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| 1 | Folate receptor-mediated boron-10 containing carbon nanoparticles as potential delivery vehicles for boron neutron capture therapy of nonfunctional pituitary adenomas显示文摘Invasive nonfunctional pituitary adenomas(NFPAs) are difficult to completely resect and often develop tumor recurrence after initial surgery.Currently,no medications are clinically effective in the control of NFPA.Although radiation therapy and radiosurgery are useful to prevent tumor regrowth,they are frequently withheld because of severe complications.Boron neutron capture therapy(BNCT) is a binary radiotherapy that selectively and maximally damages tumor cells without harming the surrounding normal tissue.Folate receptor(FR)-targeted boron-10 containing carbon nanoparticles is a novel boron delivery agent that can be selectively taken up by FR-expressing cells via FR-mediated endocytosis.In this study,FR-targeted boron-10 containing carbon nanoparticles were selectively taken up by NFPAs cells expressing FR but not other types of non-FR expressing pituitary adenomas.After incubation with boron-10 containing carbon nanoparticles and following irradiation with thermal neutrons,the cell viability of NFPAs was significantly decreased,while apoptotic cells were simultaneously increased.However,cells administered the same dose of FR-targeted boron-10 containing carbon nanoparticles without neutron irradiation or received the same neutron irradiation alone did not show significant decrease in cell viability or increase in apoptotic cells.The expression of Bcl-2 was down-regulated and the expression of Bax was up-regulated in NFPAs after treatment with FR-mediated BNCT.In conclusion,FR-targeted boron-10 containing carbon nanoparticles may be an ideal delivery system of boron to NFPAs cells for BNCT.Furthermore,our study also provides a novel insight into therapeutic strategies for invasive NFPA refractory to conventional therapy,while exploring these new applications of BNCT for tumors,especially benign tumors. | DAI CongXin CAI Feng HWANG Kuo Chu ZHOU YongMao ZHANG ZiZhu LIU XiaoHai MA SiHai YANG YaKun YAO Yong FENG Ming BAO XinJie LI GuiLin WEI JunJi JIAO YongHui WEI ZhenQing MA WenBin WANG RenZhi | 2013 | Science China(Life Sciences)2013，56，2： | 8 |
| 2 | Periodical characteristics of baseflow in the source region of the Yangtze River显示文摘Baseflow,which represents the drainage of groundwater aquifers,is an essential component of runoff in hydrological basins.In the source region of the Yangtze River,the change of baseflow typically reflects the interactions between groundwater system and climatic factors in cold and arid areas.With modified Kalinen separation method,annual baseflow between 1957 and 2009 in this region was estimated and calculated.In comparison with the inner-annual variations of total streamflow,baseflow showed a weaker fluctuation.Before the 1980s,it was in a steady state;and after then,it demonstrated dramatic variations and large amplitudes.Based on the calculation results of baseflow,the real Morlet wavelet method was applied to reveal the periodical characteristics of baseflow as well as the precipitation and air temperature in the study area.It was found that annual baseflow has a 43-year trend as well as a 21-year period and a 7-year period.The 21-year period is most significant,with its wavelet coefficient having the largest fluctuation and amplitude.Summation of wavelet coefficients on these periods exhibits a similar change pattern with respect to that of annual baseflow.The summation curve takes a'W'shape,which means that the baseflow follows a four-stage sequence of descending–ascending–descending–ascending.As analyzed,the relationship among baseflow,precipitation and temperature is implied in the correlation between their normalized wavelet coefficients at different temporal scales.By the significant positive linear correlations both between precipitation and baseflow(correlation coefficient is 0.98)and between temperature and baseflow(correlation coefficient is 0.90)for the 43-year wavelet coefficients,it is suggested that the long-term increasing trends of precipitation and air temperature will lead to an increasing trend of baseflow.For wavelet coefficients of 21-year and 7-year periods,the positive linear correlation between precipitation and baseflow is significant.However,the correlation between air temperature and baseflow is not so evident,especially for the 21-year period.As a conclusion, correlation analysis with normalized wavelet coefficients showed that the change of annual baseflow was contributed mostly by the change of precipitation and secondly by the change of temperature. | KaiZhu QIAN Li WAN XuSheng WANG JingJing LV SiHai LIANG | 2012 | Journal of Arid Land2012，4，2： | 7 |
| 3 | The RNA-binding protein Musashi2 governs osteoblast-adipocyte lineage commitment by suppressing PPARγsignaling显示文摘Osteoporosis caused by aging is characterized by reduced bone mass and accumulated adipocytes in the bone marrow cavity. How the balance between osteoblastogenesis and adipogenesis from bone marrow mesenchymal stem cells(BMSCs) is lost upon aging is still unclear. Here, we found that the RNA-binding protein Musashi2(Msi2) regulates BMSC lineage commitment. Msi2 is commonly enriched in stem cells and tumor cells. We found that its expression was downregulated during adipogenic differentiation and upregulated during osteogenic differentiation of BMSCs. Msi2 knockout mice exhibited decreased bone mass with substantial accumulation of marrow adipocytes, similar to aging-induced osteoporosis. Depletion of Msi2 in BMSCs led to increased adipocyte commitment. Transcriptional profiling analysis revealed that Msi2 deficiency led to increased PPARγ signaling.RNA-interacting protein immunoprecipitation assays demonstrated that Msi2 could inhibit the translation of the key adipogenic factor Cebpα, thereby inhibiting PPAR signaling. Furthermore, the expression of Msi2 decreased significantly during the aging process of mice, indicating that decreased Msi2 function during aging contributes to abnormal accumulation of adipocytes in bone marrow and osteoporosis. Thus, our results provide a putative biochemical mechanism for aging-related osteoporosis, suggesting that modulating Msi2 function may benefit the treatment of bone aging. | Jinlong Suo Sihai Zou Jinghui Wang Yujiao Han Lingli Zhang Chenchen Lv Bo Jiang Qian Ren Long Chen Lele Yang Ping Ji Xianyou Zheng Ping Hu Weiguo Zou | 2022 | Bone Research2022，10，3： | 5 |
| 4 | A two-parameter model for ion exchange process of ion-adsorption type rare earth ores显示文摘The establishment of a mathematical model for the ion exchange process is key to creating a theoretical basis for the mining of ion-adsorption type rare earth ores.Ore samples from Xinfeng,Xunwu and Anyuan were used as the test ore samples in the present study and equilibrium batch tests of ore sample leaching using various ammonium sulfate concentrations were performed.The results show that,after leaching,there is a negative exponential relationship between the ratio of the solid-phase rare earth ion concentration to the aqueous-phase rare earth ion concentration and the initial ammonium ion concentration.However,there is a linear relationship between the natural logarithm of the ratio of the solidphase ammonium ion concentration to the aqueous-phase ammonium ion concentration and the initial ammonium ion concentration.Based on the above two functional relationships,a two-parameter model for the equilibrium ion exchange process of ion-adsorption type rare earth ores was established.Using the established model to analyze the test data the model error for the Xunwu ore sample is found to be less than 5%.The proposed model is more accurate compared with the Kerr model.The two-parameter model proposed in this study provides theoretical support for the numerical simulation of column leaching(in-situ leaching)of ion-adsorption type rare earth ores. | Ping Long Guanshi Wang Chao Zhang Ying Huang Sihai Luo | 2020 | Journal of Rare Earths2020，38，11： | 4 |
| 5 | Effect of AAPH oxidation on digestion characteristics of seed watermelon(Citrullus lanatus var)kernels protein isolates显示文摘Seed watermelon kernel is a typical complex food with high fat and protein contents.During storage and processing,it is often affected by various factors to undergo interactions between components,which lead to its quality change.In this experiment,seed watermelon kernels were used as research objects,and the effects of 2-Azobis(2-amidinopropane)dihydrochloride(AAPH)on seed watermelon kernel protein isolates(WMP)were investigated.The structure and digestion characteristics of WMP after oxidation were studied.The results showed that with the increase of AAPH concentration(0.05−5 mol/L),WMP showed obvious aggregation,and its solubility decreased from 6.76 mg/mL to 9.59 mg/mL.The free sulfhydryl content of WMP was 18.24 mmol/g decreased to 11.25 mmol/g,α-helix decreased andβ-sheet decreased in secondary structure,and its disulfide bond increased by 43.06 mmol/g from 39.57 mmol/g,enthalpy(H)and denaturation temperature increased(Td)(P<0.05).By mass spectrometry results of simulated gastric digestion products,it was found that oxidation adversely affected the digestion characteristics of WMP.It can be seen that the lipid oxidation product APPH of seed watermelon kernel can significantly affect the structure and function of the protein extracted from the seed kernel. | Shugang Li Zhihao Li Xiuting Li Ping Wang Xiongwei Yu Qinli Fu Sihai Gao | 2020 | Food Science and Human Wellness2020，9，4： | 3 |
| 6 | Investigations on femtosecond laser-induced surface modification and periodic micropatterning with anti-friction properties on Ti6Al4V titanium alloy显示文摘Titanium alloys have a wide application in aerospace industries as it has greater strength and low density, but it has poor tribological properties. To improve its friction and wear performance, in present work, a femtosecond laser is used to directly irradiate the Ti6Al4V titanium alloy surface in air conditioning, which results in localized ablation and the formation of periodic microstructures but also a strong pressure wave, propagating the material inside. Through the optimization of processing parameters, surface modification and periodic micropatterning with effective anti-friction properties were successfully induced on the surface. After a treatment of femtosecond laser-induced surface modification(FsLSM), the surface microhardness was improved by 16.6% and compressive residual stress reached-746 MPa. Besides, laser-induced periodic surface structures(LIPSS) with a titanium oxide outer coating were fabricated uniformly on the titanium alloy surface. Rotary ball-on-disk wear experiments revealed that the average coefficient of friction(COF) and wear mass loss of the specimen with Fs LSM treatment were largely reduced by 68.9% and 90% as compared to that of untreated specimens, respectively. It was analyzed that the reason for the remarkable wear resistance was attributed to the comprehensive action of the generation of LIPSS, the titanium oxide outer coating, high amplitude compressive residual stress and gradient grain size distribution on the subsurface during the laser surface treatment. Since the findings here are broadly applicable to a wide spectrum of engineering metals and alloys, the present results offer unique pathways to enhancing the tribological performance of materials. | Xinlei PAN Weifeng HE Zhenbing CAI Xuede WANG Ping LIU Sihai LUO Liucheng ZHOU | 2022 | Chinese Journal of Aeronautics2022，35，4： | 2 |
| 7 | Novel sol-gel material for fabrication of a long period waveguide grating filter as a precise thermometer显示文摘A new kind of organic-inorganic hybrid HfO 2/SiO 2 sol-gel material with a large thermo-optic coefficient and a wide linear tunable temperature range has been developed for fabrication of a long period waveguide grating (LPWG) filter,whose parameters were optimized and designed by using finite difference time domain (FDTD) simulations.The LPWG filter,a periodic rectangle-corrugated grating structure,was easily fabricated with soft-lithography technique.At a temperature range from 19°C to 70°C,the fabricated LPWG filter element demonstrated a high temperature sensitivity of about 6.5 nm/°C and a wide linear tunable temperature range of 51°C,so that it can be used as a precise thermometer.Our results are useful for the designs of LPWG filters for the implementation of a wide range of thermo-optic functions. | WANG Xin LI XiaoChan ZHANG Tao HU CanDong ZHU QiuXiang CHEN SiHai LI Yun XU Jia HE Miao NIU QiaoLi ZHAO LingZhi LI ShuTi ZHANG Yong | 2011 | Science China(Physics,Mechanics & Astronomy)2011，54，11： | 2 |
| 8 | Distributed fiber Raman amplifiers: analytical e xpression of noise characteristics under complex conditions 显示文摘 | FAN Chongcheng | 2001 | Optics C ommunications2001，198，13： | 1 |
| 9 | Vanadium oxide thin films deposited on silicon dioxide buffer layers by magnetron sputtering显示文摘 | CI-IEN Sihai MA Hong WANG Shuangbao | 2006 | Thin Solid Films2006，497，： | 1 |
| 10 | Low temperature fabri- cation of vanadium oxide films for uncooled bolometric detectors 显示文摘 | WANG Hongchen YI Xinjian CHEN Sihai | 2006 | Infrared Physics & Technology2006，47，： | 1 |
| 11 | Algorithm research of the SQP method used in roll schedule calculation for Baosteel's 5m heavy plate显示文摘Loading distribution for heavy plate mill is to find optimal control solutions under the granted performance indicators and constraints including mill capacity and hypothesis of rolling models.The solutions are quite different for different performance indicators.In the article,the performance indicators and sequential quadratic programming(SQP for short below) methods employed in 5 000 mm heavy plate mill of BaoSteel are penetratingly analyzed.Generally,the SQP method is an effective and fast way to solve the nonlinear programming problems with small or medium scale constraints.Early in 1976,Han put forward the SQP method for the first time and Powell made it perfect and accomplished the algorithm in 1977.In fact, SQP method was to turn a nonlinear programming problem to a series of sub set of quadratic programming problems.In the algorithm,each iteration step is to solve one quadratic programming problem.The optimal solutions will be gradually approached after quadratic programming problems were totally solved.When solving the quadratic programming problem,the active set strategy were employed which turned the constrained quadratic programming problem to unconstrained quadratic programming problem.The active set strategy made the whole quadratic programming problem be solved by a least square problem.And finally, the matrix of the least square problem would be decomposed by Q matrix and R matrix.After Q matrix and R matrix were obtained,the optimal solutions would be finally found.For loading distribution,the performance indicators were composed by plate shape and draft of each pass.Plate shape is represented by rolling force gradually reduced pass by pass with a tunable factor.The mill capacity is another performance indicator represented by draft of each pass.For heavy plate mill,the mill capacity here is the motor moment. For heavy draft,the motor would be overloaded especially for the first several passes;for small draft,the motor would be loaded slightly.All these would not be permitted to happen when calculating the loading distribution.The mill capacity indicator made the loading of mill just be in the middle,not too much and not too low.In the article,these two performance indicators were analyzed in detail.Examples of loading distribution results with different performance indicators were given by the SQP method.When making changes to the performance indicators,there would be different solutions to the loading distribution.For the optimal solutions to the mill,there was supposed to make changes to the factors of the performance indicators or upgrade the accuracy of the mathematical models of the rolling process. | MIAO Yuchuan~(1)),JIAO Sihai~(1)),WANG Jian~(1)),LUO Wentao~(1)) and WANG qi~(1)) 1) Baoshan Iron & Steel Co.,Ltd.,Shanghai 201900,China 2) Shanghai Rollware.Co.,Ltd.,Shanghai 201213,China | 2010 | Baosteel Technical Research2010，4，S1： | 1 |
| 12 | Vanadium oxide thin films deposited on silicon dioxide buffer layers by magnetron sputtering 显示文摘 | Chen Sihai Ma Hong Wang Shuangbao | 2006 | Thin Solid Films2006，497，12： | 1 |
| 13 | Cooperative wireless networks for better green services显示文摘In order to guarantee the overall return on investment (ROI), improve user experience and quality of service (QoS), save energy, reduce electra magnetic interference (EMI) and radiation pollution, and enable the sustainable deployment of new profitable applications and services in heterogeneous wireless networks coexistence reality, this paper proposes a cross-network cooperation mechanism to effectively share network resources and infrastructures, and then adaptively control and match multi-network energy distribution characteristics according to actual user/service requirements in different geographic areas. Some idle or lightly-loaded base stations (BS or BSs) will be temporally turned off for saving energy and reducing EMI. Initial simulation results show that the proposed approach can significantly improve the overall energy efficiency and QoS performance across multiple cooperative wireless networks. | Yang Yang Zhang Wuxiong Hu Honglin Zhang Sihai Wang Xin Zhao Haitao Zhou Wuyang Wei Jibo | 2011 | Engineering Sciences2011，9，1： | 1 |
| 14 | Vanadium oxide thin films deposited on silicon dioxide buffer layers by magnetron sputtering显示文摘 | CHEN Sihai MA Hong WANG Shuangbao | 2006 | Thin Solid Films2006，497，： | 1 |
| 15 | Smart VO 2 thin film for protection of sensitive infrared detectors from strong laser radiation显示文摘 | Sihai Chen Hong Ma Xinjian Yi Tao Xiong Hongcheng Wang Caijun Ke | 2004 | Sensors & Actuators: A Physical2004，，1： | 1 |
| 16 | Planarization of CMOS ROIC dies for uncooled detectors 显示文摘 | Wang Hongchen Yi Xinjian Chen Sihai | 2006 | Infrared Physics & Technology2006，47，： | 1 |
| 17 | Low temperature fabrication of vanadium oxide films for uncooled bolometric detectors 显示文摘 | Hongchen Wang Xinjian Yi Sihai Chen | 2006 | Infrared Physics & Technology2006，47，3： | 1 |
| 18 | Low temperature fabrication of vanadium oxide films for uncooled bolometricdetectors显示文摘 | Wang Hongchen Yi Xinjian Chen Sihai | 2006 | Infrared Physics & Technology2006，47，3： | 1 |
| 19 | Development of a roll-bonded UNS N08825 alloy clad pipeline steel in Baosteel显示文摘In this study,a roll-bonded UNS N088225 alloy clad pipeline steel was investigated and developed in Baosteel. Based on the requirements of a number of potential projects,we performed a series of strict evaluations including mechanical and corrosion tests. The results show the mechanical properties and corrosion resistance of this clad steel to be excellent and to meet the requirements of all the design parameters. | LIANG Xiaojun MA Tianjun FU Yanhong JIAO Sihai DING Jianhua YUAN Xiangqian WANG Baosen ZHANG Qingfeng | 2017 | Baosteel Technical Research2017，11，1： | 1 |
| 20 | Vanadium oxide thin films deposited on silicon dioxide buffer layers by magnetron sputtering显示文摘 | i Chen Sihai Ma Hong Wang Shuangbao | 2006 | Thin Solid Films2006，497，12： | 1 |
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