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| 1 | Inhibition of pacemaker activity in interstitial cells of Cajal by LPS via NF-κB and MAP kinase显示文摘AIM:To investigate lipopolysaccharide(LPS) related signal transduction in interstitial cells of Cajal(ICCs) from mouse small intestine.METHODS:For this study,primary culture of ICCs was prepared from the small intestine of the mouse.LPS was treated to the cells prior to measurement of the membrane currents by using whole-cell patch clamp technique.Immunocytochemistry was used to examine the expression of the proteins in ICCs.RESULTS:LPS suppressed the pacemaker currents of ICCs and this could be blocked by AH6809,a prostaglandin E2-EP2 receptor antagonist or NG-Nitro-Larginine Methyl Ester,an inhibitor of nitric oxide(NO) synthase.Toll-like receptor 4,inducible NO synthase or cyclooxygenase-2 immunoreactivity by specific antibodies was detected on ICCs.Catalase(antioxidant agent) had no action on LPS-induced action in ICCs.LPS actions were blocked by nuclear factor kB(NF-kB) inhibitor,actinomycin D(a gene transcription inhibitor),PD 98059(a p42/44 mitogen-activated protein kinases inhibitor) or SB 203580 [a p38 mitogen-activated protein kinases(MAPK) inhibitor].SB 203580 also blocked the prostaglandin E2-induced action on pacemaker currents in ICCs but not NO.CONCLUSION:LPS inhibit the pacemaker currents in ICCs via prostaglandin E2-and NO-dependent mechanism through toll-like receptor 4 and suggest that MAPK and NF-kB are implicated in these actions. | Dong Chuan Zuo Seok Choi Pawan Kumar Shahi Man Yoo Kim Chan Guk Park Young Dae Kim Jun Lee In Yeoup Chang Insuk So Jae Yeoul Jun | 2013 | World Journal of Gastroenterology2013，19，8： | 9 |
| 2 | Identification of TRPM7 channels in human intestinal interstitial cells of Cajal显示文摘AIM:To investigate the characteristics of slow elec-trical waves and the presence of transient receptor potential melastatin-type 7(TRPM7)in the human gas-trointestinal(GI)tract.METHODS:Conventional microelectrode techniques were used to record intracellular electrical responses from human GI smooth muscle tissue.Immunohisto-chemistry was used to identify TRPM7 channels in in-terstitial cells of Cajal(ICCs).RESULTS:The human GI tract generated slow electri-cal waves and had ICCs which functioned as pacemak-er cells.Flufenamic acid,a nonselective cation channel blocker,and 2-APB(2-aminoethoxydiphenyl borate)and La3+,TRPM7 channel blockers,inhibited the slowwaves.Also,TRPM7 channels were expressed in ICCs in human tissue.CONCLUSION:These results suggest that the human GI tract generates slow waves and that TRPM7 chan-nels expressed in the ICCs may be involved in the gen-eration of the slow waves. | Byung Joo Kim Kyu Joo Park Hyung Woo Kim Seok Choi Jae Yeoul Jun In Youb Chang Ju-Hong Jeon Insuk So Seon Jeong Kim | 2009 | World Journal of Gastroenterology2009，15，46： | 3 |
| 3 | uPAR expression under hypoxic conditions depends on iNOS modulated ERK phosphorylation in the MDA-MB-231 breast carcinoma cell line显示文摘尿激 plasminogen 使活跃之物受体(uPAR ) 戏在癌症侵略和转移和 uPAR 表示的一个主要角色在各种各样的癌症类型与差的预后被相关。而且, uPAR 的表示在 hypoxic 条件下面被增加。氮的氧化物(没有) 并且它可诱导的氮的氧化物 synthase (i NOS ) 生产的代谢物是 hypoxic 应力的重要产品,并且可以不激活或调制细胞外的信号调整 kinase (英皇家空军之阶级最低之兵) 。这里,我们在 MDA-MB-231 人的乳癌房间线在 hypoxic 条件,和 i NOS 并且不的调节效果下面在 A, uPAR,和激活的英皇家空军之阶级最低之兵层次上面评估了。房间在 hypoxic 或 normoxic 孵卵器被孵化并且与 PD98059 对待(一个 MEK 1/2 禁止者,它废除英皇家空军之阶级最低之兵 phosphorylation ) 并且 aminoguanidine (选择 i NOS 禁止者) 。uPAR 表示,英皇家空军之阶级最低之兵 phosphorylation,并且在 A 上面,活动被发现在 hypoxic 条件下面被增加。而且当房间在 hypoxic 条件下面与 PD98059 被对待时, uPAR 低调整,而 aminoguanidine 显著地以一种剂量依赖者方式增加了英皇家空军之阶级最低之兵 phosphorylation。而且, aminoguanidine 增加了 uPAR 表示并且由 PD98059 阻止了 uPAR 表示的抑制。这些结果证明 uPAR 被组织缺氧导致,那增加的 uPAR 表情被英皇家空军之阶级最低之兵 phosphorylation 调停,它被 iNOS/NO 接着在 MDA-MB-231 房间调制。我们结束那 iNOS/NO 在下面经由英皇家空军之阶级最低之兵小径调整在 hypoxic 条件下面调整 uPAR 的表示。 | So Young Yoon Yoo Jung Lee Jae Hong Seo Hwa Jung Sung Kyong Hwa Park In Keun Choi Seok Jin Kim Sang Cheul Oh Chul Won Choi Byung Soo Kim Sang Won Shin Yeul Hong Kim Jun Suk Kim | 2006 | Cell Research2006，16，1： | 2 |
| 4 | Adaptive support-weight approach for correspondence search 显示文摘 | Kuk-Jin Yoon In So Kweon | 2006 | IEEE Transaction on Pattern Analysis and Machine Intelligence2006，28，4： | 1 |
| 5 | 7 macrophages 显示文摘 | Choi WS Jcong JW Kim SO Anti-inflammato-ry potential of peat moss extracts in lipopolysaccharide-stimulated RAW 264 | 2014 | Plnt MolMed2014，34，4： | 1 |
| 6 | Fuzzy QFD for supply chain manage- ment with reliability consideration 显示文摘 | SO Y S IN S C | 2001 | Reliability En- gineering and System Safety2001，，72： | 1 |
| 7 | forest: hydraulic and non- hydraulic effects 显示文摘 | Oren R Sperry J So Sensitivity of mean canopy stomatal conductance to vapor pressure deficit in a flooded Taxodium distichum L | 2001 | Oecologia2001，126，： | 1 |
| 8 | AngiopoietinI regulates endothelial cell survival through the phosphatidylinositol 3 ' -kinase/ Akt signal transduction pathway 显示文摘 | Kim I Kim HG So IN Kim JH Kwak HJ Koh GY | 2000 | Cire Res2000，86，1： | 1 |
| 9 | Robust feature point matching by preserving local geometric consistency显示文摘 | Ouk Choi In So Kweon | 2008 | Computer Vision and Image Understanding2008，，6： | 1 |
| 10 | O ral controlled -re le ase d elivery o f iv erm ectin in cattle via an o s motic p u m p 显示文摘 | P o p e D G W ilk in so n P K E g e rto n J R | | J P h a rm S c i0，74，10： | 1 |
| 11 | Contionous regional anaesthesia in infants显示文摘 | Tobias JD Lowe SO Del IN | 2001 | Can J Anaesth2001，40，： | 1 |
| 12 | Identification of ROS1 rearrangement in gastric adenocarcinoma显示文摘 | Jeeyun Lee Seung Eun Lee So Young Kang In‐Gu Do Sujin Lee Sang Yun Ha Jeonghee Cho Won Ki Kang Jiryeon Jang Sai‐Hong Ignatius Ou Kyoung‐Mee Kim | 2013 | Cancer2013，，9： | 1 |
| 13 | COP: A new corner detector显示文摘 | Sun Cheol Bae In So Kweon Choong Don Yoo | 2002 | Pattern Recognition Letters2002，23，11： | 1 |
| 14 | Adaptive support-weight ap- proach for correspondence search 显示文摘 | Kuk-Jin Yoon In So Kweon | 2006 | IEEETransactions on Pattern Analysis and Machine Intelligence2006，28，4： | 1 |
| 15 | Adaptive support-weight approach for correspondence search显示文摘 | Kuk-Jin Yoon In So Kweon | 2006 | IEEE Transactions on Pattern Analysis and Machine Intelligence2006，28，4： | 1 |
| 16 | 显示文摘 | Kim H LeeKJ Lee SO Cervial cancer screening in Korean American women findings from focus group interviews | 2004 | Daehan Ganho Haghoeji2004，34，4： | 1 |
| 17 | E d g ep reserv in g co lo u rtogreyscaleco nversion显示文摘 | W u Z R R o b in so n J | | EET Im age P ro c essin g0，8，4： | 1 |
| 18 | Adaptive support-weight approach for correspondence search显示文摘 | Kuk-jin Yoon in So Kweon | 2006 | IEEE Transactions on Pattern Analysis and Machine Intelligence2006，28，4： | 1 |
| 19 | Fuzzy QFD for Supply Chain Management with Reliability Consideration 显示文摘 | So Young Sohn In Su Choi | 2001 | Reliability Engineering and System Safety2001，，72： | 1 |
| 20 | Asian Pac显示文摘 | Chang ET Nguyen BH So SK Attitudes toward hepatitis B andliver cancer prevention among Chinese Americans in the SanFrancisco Bay Area California | 2008 | Cancer Prev2008，9，4： | 1 |
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