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| 1 | Red blood cell membrane-camouflaged nanoparticles loaded with AIEgen and Poly(I: C) for enhanced tumoral photodynamic-immunotherapy显示文摘Red blood cell(RBC)-mimicking nanoparticles(NPs) offer a promising platform for drug delivery because of their prolonged circulation time, reduced immunogenicity and specific targeting ability. Herein, we report the design and preparation of RBC membrane-bound NPs(M@AP), for tumoral photodynamic-immunotherapy. The M@AP is formed by self-assembly of the positively charged aggregation-induced emission luminogen(AIEgen)(named P2-PPh3) and the negatively charged polyinosinic : polycytidylic acid(Poly(I : C)), followed by RBC membrane encapsulation. P2-PPh3 is an AIE-active conjugated polyelectrolyte with additional photosensitizing ability for photodynamic therapy(PDT), while Poly(I : C) serves as an immune-stimulant to stimulate both tumor and immune cells to activate immunity, and thus reduces tumor cell viability. When applied in tumor-bearing mice, the M@AP NPs are enriched in both the tumor region as a result of an enhanced permeability and retention(EPR)effect, and the spleen because of the homing effect of the RBC-mimicking shell. Upon light irradiation,P2-PPh3 promotes strong ROS generation in tumor cells, inducing the release of tumor antigens(TA). The anti-tumor immunity is further enhanced by the presence of Poly(I : C) in M@AP. Thus, this strategy combines the PDT properties of the AIE-active polyelectrolyte and immunotherapy properties of Poly(I : C) to achieve synergistic activation of the immune system for anti-tumor activity, providing a novel strategy for tumor treatment. | Jun Dai Meng Wu Quan Wang Siyang Ding Xiaoqi Dong Liru Xue Qingqing Zhu Jian Zhou Fan Xia Shixuan Wang Yuning Hong | 2021 | National Science Review2021，8，6： | 1 |
| 2 | Micro-nanofiber composite biomimetic conduits promote long-gap peripheral nerve regeneration in canine models显示文摘Peripheral nerve injuries may result in severe long-gap interruptions that are challenging to repair.Autografting is the gold standard surgical approach for repairing long-gap nerve injuries but can result in prominent donor-site complications.Instead,imitating the native neural microarchitecture using synthetic conduits is expected to offer an alternative strategy for improving nerve regeneration.Here,we designed nerve conduits composed of high-resolution anisotropic microfiber grid-cordes with randomly organized nanofiber sheaths to interrogate the positive effects of these biomimetic structures on peripheral nerve regeneration.Anisotropic microfiber-grids demonstrated the capacity to directionally guide Schwann cells and neurites.Nanofiber sheaths conveyed adequate elasticity and permeability,whilst exhibiting a barrier function against the infiltration of fibroblasts.We then used the composite nerve conduits bridge 30-mm long sciatic nerve defects in canine models.At 12 months post-implant,the morphometric and histological recovery,gait recovery,electrophysiological function,and degree of muscle atrophy were assessed.The newly regenerated nerve tissue that formed within the composite nerve conduits showed restored neurological functions that were superior compared to sheaths-only scaffolds and Neurolac nerve conduit controls.Our findings demonstrate the feasibility of using synthetic biophysical cues to effectively bridge long-gap peripheral nerve injuries and indicates the promising clinical application prospects of biomimetic composite nerve conduits. | Xianhao Dong Yueyue Yang Zheheng Bao Adam C.Midgley Feiyi Li Shuxin Dai Zhuangzhuang Yang Jin Wang Lihua Liu Wenlei Li Yayuan Zheng Siyang Liu Yang Liu Weijian Yu Jun Liu Meng Fan Meifeng Zhu Zhongyang Shen Gu Xiaosong Deling Kong | 2023 | Bioactive Materials2023，，12： | 0 |
| 3 | Capacity Optimization Configuration of Hydrogen Production System for Offshore Surplus Wind Power显示文摘To solve the problem of residual wind power in offshore wind farms,a hydrogen production system with a reasonable capacity was configured to enhance the local load of wind farms and promote the local consumption of residual wind power.By studying the mathematical model of wind power output and calculating surplus wind power,as well as considering the hydrogen production/storage characteristics of the electrolyzer and hydrogen storage tank,an innovative capacity optimization allocation model was established.The objective of the model was to achieve the lowest total net present value over the entire life cycle.The model took into account the cost-benefit breakdown of equipment end-of-life cost,replacement cost,residual value gain,wind abandonment penalty,hydrogen transportation,and environmental value.The MATLAB-based platform invoked the CPLEX commercial solver to solve the model.Combined with the analysis of the annual average wind speed data from an offshore wind farm in Guangdong Province,the optimal capacity configuration results and the actual operation of the hydrogen production system were obtained.Under the calculation scenario,this hydrogen production system could consume 3,800 MWh of residual electricity from offshore wind power each year.It could achieve complete consumption of residual electricity from wind power without incurring the penalty cost of wind power.Additionally,it could produce 66,500 kg of green hydrogen from wind power,resulting in hydrogen sales revenue of 3.63 million RMB.It would also reduce pollutant emissions from coal-based hydrogen production by 1.5 tons and realize an environmental value of 4.83 million RMB.The annual net operating income exceeded 6 million RMB and the whole life cycle NPV income exceeded 50 million RMB.These results verified the feasibility and rationality of the established capacity optimization allocation model.The model could help advance power system planning and operation research and assist offshore wind farm operators in improving economic and environmental benefits. | Yanshan Lu Binbin He Jun Jiang Ruixiao Lin Xinzhen Zhang Zaimin Yang Zhi Rao Wenchuan Meng Siyang Sun | 2023 | Energy Engineering2023，120，12： | 0 |
| 4 | Active poisoning:efficient backdoor attacks on transfer learning-based brain-computer interfaces显示文摘Transfer learning(TL)has been widely used in electroencephalogram(EEG)-based braincomputer interfaces(BCIs)for reducing calibration efforts.However,backdoor attacks could be introduced through TL.In such attacks,an attacker embeds a backdoor with a specific pattern into the machine learning model.As a result,the model will misclassify a test sample with the backdoor trigger into a prespecified class while still maintaining good performance on benign samples.Accordingly,this study explores backdoor attacks in the TL of EEG-based BCIs,where source-domain data are poisoned by a backdoor trigger and then used in TL.We propose several active poisoning approaches to select source-domain samples,which are most effective in embedding the backdoor pattern,to improve the attack success rate and efficiency.Experiments on four EEG datasets and three deep learning models demonstrate the effectiveness of the approaches.To our knowledge,this is the first study about backdoor attacks on TL models in EEG-based BCIs.It exposes a serious security risk in BCIs,which should be immediately addressed. | Xue JIANG Lubin MENG Siyang LI Dongrui WU | 2023 | Science China(Information Sciences)2023，66，8： | 0 |
| 5 | Hybrid vesicles of pillar[5]arene/silica:Host-guest complexation and application in pH-triggered release显示文摘Integrating silica with organic nanoparticles can generate unique properties.Here pillar[5]arene/silica hybrid vesicles were constructed based on the amphiphilic and rigid properties of pillararenes,as well as the catalytic hydrolysis of tetraethoxysilane.Such vesicles exhibited the high strength of silica and unique molecular recognition of pillararenes,both of which could tune the pH-trigge red release behavior.Furthermore,a rhodamine B derivative with hexyl group(RhB-C6) was synthesized,which can form a complex with the pillar[5]arene.Based on the host-guest interaction and high strength of silica,the hybrid vesicles could load more RhB-C6 and the rhodamine B was released more slowly compared with the organic vesicles. | Chenghao Hou Lijing Liu Siyang Meng Yue Wu Meiran Xie Yongkui Shan Pingang He Pengfei Sun Xiaojuan Liao | 2021 | Chinese Chemical Letters2021，32，1： | 0 |
| 6 | Clinical Study of Diagnosis and Treatment of Tuberculosis in Kidney Transplant Recipients显示文摘 | Siyang Chen Changxi Wang Fanhang Meng Lizhong Chen Jiguang Fei Suxiong Deng Jiang Qiu Jun Li Guodong Chen | 2009 | 器官移植内科学杂志2009，4，3： | 0 |
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