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您的检索式：作者名="Sok Cheon Pak"
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| 1 | Neuroprotective effects of Suhexiang Wan on the in vitro and in vivo models of Parkinson’s disease显示文摘OBJECTIVE:To examine the role of KSOP1009(a modified formulation of Suhexiang Wan essential oil)in an animal model of Parkinson's disease(PD)induced by 1-methyl-4-phenyl-1,2,3,6-tetrahydro-pyridine(MPTP)injection.METHODS:Cell toxicity,apoptosis,and reactive oxygen species(ROS)levels were analyzed in the human neuroblastoma cell line SH-SY5 Y.After that,changes in animal behavior and tyrosine hydroxylase(TH)protein levels in the substantia nigra(SN)of MPTP-injected mice were examined.Three different doses of KSOP1009(30,100,and 300 mg/kg,n=8 for each group)were administered daily for 7 d before MPTP injection and 14 d after MPTP injection,totaling 21 d.RESULTS:MPP+,the active metabolite of MPTP,decreased the viability of SH-SY5 Y cells,whereas KSOP1009 alleviated MPP+-induced cytotoxicity.KSOP1009(10 and 50 mg/m L)reduced MPP+-induced ROS generation compared with the control group.Treatment with 1 m M MPP+increased the percentage of depolarized/live cells,whereas KSOP1009 intake at a dose of 10 mg/m L decreased the percentage of these cells.The mean latency to fall in the rotarod test was reduced in mice treated with MPTP compared with the control group.However,mice receiving three different doses of KSOP1009 performed better than MPTP-treated animals.MPTP-treated mice were more hesitant and took longer to traverse the balance beam than the control animals.In contrast,KSOP1009-treated mice performed significantly better than MPTPtreated mice.Furthermore,the KSOP1009-treated groups had a significantly higher number of TH-positive neurons in the lesioned SN and significantly higher expression of TH in the striatum than the MPTP-treated group.MPTP treatment strongly induced Jun-N-terminal kinase(JNK)activation,whereas KSOP1009 suppressed MPTP-induced JNK activation.In addition,KSOP1009 intake reversed the decrease in the phosphorylation levels of c AMP-response element-binding protein in the brain of MPTP-treated mice.KSOP1009 also restored the decrease in dopaminergic neurons and dopamine levels in the brain of MPTP-treated mice.CONCLUSION:KSOP1009 protected mice against MPTP-induced toxicity by decreasing ROS formation and restoring mitochondrial function. | Liu Quanfeng Sang Heon Kim Yung-Wei Sung Sok Cheon Pak Wonwoong Lee Jongki Hong Jaehwan Jang Kyoung Sang Cho Songhee Jeon Byung-Soo Koo | 2019 | Journal of Traditional Chinese Medicine2019，39，6： | 3 |
| 2 | Effects of cosmetics containing purified honeybee(Apis mellifera L.) venom on acne vulgaris显示文摘OBJECTIVE:Acne vulgaris is a chronic dermatologic problem with multiple factors involved in its pathogenesis.Alternative solutions to acne treatment were instigated by antibiotic resistance despite of its extensive use.Purified bee venom(PBV)has been proposed as a promising candidate for that purpose.The present study was designed to confirm the antibacterial effect of PBV and access the efficacy of cosmetics containing PBV in subjects with acne vulgaris.METHODS:The skin bacterium Propionibacterium acnes was incubated with PBV at various concentrations and bacterial growth was evaluated using the colony forming unit(CFU)assay.The mechanism of PBV employed in killing P.acnes was examined by scanning electron microscopy(SEM)and transmission electron microscopy(TEM).In addition,a total of 12 subjects were randomized in a double-blind,controlled trial to receive either cosmetics containing PBV or cosmetics without PBV for two weeks.Evaluations included lesion counts and skin microorganism.RESULTS:PBV exhibited antimicrobial activity in a concentration-dependent manner,reducing the number of P.acnes CFU by approximately 6 logs at a concentration of 0.5 mg.When PBV concentration was higher than 1.0 mg,no P.acnes colonies were spotted on an agar.TEM and SEM of untreated P.acnes illustrated the normal pleomorphic structure,whereas the PBVtreated bacterium lost the integrity of surface architecture.Significant difference(P=0.027)in the grading levels based on numbers of lesion counts for inflammatory and noninflammatory was observed in favour of the PBV group compared with the control group.In terms of average decrement of skin microorganism,subjects receiving cosmetics containing PBV experienced a significant 57.5%decrease of adenosine triphosphate levels,whereas participants receiving cosmetics without PBV experienced a nonsignificant decrease of 4.7%.CONCLUSION:These results show that the in vitro actions of antimicrobial activity of PBV were translated in vivo.Cosmetics containing PBV provided a certain degree of efficacy in terms of lesion counts and skin microorganism concentration compared with cosmetics without PBV in subjects with acne vulgaris.PBV may be a good candidate compound for developing therapeutic drug for the treatment of acne vulgaris. | Sang Mi Han Kwang Gill Lee Sok Cheon Pak | 2013 | Journal of Integrative Medicine2013，11，5： | 2 |
| 3 | Borneol alleviates oxidative stress via upregulation of Nrf2 and Bcl-2 in SH-SY5Y cells显示文摘 | Jinyoung Hur Sok Cheon Pak Byung-Soo Koo Songhee Jeon | 2013 | Pharmaceutical Biology2013，，1： | 1 |
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