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| 1 | Rapid and Efficient Gene Modification in Rice and Brachypodium Using TALENs显示文摘 | Qiwei Shan Yanpeng Wang Kunling Chen Zhen Liang Jun Li Yi Zhang Kang Zhang Jinxing Liu Daniel F. Voytas Xuelian Zheng Yong Zhang Caixia Gao | 2013 | Molecular Plant2013，6，4： | 37 |
| 2 | Plant Prime Editors Enable Precise Gene Editing in Rice Cells显示文摘Genome editing is revolutionizing plant research and crop breeding.Sequence-specific nucleases(SSNs)such as zinc finger nuclease(ZFN)and TAL effector nuclease(TALEN)have been used to create site-specific DNA double-strand breaks and to achieve precise DNA modifications by promoting homology-directed repair(HDR)(Steinert et al.,2016;Voytas,2013).Later,RNA-guided SSNs such as CRISPR-Cas9,Cas12a,Cas12b,and their variants were applied for genome editing in plants(Li et al.,2013;Nekrasov et alM 2013;Tang et al.,2017;Zhong et al.,2019;Ming et al.,2020;Tang et al.,2019).However,HDR relies on simultaneous delivery of SSNs and DNA donors,which has been challenging in plants(Steinert et al.,2016;Zhang et aL,2019).Another challenge for realizing efficient HDR in plants is that DNA repair favors nonhomologous end joining(NHEJ)pathways over HDR in most cell types(Puchta,2005;Qi et al.,2013). | Xu Tang Simon Sretenovic Qiurong Ren Xinyu Jia Mengke Li Tingting Fan Desuo Yin Shuyue Xiang Yachong Guo Li Liu Xuelian Zheng Yiping Qi Yong Zhang | 2020 | Molecular Plant2020，13，5： | 20 |
| 3 | Effects of process parameters on pore structure of semi-coke prepared by solid heat carrier with dry distillation显示文摘The semi-coke was prepared by solid heat carrier with dry distillation in single factor method. The pore structures of raw coal and semi-coke were characterized by Brunauer-Emmett-Teller (BET) and scanning electron microscope (SEM). The results show that the adsorption and desorption isotherm of semi-coke are not coincident. There was a wide pore distribution on the semi-coke, in which mesopores and micropores account for a considerable proportion. Also there are many more secondary pores. With the increase of the final temperature of heat carrier and constant temperature, as well as the decrease of volume ratio of coal and hot carrier reactor, specific surface area and pore volume of semi-coke increased rapidly first and then decreased and finally increased, along with the rapidly reduction of average pore size. SEM photos show that the surface of semi-coke becomes increasingly rough and glossy. | Zhou, Guoli Wu, Jianjun Miao, Zhenyong Hu, Xuelian Li, Xia Shi, Xin Cai, Zhidan Shang, Yukun | 2013 | International Journal of Mining Science and Technology2013，23，3： | 20 |
| 4 | Laboratory simulation on acoustic well-logging with phased array transmitter显示文摘Two small scale acoustic phased arrays with 4 elements have been designed and assembled in the laboratory. Experiments have been carried out with them. It is found that both directivity and radiation lobe width of the phased array can be regulated by changing the time delay between the input signals on neighboring elements. Results measured are in good agreement with those calculated. By using the phased array as an acoustic transmitter and hydrophone as a receiver, small scale acoustic well-logging simulations have been carried out both on an aluminum model well and on a concrete one. Experimental results show that, by increasing the time delay of the input signals on neighboring elements, the steered radiation angle of the phased array becomes larger and larger, and generation conditions of the refracted compressional wave and the refracted shear wave are reached successively, and the refracted compressional wave, the refracted shear wave and the Stoneley wave axe strengthened, respectively. Therefore, by choosing element spacing of a phased array and acoustic wave frequency appropriately, the main radiation lobe of the phased array can be widened to cover the first critical angle of all kinds of formations, which makes it possible to apply phased array acoustic well-logging in any formation continuously without regulating directivity of the phased array. | QIAO Wenxiao CHEN Xuelian DU Guangsheng FANG Jun LI Gang(Faculty of Natural Resources and Information Technology, University of Petroleum Beijing 102249) | 2003 | Chinese Journal of Acoustics2003，22，4： | 14 |
| 5 | Interactions of OsMADS1 with Floral Homeotic Genes in Rice Flower Development显示文摘在繁殖开发期间,米饭植物开发决定最后的谷物收益的唯一的花器官。OsMADS1,象 SEPALLATA 一样疯盒子的基因之一,被解开了玩关键角色 inrice 花的机关身份说明和花的分裂组织确定性。然而,在调整花开发与另外的花的 homeotic 基因位于 OsMADS1 的相互作用下面的分子的机制 remainslargely 逃犯。在这个工作,我们在他们的蛋白质之中与物理相互作用一起与 B- , C- ,和 D 班基因学习了 OsMADS1 的基因相互作用。我们证明在 OsMADS1 和 OsMADS3 之间的物理、基因的相互作用为花的分裂组织活动维护和机关身份说明是必要的;当 OsMADS1 身体上并且遗传上在调整花的分裂组织确定性和 suppressingspikelet 分裂组织回复与 OsMADS58 交往时。我们提供了重要基因证据在花开发期间支持二米饭 C 班基因(OsMADS3 和 OsMADS58 ) 的 neofunctionalization。基因表示介绍和量的 RT-PCR 分析进一步表明 OsMADS1 影响涉及发信号的花的身份和荷尔蒙的许多基因的表达式,并且染色质 immunoprecipitation (芯片)-PCR 试金进一步证明 OsMADS17 是 OsMADS1 的直接目标基因。一起拿,这些结果表明 OsMADS1 在指定米饭有多样化的规章的功能花的机关和分裂组织身份,可能通过它和不同花的 homeotic 管理者的基因、物理的相互作用。 | Yun Hu Wanqi Liang Changsong Yin Xuelian Yang Baozhe Ping Anxue Li Ru Jia Mingjiao Chen Zhijing Luo Qiang Cai Xiangxiang Zhao Dabing Zhang Zheng Yuan | 2015 | Molecular Plant2015，8，9： | 10 |
| 6 | Planting density affected biomass and grain yield of maize for seed production in an arid region of Northwest China显示文摘Field experiments were conducted from 2012 to 2015 in an arid region of Northwest China to investigate the effects of planting density on plant growth, yield, and water use efficiency(WUE) of maize for seed production. Five planting densities of 6.75, 8.25, 9.75, 11.25 and 12.75 plants/m^2 were conducted in 2012, and a planting density of 14.25 plants/m^2 was added from 2013 to 2015. Through comparison with the Aqua Crop yield model, a modified model was developed to estimate the biomass accumulation and yield under different planting densities using adjustment coefficient for normalized biomass water productivity and harvest index. It was found that the modified yield model had a better performance and could generate results with higher determination coefficient and lower error. The results indicated that higher planting density increased the leaf area index and biomass accumulation, but decreased the biomass accumulation per plant. The total yield increased rapidly as planting density increased to 11.25 plants/m^2, but only a slight increase was observed when the density was greater than 11.25 plants/m^2. The WUE also reached the maximum when planting density was 11.25 plants/m^2, which was the recommended planting density of maize for seed production in Northwest China. | JIANG Xuelian TONG Ling KANG Shaozhong LI Fusheng LI Donghao QIN Yonghui SHI Rongchao LI Jianbing | 2018 | Journal of Arid Land2018，10，2： | 9 |
| 7 | Differentiation potential of bone marrow mesenchymal stem cells in duck显示文摘The bone marrow mesenchymal stem cells(MSCs) are multipotent stem cells which can differentiate into mesenchymal cells in vitro.In this study,MSCs in duck were isolated from bone marrow by density gradient centrifuge separation,purified and expanded in the me-dium.The primary MSCs were expanded for 11 passages.The different-passage MSCs were induced to differentiate into osteoblasts and neuron-like cells.Karyotype analysis indicated that MSCs kept diploid condition and the hereditary feature was stable.The different-passage MSCs expressed CD44,ICAM-1 and SSEA-4,but not CD34,CD45 and SSEA-1 when detected by immunofluorescence staining.There was no significant difference among the positive rates of passages 2,6 and 8(P > 0.05),but a significant difference existed among those of passages 2,6,8 and 11(P < 0.05).After the osteogenic inducement was added,the induced different-passage MSCs expressed high-level alkaline phosphatase(ALP),and are positive for tetracycline staining,Alizarin Red staining and Von Kossa staining.After the neural inducement was added,about 70% cells exhibited typical neuron-like phenotype,the induced different-passage MSCs expressed Nestin,neuron-specific enolase(NSE) and glial fibrillary acidic protein(GFAP) when detected by immunofluorescence staining.There was no significant difference among the positive rates of passages 3,4 and 6(P>0.05),but a significant difference existed among those of passages 3,4,6 and 8(P<0.05).These results suggest that MSCs in duck were capable of differentiating into osteoblasts and neuron-like cells in vitro. | Linfeng Li Xiujuan Bai Xuelian Gong Hongkun Liu Lina Chen Weijun Guan Yuehui Ma | 2009 | Journal of Genetics and Genomics2009，36，3： | 8 |
| 8 | High-performance asymmetrical supercapacitor composed of rGO-enveloped nickel phosphite hollow spheres and N/S co-doped rGO aerogel显示文摘不均匀的 supercapacitor (ASC ) ,包括减少的 graphene 氧化物(rGO ) 包含了镍亚磷酸盐空 microspheres (NPOH-0.5@rGO ) 作为积极电极,和多孔的氮 / 硫,共同做的 rGO aerogel (NS-3D rGO ) 作为否定电极被准备了。NPOH-0.5@rGO 电极联合 NPOH 空 microspheres 和产生一个大特定的电容,高骑车可逆性,和优秀的率性能的传导性的 rGO 层的优点。有丰富的孔和活跃地点的 NS-3D rGO 电极支持电解质渗入并且拓宽工作电压范围。ASC (NPOH-0.5@rGO//NS-3D rGO ) 显示出多达 1.4 V,突出的骑车能力(在 10,000 个周期以后的 95.5% 的电容保留) ,和优秀的率能力的最大的电压(77% 的电容保留作为当前的密度被增加十次) 。ASC 能容光焕发一轻射出的二极管(带) 为在为 20 s 收费以后的超过 20 min。制造技术和设备建筑学能为下一代的高效的电气化学的存储设备被扩大到另外的活跃氧化物和基于碳的材料。 | Deyang Zhang Yihe Zhang Yongsong Luo Yu Zhang Xiaowei Li Xuelian Yu Hao Ding PaulK. Chu Li Sun | 2018 | Nano Research2018，11，3： | 7 |
| 9 | High-strength wrought magnesium alloy with dense nano-scale spherical precipitate显示文摘This paper reported the influences of Yb addition on the precipitate and mechanical properties of wrought magnesium alloy ZK60. The ingots of ZK60-1.78Yb (wt%, 0.26 at%) alloys were cast using permanent mould and extruded at 370℃ . By means of TEM and HRTEM, it was observed that Yb affected the precipitate and precipitation of ZK60-1.78Yb alloys significantly. Dynamic precipitation occurred in the as-extruded alloy and spherical nano-scale precipitate with high density and homoge-neity exhibited in the aged alloys. The precipitate particles were about 5-20 nm in diameter, 10-30 nm in average space length. The tensile test results showed that the ZK60-1.78Yb alloy had excellent pre-cipitation strengthening response with the maximum tensile strength 417.5 MPa at ambient tempera-ture. | YU WenBin CHEN ZhiQian CHENG NanPu GAN BingTai HE Hong LI XueLian HU JinZhu | 2007 | Chinese Science Bulletin2007，52，13： | 7 |
| 10 | The relationship between viscosity and glass forming ability of Al-(Ni)-Yb alloy systems显示文摘The dynamic viscosity of Al-Yb and Al-Ni-Yb superheated melts was measured using a torsional oscillation viscometer. The results show that the temperature dependence of viscosity fits the Arrhenius law well and the fitting factors are calculated. The amorphous ribbons of these alloys were produced by the melt spinning technique and the thermal properties were characterized by using a differential scanning calorimetry (DSC). E (the activation energy for viscous flow), which reflects the change rate of viscosity, has a good negative relation with the GFA in both Al-Yb and Al-Ni-Yb systems. However, there is no direct relation between liquidus viscosity (ηL) and GFA. The superheated fragility M can predict GFA in Al-Yb or Al-Ni-Yb alloy system. | JIA Ran, BIAN XiuFang, Lü XiaoQian, SONG KaiKai & LI XueLian Key Laboratory for Liquid-Solid Structural Evolution and Processing of Materials (Ministry of Education), Shandong University, Jinan 250061, China | 2010 | Science China(Physics,Mechanics & Astronomy)2010，53，3： | 6 |
| 11 | Acetyl salicylic acid attenuates cardiac hypertrophy through Wnt signaling显示文摘室的肥大是心血管的疾病的事件的一个强大、独立的预言者。低剂量的乙酰水杨酸酸(阿司匹林) 的脉管的性质通过血小板 cyclooxygenase 的不可逆的抑制提供心血管的好处 1;然而,可能的 anti-hypertrophic 性质和阿司匹林的潜在的机制没详细被调查。在这研究,健康野类型的雄的老鼠随机被划分成三个组并且使遭到了到横向的大动脉的收缩(TAC ) 或假冒的操作。操作 TAC 的老鼠与低剂量的阿司匹林的人的等价物被对待(10 mg 吗? | Samuel Chege Gitau Xuelian Li Dandan Zhao Zhenfeng Guo Haihai Liang Ming Qian Lifang Lv Tianshi Li Bozhi Xu Zhiguo Wang Yong Zhang Chaoqian Xu Yanjie Lu Zhiming Du Hongli Shan Baofeng Yang | 2015 | Frontiers of Medicine2015，9，4： | 6 |
| 12 | Reservoir Characteristics and Genetic Mechanisms of the Mesozoic Granite Buried Hills in the Deep-water of the Qiongdongnan Basin,Northern South China Sea显示文摘Due to its structure,rock and mineral composition,fluid and other factors,the granite Buried Hill Reservoir is highly heterogeneous with a complex longitudinal structure and a reservoir space made up of a combination of dissolution pores and fractures.This paper is based on current understanding of tectonic evolution in the northern part of the South China Sea,in conjunction with the seismic phase characteristics.It is determined that the meshed fault system was formed by three stages of movement-tectonic compression orogeny during the Indochinese epoch,strike-slip compression-tension during the Yanshanian Period,early fracture extension activation during the Himalayan-which controlled the distribution of the Buried Hill Reservoir.Drilling revealed two types of buried hills,faulted anticline and fault horst,their longitudinal structure and the reservoir space type being significantly different.The mineral composition,reservoir space and diagenetic characteristics of the reservoir rocks and minerals were analyzed by lithogeochemistry,micro section and logging etc.,it thus being determined that the Mesozoic rocks of the Songnan Low Uplift in the Qiongdongnan Basin are mainly composed of syenogranite,granodiorite,monzogranite,which is the material basis for the development of the Buried Hill Reservoir.The content of felsic and other brittle minerals is more than 70%,making it easy for it to be transformed into fractures.At the same time,the weathering resistance of granodiorite and monzogranite is weaker than that of syenogranite,which is easily weathered and destroyed,forming a thick sand gravel weathering zone.With increasing depth of burial,weathering and dissolution gradually weaken,the deep acidic fluid improving the reservoir property of internal fractures and expanding the vertical distribution range of the reservoirs.The research results lay a foundation for the exploration of Buried Hill in the deep-water area of the Qiongdongnan Basin. | YOU Li XU Shouli MAO Xuelian ZHONG Jia JIAO Yaoqi XIONG Xiaofeng | 2021 | Acta Geologica Sinica(English Edition)2021，95，1： | 5 |
| 13 | Experimental studies of linear phased-array transmitter acoustic logging in cased wells with scaled borehole models显示文摘Laboratory cased-hole acoustic logging simulations are developed with the linear phased-array transmitter in scaled cased well models for evaluating the feasibility of extracting formation acoustic parameters through casing.The full waveforms are measured with different cement bonding models.By analyzing the measured wavetrains and the time-slowness correlation graphs,it is showed that when the generation conditions of the refracted compressional wave and the refracted shear wave are reached successively by regulating the direction of acoustic beam radiated from the linear phased-array transmitter,steered angle of the main radiation lobe with both good bonding interfaces.The refracted compressional wave and the refracted shear wave can be stimulated obviously and the casing wave can be suppressed effectively,even when the casing and cement(or the cement and formation) is not bonded.Based on these observations, it is worthwhile to apply the linear phased-array transmitter to determine formation velocities,particularly in poorly bonded cased well.The works establish the experimental and theoretical foundation for new generation cased-hole acoustic logging tool development. | CHEN Xuelian DONG Xingmeng TAN Baohai LI Gang | 2013 | Chinese Journal of Acoustics2013，32，3： | 5 |
| 14 | Integrated genomic analysis identifies deregulated JAK/STAT-MYC-biosynthesis axis in aggressive NK-cell leukemia显示文摘好攻击的 NK 房间白血病(ANKL ) 是在从亚洲的人之中是更流行的 NK 房间瘤的一种稀罕形式并且中央并且南美洲。病人们通常在天以内死到月,甚至在收到迅速的治疗学的管理以后。这里,我们由集成整个染色体执行了 ANKL 的第一全面研究, transcriptome 并且定序指向,象功能的试金一样的 cytokine 数组。在 JAK-STAT 小径的变化在 48% 被识别(14/29 ) ANKL 病人,当细胞外的 STAT3 激发器 IL10 被 56 褶层的一般水准提高时(P < 0.0001 ) 在检查的所有病人的血浆。另外的经常变异的基因包括的 TP53 (34%) , TET2 (28%) , CREBBP (21%) 和 MLL2 (21%) 。耐心的 NK 白血病房间在多重新陈代谢的小径显示出 STAT3 phosphorylation, MYC 表示和 transcriptional 活动的突出的激活。机能上地, STAT3 激活和 MYC 表示为 ANKL 房间的增长和幸存是批评的。发信号的 STAT 调整了发信号的 MYC 抄写节目,和两 STAT, MYC 抄写被要求维持核苷酸合成和 glycolysis 的激活。一起, JAK-STAT 小径在 ANKL 为 genomic 改变和 IL10 刺激代表一个主要目标。这最新发现的 JAK/STAT-MYC-biosynthesis 轴可以在对待白血病的这种子类型为新奇治疗学的策略的发展提供机会。 | Liang Huang Dan Liu Na Wang Shaoping Ling Yuting Tang Jun Wu Lingtong Hao Hui Luo Xuelian Hu Lingshuang Sheng Lijun Zhu Di Wang Yi Luo Zhen Shang Min Xiao Xia Mao Kuangguo Zhou Lihua Cao Lili Dong Xinchang Zheng Pinpin Sui Jianlin He Shanlan Mo Jin Yan Qilin Ao Lugui Qiu Hongsheng Zhou Qifa Liu Hongyu Zhang Jianyong Li Jie Jin Li Fu Weili Zhao Jieping Chen Xin Du Guoliang Qing Hudan Liu Xin Liu Gang Huang Ding Ma Jianfeng Zhou Qian-fei Wang | 2018 | Cell Research2018，28，2： | 5 |
| 15 | Optimization of Extraction of Total Flavonoids from HERBA BLUMEAE RIPARIAE Using Response Surface Methodology显示文摘[Objectives]This study aimed to optimize the ultrasonic-assisted extraction process of total flavonoids from a Zhuang medicine HERBA BLUMEAE RIPARIAE using response surface methodology.[Methods]Using rutin as a reference substance,a standard curve was drawn at a wavelength of 292 nm.Content determination was performed through absorbance under different conditions.The effects of ultrasonic time,ethanol volume fraction and liquid-to-solid ratio on the yield of total flavonoids from HERBA BLUMEAE RIPARIAE were investigated by single-factor tests.By using Box-Behnken test,the ultrasonic-assisted extraction process of total flavonoids from HERBA BLUMEAE RIPARIAE was optimized.[Results]The optimal extraction process of total flavonoids from HERBA BLUMEAE RIPARIAE was as follows:ultrasonic time of 30 min,ethanol volume fraction of 50%and liquid-to-solid ratio of 40∶1(mL/g).Under the optimal extraction conditions,the average yield of total flavonoids from HERBA BLUMEAE RIPARIAE was 85.47 mg/g.[Conclusions]The optimized extraction process was convenient and feasible.This study will provide a reference for the extraction of total flavonoids from HERBA BLUMEAE RIPARIAE,and provide certain guidance and basis for further development and utilization of the plan resource of Blumea riparia(Bl.)DC. | Hongna SU Yining ZHANG Xuexue LI Xuelian ZHAO Yisong LI Wenbing LI Yuan LIU | 2020 | Medicinal Plant2020，11，2： | 5 |
| 16 | Big graph search: challenges and techniques显示文摘 | Shuai MA Jia LI Chunming HU Xuelian LIN Jinpeng HUAI | 2016 | Frontiers of Computer Science2016，10，3： | 5 |
| 17 | Nuclear m^(6)A reader YTHDC1 regulates the scaffold function of LINE1 RNA in mouse ESCs and early embryos显示文摘N^(6)-methyladenosine(m^(6)A)on chromosome-associated regulatory RNAs(carRNAs),including repeat RNAs,plays important roles in tuning the chromatin state and transcription,but the intrinsic mechanism remains unclear.Here,we report that YTHDC1 plays indispensable roles in the self-renewal and differentiation potency of mouse embryonic stem cells(ESCs),which highly depends on the m^(6)A-binding ability.Ythdcl is required for sufficient rRNA synthesis and repression of the 2-cell(2C)transcriptional program in ESCs,which recapitulates the transcriptome regulation by the LINE1 scaffold.Detailed analyses revealed that YTHDC1 recognizes m^(6)A on LINE1 RNAs in the nucleus and regulates the formation of the LINE1-NCL partnership and the chromatin recruitment of KAP1.Moreover,the establishment of H3K9me3 on 2C-related retrotrans-posons is interrupted in Ythdcl-depleted ESCs and inner cell mass(ICM)cells,which consequently increases the transcriptional activities.Our study reveals a role of m^(6)A in regulating the RNA scaffold,providing a new model for the RNA-chromatin cross-talk. | Chuan Chen Wenqiang Liu Jiayin Guo Yuanyuan Liu Xuelian Liu Jun Liu Xiaoyang Dou Rongrong Le Yixin Huang Chong Li Lingyue Yang Xiaochen Kou Yanhong Zhao You Wu Jiayu Chen Hong Wang Bin Shen Yawei Gao Shaorong Gao | 2021 | Protein & Cell2021，12，6： | 4 |
| 18 | The investigation for the relationship among serum leptin, erythrocyte membrane Ca^(2+)-ATPase activity and hypertensive disorder complicating pregnancy显示文摘Objective: To study the significance of Leptin and the activity of erythrocyte membrane Ca2+-ATPase(EMCA) in the development of hypertensive disorder complicating pregnancy. Methods: Radioimmunoassay was used to test the level of serum Leptin,and the activity of EMCA was determined chemically in 38 pregnant women with hypertensive disorder complicating pregnancy and 36 normotensive pregnant women. Results: The level of serum Leptin in hypertensive disorder complicating pregnancy(gestational hypertension: 13.76 ± 3.46 ng/ml; preeclampsia:15.76 ± 5.47 ng/ml; eclampsia: 18.32 ± 6.38 ng/ml)was significantly higher than that in normotensive pregnant women(11.33 ± 2.93 ng/ml),respectively. The average EMCA activity of patients with hypertensive disorder complicating pregnancy(gestational hypertension:1.65 ± 0.24 μmol·pi/mg·h ; preeclampsia:1.37 ± 0.19 μ mol·pi/mg·h; eclampsia:1.12 ± 0.14 μ mol·pi/mg·h) was significantly lower than that of normotensive pregnant women(1.83 ± 0.38 μ mol·pi/mg·h),respectively. There was a negative correlation between the level of serum Leptin and the activity of RMCA in hypertensive disorder complicating pregnancy(r = -0.63). Conclusion: Inhibition of EMCA activity of erythrocyte in hypertensive disorder complicating pregnancy may increase cytoplasmic free calcium, which contributes to the development of hypertensive disorder complicating pregnancy. The negative correlation between the level of serum Leptin and the activity of EMCA, also suggested that serum Leptin and the activity of EMCA may play a role in the development of hypertensive disorder complicating pregnancy. | Chunfang Li Wenli Gou Xuelian Chen Shuping Zhang | 2007 | Journal of Nanjing Medical University2007，21，3： | 4 |
| 19 | Origin and Classification of Geothermal Water from Guanzhong Basin,NW China:Geochemical and Isotopic Approach显示文摘Combined with tectonic evolution,a multi-isotopic method(δD,δ18O,87Sr/86Sr and 14C)and hydrochemistry data have been used to study the origin and classification of geothermal water in the Guanzhong Basin.The study shows that geothermal water of Xianli terrace primarily came from northwest direction when accepting recharge.A small amount supply source of geothermal water in Xi’an City is from Qinling Mountain and the principal supply source comes from the west direction,but geothermal water of Chang’an District mainly accepts supply from Qinling Mountain.Based on geothermal environment is open or not,the degree of water-rock interaction,and the origin of geothermal water,geothermal water of the study area can be divided into four types:A,geothermal water of Gushi depression,perfect closed thermal environment and significant water-rock interaction,belonged to residual sedimentary water origin;B,geothermal water of Xianyang City,good closed environment and relatively significant water-rock interaction,belonged to residual sedimentary water origin mixed with fossil leaching water;C,geothermal water of Xi’an City,half closed environment and some water-rock interaction,belonged to fossil leaching water origin;D,geothermal water of Chang’an District,open environment and mixed with modern precipitation,belonged to fossil leaching water origin. | Zhiyuan Ma Xiucheng Li Huiju Zheng Jingbin Li Bei Pei Sen Guo Xuelian Zhang | 2017 | Journal of Earth Science2017，28，4： | 4 |
| 20 | Kruppel-like factor 10 protects against acute viral myocarditis by negatively regulating cardiac MCP-1 expression显示文摘Viral myocarditis(VMC)is a cardiac disease associated with myocardial inflammation and injury induced by virus infection.Cardiomyocytes have recently been regarded as key players in eliciting and modulating inflammation within the myocardium.Kruppel-like factor 10(KLF10)is a crucial regulator of various pathological processes and plays different roles in a variety of diseases.However,its role in VMC induced by coxsackievirus B3(CVB3)infection remains unknown.In this study,we report that cardiac KLF10 confers enhanced protection against viral myocarditis.We found that KLF10 expression was downregulated upon CVB3 infection.KLF10 deficiency enhanced cardiac viral replication and aggravated VMC progress.Bone marrow chimera experiments indicated that KLF10 expression in nonhematopoietic cells was involved in the pathogenesis of VMC.We further identified MCP-1 as a novel target of KLF10 in cardiomyocytes,and KLF10 cooperated with histone deacetylase 1(HDAC1)to negatively regulate MCP-1 expression by binding its promoter,leading to activation of MCP-1 transcription and recruitment of Ly6C^(high) monocytes/macrophages into the myocardium.This novel mechanism of MCP-1 regulation by KLF10 might provide new insights into the pathogenesis of VMC and a potential therapeutic target for VMC. | Jie Yang Hongkai Zhang Xuelian Wang Jing Guo Lin Wei Yahui Song Yuan Luo YinXia Zhao Malayannan Subramaniam Thomas C.Spelsberg Lie Wang Wei Xu Min Li | 2021 | Cellular & Molecular Immunology2021，18，9： | 3 |
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