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| 1 | Role of Hox genes in stem cell differentiation显示文摘Hox genes are an evolutionary highly conserved gene family. They determine the anterior-posterior body axis in bilateral organisms and influence the developmental fate of cells. Embryonic stem cells are usually devoidof any Hox gene expression, but these transcription factors are activated in varying spatial and temporal patterns defining the development of various body regions. In the adult body, Hox genes are among others responsible for driving the differentiation of tissue stem cells towards their respective lineages in order to repair and maintain the correct function of tissues and organs. Due to their involvement in the embryonic and adult body, they have been suggested to be useable for improving stem cell differentiations in vitro and in vivo. In many studies Hox genes have been found as driving factors in stem cell differentiation towards adipogenesis, in lineages involved in bone and joint formation, mainly chondrogenesis and osteogenesis, in cardiovascular lineages including endothelial and smooth muscle cell differentiations, and in neurogenesis. As life expectancy is rising, the demand for tissue reconstruction continues to increase. Stem cells have become an increasingly popular choice for creating therapies in regenerative medicine due to their self-renewal and differentiation potential. Especially mesenchymal stem cells are used more and more frequently due to their easy handling and accessibility, combined with a low tumorgenicity and little ethical concerns. This review therefore intends to summarize to date known correlations between natural Hox gene expression patterns in body tissues and during the differentiation of various stem cells towards their respective lineages with a major focus on mesenchymal stem cell differentiations. This overview shall help to understand the complex interactions of Hox genes and differentiation processes all over the body as well as in vitro for further improvement of stem cell treatments in future regenerative medicine approaches. | Anne Seifert David F Werheid Silvana M Knapp Edda Tobiasch | 2015 | World Journal of Stem Cells2015，7，3： | 10 |
| 2 | Environmental expo- sure to asbestos and other inorganic fibers using animal lung model显示文摘 | Elisa F Elena B Silvana C | 2009 | Total Envir2009，407，3： | 1 |
| 3 | Effect of sewage sludge on microbial biomass,basal respiration,metabolic quotient and soil enzymatic activity显示文摘 | Silvana A P F Wagner B Carlos C C | 2005 | Applied Soil Ecology2005，30，： | 1 |
| 4 | Coenzyme Q10 in cardiovascular disease显示文摘 | SALVATOR P SILVANA F STEVEN J | 2007 | Mitochondrion2007，7，1： | 1 |
| 5 | Production of extracellular β-glucosidase by Monascus purpureus on different growth substrates显示文摘 | DANELJ DAROTT SILVANA T SILVEIVA PLINHO F HERTZ | 2007 | Process Biochemistry2007，42，5： | 1 |
| 6 | Bioactive extracts of red seaweeds Pterocladiella capillacea and Osmundaria obtusiloba(Floridophyceae:Rhodophyta) with antioxidant and bacterial agglutination potential显示文摘Objective:To evaluate the antioxidant,antibacterial and bacterial cell agglutination activities of the hexane(Hex) and 70%ethanol(70%EtOH) extracts of two species of red seaweeds Pterocladiella capillacea(P.capillacea) and Osmundaria obtusiloba.Methods:In vitro antioxidant activity was determined by DPPH radical scavenging assay,ferric-reducing antioxidant power assay,ferrous ion chelating assay,β-carotene bleaching assay and total phenolic content quantification.Antimicrobial activity was tested using the method of disc diffusion on Mueller-Hinton medium.The ability of algal extracts to agglutinate bacterial cells was also tested.Results:The 70%EtOH extract of the two algae showed the highest values of total phenolic content compared to the Hex extract.The results of DPPH for both extracts(Hex,70%EtOH) of Osmundaria obtusiloba(43.46%and 99.47%) were higher than those of P.capillacea(33.04%and 40.81%) at a concentration of 1 000 μg/mL.As for the ferrous ion chelating,there was an opposite behavior,extracts of P.capillacea had a higher activity.The extracts showed a low ferric-reducing antioxidant power,with optical density ranging from0.054 to 0.180.Antioxidant activities of all extracts evaluated for β-carotene bleaching were above 40%.There was no antibacterial activity against bacterial strains tested.However,the extracts of both species were able to agglutinate bacterial Gram positive cells of Staphylococcus aureus and Gram negative cells of Escherichia coli,multidrug-resistant Salmonella and Vibrio harveyi.Conclusions This is the first report of the interaction between these algal extracts,rich in natural compounds with antioxidant potential,and Gram positive and Gram negative bacterial cells. | Daniel Barroso de Alencar Fátima Cristiane Teles de Carvalho Rosa Helena Rebouas Daniel Rodrigues dos Santos Kelma Maria dos Santos Pires-Cavalcante Rebeca Larangeira de Lima Bárbara Mendes Baracho Rayssa Mendes Bezerra Francisco Arnaldo Viana Regine Helena Silva dos Fernandes Vieira Alexandre Holanda Sampaio Oscarina Viana de Sousa Silvana Saker-Sampaio | 2016 | Asian Pacific Journal of Tropical Medicine2016，9，4： | 1 |
| 7 | Amoxicillin-loaded polyethylcyanoacrylate nanoparticles: Influence of PEG coating on the particle size, drug release rate and phagocytic uptake显示文摘 | Giacomo F Mariano L Silvana M | 2001 | Biomaterials2001，22，： | 1 |
| 8 | Managing workflow authorization constraints through active database technology显示文摘 | FABIO C SILVANA C MARIA G F | 2001 | Information Systems Frontiers2001，3，3： | 1 |
| 9 | Production of extracellular 13-glucosidase by Monascus purpureus on different growth substrates显示文摘 | Daniel J Daroit Silvana T Silveira Plinho F Hertz | 2007 | Process Biochemistry2007，42，： | 1 |
| 10 | Anemone Toxin (ATX Ⅱ)-induced Increase in Persistent Sodium Current: Effects on the Firing Properties of Rat Neocortical Pyramidal Neurons显示文摘 | MASSIMO M SILVANA F GIULIANO A | 1998 | J Phsiol1998，507，1： | 1 |
| 11 | Intellectual and language findings and their relationship to EEG characteristics in benign childhood epilepsy with centrotemporal spikes 显示文摘 | Daria R Chiara V Silvana F | 2007 | Epilepsy Behav2007，10，2： | 1 |
| 12 | Action of Microbial Transglutaminase (MTGase) in the Modification of Food Proteins : A Review 显示文摘 | Ana L C G Silvana P D G F | 2015 | Food Chem2015，171，2： | 1 |
| 13 | Transient simula-tion of a storage floor with a heating/cooling parallel pipe sys-tem显示文摘 | SILVANA F L FILIPPIN C LESINO G | 2010 | Building Simulation2010，3，2： | 1 |
| 14 | Microbial enzymatic activity and thermal effect in a tropical soil treated with organic materials显示文摘 | KARINA C SUELI S F SILVANA A M C | 2008 | Soils and Plant Nutrition2008，65，6： | 1 |
| 15 | Environmental exposure to asbestos and other inorganic fibres using animal lung model 显示文摘 | Elisa F Elena B Silvana C | 2009 | Sci Total Envir2009，407，3： | 1 |
| 16 | Amoxicillin-loaded polyethylcyanoacrylate nanoparticles: Influenceof PEG coating on the particle size, drug release rate and phagocytic uptake显示文摘 | Mariano L Silvana M | 2001 | Biomaterials2001，22，： | 1 |
| 17 | Production of extracellular β-glucosidase by monascus purpureus on different growth substrates显示文摘 | Daniel J Daroit Silvana T Silveira Plinho F Hertz | 2007 | Process Biochemistry2007，42，5： | 1 |
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