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| 1 | 血浆游离DNA水平增高可作为预测重型颅脑损伤患者死亡率的独立指标(英文)显示文摘Trauma is the leading cause of death under 45 years worldwide and up to 50% of trauma fatalities are due to brain injury.Prediction of outcome is one of the major problems associated with severe TBI and research efforts have focused on the investigation of biomarkers with prognostic value following TBI. Therefore,our aim was to investigate whether cell-free DNA concentrations correlated to short-term primary outcome( survivor or death) and GCS scores following severe TBI. A total of 188 victims of severe TBI were enrolled in this prospective study,outcome variables comprised: survival and neurological assessment using the GCS at ICU discharge. Control blood samples were obtained from 25 healthy volunteers. Peripheral venous blood was collected at admission in the ICU. Plasma DNA was measured using a real-time quantitative PCR assay for the β-globin gene. There was correlation between higher DNA levels and both fatal outcome and lower hospital admission GCS scores. Plasma DNA concentrations at the chosen cut- off point( ≥171,381 kilogenomesequivalents /L) predicted mortality with a specificity of 90% and a sensitivity of 43%. Logistic regression analysis showed that elevated plasma DNA levels were independently associated with death( P < 0. 001). In conclusion,high cell-free DNA concentration was a predictor of short-term mortality following severe TBI. | Rodrigues Filho EM1 Simon D Ikuta N Klovan C Dannebrock F de Oliveira CO Regner A | 2014 | 中华神经外科疾病研究杂志2014，13，3： | 6 |
| 2 | Cholangiocarcinoma显示文摘 | Shahid A Khan Howard C Thomas Brian R Davidson Simon D Taylor-Robinson | 2005 | The Lancet . 2005 (9493)2005，，： | 3 |
| 3 | Alternative treatments to inhibit VEGF in age-related choroidal neovascularisation: 2-year findings of the IVAN randomised controlled trial显示文摘 | Usha Chakravarthy Simon P Harding Chris A Rogers Susan M Downes Andrew J Lotery Lucy A Culliford Barnaby C Reeves | 2013 | The Lancet2013，，： | 2 |
| 4 | Cholangiocarcinoma显示文摘 | Shahid A Khan Howard C Thomas Brian R Davidson Simon D Taylor-Robinson | 2005 | The Lancet2005，，9493： | 2 |
| 5 | 植物鞣剂/MUF树脂鞣制时皮革的耐光性及鞣剂的抗老化性显示文摘制备了一种蜜胺含量相对较低的新型磺化蜜胺-脲-甲醛(MUF)缩聚树脂,此树脂与不同的天然植物鞣质复合鞣革,成革具有和铬鞣革一样良好的性能。提出了不同的鞣质/MUF树脂复合物鞣制的皮革,在长时间的紫外线辐射下,以革色的变化作为老化时间的函数,建立并阐明了此函数的预测模型和公式。此函数不仅与固态纯鞣质的抗老化能力有关,还与其在皮革内总体的抗老化能力有关。 | B George A Pizzi C Simon M C Triboulot 张业聪 付丽红 | 2007 | 中国皮革2007，36，15： | 2 |
| 6 | TNFalpha and its receptors in psoriatic skin,before and after treatment with etanercept显示文摘 | Caldarola G De Simone C Carbone A Tulli A Amerio P Feliciani C | 2009 | Int J Immunopathol Pharmacol2009，22，4： | 1 |
| 7 | In Search of Insight显示文摘 | Kaplan C A Simon H A | 1990 | Cognitive Psychology1990，32，： | 1 |
| 8 | Residual-effeeted homogeneous charge compression ignition at a low compression ratio using exhaust reinduetion显示文摘 | Citon P A Simon A J Jerdes J C | 2003 | Int J Engine Res2003，4，3： | 1 |
| 9 | The parallel use of endoscopic fenestration anti a eystoperitoneal shunt with programmable valve to treat araehnoid cysts: experience and hypothesis显示文摘 | Mottolese C Szathmari A Simon E | 2010 | J Neurosurg Pediatr2010，5，： | 1 |
| 10 | 查看详情显示文摘 | Simon T Kroger A Somsen C Dlouhy A Eggeler G | | 0，，： | 1 |
| 11 | Magmatic--hydrothermal origin of Ne- vada~ s Carlin- type gold deposits显示文摘 | Muntean J L J S Cline A C Simon | 2011 | Nature Geoscience2011，4，12： | 1 |
| 12 | Association of Enterococcus cecorum with vertebral osteomyelitis and spondylolisthesis in broiler parent chicks显示文摘 | MAKRAI L NENES C SIMON A | 2011 | Acta Vet Hung2011，59，1： | 1 |
| 13 | In Search of Insight 显示文摘 | Kaplan C A Simon H A | 1990 | Cognitive Psychology1990，，32： | 1 |
| 14 | Evaluation of an institutional guideline for the treatment of cerebrospinal fluid shunt-associated infections显示文摘 | von der Brelie C Simon A Gr(o)ner A | 2012 | Acta Neurochir(Wien)2012，154，9： | 1 |
| 15 | Lensed fiber-array assembly with individu- al fiber fine positioning in the submicrometer range 显示文摘 | Johan H C van Zantvoort Simon G L Plukker Erwin C A Dekkers | 2006 | IEEE Selected Topics in Quantum Electronics2006，12，05： | 1 |
| 16 | Characterization of 14 microsatellite markers for genetic analysis and cultivar identification of walnut显示文摘 | Dangl GS Woeste K Aradhya MK Koehmstedt A simon C Potter D Leslie CA.McGranahan G | | 0，，： | 1 |
| 17 | Gut liver axis:a new point of attack to treat chronic liver damage? 显示文摘 | Loguereio C De Simone T Federico A | 2002 | Am J Gastroenterol2002，97，8： | 1 |
| 18 | Evolution, weighting, and phylogenetic utility of mitochondrial gene sequences and a compilation of conserved polymerase chain reaction primers 显示文摘 | SIMON C FRATI F BECKENBACH A | 1994 | Annals of the Entomological Society of America1994，87，： | 1 |
| 19 | Tight bounds on the information rate of secret sharing schemes显示文摘 | Blundo C Santis A D Simone R D | 1997 | Designs Codes and Cryptography1997，11，2： | 1 |
| 20 | The rheology of two-dimensional foams显示文摘 | Simon C Denis W James A G | 2004 | Rheol Acta2004，43，5： | 1 |
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