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| 1 | 术中应用荧光素钠有利于胶质母细胞瘤浸润边缘的手术切除(英文)显示文摘Objective Extent of resection is an important prognostic factor in patients undergoing surgery for glioblastoma( GBM).Recent evidence suggests that intravenously administered fluorescein sodium associates with tumor tissue,facilitating safe maximal resection of GBM. In this study,the authors evaluate the safety and utility of intraoperative fluorescein guidance for the prediction of histopathological alteration both in the contrast-enhancing( CE) regions,where this relationship has been established,and into the nonCE( NCE),diffusely infiltrated margins. Methods Thirty-two patients received fluorescein sodium( 3 mg/kg) intravenously prior to resection. Fluorescence was intraoperatively visualized using a Zeiss Pentero surgical microscope equipped with a YELLOW 560 filter.Stereotactically localized biopsy specimens were acquired from CE and NCE regions based on preoperative MRI in conjunction with neuronavigation. The fluorescence intensity of these specimens was subjectively classified in real time with subsequent quantitative image analysis,histopathological evaluation of localized biopsy specimens,and radiological volumetric assessment of the extent of resection.Results Bright fluorescence was observed in all GBMs and localized to the CE regions and portions of the NCE margins of the tumors,thus serving as a visual guide during resection. Gross-total resection( GTR) was achieved in 84% of the patients with an average resected volume of 95%,and this rate was higher among patients for whom GTR was the surgical goal( GTR achieved in 93. 1% of patients,average resected volume of 99. 7%). Intraoperative fluorescein staining correlated with histopathological alteration in both CE and NCE regions,with positive predictive values by subjective fluorescence evaluation greater than 96% in NCE regions. Conclusions Intraoperative administration of fluorescein provides an easily visualized marker for glioma pathology in both CE and NCE regions of GBM. These findingssupport the use of fluorescein as a microsurgical adjunct for guiding GBM resection to facilitate safe maximal removal. | Neira JA Ung TH Sims J Malone HR Chow DS Samanamud JL Zanazzi GJ Guo X Bowden SG Zhao B Sheth SA McKhann GM 2nd Sisti MB Canoll P D'Amico RS Bruce JN | 2016 | 中华神经外科疾病研究杂志2016，15，5： | 2 |
| 2 | Six-beam piezoresistive accelerometer with self-cancelling cross-axis sensitivity显示文摘 | Kim D K Bae Y H | 1998 | Electron Lett1998，34，5： | 1 |
| 3 | Scaling laws of marine predator search behavior 显示文摘 | Sims D W Southall E J Humphries N E | 2008 | Nature2008，451，： | 1 |
| 4 | Molecular cloning and biological characterization of a novel murine lymphoid growth factor显示文摘 | Sims J E Williams D E Morrissey P J | 2000 | J Exp Med2000，192，： | 1 |
| 5 | Characteristics of basalt fiber as a strengthening material for concrete structures 显示文摘 | Sim J Park C Moon D Y | 2005 | Composites Part B2005，36，： | 1 |
| 6 | Inhibition of biofihn formation and swarming of Bacillus subtilis by ( 5 Z ) -4 -bromo-5- ( bromomethylmm ) - 3-butyl-2(5n)-furanone显示文摘 | Ren D Sims J J Wood T K | 2002 | Lett Appl Microbiol2002，34，4： | 1 |
| 7 | Genome-wide association study of ankylosing spondylifts identifies nonMHC susceptibility loci显示文摘 | Reveille J D Sims A M Danoy P | | 0，，2： | 1 |
| 8 | Concepts of plant biotic stress: Some insights into the stress physiology of virus-infected plant from the perspective of photosynthesis 显示文摘 | Balachandran S Hurry V M Kelley S E Osmond C B Robinson S A Rohozinski J Seaton G G R Sims D A | 1997 | Physiologia Plantarum1997，100，： | 1 |
| 9 | Characteristics of basalt fiber as a strengthening material for concrete structures 显示文摘 | Sim J S Park C W Moon D Y | 2005 | Composites Part B2005，，36： | 1 |
| 10 | cDNA expression cloning of the IL-1 receptor, a member of the immunoglobulin superfamily显示文摘 | Sims JE March C J Cosman D | 1988 | Scienee1988，241，4865： | 1 |
| 11 | Characteristics of basalt fiber as a strengthening material for concrete structure 显示文摘 | SIM J PARK C MOON D Y | 2005 | Composites : Part B Engineering2005，，36： | 1 |
| 12 | Influence of dietary energy source on performance and fatty liver syn- drome in White Leghorn laying hens显示文摘 | Bragg D B Sim J S Hodgson G C | 1973 | Poult Sci1973，52，2： | 1 |
| 13 | Chelate-assisted Phytoextraction of Lead from Contaminated Soils显示文摘 | Cooper E M Sims J T Cumningham S D | 1999 | Environ Qual1999，28，： | 1 |
| 14 | Investigation on the thermalbehavior of HTS power cable under fault current显示文摘 | Kim S Cho J Sim K D | 2006 | IEEE Transactions on Applied Superconductivity2006，16，2： | 1 |
| 15 | CX3CR1+ interstitial dendritic cells form a contiguous network throughout the entire kidney显示文摘 | Soos T J Sims T N Barisoni L Lin K Littman D R Dustin M L | 2006 | Kidney lnt2006，70，： | 1 |
| 16 | Estimation of vegetation water content and photosynthetic tissue area from spectral reflectance:A comparison of indices based on liquid water and chlorophyll absorption features显示文摘 | SIMS D A GAMON J A | 2003 | Remote Sensing of Environment2003，，84： | 1 |
| 17 | Determination of pyrazine and flavor variations inpeanutgenotypes during roasting显示文摘 | Baker G L Cornell J A Gorbet D W Okeefe S F Sims C A Talcott ST | 2003 | Journal of Food Science2003，68，1： | 1 |
| 18 | Characteristics of basalt fiber as a strengthening material for concrete structures显示文摘 | Sim J Park C Moon D Y | 2005 | Composites Part B Engineering2005，36，： | 1 |
| 19 | Relationships between leaf pigment content and spectral reflectance across awide range of species, leaf structures and developmental stages显示文摘 | Sims D A Gamon J A | 2002 | Remote Sensing of Environment2002，81，： | 1 |
| 20 | Nitrogen transforming in soil: Temperature and moisture Effects显示文摘 | Sim J T John D | 1986 | J Encron Qual1986，15，： | 1 |
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