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4篇 您的检索式：作者名="Siyoung Kim"

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		题名	作者	年代	出处	被引量
	1	Sulforaphane alleviates scopolamine-induced memory impairment in mice显示文摘	Siyoung Lee Jisung Kim Sang Gwon Seo Bo-Ryoung Choi Jung-Soo Han Ki Won Lee Jiyoung Kim	2014	Pharmacological Research2014，，：	1
	2	AC/AC Power Conversion Basedon Matrix Converter Topology with Unidirectional Switches显示文摘	Siyoung Kim Seung-Ki Sul	2000	IEEE Transactions on Industry Applications2000，36，1：	1
	3	Performance of Tractor Diesel Engine with Animal-Fats Biodiesel显示文摘	Youngjung Kim Siyoung Lee Jonggoo Kim Donghyeon Kim Honggi Choi	2013	Journal of Agricultural Science and Technology(B)2013，3，9：	0
	4	APOE ε4-dependent effects on the early amyloid pathology in induced neurons of patients with Alzheimer’s disease显示文摘Background: The ε4 allele of apolipoprotein E (APOE ε4) is the strongest known genetic risk factor for late-onset Alzheimer’s disease (AD), associated with amyloid pathogenesis. However, it is not clear how APOE ε4 accelerates amyloid-beta (Aβ) deposition during the seeding stage of amyloid development in AD patient neurons. Methods: AD patient induced neurons (iNs) with an APOE ε4 inducible system were prepared from skin fibroblasts of AD patients. Transcriptome analysis was performed using RNA isolated from the AD patient iNs expressing APOE ε4 at amyloid-seeding and amyloid-aggregation stages. Knockdown of IGFBP3 was applied in the iNs to investigate the role of IGFBP3 in the APOE ε4-mediated amyloidosis. Results: We optimized amyloid seeding stage in the iNs of AD patients that transiently expressed APOE ε4. Remarka-bly, we demonstrated that Aβ pathology was aggravated by the induction of APOE ε4 gene expression at the amyloid early-seeding stage in the iNs of AD patients. Moreover, transcriptome analysis in the early-seeding stage revealed that IGFBP3 was functionally important in the molecular pathology of APOE ε4-associated AD. Conclusions: Our findings suggest that the presence of APOE ε4 at the early Aβ-seeding stage in patient iNs is critical for aggravation of sporadic AD pathology. These results provide insights into the importance of APOE ε4 expression for the progression and pathogenesis of sporadic AD.	Hongwon Kim Siyoung Kim Byounggook Cho Jaein Shin Jongpil Kim	2022	Translational Neurodegeneration2022，11，1：	0

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