imaging international colorectal endoscopic classifications for colorectal lesions显示文摘AIM To assess the utility of modified Sano′s(MS) vs thenarrow band imaging international colorectal endoscopic(NICE) classification in differentiating colorectal polyps.METHODS Patients undergoing colonoscopy between 2013 and 2015 were enrolled in this trial.Based on the MS or the NICE classifications,patients were randomised for real-time endoscopic diagnosis.This was followed by biopsies,endoscopic or surgical resection.The endoscopic diagnosis was then compared to the final(blinded) histopathology.The primary endpoint was the sensitivity(Sn),specificity(Sp),positive predictive value(PPV) and negative predictive value(NPV) of differentiating neoplastic and non-neoplastic polyps(MSⅡ/Ⅱo/Ⅲa/Ⅲb vs I or NICE 1 vs 2/3).The secondary endpoints were 'endoscopic resectability'(MSⅡ/Ⅱo/Ⅲa vs Ⅰ/Ⅲb or NICE 2 vs 1/3),NPV for diminutive distal adenomas and prediction of post-polypectomy surveillance intervals.RESULTS A total of 348 patients were evaluated.The Sn,Sp,PPV and NPV in differentiating neoplastic polyps from non-neoplastic polyps were,98.9%,85.7%,98.2% and 90.9% for MS;and 99.1%,57.7%,95.4% and 88.2% for NICE,respectively.The area under the receiver operating characteristic curve(AUC) for MS was 0.92(95%CI:0.86-0.98);and AUC for NICE was 0.78(95%CI:0.69,0.88).The Sn,Sp,PPV and NPV in predicting 'endoscopic resectability' were 98.9%,86.1%,97.8% and 92.5% for MS;and 98.6%,66.7%,94.7% and 88.9% for NICE,respectively.The AUC for MS was 0.92(95%CI:0.87-0.98);and the AUC for NICE was 0.83(95%CI:0.75-0.90).The AUC values were statistically different for both comparisons(P = 0.0165 and P = 0.0420,respectively).The accuracy for diagnosis of sessile serrated adenoma/polyp(SSA/P) with high confidence utilizing MS classification was 93.2%.The differentiation of SSA/P from other lesions achieved Sp,Sn,PPV and NPV of 87.2%,91.5%,89.6% and 98.6%,respectively.The NPV for predicting adenomas in diminutive rectosigmoid polyps(n = 150) was 96.6% and 95% with MS and NICE respectively.The calculated accuracy of post-polypectomy surveillance for MS group was 98.2%(167 out of 170) and for NICE group was 92.1%(139 out of 151).CONCLUSION The MS classification outperformed the NICE classification in differentiating neoplastic polyps and predicting endoscopic resectability.Both classifications met ASGE PIVI thresholds. | Leonardo Zorrón Cheng Tao Pu Kuan Loong Cheong Doreen Siew Ching Koay Sze Pheh Yeap Amanda Ovenden Mahima Raju Andrew Ruszkiewicz Philip W Chiu James Y Lau Rajvinder Singh | 2018 | World Journal of Gastrointestinal Endoscopy2018，10，9： | 4 |
| 2 | Effects of degumming and bleaching on 3-MCPD esters formation during physical refining 显示文摘 | RAMLI M R SIEW W L IBRHIM N A | 2011 | Journal of the American Oil Chemists'' Society2011，88，11： | 1 |
| 3 | Changes of volatiles attribute in durian pulp during freeze- and spraydrying process显示文摘 | Song T C Sheikh A H N Siew Y Q | 2008 | LWT - Food Science and Technology2008，10，： | 1 |
| 4 | Enhanced rhythm extration using btind source separation and wavelet transform显示文摘 | SIEW CHEOK N PARAMESRAN R | | 0，，08： | 1 |
| 5 | Osteosarcoma presenting as an aggressive nodular mass in the ot of the mandible Journal of Oral显示文摘 | Siew Tin O Chen - Kiong S Kok- Han N | 2004 | Science2004，，： | 1 |
| 6 | Corrosion protection of lowcarbon steel with polyaniline: passivation or inhibition? 显示文摘 | Cook A Gabriel A Siew D Laycock N | 2004 | CurrentApplied Physics2004，4，234： | 1 |
| 7 | MaxSub: an automated measure for the assessment of protein structure prediction quality 显示文摘 | SIEW N ELOFSSON A RYCHLEWSKI L | 2000 | Bioinformatics2000，16，9： | 1 |
| 8 | Maxsub: an automated measure for the assessment of protein structure prediction quality显示文摘 | Siew N Elofsson A Rychlewski L | 2000 | Bioinformatics2000，16，9： | 1 |
| 9 | Investigating bifurca-tions and chaos in magneto piezoelectric vibrating energy harvesters using Melnikov theory 显示文摘 | Buckjohn C N D Siewe M S Fokou I S M Tchawoua C Kofane T C | 2013 | Physica Scripta2013，88，01： | 1 |
| 10 | MaxSub: An automated measure to assess the quality of protein structure predictions显示文摘 | Siew N | 2000 | Bioinformatics2000，16，： | 1 |
| 11 | New insights into the mechanism of gelation of alginate and pectin: charge annihilation and reversal mechanima显示文摘 | SIEW C K WILLIAMS P A YOUNG N W G | 2005 | Biomacromolecules2005，6，2： | 1 |
| 12 | Convergent evolutions of protein structure prediction and computer chess tournaments: CASP, Kasparov and CAFASP显示文摘 | SIEW N FISCHER D | 2001 | IBM Sys J2001，40，： | 1 |
| 13 | The Physicochemical Properties of Spray - Dried Watermelon Powders 显示文摘 | Siew Y Quek N K Chok P Swedlund | 2007 | Chemical Engineering and Processing2007，46，5： | 1 |
| 14 | Convergent evolutions of protein structure prediction and computer chess tournaments: CASP, Kasparov and CAFASP 显示文摘 | Siew N Fischer D | 2001 | IBM Sys J2001，40，2： | 1 |
| 15 | The Physicochemical Properties of Spray-Dried Watermelon Powders显示文摘 | Siew Y Quek N K Chok P Swedlund | 2007 | Chemical Engineering and Processing2007，46，5： | 1 |
| 16 | Classification of Natural Ventilation Strategies in Optimizing Energy Consumption in Malaysian Office Buildings 显示文摘 | Siew C C Che-Ani A I Tawil N M | 2011 | Procedia Engineering2011，20，： | 1 |
| 17 | FRP as strengthening material for Reinforced Concrete beams with openings-A review 显示文摘 | Siew C C Nasir S Muhd F N | 2015 | KSCE Journal of Civil Engineering2015，19，1： | 1 |
| 18 | Training and organizational effective- ness Moderating role of knowledge management process 显示文摘 | AZMAWANI A R SIEW I N | 2013 | Europe- an Journal of Training and Development2013，37，5： | 1 |
| 19 | Snake postsynaptic neurotoxins: gene structure, phylogeny and applications in research and therapy 显示文摘 | JOYCE SIEW P Y GONG N L FATEMAH A | 2004 | Biochimie2004，86，2： | 1 |
| 20 | In vitro biocompatibility evaluation of poly (3-hydroxybutyrate-co-4- hydroxybutyrate) copolymer in fibroblast cells 显示文摘 | Siew E L Rajab N F Osman A B | 2007 | J Biomed Mater Res A2007，81，2： | 1 |
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