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| 1 | Lactate regulates major zygotic genome activation by H3K18 lactylation in mammals显示文摘Lactate is present at a high level in the microenvironment of mammalian preimplantation embryos in vivo and in vitro.However,its role in preimplantation development is unclear.Here,we report that lactate is highly enriched in the nuclei of early embryos when major zygotic genome activation(ZGA)occurs in humans and mice.The inhibition of its production and uptake results in developmental arrest at the 2-cell stage,major ZGA failure,and loss of lactate-derived H3K18lac,which could be rescued by the addition of Lac-CoA and recapitulated by overexpression of H3K18R mutation.By profiling the landscape of H3K18lac during mouse preimplantation development,we show that H3K18lac is enriched on the promoter regions of most major ZGA genes and correlates with their expressions.In humans,H3K18lac is also enriched in ZGA markers and temporally concomitant with their expressions.Taken together,we profile the landscapes of H3K18lac in mouse and human preimplantation embryos,and demonstrate the important role for H3K18lac in major ZGA,showing that a conserved metabolic mechanism underlies preimplantation development of mammalian embryos. | Jingyu Li Weibo Hou Qi Zhao Wei Han Hongdi Cui Songling Xiao Ling Zhu Jiadan Qu Xiaoyu Liu Weitao Cong Jingling Shen Yuzheng Zhao Shaorong Gao Guoning Huang Qingran Kong | 2024 | National Science Review2024，11，2： | 0 |
| 2 | Design and test of the key components for a combing-type tobacco harvester显示文摘In response to the problems of low efficiency,high labor intensity,and low mechanization in manual tobacco harvesting,a comb-off tobacco picking device for southern hilly tobacco areas was designed following the agronomic requirements and the principle of manual picking of tobacco harvesting in southern China.The device was composed of the power chassis,picking mechanism,and storage mechanism.This study involved the theoretical analysis,structural design,and modeling of the key components,such as chassis structure,combing-type picking mechanism,and power synchronization mechanism.The results of the motion analysis and calculation of the picking process demonstrated that the adjustment range of the comb chain elevation angles was from 12.4°to 20.9°,the comb rod installation distance was 76.2 mm,and the synchronizing mechanism transmission ratio was 3:10.One-factor test and three-factor three-level orthogonal test was performed with the forward speed of the chassis,the distance between the picking device baffles and the elevation angle of the chain with the combing bar as test factors,and the rate of broken and missed tobacco picking as evaluation indicators.It was revealed that the optimal combination of the forward speed of the chassis,the distance between the baffles,and the chain elevation angle were 1.5 km/h,75 mm,and 12.4°,respectively.Moreover,verification tests suggested that the breakage rate of tobacco leaves was 9.99%,and the probability of missed tobacco picking was 7.31%,both of which satisfy the agriculture requirements and the operational requirements in the agricultural machinery certification syllabus. | Chaoran Sun Shaohui Tan Songling Sun Mingtao Xiao Limei Chen Wenke Ai Zhihua Qiu Ping Jiang Yang He | 2024 | International Journal of Agricultural and Biological Engineering2024，17，1： | 0 |
| 3 | Accurate Online MTPA Control of IPMSM Considering Derivative Terms显示文摘The conventional maximum torque per ampere(MTPA)operation usually neglects the derivative terms of interior permanent magnet synchronous motor(IPMSM)parameters,which significantly influences MTPA control accuracy.In this study,an MTPA control scheme that considers the derivative terms is developed,and a parameter identification strategy that considers the inverter to be non-ideal is developed for the calculation of the IPMSM parameters and derivative terms.In addition,the estimation accuracy of the motor parameters is further improved through the calibration of the nonlinear factors of the inverter.Finally,the effectiveness and accuracy of the proposed method is verified by simulation.This paper proposes practical methods for both inverter parameter estimation and accurate online MTPA control. | Riyang Yang Tianfu Sun Wei Feng Shaojia He Songling Zhu Xiao Chen | 2021 | Chinese Journal of Electrical Engineering2021，7，3： | 0 |
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