|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Evaluation of the anti-diabetic properties of Mucuna pruriens seed extract显示文摘Objective:To explore the antidiabetic properties of Mucuna pruriens(M.pruriens).Methods: Diabetes was induced in Wistar rats by single intravenous injection of 120 mg/kg of alloxan monohydrate and different doses of the extract were administered to diabetic rats.The blood glucose level was determined using a glucometer and results were compared with normal and untreated diabetic rats.The acute toxicity was also determined in albino mice.Results:Results showed that the administration of 5,10,20,30,40,50,and 100 mg/kg of the crude ethanolic extract of M.pruriens seeds to alloxan-induced diabetic rats(plasma glucose > 450 mg/dL) resulted in 18.6%,24.9%,30.8%,41.4%,49.7%,53.1%and 55.4%reduction,respectively in blood glucose level of the diabetic rats after 8h of treatment while the administration of glibenclamide (5 mg/kg/day) resulted in 59.7%reduction.Chronic administration of the extract resulted in a significant dose dependent reduction in the blood glucose level(P<0.001).It also showed that the antidiabetic activity of M.pruriens seeds resides in the methanolic and ethanolic fractions of the extract.Acute toxicity studies indicated that the extract was relatively safe at low doses,although some adverse reactions were observed at higher doses(8-32 mg/kg body weight),no death was recorded.Furthermore,oral administration of M.pruriens seed extract also significandy reduced the weight loss associated with diabetes.Conclusions:The study clearly supports the traditional use of M.pruriens for the treatment of diabetes and indicates that the plant could be a good source of potent antidiabetic drug. | Stephen O Majekodunmi Ademola A Oyagbemi Solomon Umukoro Oluwatoyin A Odeku | 2011 | Asian Pacific Journal of Tropical Medicine2011，4，8： | 8 |
| 2 | 射血分数保留的心力衰竭患者服用螺内酯治疗难治性高血压的效果显示文摘最近的研究表明,醛固酮受体拮抗剂螺内酯应作为治疗难治性高血压(resistant hypertension,RHTN)优选的第四线抗高血压药物。目前螺内酯是否能改善射血分数保留的心力衰竭(heart failure with preserved ejection fraction,HFpEF)和RHTN患者的血压控制情况尚不清楚。 | Rossignol P Claggett BL Liu J Vardeny O Pitt B Zannad F Solomon S 陈云(编译) 叶鹏(审校) | 2019 | 中华高血压杂志2019，0，3： | 5 |
| 3 | Association between thrombotic risk factors and extent of fibrosis in patients with non-alcoholic fatty liver diseases显示文摘AIM: To evaluate the prevalence of genetic and acquired prothrombotic risk factors and their association with the extent of fibrosis and fatty infiltration in patients with non-alcoholic fatty liver disease (NAFLD).METHODS: Forty-four patients with chronic hepatitis (28 men and 16 women, with mean age of 45±11 and 49±12 years, respectively) constituted the patient population of this study. The groups were divided as follows: 15 patients with fatty liver (FL); 15 with non-alcoholic steatohepatitis (NASH); 14 with chronic viral hepatitis (CH) diagnosed by histology and liver technetium scan or ultrasound; and 10 healthy individuals. Thrombophilic, coagulation factors and genetic mutations were diagnosed by standard hemostatic and molecular coagulation assays.RESULTS: Activated protein C (APC) resistance and protein S were the most prevalent thrombotic risk factors (6% and 10% in NAFLD vs 21% and 14% in CH; P<0.01 and P<0.05, respectively). One thrombotic risk factor was identified in 41% of patients (23% mild fibrosis, 18% severe fibrosis) and two thrombotic risk factors in 6% of patients with NAFLD and severe fibrosis. While no differences in APC ratio, lupus anticoagulant, fibrinogen, factor V Leiden,prothrombin, and MTHFR mutation were found. Protein S levels were significantly lower in NASH patients than in patients with FL alone (92±19 vs106±2, P<0.01). Protein C levels were markedly higher in patients with NAFLD and mild or severe fibrosis as compared to the patients with CH, respectively (128±40 vs96±14, P<0.001 or 129±36 vs 88±13, P<0.01).CONCLUSION: Up to 46% of patients with NAFLD may have thrombotic risk factors, and the presence of thrombotic risk factors is correlated with the extent of hepatic fibrosis,suggesting a crucial role of the coagulation system in the pathogenesis of hepatic fibrosis. | N Assy I Bekirov Y Mejritsky L Solomon S Szvalb O Hussein | 2005 | World Journal of Gastroenterology2005，11，37： | 3 |
| 4 | 尼日利亚博尔努盆地沉积地层分布特征显示文摘利用博尔努盆地内23口探井的钻井、测井资料,借助于Excel、Petrel及Surfer等软件,确定了盆地Kerri-Kerri组、Gombe组、Fika组、Gongila组和Bima组及整个沉积地层的空间分布。对整个沉积地层空间分布研究发现,博尔努盆地共有3个主要坳陷(A、C、D)和1个构造高点B。坳陷A位于盆地东北部,坳陷C和D分别位于盆地东南部和西南部,构造高点B分隔坳陷A和坳陷C。Kerri-Kerri组、Gombe组、Fika组、Gongila组和Bima组在盆地广泛分布,但地层厚度存在变化;3口深层探井(Kadaru-1井、Herwa-1井及Kinasar-1井)仅钻揭Bima组上部层段(岩性为中—粗粒长石砂岩),对Bima组下部层段尚未钻遇。因此建议针对盆地内部的潜在含油气坳陷区开展深层钻探。 | Olabode Solomon O Adekoya John A Ola Peter S | 2015 | 石油勘探与开发2015，42，5： | 2 |
| 5 | Bounds on least-squares four-parameter sine-fit errors due to harmonic distortion and noise显示文摘 | Deyst J P Soulders T M Solomon O M | 1995 | IEEE Transactions on Instrumentation and Measurement1995，44，3： | 1 |
| 6 | Combined neprilysin and renin-angiotensin system inhibition for the treatment of heart failure 显示文摘 | Vardeny O Miller R Solomon S D | 2014 | JACC Heart Fail2014，2，6： | 1 |
| 7 | Combined neprilysin and renin-angiotensin system inhibition for the treatment of heart failure显示文摘 | Vardeny O Miller R Solomon S D | 2014 | JACC Heart Fail2014，2，： | 1 |
| 8 | Effects of substracte limi-tation on products distribution and H2/CO2 ratio in Klebsiella pneumoniae during anaerobic fermentation of glycerol显示文摘 | Solomon B O Zeng AP Biebl H | 1994 | Appl Microbiol Bioteehnol1994，42，3： | 1 |
| 9 | Effect of oxygen and fluorescent light on the quality of orange juice during storage at 8℃显示文摘 | Solomon O Svanberg U Sahlstrm A | 1995 | Food Chemistry1995，53，4： | 1 |
| 10 | H erpes zoster revisited: implicatedin root re so rp tio n 显示文摘 | Solomon C S C o^iner M O Chalfin H E | | J E n d o d0，12，5： | 1 |
| 11 | Peripheral nerve-stimulated macrophages simulate a peripheral nerve-like regenerative response in rat transected optic nerve显示文摘 | Lazarov-Spiegler O Solomon A S Schwartz M | 1998 | Glia1998，24，： | 1 |
| 12 | Study on the physicochemical properties and heavy metal status of sediment samples from Ohii Miri river in Abia State,Nigeria显示文摘 | Solomon M M Jonah A E Ano A O | 2014 | Fountain Journal of Natural and Applied Sciences2014，3，1： | 1 |
| 13 | Lean construction: from theory to implementation显示文摘 | Salem O Solomon J Genaidy A | 2006 | Journal of Management in Engineering2006，，22： | 1 |
| 14 | Bounds on Least-Squares Four-Parameter Sine-Fit Errors Due to Harmonic Distortion and Noise显示文摘 | Deyst J P Soulders T M Solomon O M Jr | 1995 | IEEE Trans on I M1995，44，3： | 1 |
| 15 | Bounds on least-squares four-parameter sine-fit errors due to harmonic distortion and noise显示文摘 | DEYST J P SOULDERS T M SOLOMON JR O M | 1995 | IEEE Transaction on Instrumentation & Measurement1995，44，3： | 1 |
| 16 | Combined neprilysin and renin-angiotensin system inhibition for the treatment of heart failure显示文摘 | VARDENY O MILLER R SOLOMON S D | 2014 | JACC Heart Fail2014，2，： | 1 |
| 17 | First-in-class angiotensin receptor neprilysin inhibitor in heart failure显示文摘 | VARDENY O TACHENY T SOLOMON S D | 2013 | Clin Pharmacol Ther2013，94，： | 1 |
| 18 | Identification of the complex ions in liquid cryolite显示文摘 | Solomons C Clarke J H R Bockris J O M | 1968 | The Journal of Chemical Physics1968，49，1： | 1 |
| 19 | The Atrial Fibrillation Follow-up Investigation of Rhythm Management (AFFIRM) study显示文摘 | Brian Olshansky Lynda E. Rosenfeld Alberta L. Warner Allen J. Solomon Gearoid O’Neill Arjun Sharma Edward Platia Gregory K. Feld Toshio Akiyama Michael A. Brodsky H.Leon Greene | 2004 | Journal of the American College of Cardiology2004，，7： | 1 |
| 20 | D&ermination de la vi osit , imrins,Sque de solutions de polym res par une simple d&ermination de la viseosite 显示文摘 | Solomon O F Ciuta I Z | 1962 | Journal of Applied Polymer Science1962，4，6： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员