|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Surveillance, epidemiology, and pathogen spectrum of hand, foot, and mouth disease in mainland of China from 2008 to 2017显示文摘Hand,foot and mouth disease(HFMD)was reported in May 2,2008 to be the 38th legally notifiable disease in China's National Notifiable Disease Reporting and Surveillance System.In order to solve the infection,an extensive three-level HFMD surveillance laboratory network was established.In this study,the framework of that network is assessed and the incidence of HFMD in China from 2008 to 2017 is reported using a descriptive epidemiologic method.During these 10 years,a series of techniques have been widely applied in all the network laboratories.Using information and material obtained from the network,a virus bank and database containing 18,238 viruses were established.Nationally,18,184,834 HFMD cases,including 152,436 severe cases and 3633 fatal cases,were reported in mainland of China.The average annual incidence in the population was 133.99/100,000 people,with a maximum incidence of 205.06/100,000 people in 2014.The incidence and mortality rates of HFMD were the highest in children aged 1–2 years.The numbers of reported cases fluctuated,with a high incidence observed every 2 years.An overall increase in the number of reported cases was also observed throughout the study period.Despite this,the incidence of severe cases and the mortality rate have been decreasing.High-risk regions are located in southern,eastern,and central China.Two peaks of HFMD infection cases were observed annually except for Northeast China.Different proportions of enterovirus serotypes were observed during the studied years.The predominant enterovirus varies from year to year,but the disease severity is always closely related to the specific serotype.EV-A71 is the dominant serotype associated with severe and fatal cases,with constituent ratios of 70.03%and 92.23%,respectively.The studied highly sensitive and efficient surveillance network provides information that is critical for prevention and control of the disease.It is extremely necessary and important to continuously conduct extensive virological surveillance for HFMD. | Tianjiao Ji Taoli Han Xiaojuan Tan Shuangli Zhu Dongmei Yan Qian Yang Yang Song Aili Cui Yan Zhang Naiying Mao Songtao Xu Zhen Zhu Dandan Niu Yong Zhang Wenbo Xu | 2019 | Biosafety and Health2019，1，1： | 26 |
| 2 | Emerging role of natural products in cancer immunotherapy显示文摘Cancer immunotherapy has become a new generation of anti-tumor treatment,but its indications still focus on several types of tumors that are sensitive to the immune system.Therefore,effective strategies that can expand its indications and enhance its efficiency become the key element for the further development of cancer immunotherapy.Natural products are reported to have this effect on cancer immunotherapy,including cancer vaccines,immune-check points inhibitors,and adoptive immune-cells therapy.And the mechanism of that is mainly attributed to the remodeling of the tumorimmunosuppressive microenvironment,which is the key factor that assists tumor to avoid the recognition and attack from immune system and cancer immunotherapy.Therefore,this review summarizes and concludes the natural products that reportedly improve cancer immunotherapy and investigates the mechanism.And we found that saponins,polysaccharides,and flavonoids are mainly three categories of natural products,which reflected significant effects combined with cancer immunotherapy through reversing the tumor-immunosuppressive microenvironment.Besides,this review also collected the studies about nano-technology used to improve the disadvantages of natural products.All of these studies showed the great potential of natural products in cancer immunotherapy. | Songtao Dong Xiangnan Guo Fei Han Zhonggui He Yongjun Wang | 2022 | Acta Pharmaceutica Sinica B2022，12，3： | 5 |
| 3 | THE EFFECT OF IMU INACCURACIES ON AIRBORNE SAR IMAGING显示文摘When using motion compensation approaches based on the measurement of motion sensors, the residual uncompensated motion errors due to measurement instrument inaccuracies contribute to phase errors and hence degrade Synthetic Aperture Radar (SAR) images. This paper presents a model to compute the phase error caused by Inertial Measurement Unit (IMU) measurement inaccuracies. By analyzing SAR motion compensation method and the effect of lever arm, this model derives the con-tribution of each term of IMU inaccuracies towards the residual uncompensated motion errors and provides a method to calculate each order of the residual phase error. According to the model, com-puted results of the airborne X-band SAR system with POS AV510 accord closely with the actual image quality. | Mao Yongfei Xiang Maosheng Wei Lideng Han Songtao | 2011 | Journal of Electronics(China)2011，28，4： | 5 |
| 4 | Analysis and prediction of surface roughness for robotic belt grinding of complex blade considering coexistence of elastic deformation and varying curvature显示文摘Precision prediction of machined surface roughness is challenging facing the robotic belt grinding of complex blade,since this process is accompanied by significant elastic deformation.The resulting poor prediction accuracy,to a great extent,is attributed to the existing prediction model which less considers the dynamics.In this paper,an improved scallop height model is developed to predict and assess the machined surface roughness by taking into account the elastic deformation and the varying curvature of blade,then robotic belt grinding experiments are carried out to evaluate the proposed model from the perspective of surface roughness.Finally factors that influence the scallop height are analyzed,and the suitable empirical equation of surface roughness is proposed to assess and predict the surface quality from the aspect of blade concave and convex surface by adopting the constant scallop height machining. | XU XiaoHu YE SongTao YANG ZeYuan YAN SiJie ZHU DaHu DING Han | 2021 | Science China(Technological Sciences)2021，64，5： | 2 |
| 5 | Photocrosslinking silver nanoparticles–aloe vera–silk fibroin composite hydrogel for treatment of full-thickness cutaneous wounds显示文摘Damage to the skin causes physiological and functional issues.The most effective treatment approach is the use of wound dressings.Silk fibroin(SF)is a promising candidate biomaterial for regulating wound healing;however,its antibacterial properties and biological activity must be further improved.In this study,a photocrosslinking hydrogel was developed to treat full-thickness cutaneous wounds.The composite hydrogel(Ag-AV-SF hydrogel)was prepared by introducing the silver nanoparticles(AgNPs)and aloe vera(AV)as the modifiers.In vitro study exhibited great antibacterial ability,biocompatibility and cell-proliferation and-migration-promoting capacities.It also showed the pH-response releasing properties which release more AgNPs in a simulated chronic infection environment.The healing effect evaluation in vivo showed the healing-promoting ability of the Ag-AV-SF hydrogel was stronger than the single-modifiers groups,and the healing rate of it reached 97.02%on Day 21,higher than the commercial wound dressing,silver sulfadiazine(SS)cream on sale.Additionally,the histological and protein expression results showed that the Ag-AV-SF hydrogel has a greater effect on the pro-healing regenerative phenotype with M2 macrophages at the early stage,reconstructing the blood vessels networks and inhibiting the formation of scars.In summary,the Ag-AV-SF hydrogel developed in this study had good physical properties,overwhelming antibacterial properties,satisfactory biocompatibility and significantly promoting effect on cell proliferation,migration and wound healing.Overall,our results suggest that the Ag-AV-SF hydrogel we developed has great potential for improving the wound healing in clinical treatment. | Yangkun Liu JinChuan Fan MingQi Lv Kepeng She Jiale Sun Qingqing Lu Changhao Han SongTao Ding Shuang Zhao GuiXue Wang YuChan Zhang GuangChao Zang | 2021 | Regenerative Biomaterials2021，8，6： | 2 |
| 6 | SeDeM Expert System: A review and new perspectives显示文摘The SeDeM Expert System was first known as a galenic pre-formulation system, which was based on the experimental research and quantitative determination of powdered substances. And the mathematical formula provided by the SeDeM Expert System has plays an important role in the study of powder properties. The system can be used not only to evaluate the powder direct compression (DC) of excipients and active pharmaceutical ingredients (API’s), but also to predict the possible formulations, so it can reduce unnecessary research and trials, and shorten the time of development. In this paper, the research development and application of SeDeM Expert System in DC was summarized, and the results showed that with a few exceptions, the system was skilled in predicting acceptable tablet formulations. Finally, the new application prospect of the system is presented, including the application of the Internet traffic and content management (iTCM) database and the new co-processed excipients. | Mingxian Gu Tianbing Guan Shulin Wan Han Zhang Xuelian Li Songtao Kong Jianbing Ren Huimin Sun Chuanyun Dai | 2019 | Journal of Pharmaceutical and Biopharmaceutical Research2019，1，1： | 1 |
| 7 | Logging evaluation of deep multi-type unconventional gas reservoirs in the Songliao basin,northeast China:Implications from continental scientific drilling显示文摘Multi-type unconventional gas-bearing reservoirs with different lithologies and gas accumulation potential occur in the deep part of the Songliao basin.However,the reservoirs are non-homogeneous,the gas components differ substantially,and not all types of gas-bearing reservoirs have been identified or evaluated.The International Continental Scientific Drilling Program(ICDP)is used as an example to conduct qualitative and quantitative evaluations of deep multi-type unconventional gas-bearing reservoirs using conventional and specialized logging data.The core test data are used to determine the physical properties.The porosity and permeability are compared and analyzed using different methods and models.The results show that the reservoirs have low to ultra-low porosity and ultra-low permeability.Based on the comparison of the rock mechanical parameters and mineral composition,brittleness evaluation parameters are proposed for different types of deep reservoirs in the study region.The mineral brittleness index is highly consistent with the brittleness index based on rock mechanics.An identification method for deep multi-type gas-bearing reservoir and a classification approach for different gas properties are established based on the logging response and parameter interpretation.The methane gas reservoirs have low density(DEN)and low compensated neutron logging(CNL)values and high acoustic(AC)time difference and high resistivity(RT)values.The CO_(2)gas reservoirs have lower RT values and higher CNL values than the hydrocarbon gas reservoirs.The comprehensive analysis of deep gas source rock conditions and of the source-reservoir relationship provides insights for the evaluation of deep multi-type unconventional gas reservoirs.The discovery of high hydrogen content is of significant importance for developing new areas for deep natural gas exploration. | Shuangbiao Han Chaohan Xiang Xin Du Linfeng Xie Songtao Bai Chengshan Wang | 2022 | Geoscience Frontiers2022，13，6： | 1 |
| 8 | Identification of sweet spots in shale-type and siltstone-type“shale oil systems”:A case study of the Chang 7 Member in Ordos Basin显示文摘Mid-high maturity shale oil is the most realistic field for the scale breakthrough of terrestrial shale oil production in China.Generally,three deficiencies hinder shale oil development in China:heavy oil density,small sweet spot areas,and poor distribution continuity.Thus,identifying the“sweet spots”in shale oil reservoirs is critical for the efficient exploration and development of terrestrial shale oil.This study targets the siltstone type(Class-Ⅱshale oil)and pure shale type(Class-Ⅲshale oil)of the Chang 7 Member in the Ordos Basin,and identifies three stratigraphic units,namely the hydrocarbon accumulation unit,hydrocarbon generation unit,and hydrocarbon retention unit,which together constitute the in-source“shale oil system”.The hydrocarbon accumulation unit is mainly siltstone,where the hydrocarbons are migrated from shales.It has favorable porethroat network connectivity with a pore connectivity ratio of 32–57%,being the siltstone-type sweet spots.The hydrocarbon generation unit is mainly composed of high-TOC mudstone/shale and is the main contributor to in-source hydrocarbon generation and expulsion.This unit has high three-dimensional connectivity(28–30%),as shown by the pore-throat network model,associated with vertical paths for hydrocarbon expulsion.The hydrocarbon retention unit is mainly composed of low-TOC mudstone/shale retaining self-generated and migrated hydrocarbons.The pore connectivity rate is 17–42%,and the pore-throat network connectivity direction is uneven.Light and low-carbon-number hydrocarbons are preferentially trapped or even sealed in small pores of the retention unit,forming the typical mudstone/shale-type sweet spots.In the process called shale oil intrasource migration,the oil migrates in source rocks causing component fractionation,which allows more shale oil to enrich in the hydrocarbon accumulation and retention units to form sweet spots,compared with the hydrocarbon generation unit.The migration paths include the one from mudstone/shale to siltstone interlayers and that from the high-TOC mudstone/shale intervals to the low-TOC intervals.The in-source accumulation of shale oil shows the differentiated enrichment model featuring“high-TOC mudstone/shale generating hydrocarbons,low-TOC mudstone/shale retaining hydrocarbons,siltstone accumulating hydrocarbons and multiple intra-source migration paths”.In the Ordos Basin,the organic-lean(TOC 1–3%)mudstone/shale intervals appear to be the sweet spots of shale oil,where there are abundant medium-short-chain hydrocarbons retained with high flowability.After fracturing stimulation,their production conditions may be even superior to those of siltstones.This proposed idea changes the previous strategy to look for sweet spots in high-TOC intervals derived from the shale gas industry. | Songqi PAN Qiulei GUO Caineng ZOU Zhenhua JING Ming YUAN Ying HE He ZHENG Ying MU Zhi YANG Shixiang LI Xinping ZHOU Songtao WU Hanlin LIU Feng YANG Yuanjia HAN | 2023 | Science China Earth Sciences2023，66，7： | 1 |
| 9 | A heavy metal transporter gene ZmHMA3a promises safe agricultural production on cadmium-polluted arable land显示文摘In China,19%of agricultural soils contain harmful heavy metal pollutants at levels exceeding environmentally recommended standards,whilst around 3 million hectares of arable land are too polluted to grow crops on(Zhao et al.,2015;Hu et al.,2016).Among the deleterious heavy metals,cadmium(Cd)is the most bioavailable toxic metallic pollutant and is rapidly transferable through the food chain(Wang et al.,2019).Concerning the current dilemma of the enhanced food demands of a rising population and decreasing availability of arable land,it is promising to cultivate field crops that produce enough safe foods for human consumption and simultaneously remove the pollutants from contaminated arable lands. | Yuanyuan Chen Zhen-Fei Chao Min Jin Ya-Ling Wang Yaoyao Li Jia-Chen Wu Yingjie Xiao Yong Peng Qiao-Yan Lv Songtao Gui Xiaqing Wang Mei-Ling Han Alisdair R.Fernie Dai-Yin Chao Jianbing Yan | 2023 | Journal of Genetics and Genomics2023，50，2： | 0 |
| 10 | Ce&F multifunctional modification improves the electrochemical performance of LiCoO_(2)at 4.60 V显示文摘Lithium cobalt oxide(LiCoO_(2))is proverbially employed as cathode materials of lithium-ion batteries attributed to the high theoretical capacity,and currently,it is developing towards higher cut-off voltages in the pursuit of higher energy density.However,it suffers from serious structural degradation and surface side reactions,in particular,at the voltage above 4.60 V,leading to rapid decay of the battery life.Taking into account the desirable oxygen buffering property and the fast ion mobility characteristic of cerium oxide fluoride,in this work,we prepared Ce&F co-modified LiCoO_(2)by using the precursors of Ce(NO_(3))_(3)·6H_(2)O and NH_(4)F,and evaluated the electrochemical performance under voltages exceeding 4.60 V.The results indicated that the modified samples have multiphase heterostructure of surface CeO_(2-x)and unique Ce-O-F solid solution phase.At 3.0–4.60 V and 25℃,the preferred sample LCO-0.5Ce-0.3F has a high initial discharge specific capacity of 221.9 mA h g^(-1)at 0.1 C,with the retention of 80.3%and 89.6%after 300 cycles at 1 and 5 C,comparing with the pristine LCO(56.4%and 22.6%).And at 3.0–4.65 V,its retention is 64.0%after 300 cycles at 1 C,versus 8.5%of the pristine LCO.Through structural characterizations and DFT calculations,it suggests that Ce^(4+)&F^(-)co-doping suppresses the H3 to H1/3 irreversible phase transition,stabilizes the lattice structure,and reduces the redox activity of the lattice oxygen by modulating the Co 3d–O 2p energy band,consequently improving the electrochemical performance of LiCoO_(2)at high voltages. | Jiangli Feng Chenhui Wang Hailin Lei Songtao Liu Jing Liu You Han Jinli Zhang Wei Li | 2023 | Journal of Energy Chemistry2023，，10： | 0 |
| 11 | Countermeasure against blinding attack for single-photon detectors in quantum key distribution显示文摘Quantum key distribution(QKD),rooted in quantum mechanics,offers information-theoretic security.However,practi-cal systems open security threats due to imperfections,notably bright-light blinding attacks targeting single-photon detectors.Here,we propose a concise,robust defense strategy for protecting single-photon detectors in QKD systems against blinding attacks.Our strategy uses a dual approach:detecting the bias current of the avalanche photodiode(APD)to defend against con-tinuous-wave blinding attacks,and monitoring the avalanche amplitude to protect against pulsed blinding attacks.By integrat-ing these two branches,the proposed solution effectively identifies and mitigates a wide range of bright light injection attempts,significantly enhancing the resilience of QKD systems against various bright-light blinding attacks.This method forti-fies the safeguards of quantum communications and offers a crucial contribution to the field of quantum information security. | Lianjun Jiang Dongdong Li Yuqiang Fang Meisheng Zhao Ming Liu Zhilin Xie Yukang Zhao Yanlin Tang Wei Jiang Houlin Fang Rui Ma Lei Cheng Weifeng Yang Songtao Han Shibiao Tang | 2024 | Journal of Semiconductors2024，45，4： | 0 |
| 12 | Comparative Study on Heat Flux and Temperature Distribution Performance of Linear Fresnel Collector Based on Uniformity Index显示文摘Linear Fresnel collector system as main solar energy collecting technology is widely studied.The secondary reflector has significant influence on the heat flux distribution on the linear Fresnel collector.In this work,the heat flux and temperature distribution on linear Fresnel collector is compared with different secondary reflectors of simple trapezoidal concentrator,segmented parabolic concentrator and compound parabolic concentrator under varied incident ray angle.The uniformity index is applied to evaluate the Linear Fresnel reflector system heat flux distribution performance.The results show that the value of uniformity index increases with the increasing of incident ray angle.The compound parabolic concentrator has the highest value of uniformity index compared with simple trapezoidal concentrator and segmented parabolic concentrator in this work.The highest value of uniformity index is 0.8137 with compound parabolic concentrator.This work provides effective and practical guide to design and evaluate the secondary reflector in linear Fresnel reflector system. | WU Yuting QIAN Li ZHANG Cancan HAN Songtao SUN Hexin NIU Junnan CHENG Yingkun SANG Shengjie | 2022 | Journal of Thermal Science2022，31，3： | 0 |
您所在的机构暂未开通此部分的功能，请联系管理员