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您的检索式：作者名="Songqiang Xie"
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| 1 | Modeling study of a severe aerosol pollution event in December 2013over Shanghai China:An application of chemical data assimilation显示文摘This study focuses on the importance of initial conditions to air-quality predictions.We ran assimilation experiments using the WRF-Chem model and grid-point statistical interpolation(GSI),for a 9-day severe particulate matter pollution event that occurred in Shanghai in December 2013.In this application,GSI used a three-dimensional variational approach to assimilate ground-based PM2.5 observations into the chemical model,to obtain initial fields for the aerosol species.In our results,data assimilation significantly reduced the errors when compared to a simulation without assimilation,and improved forecasts of PM_(2.5)concentrations.Despite a drop in skill directly after the assimilation,a positive effect was present in forecasts for at least 12-24 h,and there was a slight improvement in the 48-h forecasts.In addition to performing well in Shanghai,the verification statistics for this assimilation experiment are encouraging for most of the surface stations in China. | Jian-Bin Wu Jianming Xu Mariusz Pagowski Fuhai Geng Songqiang Gu Guangqiang Zhou Ying Xie Zhongqi Yu | 2015 | Particuology2015，13，3： | 4 |
| 2 | Design,synthesis and antitumor activities of fluoroquinolone C-3 heterocycles(Ⅳ):s-triazole Schiff-Mannich bases derived from of loxacin显示文摘The aim of this research was to produce novel antitumor fluoroquinolones from antibacterial analogs by introduction of a heterocyclic ring as a bioisostere of the C-3 carboxylic acid group.To this end,two series of eleven s-triazole derivatives bearing functionalized side chains of Schiff bases and Schiff Mannich bases were designed and synthesized.Structures were characterized by elemental analysis and spectral data after which in vitro antitumor activity against L1210,CHO and HL60 cell lines was evaluated in the MTT assay.Compounds posssing a free phenol group were particularly active and warrant further development. | Guoqiang Hu Guoqiang Wang Nannan Duan Xiaoyi Wen Tieyao Cao Songqiang Xie Wenlong Huang | 2012 | Acta Pharmaceutica Sinica B2012，2，3： | 3 |
| 3 | Gestational dexamethasone exposure impacts hippocampal excitatory synaptic transmission and learning and memory function with transgenerational effects显示文摘The formation of learning and memory is regulated by synaptic plasticity in hippocampal neurons.Here we explored how gestational exposure to dexamethasone,a synthetic glucocorticoid commonly used in clinical practice,has lasting effects on offspring's learning and memory.Adult offspring rats of prenatal dexamethasone exposure(PDE)displayed significant impairments in novelty recognition and spatial learning memory,with some phenotypes maintained transgenerationally.PDE impaired synaptic transmission of hippocampal excitatory neurons in offspring of F1 to F3 generations,and abnormalities of neurotransmitters and receptors would impair synaptic plasticity and lead to impaired learning and memory,but these changes failed to carry over to offspring of F5 and F7 generations.Mechanistically,altered hippocampal miR-133a-3p-SIRT1-CDK5-NR2B signaling axis in PDE multigeneration caused inhibition of excitatory synaptic transmission,which might be related to oocyte-specific high expression and transmission of miR-133a-3p.Together,PDE affects hippocampal excitatory synaptic transmission,with lasting consequences across generations,and CDK5 in offspring's peripheral blood might be used as an early-warning marker for fetal-originated learning and memory impairment. | Mingcui Luo Yiwen Yi Songqiang Huang Shiyun Dai Lulu Xie Kexin Liu Shuai Zhang Tao Jiang Tingting Wang Baozhen Yao Hui Wang Dan Xu | 2023 | Acta Pharmaceutica Sinica B2023，13，9： | 0 |
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