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| 1 | Safety,immunogenicity,and protection provided by unadjuvanted and adjuvanted formulations of a recombinant plant-derived virus-like particle vaccine candidate for COVID-19 in nonhuman primates显示文摘Although antivirals are important tools to control severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)infection,effective vaccines are essential to control the current coronavirus disease 2019(COVID-19)pandemic.Plant-derived virus-like particle(VLP)vaccine candidates have previously demonstrated immunogenicity and efficacy against influenza.Here,we report the immunogenicity and protection induced in rhesus macaques by intramuscular injections of a VLP bearing a SARS-CoV-2 spike protein(CoVLP)vaccine candidate formulated with or without Adjuvant System 03(AS03)or cytidine-phospho-guanosine(CpG)1018.Although a single dose of the unadjuvanted CoVLP vaccine candidate stimulated humoral and cell-mediated immune responses,booster immunization(at 28 days after priming)and adjuvant administration significantly improved both responses,with higher immunogenicity and protection provided by the AS03-adjuvanted CoVLP.Fifteen micrograms of CoVLP adjuvanted with AS03 induced a polyfunctional interleukin-2(IL-2)-driven response and IL-4 expression in CD4 T cells.Animals were challenged by multiple routes(i.e.,intratracheal,intranasal,and ocular)with a total viral dose of 106 plaque-forming units of SARS-CoV-2.Lower viral replication in nasal swabs and bronchoalveolar lavage fluid(BALF)as well as fewer SARS-CoV-2-infected cells and immune cell infiltrates in the lungs concomitant with reduced levels of proinflammatory cytokines and chemotactic factors in the BALF were observed in animals immunized with the CoVLP adjuvanted with AS03.No clinical,pathologic,or virologic evidence of vaccineassociated enhanced disease was observed in vaccinated animals.The CoVLP adjuvanted with AS03 was therefore selected for vaccine development and clinical trials. | Stéphane Pillet Prabhu SArunachalam Guadalupe Andreani Nadia Golden Jane Fontenot Pyone Pyone Aye Katharina Röltgen Gabrielle Lehmicke Philipe Gobeil Charlotte Dubé Sonia Trépanier Nathalie Charland Marc-AndréD’Aoust Kasi Russell-Lodrigue Christopher Monjure Robert V.Blair Scott D.Boyd Rudolf P.Bohm Jay Rappaport François Villinger Nathalie Landry Bali Pulendran Brian J.Ward | 2022 | Cellular & Molecular Immunology2022，19，2： | 2 |
| 2 | Probiotic food supplement reduces stress-induced gastrointestinal symptoms in volunteers a double-blind,placebo-controlled,randomized trial显示文摘 | Laurent D Sonia G Henri D | 2008 | Nutrition Research2008，28，1： | 1 |
| 3 | Increased topsoil mineral nutrient concentrations under exotic invasive plants in Belgium显示文摘 | Sonia V Nicolas D Pierre M | 2005 | Plant and soil2005，275，12： | 1 |
| 4 | Purification and partial amino acid sequence of thuricin S,a new anti-Listeria bacteriocin from Bacillus thuringiensis显示文摘 | Sonia C Francois D Sophie S | | 0，，02： | 1 |
| 5 | Sleep apnoea-hypopnoea index is an independent predictor of high-sensitivity C reactive protein elevation显示文摘 | Karim ZB Alain VM Sonia D | 2006 | Respiration2006，73，2： | 1 |
| 6 | Association Between Corticos- teroids and Infection, Sepsis, and Infectious Death in Pediatric A- cute Myeloid Leukemia (AML): Results From theCanadian Infec- tions in AML Research Group 显示文摘 | David D Sonia C Victoria P | 2012 | Clin Infect Dis2012，55，12： | 1 |
| 7 | Role of TM6SF2 rs58542926 in the pathogenesis of nonalcoholic pediatric fatty liver disease: A multiethnic study显示文摘 | Martina Goffredo Sonia Caprio Ariel E. Feldstein Ebe D’Adamo Melissa M. Shaw Bridget Pierpont Mary Savoye Hongyu Zhao Allen E. Bale Nicola Santoro | 2016 | Hepatology2016，，1： | 1 |
| 8 | Acid Suppressants Reduce Risk of Gastrointestinal Bleeding in Patients on Antithrombotic or Anti-Inflammatory Therapy显示文摘 | Kueiyu Joshua Lin Sonia Hernández–Díaz Luis A. García Rodríguez | 2011 | Gastroenterology2011，，1： | 1 |
| 9 | Studies on blends ofnatural rubber and ethylene propylene diene rubber modified withphosphorylated cardanol prepolymer:Processability,physicomechanicalproperties,and morphology显示文摘 | Menon A R R Sonia T A Sudha J D | 2006 | Journal of AppliedPolymer Science2006，102，51： | 1 |
| 10 | Facility layout problems: a survey显示文摘 | AMINE D HENRI P SONIA H G | 2007 | Annual Reviews in Control2007，，31： | 1 |
| 11 | Eeerging risk factors for atherosclerotic vascular disease显示文摘 | DANIEL G HACKAM M D SONIA S | 2003 | JAMA2003，290，： | 1 |
| 12 | Rejection after conversion to a proliferation signal inhibitor in chronic heart transplantation显示文摘 | Francisco González‐Vílchez José A. Vázquez de Prada María J. Paniagua Luis Almenar Sonia Mirabet Manuel Gómez‐Bueno Beatriz Díaz‐Molina Jose M. Arizón Juan Delgado Félix Pérez‐Villa María G. Crespo‐Leiro Luis Martínez‐Dolz Eulalia Roig Javier Segovia José | 2013 | Clin Transplant2013，，6： | 1 |
| 13 | Kinetics of trictosan oxidation by aqueous ozone and consequent loss of antibacterial activity:Relevance to municipal wastewater ozonation显示文摘 | SONIA S MICHAEL C D FRANCISCO O | 2007 | Water Research2007，41，12： | 1 |
| 14 | Approximate parametrization of plane algebraic curves by linear systems of curves显示文摘 | Sonia P D Sendra J R Sonia L R | | 0，，02： | 1 |
| 15 | Chiral separation of kgycidol enantiomers by normal-phase high-performance liquid chromatography coupled to atmospheric pressure chemical ionization mass spectrometry显示文摘 | SONIA M Z HIERRO I D FAJARDO M | 2006 | Analytica Chimica Acta2006，566，： | 1 |
| 16 | Parametrization of approximate algebraic curves by lines显示文摘 | Sonia P D Sendra J Sendra J R | | 0，，02： | 1 |
| 17 | Purification and characterization of phycocyanin from the blue-green alga Aphanizomenon flos-aquae显示文摘 | Serena Benedetti Sara Rinalducci Francesca Benvenuti Sonia Francogli Silvia Pagliarani Luca Giorgi Mauro Micheloni Gian Maria D’Amici Lello Zolla Franco Canestrari | 2005 | Journal of Chromatography B2005，，： | 1 |
| 18 | A comparative study of oxidant-antioxidant status in stable and active vitiligu patients 显示文摘 | Ines D Sonia B Riadh BM | 2006 | Arch Dermatol Res2006，298，： | 1 |
| 19 | Immunological driven chemical engineering of antibodies for catalytic activity显示文摘 | Florence J Renard P P | 2002 | Journal of Immunological Methods2002，269，： | 1 |
| 20 | Plasma advanced glycation end products(AGEs)and NF-κB activity are independent determinants of diastolic and pulse pressure显示文摘 | KARLY C S JASMINE G L SONIA L D | 2014 | Clinical Chemistry and Laboratory Medicine2014，52，1： | 1 |
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