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7篇 您的检索式:作者名="Simianu"
    题名 作者 年代 出处 被引量
1Use of the surgical safety checklist to improve communication and reduce complications 显示文摘Pugel AE Simianu VV Flum DR 2015J Infect Public Health2015,8,3:1
2Evaluating the mechanisms of improved glucose homeostasis after bariatric surgery in Ossabaw miniature swine显示文摘Sham JG Simianu VV Wright AS 2014J Diabetes Res2014,2014,52:1
3SJWK14081300000036显示文摘Vlad V. Simianu Amir L. Bastawrous Richard P. Billingham Ellen T. Farrokhi Alessandro Fichera Daniel O. Herzig Eric Johnson Scott R. Steele Richard C. Thirlby David R. Flum 2014Annals of Surgery2014,,3:1
4Contemporary,national patterns of surgery after preoperative therapy for stageⅡ/Ⅲrectal adenocarcinoma显示文摘BACKGROUND Contemporary treatment of stageⅡ/Ⅲrectal cancer combines chemotherapy,chemoradiation,and surgery,though the sequence of surgery with neoadjuvant treatments and benefits of minimally-invasive surgery(MIS)is debated.AIM To describe patterns of surgical approach for stageⅡ/Ⅲrectal cancer in relation to neoadjuvant therapies.METHODS A retrospective cohort was created using the National Cancer Database.Primary outcome was rate of sphincter-sparing surgery after neoadjuvant therapy.Secondary outcomes were surgical approach(open,laparoscopic,or robotic),surgical quality(R0 resection and 12+lymph nodes),and overall survival.RESULTS A total of 38927 patients with clinical stageⅡorⅢrectal adenocarcinoma underwent surgical resection from 2010-2016.Clinical stageⅡpatients had neoadjuvant chemoradiation less frequently compared to stageⅢ(75.8%vs 84.7%,P<0.001),but had similar rates of total neoadjuvant therapy(TNT)(27.0%vs 27.2%,P=0.697).Overall rates of total mesorectal excision without sphincter preservation were similar between clinical stageⅡandⅢ(30.0%vs 30.3%)and similar if preoperative treatment was chemoradiation(31.3%)or TNT(30.2%).Over the study period,proportion of cases approached laparoscopically increased from 24.9%to 32.5%and robotically 5.6%to 30.7%(P<0.001).This cohort showed improved survival for MIS approaches compared to open surgery(laparoscopy HR 0.85,95%CI 0.78-0.93,and robotic HR 0.82,95%CI 0.73-0.92).CONCLUSION Sphincter preservation rates are similar across stageⅡandⅢrectal cancer,regardless of delivery of preoperative chemotherapy,chemoradiation,or both.At a national level,there is a shift to predominantly MIS approaches for rectal cancer,regardless of whether sphincter sparing procedure is performed.Celine Soriano Henry T Bahnson Jennifer A Kaplan Bruce Lin Ravi Moonka Huong T Pham Hagen F Kennecke Vlad Simianu 2022World Journal of Gastrointestinal Oncology2022,14,6:0
5Rethinking elective colectomy for diverticulitis: A strategic approach to population health显示文摘Diverticulitis is one of the leading indications for elective colon resection. Surgeons are trained to offer elective operations after a few episodes of diverticulitis in order to prevent future recurrences and potential emergency. However, most emergency surgery happens during the initial presentation. After recovery from an episode, much of the subsequent management of diverticulitis occurs in the outpatient setting, rendering inpatient 'episode counting' a poor measure of the severity or burden of disease. Evidence also suggests that the risk of recurrence of diverticulitis is small and similar with or without an operation. Accordingly, contemporary evaluations of the epidemiologic patterns of treatments for diverticulitis have failed to demonstrate that the substantial rise in elective surgery over the last few decades has been successful at preventing emergency surgery at a population level. Multiple professional societies are calling to 'individualize' decisions for elective colectomy and there is an international focus on 'appropriate' indications for surgery. The rethinking of elective colectomy should come from a patient-centered approach that considers the risks of recurrence, quality of life, patient wishes and experiences about surgical and medical treatment options as well as operative morbidity and risks.Vlad V Simianu David R Flum 2014World Journal of Gastroenterology2014,20,44:0
6Diverticulitis is a population health problem:Lessons and gaps in strategies to implement and improve contemporary care显示文摘The disease burden of diverticulitis is high across inpatient and outpatient settings,and the prevalence of diverticulitis has increased.Historically,patients with acute diverticulitis were admitted routinely for intravenous antibiotics and many had urgent surgery with colostomy or elective surgery after only a few episodes.Several recent studies have challenged the standards of how acute and recurrent diverticulitis are managed,and many clinical practice guidelines(CPGs)have pivoted to recommend outpatient management and individualized decisions about surgery.Yet the rates of diverticulitis hospitalizations and operations are increasing in the United States,suggesting there is a disconnect from or delay in adoption of CPGs across the spectrum of diverticular disease.In this review,we propose approaching diverticulitis care from a population level to understand the gaps between contemporary studies and real-world practice and suggest strategies to implement and improve future care.Stephanie Lee Stovall Jennifer A Kaplan Joanna K Law David R Flum Vlad V Simianu 2023World Journal of Gastrointestinal Surgery2023,15,6:0
7Role of hospitalization for inflammatory bowel disease in the postbiologic era显示文摘Treatment for inflammatory bowel disease (IBD) often requires specialized care.While much of IBD care has shifted to the outpatient setting, hospitalizationsremain a major site of healthcare utilization and a sizable proportion of patientswith inflammatory bowel disease require hospitalization or surgery during theirlifetime. In this review, we approach IBD care from the population-level with aspecific focus on hospitalization for IBD, including the shifts from inpatient tooutpatient care, the balance of emergency and elective hospitalizations, regionalizationof specialty IBD care, and contribution of surgery and endoscopy tohospitalized care.Celine R Soriano Charleston R Powell Michael V Chiorean Vlad V Simianu 2021World Journal of Clinical Cases2021,9,26:0
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