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| 1 | Tissue transglutaminase and the progression of human renal scarring显示文摘 | Johnson T S El-Koraie A F Skill N J | 2003 | J Am Soc Nephrol2003，14，8： | 1 |
| 2 | Contextualizing SEGUE:Evaluating Residents’ Communication Skills Within the Framework of a Structured Medical Interview显示文摘 | Skillings J L Porcerelli J H Markova T | 2010 | J Grad Med Educ2010，，1： | 1 |
| 3 | Tissue transglutaminase and the progression of human renal scarring显示文摘 | Johnson T S El-Koraie A F Skill N J | 2003 | J Am Soc Nephrol2003，14，8： | 1 |
| 4 | Increases in renal epsilon- (g-glutamyl) -Iysine crosslinks resuit from compartment-specific changes in tissue transglutaminase in early experimental diabetic nephropathy : pathologic implications 显示文摘 | Skill N J Griffin M El Nahas A M | 2001 | Lab Invest2001，81，5： | 1 |
| 5 | Multicenter phase III study of uracil/tegafur and oral leucovin versus fluorouracil and leucovorin in patients with previously untreated metastatic colorectal cancer显示文摘 | Douillard J Y Hoff P M Skillings J | 2002 | J Clin Oncol2002，20，17： | 1 |
| 6 | Tissue transglutaminase and the progression of human renal scarring显示文摘 | Johnson T S EL-Koraie A F Skill N J | 2003 | J Am Soc Nephol2003，14，8： | 1 |
| 7 | Autotaxin expression and its connection with the TNF-alpha-NF-kappa B axis in human hepatocellular carcinoma显示文摘 | Wu JM Xu Y Skill N J | 2010 | Mol Cancer2010，9，： | 1 |
| 8 | Tissue transglutaminase: a mediator and predictor of chronic allograft nephropathy 显示文摘 | Johnson T S Abo-zenah H Skill N J | 2004 | Transplatation2004，77，11： | 1 |
| 9 | Tissue transglutaminase and the progression of human renal scarring 显示文摘 | Johnson TS El-Koraie AF Skill N J | 2003 | J Am Soc Nephrol2003，14，8： | 1 |
| 10 | Maximum entropy method in image processing显示文摘 | Gull S F Skilling J | 1984 | Communications Radar and Signal Processing IEE Proceedings F1984，131，6： | 1 |
| 11 | Thalidomide ameliorates portal hypertension via nitric oxide synthase independent reduced systolic blood pressure显示文摘AIM: Portal hypertension is a common complication of liver cirrhosis and significantly increases mortality and morbidity.Previous reports have suggested that the compound thalidomide attenuates portal hypertension(PHT).However, the mechanism for this action is not fully elucidated.One hypothesis is that thalidomide destabilizes tumor necrosis factor α(TNFα) mR NA and therefore diminishes TNFα induction of nitric oxide synthase(NOS) and the production of nitric oxide(NO).To examine this hypothesis, we utilized the murine partial portal vein ligation(PVL) PHT model in combination with endothelial or inducible NOS isoform gene knockout mice.METHODS: Wild type, inducible nitric oxide synthase(i NOS)-/- and endothelial nitric oxide synthase(e NOS)-/-mice received either PVL or sham surgery and were given either thalidomide or vehicle.Serum nitrate(total nitrate, NOx) was measured daily for 7 d as a surrogate of NO synthesis.Serum TNFα level was quantified by enzyme-linked immunosorbent assay.TNFα m RNA was quantified in liver and aorta tissue by reverse transcription-polymerase chain reaction.PHT was determined by recording splenic pulp pressure(SPP) and abdominal aortic flow after 0-7 d.Response to thalidomide was determined by measurement of SPP and mean arterial pressure(MAP).RESULTS: SPP, abdominal aortic flow(Qao) and plasma NOx were increased in wild type and i NOS-/-PVL mice when compared to sham operated control mice.In contrast, SPP, Qao and plasma NOx were not increased in e NOS-/- PVL mice when compared to sham controls.Serum TNFα level in both sham and PVL mice was below the detection limit of the commercial ELISA used.Therefore, the effect of thalidomide on serum TNFα levels was undetermined in wild type, e NOS-/-or i NOS-/- mice.Thalidomide acutely increased plasma NOx in wild type and e NOS-/- mice but not i NOS-/-mice.Moreover, thalidomide temporarily(0-90 min) decreased mean arterial pressure, SPP and Qao in wild type, e NOS-/- and i NOS-/- PVL mice, after which time levels returned to the respective baseline.CONCLUSION: Thalidomide does not reduce portalpressure in the murine PVL model by modulation of NO biosynthesis.Rather, thalidomide reduces PHT by decreasing MAP by an undetermined mechanism. | Nicholas G Theodorakis Yining N Wang Vyacheslav A Korshunov Mary A Maluccio Nicholas J Skill | 2015 | World Journal of Gastroenterology2015，21，14： | 1 |
| 12 | Maximum entropy image reconstruction: general algorithm显示文摘 | Skilling J Bryan R K | 1984 | Mon Not R astr Soc1984，211，1： | 1 |
| 13 | Detection of Ca2+-dependent transglutaminase activity in root and leaf tissue of monocotyledonous and dicotyledonousplants显示文摘 | Lilley G R Skill J Griffin M | 1998 | Plant Physiol Ogy1998，117，： | 1 |
| 14 | Maximum entropy method in image processing 显示文摘 | Gull S F Skilling J | 1984 | IEE Proceedings F1984，131，6： | 1 |
| 15 | The role of nitric oxide synthase isoforms in extrahepatic portal hypertension: studies in gene-knockout mice显示文摘 | Nicholas G Theodorakis Yi-ning Wang Nicholas J Skill Matthew A Metz Paul A Cahill Eileen M Redmond James V Sitzmann | 2003 | Gastroenterology2003，，5： | 1 |
| 16 | Bayesian maximum entropy image reconstruction 显示文摘 | Skilling J Gull S F | 1991 | Institute ofMathematical Statistics1991，20，： | 1 |
| 17 | Multicenter phase III study of uracil/tegafur and oral leucovin versus fluorouracil and leucovin in patients with previously untreated metastatic colorectal cancer显示文摘 | Douillard J Y Hoff P M Skillings J | 2002 | J Clin Oncol2002，20，6： | 1 |
| 18 | Image restoration by a powerful maximum entropy method显示文摘 | Burch S F Gull S F Skilling J | 1983 | CVGIP1983，23，： | 1 |
| 19 | Maximum entropy reconstruction general algorithm显示文摘 | Skilling J Bryan RK | 1984 | Mon Not R Astr Soc1984，211，： | 1 |
| 20 | Rules knowledge: Signals, signs and symbols and other distinctions in human performance models显示文摘 | | 1983 | IEEE Trans on SMC1983，13，3： | 1 |
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