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| 1 | Neuroprotective effects of Suhexiang Wan on the in vitro and in vivo models of Parkinson’s disease显示文摘OBJECTIVE:To examine the role of KSOP1009(a modified formulation of Suhexiang Wan essential oil)in an animal model of Parkinson's disease(PD)induced by 1-methyl-4-phenyl-1,2,3,6-tetrahydro-pyridine(MPTP)injection.METHODS:Cell toxicity,apoptosis,and reactive oxygen species(ROS)levels were analyzed in the human neuroblastoma cell line SH-SY5 Y.After that,changes in animal behavior and tyrosine hydroxylase(TH)protein levels in the substantia nigra(SN)of MPTP-injected mice were examined.Three different doses of KSOP1009(30,100,and 300 mg/kg,n=8 for each group)were administered daily for 7 d before MPTP injection and 14 d after MPTP injection,totaling 21 d.RESULTS:MPP+,the active metabolite of MPTP,decreased the viability of SH-SY5 Y cells,whereas KSOP1009 alleviated MPP+-induced cytotoxicity.KSOP1009(10 and 50 mg/m L)reduced MPP+-induced ROS generation compared with the control group.Treatment with 1 m M MPP+increased the percentage of depolarized/live cells,whereas KSOP1009 intake at a dose of 10 mg/m L decreased the percentage of these cells.The mean latency to fall in the rotarod test was reduced in mice treated with MPTP compared with the control group.However,mice receiving three different doses of KSOP1009 performed better than MPTP-treated animals.MPTP-treated mice were more hesitant and took longer to traverse the balance beam than the control animals.In contrast,KSOP1009-treated mice performed significantly better than MPTPtreated mice.Furthermore,the KSOP1009-treated groups had a significantly higher number of TH-positive neurons in the lesioned SN and significantly higher expression of TH in the striatum than the MPTP-treated group.MPTP treatment strongly induced Jun-N-terminal kinase(JNK)activation,whereas KSOP1009 suppressed MPTP-induced JNK activation.In addition,KSOP1009 intake reversed the decrease in the phosphorylation levels of c AMP-response element-binding protein in the brain of MPTP-treated mice.KSOP1009 also restored the decrease in dopaminergic neurons and dopamine levels in the brain of MPTP-treated mice.CONCLUSION:KSOP1009 protected mice against MPTP-induced toxicity by decreasing ROS formation and restoring mitochondrial function. | Liu Quanfeng Sang Heon Kim Yung-Wei Sung Sok Cheon Pak Wonwoong Lee Jongki Hong Jaehwan Jang Kyoung Sang Cho Songhee Jeon Byung-Soo Koo | 2019 | Journal of Traditional Chinese Medicine2019，39，6： | 3 |
| 2 | Helicobacter pylori arginase mutant colonizes arginase Ⅱ knockout mice显示文摘AIM: To investigate the role of host and bacterial arginases in the colonization of mice by Helicobacter pylori (H.pylori).METHODS: H.pylori produces a very powerful urease that hydrolyzes urea to carbon dioxide and ammonium,which neutralizes acid.Urease is absolutely essential to H.pylori pathogenesis;therefore,the urea substrate must be in ample supply for urease to work efficiently.The urea substrate is most likely provided by arginase activity,which hydrolyzes L-arginine to L-ornithine and urea.Previous work has demonstrated that H.pylori arginase is surprisingly not required for colonization of wild-type mice.Hence,another in vivo source of the critical urea substrate must exist.We hypothesized that the urea source was provided by host arginase Ⅱ,since this enzyme is expressed in the stomach,and H.pylori has previously been shown to induce the expression of murine gastric arginase Ⅱ.To test this hypothesis,wild-type and arginase (rocF) mutant H.pylori strain SS1 were inoculated into arginase Ⅱ knockout mice.RESULTS: Surprisingly,both the wild-type and rocF mutant bacteria still colonized arginase Ⅱ knockout mice.Moreover,feeding arginase Ⅱ knockout mice the host arginase inhibitor S-(2-boronoethyl)L-cysteine (BEC),while inhibiting > 50% of the host arginase Ⅰ?activity in several tissues,did not block the ability of the rocF mutant H.pylori to colonize.In contrast,BEC poorly inhibited H.pylori arginase activity.CONCLUSION: The in vivo source for the essential urea utilized by H.pylori urease is neither bacterial arginase nor host arginase Ⅱ;instead,either residual host arginase Ⅰ?or agmatinase is probably responsible. | Songhee H Kim Melanie L Langford Jean-Luc Boucher Traci L Testerman David J McGee | 2011 | World Journal of Gastroenterology2011，17，28： | 3 |
| 3 | miR-133b acts as a tumor suppressor and negatively regulates FGFR1 in gastric cancer显示文摘 | Dacheng Wen Songhe Li Fujian Ji Hong Cao Weidong Jiang Jiaming Zhu Xuedong Fang | 2013 | Tumor Biology2013，，： | 2 |
| 4 | Attention-driven salient edge(s) and region(s) extraction with application to CBIR显示文摘 | Songhe Feng De Xu Xu Yang | 2009 | Signal Processing2009，，1： | 1 |
| 5 | Preparation, characterization, photocatalytic properties of titania hollow sphere doped with cerium显示文摘 | Chao Wang Yanhui Ao Peifang Wang Jun Hou Jin Qian Songhe Zhang | 2010 | Journal of Hazardous Materials2010，，1： | 1 |
| 6 | Effects of Pb stress on nutrient uptake and secondary metabolism in submerged macrophyte Vallisneria natans显示文摘 | Chao Wang Jie Lu Songhe Zhang PeiFang Wang Jun Hou Jin Qian | 2011 | Ecotoxicology and Environmental Safety2011，，5： | 1 |
| 7 | Borneol alleviates oxidative stress via upregulation of Nrf2 and Bcl-2 in SH-SY5Y cells显示文摘 | Jinyoung Hur Sok Cheon Pak Byung-Soo Koo Songhee Jeon | 2013 | Pharmaceutical Biology2013，，1： | 1 |
| 8 | Thermal shock resistance of a ZrB 2 –SiC–graphite composite in low oxygen partial pressure environment显示文摘 | Jin Hua Meng Songhe Yang Qiang Zhu Yanwei | 2013 | Ceramics International2013，，： | 1 |
| 9 | Mechanism analysis of thermal shock properties for ZrB 2 -20%SiCp-10%AlN ultra-high temperature ceramic with the surface defects显示文摘 | Songhe Meng Hua Jin Jing An Guanghui Bai Weihua Xie | 2010 | Solid State Sciences2010，，9： | 1 |
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