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您的检索式：作者名="Siming Dai"
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| 1 | Evaluation of dimension of fractal time series with the least square method显示文摘Properties of fractional Brownian motions(f Bms)have been investigated by researchers in different fields,e.g.statistics,hydrology,biology,finance,and public transportation,which has helped us better understand many complex time series observed in nature[1-4].The Hurst exponent H(0 | BingQiang Qiao SiMing Liu HouDun Zeng Xiang Li BenZhong Dai | 2017 | Science China(Physics,Mechanics & Astronomy)2017，60，4： | 1 |
| 2 | Identification of key genes underlying the effects of obesity on knee osteoarthritis显示文摘To the Editor:Osteoarthritis(OA)is a disease associated with high morbidity and disability.Obesity,typically measured as a body mass index(BMI)≥30 kg/m2,is a well-known risk factor for the onset of OA and its related complications.[1]Interestingly,these two diseases may have common underlying mechanisms which contribute to the pathogenesis,such as genetic changes,and these mechanisms have not yet been fully explored.Gene expression profiling is a powerful tool used to systematically identify the molecular features underlying genetic variations associated with complex multifactorial diseases such as OA.In addition,it has been shown the significance of gene expression in understanding the mechanisms in the pathogenesis of obesity and OA.[2]This study hypothesized that hub genes could explain the relationship between obesity and OA.Consequently,identifying that these genes are involved could provide insights into the detailed regulatory mechanisms of obesity on OA. | Siming Dai Juan Zhang Xiaoying Zhu Yuxuan Lin Ying Cui Zhiyi Zhang Zhiguo Lin | 2022 | Chinese Medical Journal2022，，4： | 1 |
| 3 | Celastrol promotes chondrocyte autophagy by regulating mTOR expression显示文摘Osteoarthritis(OA)is a debilitating disease with limited treatment options.[1]Autophagy serves as an important protective mechanism against the deterioration of cartilage and is negatively regulated by the mammalian target of rapamycin(mTOR).[2]In previous studies,celastrol could promote autophagy in various cell types and had the promising therapeutic potential for OA.[3]However,the effect and underlying mechanisms of celastrol on autophagy in OA remain unclear.Our preliminary study using transcriptome sequencing and a network pharmacology analysis identified mTOR as a potential direct target of celastrol for protection against OA.[4]In this study,we aim to evaluate the effects of celastrol on mTOR activity in primary human osteoarthritic chondrocytes and to determine the mechanism by which it affects autophagy and endoplasmic reticulum(ER)stress. | Siming Dai Jiankun Fan Yue Zhang Zhenyong Hao Huiming Yu Zhiyi Zhang | 2022 | Chinese Medical Journal2022，，1： | 0 |
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