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| 1 | Characterisation of a novel oral iron chelator: 1‐( N ‐ A cetyl‐6‐ A minohexyl)‐3‐ H ydroxy‐2‐ M ethylpyridin‐4‐one显示文摘 | Kanjana Pangjit Ratana Banjerdpongchai Chada Phisalaphong Suthat Fucharoen Yuan Yuan Xie Zi Dong Lu Robert C. Hider Somdet Srichairatanakool | 2015 | J Pharm Pharmacol2015，，5： | 2 |
| 2 | Effect of a novel oral active iron chelator: 1-(N-acetyl-6-aminohexyl)-3-hydroxy-2-methylpyridin-4-one (CM1) in iron-overloaded and non-overloaded mice显示文摘 | Nittaya Chansiw Kanjana Pangjit Chada Phisalaphong John B. Porter Patricia Evans Suthat Fucharoen Somdet Srichairatanakool | 2014 | Asian Pacific Journal of Tropical Medicine2014，，： | 1 |
| 3 | Effects of Phenolic Compounds of Fermented Thai Indigenous Plants on Oxidative Stress in Streptozotocin-Induced Diabetic Rats显示文摘 | Chaiyavat Chaiyasut Winthana Kusirisin Narissara Lailerd Peerasak Lerttrakarnnon Maitree Suttajit Somdet Srichairatanakool | 2011 | Evidence-Based Complementary and Alternative Medicine2011，，： | 1 |
| 4 | Expression of fluorescent tagged recombinant erythroferrone protein显示文摘Objective: To produce fluorescent tagged recombinant erythroferrone protein(ERFE_eGFP) for laboratory investigations. Methods: Erythroferrone(ERFE) gene was fused to green fluorescent protein(eGFP) gene and cloned in a pSecTag2Hygro plasmid. The constructed plasmid was amplified in Escherichia coli DH5α and the eGFP-fused ERFE(ERFE_eGFP) protein was expressed in human embryonic kidney(HEK293T) cell line. Results: The plasmid constructed from colony C6 contained ERFE_eGFP with the correct restriction sizes of 4.2 kb and expressed secretory ERFE_eGFP fusion protein(approximately size of 75 kDa) in HEK293T cell line. Conclusions: ERFE_eGFP recombinant protein is successfully expressed as a secretory functional protein and could be sensitively detected using fluorometry. This fusion protein might benefit future applications for localization of cellular ERFE receptors and competitive immunoassay of ERFE concentration. | Min Min Than Jetsada Ruangsuriya Chairat Uthaipibull Somdet Srichairatanakool | 2018 | Asian Pacific Journal of Tropical Biomedicine2018，8，7： | 1 |
| 5 | Combined treatment of 3-hydroxypyridine-4-one derivatives and green tea extract to induce hepcidin expression in iron-overloaded b-thalassemic mice显示文摘Objective:To evaluate the efficacy of deferiprone(DFP),1-(N-acetyl-6-aminohexyl)-3-hydroxy-2-methylpyridin-4-one(CM1)or green tea extract(GTE)in enhancing expression of hepatic hepcidin1(Hamp1)m RNA and relieving iron overload in b-globin knockout thalassemic mice.Methods:The b-globin knockout thalassemic mice were fed with a ferrocenesupplemented diet for 2 months and oral administration of deionized water,DFP(50 mg/kg),CM1(50 mg/kg),GTE(50 mg epigallocatechin 3-gallate equivalent/kg),GTE along with DFP(50 mg/kg),and GTE along with CM1(50 mg/kg)every day for 3months.Levels of hepatic Hamp1 m RNA,plasma non-transferrin bound iron,plasma alanine aminotransferase activity and tissue iron content were determined.Results:All chelation treatments could reduce plasma non-transferrin bound iron concentrations.Additionally,hepatic Hamp1 m RNA expression was significantly upregulated in the mice in a GTE+DFP combined treatment,correlating with a decrease in the plasma alanine aminotransferase activity and tissue iron deposition.Conclusions:The GTE+DFP treatment could ameliorate iron overload and liver oxidative damage in non-transfusion dependent b-thalassemic mice,by chelating toxic iron in plasma and tissues,and increasing hepcidin expression to inhibit duodenal iron absorption and iron release from hepatocytes and macrophages in the spleen.There is probably an advantage in giving GTE with DFP when treating patients with iron overload. | Supranee Upanan Kanjana Pangjit Chairat Uthaipibull Suthat Fucharoen Andrew T.Mc Kie Somdet Srichairatanakool | 2015 | Asian Pacific Journal of Tropical Biomedicine2015，5，12： | 0 |
| 6 | Iron-chelating and anti-lipid peroxidation properties of 1-(N-acetyl-6-aminohexyl)-3-hydroxy-2-methylpyridin-4-one(CM1)in longterm iron loading β-thalassemic mice显示文摘Objective:To evaluate the iron—chelating properties and free—radical scavenging activities of1-(N-acetyl-6-aminohexyl)-3-hydroxy-2-methyIpyridin—4-one(CM1) treatment in chronic iron-loaded β-thalassemic(BKO) mice.Methods:The BKO mice were fed with a ferrocene-rich diet and were orally administered with CM1|50 mg/(kg·day)| for 6 months.Blood levels of non-transferrin hound iron,labile plasma iron.ferritin(Ft) and malondialdehyde were determined.Results:The BKO mice were fed with an iron diet for 8 months which resulted in iron overload.Interestingly,the mice showed a decrease in the non—transferrin bound iron,labile plasma iron and malondialdehyde levels,but not the Ft levels after continuous CM1 treatment.Conclusions:CM1 could be an effective oral iron chelator that can reduce iron overload and lipid peroxidation in chronic iron overload β—thalassemic mice. | Kanokwan Kulprachakarn Nittaya Chansiw Kanjana Pangjit Chada Phisalaphong Suthat Fucharoen Robert C.Hider Sineenart Santitherakul Somdet Srichairatanakool | 2014 | Asian Pacific Journal of Tropical Biomedicine2014，4，8： | 0 |
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