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| 1 | 42,573 cases of hepatectomy in China: a multicenter retrospective investigation显示文摘Hepatectomy is currently routinely performed in most hospitals in China. China owns the largest population of liver diseases and the biggest number of liver resection cases. A nationwide multicenter retrospective investigation involving 112 hospitals was performed, and focused on liver resection for patients with hepatocellular carcinoma(HCC). 42,573 cases of hepatectomy were enrolled, and 18,275 valid cases of liver resection for HCC patients were selected for statistical analysis. The epidemiology of HCC, distribution of hepatectomy, postoperative complications and prognosis were finally analyzed. In the 18,275 HCC patients,81% had hepatitis B virus infection and 10% had hepatitis C virus infection. 38% of the HCC patients had normal Alphafetoprotein(AFP) level, and other 35% had an AFP level lower than 400 ng mL^(-1). In the study period, 97% of the hepatectomy for HCC were treated with open surgery, and 23.81% had vascular exclusion techniques. The operation time was(191.7±105.6) min,the blood loss was(546.0±562.8) m L, and blood transfusion was(543.0±1,035.2) m L. The median survival for HCC patients was 631 days, with 1-, 3-, and 5-year overall survival of 73.2%, 28.8% and 19.6%, respectively. Liver cirrhosis, multiple nodules,tumor thrombosis and high AFP level were risk factors that affect postoperative survival. | Binhao Zhang Bixiang Zhang Zhiwei Zhang Zhiyong Huang Yifa Chen Minshan Chen Ping Bie Baogang Peng Liqun Wu Zhiming Wang Bo Li Jia Fan Lunxiu Qin Ping Chen Jingfeng Liu Zhe Tang Jun Niu Xinmin Yin Deyu Li Songqing He Bin Jiang Yilei Mao Weiping Zhou Xiaoping Chen | 2018 | Science China(Life Sciences)2018，61，6： | 39 |
| 2 | Identification of aberrant cell cycle regulation in Epstein-Barr virus-associated nasopharyngeal carcinoma by cDNA microarray and gene set enrichment analysis显示文摘 | Wenling Zhang Zhaoyang Zeng Yanhong Zhou Wei Xiong Songqing Fan Lan Xiao Donghai Huang Zheng Li Dan Li Minghua Wu Xiaoling Li Shourong Shen Rong Wang Li Cao Ke Tang Guiyuan Li | 2009 | Acta Biochimica et Biophysica Sinica2009，41，5： | 11 |
| 3 | The Arabidopsis P450 protein CYP82C2 modulates jasmonateinduced root growth inhibition, defense gene expression and indole glucosinolate biosynthesis显示文摘Jasmonic 酸(JA ) 是对草食动物和一些微生物引起的病原体调整大量植物防卫回答的一个丰满的导出酸的发信号分子。分子的基因研究证实了 JA 也在植物开发的几个方面执行一个关键角色。这里,我们描述 Arabidopsis 变异的 jasmonic acid-hypersensitive1-1 (jah1-1 ) 的描述,它在 JA 回答的几个方面是有缺点的。尽管异种在根生长抑制展出增加的敏感到 JA,它显示出 JA 可诱导的防卫基因和减少的抵抗的减少的表示到 necrotrophic 真菌 Botrytis cinerea。基因克隆研究显示这些缺点被一个变化在细胞色素 P450 蛋白质 CYP82C2 引起。我们提供证明的证据到 B 的 jah1-1 异种的损害抵抗。cinerea 被导致 JA 的防卫基因的减少的表示伴随并且减少了导致 JA 的吲哚 glucosinolates (IG ) 的累积。相反地,提高的抵抗到 B。在 CYP82C2-overexpressing 植物的 cinerea 被导致 JA 的防卫基因的增加的表示伴随并且提高了导致 JA 的 IG 的层次。我们证明 CYP82C2 影响 IG biosynthetic 先锋的导致 JA 的累积色氨酸(Trp ) ,然而并非导致 JA 的 IAA 或导致病原体的 camalexin。一起,我们 CYP82C2 可以在导出 Trp 的第二等的代谢物的新陈代谢扮演在下面的一个假设在 JA 在哪个铺平调节的结果支持被提高。jah1-1 异种应该因此在向理解位于调停 JA 的微分回答的复杂性下面的机制的未来研究是重要的,它是重要的让植物使他们的生长适应千变万化环境。 | Fang Liu Hongling Jiang Songqing Ye Wen-Ping Chen Wenxing Liang Yingxiu Xu Bo Sun Jiaqiang Sun Qiaomei Wang Jerry D Cohen Chuanyou Li | 2010 | Cell Research2010，20，5： | 10 |
| 4 | NGX6 inhibits AP-1 and Ets-1 expression and down-regulates cyclin D1 in human coloreetal cancer显示文摘Colorectal 癌症(CRC ) 是与病态和死亡的增加的发生被联系的一个普通恶意的肿瘤。鼻咽的联系癌的基因(NGX6 ) 6 是肿瘤转移的新奇候选人 suppressor 基因,它在 CRC 是下面调整的。在现在的学习,我们构造了 colorectal 织物 microarray 在 CRC 纸巾检验 NGX6, phospho-c-Jun N 终端 kinase (p-JNK ) ,和 phospho 细胞外的调整信号的 kinase (津贴) 的表示侧面。而 p-JNK 和津贴的表情在 CRC 纸巾是更高的,我们发现 NGX6 表示在 CRC 纸巾和变形淋巴节点是更低的,比在正常肠的 mucosa。NGX6, p-JNK,和津贴的表情与 colorectal 纸巾的临床的病理学的特征被联系。NGX6 overexpression 禁止了激活和 JNK1 的原子 translocation,它在细胞质导致了 p-JNK 的累积,但是没禁止激活和 ERK1/2 的原子 translocation。NGX6 也禁止了抄写因素 AP-1 (c-jun 和 c-fos ) 和 Ets-1 的表示。另外, NGX6 overexpression 减少了 cyclin D1 并且戏剧性地的表示压制了 cyclin D1 倡导者的 transcriptional 效率。我们建议那 NGX6 表情沉醉于人的 colorectal carcinogenesis 的多步过程。它的 overexpression 能禁止抄写因素的表示 AP-1 和 Ets-1,和下面调整在人的 CRC 的 cyclin D1 倡导者的 transcriptional 活动。 | Ya Peng Hongtao Li Minghua Wu Xiaoyan Wang Songqing Fan Fen Liu Bo Xiang Qin Guo Xueyuan Tang Shourong Shen | 2009 | Acta Biochimica et Biophysica Sinica2009，41，6： | 8 |
| 5 | Effect of ambient oxygen pressure on structural, optical and electrical properties of SnO_2 thin films显示文摘Polycrystalline SnO2 thin films were deposited on sapphire substrates at 450°C under different ambient oxygen pressures by pulsed laser deposition technique. The effect of ambient oxygen pressure on the structural, optical and electri- cal properties of SnO2 thin films was studied. X-ray diffraction and Hall measurements show that increasing the ambient oxygen pressure can improve crystallization of the films and decrease resistivity of the films. A violet emission peak cen- tered at 409 nm was observed from photoluminescence measurements for SnO2 films under deposition ambient oxygen pressure above 5 Pa, which is related to the improvement of crystalline of the films. | ZHAO Songqing ZHOU Yueliang WANG Shufang ZHAO Kun HAN Peng | 2006 | Rare Metals2006，25，6： | 4 |
| 6 | Extracellular calcium elicits feedforward regulation of the roll-like receptor-triggered innate immune response显示文摘 | Songqing Tang Taoyong Chen Mingjin Yang Lei Wang Zhou Yu Bin Xie Cheng Qian Sheng Xu Nan Li Xuetao Cao Jianli Wang | 2017 | Cellular & Molecular Immunology2017，14，2： | 3 |
| 7 | Reliable Space Pursuing for Reliability-based Design Optimization with Black-box Performance Functions显示文摘Reliability-based design optimization(RBDO) is intrinsically a double-loop procedure since it involves an overall optimization and an iterative reliability assessment at each search point.Due to the double-loop procedure, the computational expense of RBDO is normally very high.Current RBDO research focuses on problems with explicitly expressed performance functions and readily available gradients.This paper addresses a more challenging type of RBDO problem in which the performance functions are computation intensive.These computation intensive functions are often considered as a'black-box'and their gradients are not available or not reliable.On the basis of the reliable design space(RDS) concept proposed earlier by the authors, this paper proposes a Reliable Space Pursuing(RSP) approach, in which RDS is first identified and then gradually refined while optimization is performed.It fundamentally avoids the nested optimization and probabilistic assessment loop.Three well known RBDO problems from the literature are used for testing and demonstrating the effectiveness of the proposed RSP method. | SHAN Songqing WANG G Gary | 2009 | Chinese Journal of Mechanical Engineering2009，22，1： | 2 |
| 8 | Synthesis of Well-Aligned ZnO Nanowires by Simple Physical Vapor Deposition on C-Oriented ZnO Thin Films without Catalysts or Additives显示文摘 | Wang Lisheng Zhang Xiaozhong Zhao Songqing | 2005 | Appl Phys Lett2005，86，2： | 1 |
| 9 | Survey of modeling and opti- mization strategies to solve high-dimensional design problems with computationally-expensive black-box functions显示文摘 | SHAN Songqing WANG G G | 2010 | Struct Multidisc Optim2010，41，2： | 1 |
| 10 | Mode-pursuing sampling method for global optimization on expensive black-box functions显示文摘 | WANG Liqun SHAN Songqing WANG Gg G | 2004 | Engineering Optimization2004，36，4： | 1 |
| 11 | Composite Metallogenic Systems in the Weihai Area of Shandong and Evolution of Continental Dynamic Regimes显示文摘摘要:把地区性的地质的调查基于9张l:50,000规模并且由 metallogenic 系统的理论和综合分析指导了结构并且 metallogenic 特征,这份报纸在此提出 Weihai 区域的合成 metallogenic 系统,山东省,瞄准在区域在起源和众多的存款的控制矿石的结构上解决这些问题。它的科学意义在下列三个方面被反映:(1 ) 合成 metallogenic 系统的基本特征能被认出,它由二种类型组成:原生地变形热水的 metallogenic 系统和中生代 magmatic 热水的 metallogenic 系统(即 Indosinian 早 Yanshanian 接触交代矿床 metallogenic 系列和中间迟了的 Yanshanian magmatic 热水的 metallogenic 系列) 。二个系列分别地显示弓形、 NW 正确的侧面的安排和 N-S 平行带的分布,与相应矿物质集合是 Au+Ag+Pb+Zn,等等;并且 Cu+Mo+Fe, Au+Ag+Cu+Pb-Zn+Mo+Co-Ni+suIfides+silicides+K-feldspar,等等(2 ) 合成 metallogenic 系统可以被用来解释沉积物的复杂基因关系。通过在三主要 metallogenic 之间的关系的分析,间隔和他们的相应来源摇系列(Jingshan 和 Rongcheng 组;超级单位的 Wendong 和早中间的 Yanshanian Weideshan 超级单位;并且中间迟了的 Yanshanian Weideshan 和 Laoshan 超级单位) 象 Fanjiabu 金沉积物的案例研究一样,我们区分了在接触交代矿床(skarn类型)之间的同宗象 noncognate 重叠在之间一样的 metallogenic 系列和magmatic热水的 metallogenic 系列二并且变形热水的 metallogenic 系统。(3 ) 合成 metallogenic 系统是容易与大陆人的进化有关动态政体。变形热水的 metallogenic 系统的形成从扩展经历了 tectono 动态的政体的三种不同类型的转变 ? 压缩 ? 砍接触交代矿床(skarn 类型) 的从压缩的 metallogenic 系统 ? 扩展 ? 压缩;并且从扩展的 magmatic 热水的 metallogenic 系统的 ? 和平的板的 subductive 压缩。三种类型的进化都被归因于洞关上或 paleocontinent 的分叉集中,和所有他们的矿化作用从集中的结束对应于转变的间隔到 Weihai paleocontinent 的早集成。都,这些将有益于我们大陆人 metallogenic 过程的动力学的更深的学习。 | SUN Zhongshi WANG Peifu DENG Jun WANG Qingfei WANG Jianping MU Taisheng SUN Li FAN Siqi YE Songqing LIU Zhenghong CUI Shuxue | 2007 | Acta Geologica Sinica(English Edition)2007，81，2： | 1 |
| 12 | 显示文摘 | Wang Lisheng Zhang Xiaozhong Zhao Songqing | 2005 | Appl Phy Lett2005，86，2： | 1 |
| 13 | Segment-based Proxy Caching for Internet Streaming Media Delivery显示文摘 | Chen Songqing Wang Haining Zhang Xiaodong | 2005 | IEEE Multimedia2005，12，3： | 1 |
| 14 | Reliable design space and complete single-loop reliability based design optimization显示文摘 | SHAN Songqing WANG G G | 2008 | Reliability Engineering and System Safety2008，93，8： | 1 |
| 15 | Laser-induced voltage characteristics of Bi 2 Sr 2 Co 2 O y thin films on LaAlO 3 substrates显示文摘 | Shufang Wang Jinchun Cheng Xiaohui Zhao Songqing Zhao Liping He Mingjing Chen Wei Yu Jianglong Wang Guangsheng Fu | 2010 | Applied Surface Science2010，，1： | 1 |
| 16 | Mode-pursuingsampling method for global optimization on expensive black-box functions显示文摘 | WANG Liqun SHAN Songqing WANG G G | 2004 | Journal of Engineering Optimization2004，36，： | 1 |
| 17 | An efficient pareto set identification approach for multi-objective optimization on black-box functions显示文摘 | SHAN Songqing WANG G G | 2005 | Transactions of the ASME Journal of Mechanical Design2005，127，： | 1 |
| 18 | Failure surface frontier for reliability assessment on expensive performance function显示文摘 | SHAN Songqing WANG G G | 2006 | Transactions of ASME Journal of Mechanical Design2006，128，： | 1 |
| 19 | 显示文摘 | Wang Lisheng Zhang Xiaozhong Zhao Songqing | 2005 | Appl Phy Lett2005，86，2： | 1 |
| 20 | Segment-based Proxy Caching for Intemet Streaming Media Delivery显示文摘 | Chen Songqing Wang Haining Shen Bo | 2005 | IEEE Multimedia2005，12，3： | 1 |
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