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| 1 | 新生儿复苏培训降低新生儿死亡率的效能分析:文献综述,meta分析与Delphi法的应用显示文摘[背景]全球每年13600万新生儿中,约1000万需要外界的帮助才能建立自主呼吸,每年有约814000例新生儿死亡是由分娩相关足月儿死亡(以往定义为'出生窒息')所导致的。目前尚缺乏关于新生儿复苏培训降低新生儿死亡率效能的系统性评价。[目的]对在医院和社区层面开展的快速评估及初步刺激、基本的复苏措施这两种新生儿复苏培训干预方法在降低足月新生儿分娩相关死亡率('出生窒息')、早产相关并发症死亡率这两个生命指标方面的效能进行评价。[方法]采用系统综述的方法,检索并筛选符合标准的新生儿复苏培训研究文献。采用GRADE方法对文献的质量进行评价。对符合要求的文件进行Meta分析。对数据质量较低的文献采用专家咨询法估计效能大小。[结果]通过文献检索筛选了24篇新生儿复苏培训干预研究(20篇观察性研究,2篇半试验研究,2篇随机对照研究)。对其中3篇文献进行Meta分析结果显示,以医院为基础的新生儿复苏培训可使分娩相关足月儿死亡降低30%(RR=0.70,95%CI0.59~0.84);文献中涉及早产儿死亡率效能的数据质量不高,因此采用专家咨询法进行估计。以社区为基础的新生儿复苏培训干预研究具有较高的异质性,复苏培训通常是一系列培训包的一部分,且对早产儿和足月儿的定义标准不一致。专家咨询法估计结果显示,新生儿快速评估和初步刺激可使分娩相关新生儿死亡、早产儿死亡均降低10%;以医院为基础的培训可使早产儿死亡进一步降低10%,以社区为基础的培训可使分娩相关足月儿死亡率进一步降低20%,早产儿死亡率进一步降低5%。[结论]新生儿复苏培训在医院层面可以使足月新生儿分娩相关死亡率降低30%,然而中低收入水平的国家培训覆盖率仍较低。专家咨询法估计新生儿复苏培训在社区层面降低足月儿及早产儿死亡率的效能较小。需要对新生儿复苏培训的效果、成本、实施策略等进行更深入的研究与评价。 | Anne CC Lee Simon Cousens Stephen N Wall 徐韬 | 2012 | 中国妇幼卫生杂志2012，3，2： | 11 |
| 2 | Survival analysis of breast cancer liver metastasis treated by hepatectomy: A propensity score analysis for Chinese women in Hong Kong显示文摘Background: Survival of patients with breast cancer liver metastasis is very poor. This study aimed to analyze the survival outcome of hepatectomy for this patient population. Methods: From January 1995 to December 2014, 2522 patients with liver cancer received hepatectomy at our hospital. Twenty-one of them, all female, received the operation for breast cancer liver metastasis. Performance was compared with patients with colorectal liver metastasis treated with hepatectomy after propensity score analysis in a ratio of 1:3. Results: Twenty-one patients received hepatectomy for breast cancer. After propensity score matching, 63 patients who had hepatectomy for colorectal cancer were selected for comparison. There was no significant difference in immediate or short-term outcomes between the two groups of patients in terms of operative time, blood loss and surgical morbidities. All patients with breast cancer had R0 resection. No hospital death occurred. After hepatectomy, the 1-, 3- and 5-year overall survival rates were 100.0%, 58.9% and 58.9% respectively in patients with breast cancer. The 1-, 3- and 5-year overall survival rates were 95.0%, 57.2% and 39.7% respectively in patients with colorectal cancer (P = 0.572). On multivariate analysis, triple negative status was the only independent poor prognostic factor in breast cancer liver metastasis (OR = 6.411;95% CI: 1.351–30.435;P = 0.019). Conclusions: Hepatectomy is a safe and effective way of treating breast cancer liver metastasis at experienced centers where multidisciplinary adjuvant treatments are available. It can be considered more frequently as part of the multidisciplinary care for this patient population. | Tan To Cheung Kenneth SH Chok Albert CY Chan Simon HY Tsang Wing Chiu Dai Thomas CC Yau Ava Kwong Chung Mau Lo | 2019 | Hepatobiliary & Pancreatic Diseases International2019，18，5： | 3 |
| 3 | Molecular analysisdirected individualized therapy (MADIT) in advanced non-small cell lung cancer (NSCLC) 显示文摘 | Simon GR Williams CC Chiappori AA | 2007 | Chiappori J Clin Oncol2007，25，18： | 1 |
| 4 | Autophagy regutatiun in maerophages and neutrophils 显示文摘 | Mihalache CC Simon HU | 2012 | Exp Cell Res2012，18，11： | 1 |
| 5 | A novel classification of colorectal tumors based on microsatellite instability,the Cp G island methylator phenotype and chromosomal instability:implications for prognosis显示文摘 | Simons CC Hughes LA Smits KM | 2013 | Ann Oncol2013，24，8： | 1 |
| 6 | Use of a three-dimensional cell culture model to study airway smooth muscle-mast cell interactions in airway remodeling 显示文摘 | Claudia CC Alan JK and Simon RJ | 2009 | Am J Physiol Lung Cell Mol Physiol2009，296，： | 1 |
| 7 | Autophagy regulation in macmphages and neutrophils显示文摘 | Mihalache CC Simon HU | 2012 | Exp Cell Res2012，18，11： | 1 |
| 8 | Molecular analysis-directed individualized therapy (MADeIT) in advanced non-small cell lung cancer (NSCLC)显示文摘 | Simon GR Williams CC Chiappori AA | 2007 | J Clin Oncol2007，25，18： | 1 |
| 9 | Rethinking orbitalimaging establishing guidelines for interpreting orbital imagingstudies and evaluating their predictive value in patients withorbital tumors显示文摘 | Ben Simon GJ Annunziata CC Fink J | 2005 | Ophthalmology2005，12，12： | 1 |
| 10 | Rethinking orbital imaging establishing guidelines for interpreting orbital imaging studies and evaluating their predictive value in patients with or bital tumors显示文摘 | Ben Simon GJ Annunziata CC Fink J | 2005 | Ophthalmology2005，12，12： | 1 |
| 11 | Progress, priorities, and potential beyond survival显示文摘 | Joy E Lawn Hannah Blencowe Shefali Oza Danzhen You Anne CC Lee Peter Waiswa Marek Lalli Zulfiqar Bhutta Aluisio JD Barros Parul Christian Colin Mathers Simon N Cousens | 2014 | The Lancet2014，，： | 1 |
| 12 | Autophagy regulation in macrophages and neutrophils显示文摘 | Mihalache CC Simon HU | 2012 | Exp Cell Res2012，18，11： | 1 |
| 13 | Phenotypic differences between dermal fibro- blasts from different body sites determine their responses to tension and TGFbetal 显示文摘 | Chipev CC Simon M | 2002 | BMC Dermatol2002，2，： | 1 |
| 14 | Molecular analysis-directed individualized therapy (MADeIT) in advanced non-small cell lung cancer (NSCLC)显示文摘 | Simon CR Williams CC Chiappori AA | 2007 | JCO2007，25，18： | 1 |
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