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| 1 | Dendritic cell deficiencies persist seven months after SARS-CoV-2 infection显示文摘Severe Acute Respiratory Syndrome Coronavirus(SARS-CoV)-2 infection induces an exacerbated inflammation driven by innate immunity components.Dendritic cells(DCs)play a key role in the defense against viral infections,for instance plasmacytoid DCs(pDCs),have the capacity to produce vast amounts of interferon-alpha(IFN-α).In COVID-19 there is a deficit in DC numbers and IFN-αproduction,which has been associated with disease severity.In this work,we described that in addition to the DC deficiency,several DC activation and homing markers were altered in acute COVID-19 patients,which were associated with multiple inflammatory markers.Remarkably,previously hospitalized and nonhospitalized patients remained with decreased numbers of CD1c+myeloid DCs and pDCs seven months after SARS-CoV-2 infection.Moreover,the expression of DC markers such as CD86 and CD4 were only restored in previously nonhospitalized patients,while no restoration of integrinβ7 and indoleamine 2,3-dyoxigenase(IDO)levels were observed.These findings contribute to a better understanding of the immunological sequelae of COVID-19. | Alberto Pérez-Gómez Joana Vitallé Carmen Gasca-Capote Alicia Gutierrez-Valencia María Trujillo-Rodriguez Ana Serna-Gallego Esperanza Muñoz-Muela María de los Reyes Jiménez-Leon Mohamed Rafii-El-Idrissi Benhnia Inmaculada Rivas-Jeremias Cesar Sotomayor Cristina Roca-Oporto Nuria Espinosa Carmen Infante-Domínguez Juan Carlos Crespo-Rivas Alberto Fernández-Villar Alexandre Pérez-González Luis Fernando López-Cortés Eva Poveda Ezequiel Ruiz-Mateos JoséMiguel Cisneros Sonsoles Salto-Alejandre Judith Berastegui-Cabrera Pedro Camacho-Martínez Carmen Infante-Domínguez Marta Carretero-Ledesma Juan Carlos Crespo-Rivas Eduardo Márquez JoséManuel Lomas Claudio Bueno Rosario Amaya JoséAntonio Lepe Jerónimo Pachón Elisa Cordero Javier Sánchez-Céspedes Manuela Aguilar-Guisado Almudena Aguilera Clara Aguilera Teresa Aldabo-Pallas Verónica Alfaro-Lara Cristina Amodeo Javier Ampuero María Dolores Avilés Maribel Asensio Bosco Barón-Franco Lydia Barrera-Pulido Rafael Bellido-Alba Máximo Bernabeu-Wittel Candela Caballero-Eraso Macarena Cabrera Enrique Calderón Jesús Carbajal-Guerrero Manuela Cid-Cumplido Yael Corcia-Palomo Juan Delgado Antonio Domínguez-Petit Alejandro Deniz Reginal Dusseck-Brutus Ana Escoresca-Ortega Fátima Espinosa Nuria Espinosa Michelle Espinoza Carmen Ferrándiz-Millón Marta Ferrer Teresa Ferrer Ignacio Gallego-Texeira Rosa Gámez-Mancera Emilio García Horacio García-Delgado Manuel García-Gutiérrez María Luisa Gascón-Castillo Aurora González-Estrada Demetrio González Carmen Gómez-González Rocío González-León Carmen Grande-Cabrerizo Sonia Gutiérrez Carlos Hernández-Quiles Inmaculada Concepción Herrera-Melero Marta Herrero-Romero Luis Jara Carlos Jiménez-Juan Silvia Jiménez-Jorge Mercedes Jiménez-Sánchez Julia Lanseros-Tenllado Carmina López Isabel López Álvaro López-Barrios Luis F.López-Cortés Rafael Luque-Márquez Daniel Macías-García Guillermo Martín-Gutiérrez Luis Martín-Villén JoséMolina Aurora Morillo María Dolores Navarro-Amuedo Dolores Nieto-Martín Francisco Ortega María Paniagua-García Amelia Peña-Rodríguez Esther Pérez Manuel Poyato Julia Praena-Segovia Rafaela Ríos Cristina Roca-Oporto Jesús F.Rodríguez María Jesús Rodríguez-Hernández Santiago Rodríguez-Suárez Ángel Rodríguez-Villodres Nieves Romero-Rodríguez Ricardo Ruiz Zida Ruiz de Azua Celia Salamanca Sonia Sánchez Víctor Manuel Sánchez-Montagut César Sotomayor Alejandro Suárez Benjumea Javier Toral | 2021 | Cellular & Molecular Immunology2021，18，9： | 2 |
| 2 | Extensive neurite out-growth and active synapse formation on self-assembling peptide scaffolds 显示文摘 | Todd C H Sonsoles L Xing S | 2000 | PNAS2000，97，12： | 1 |
| 3 | Nitre Oxide in Liver Inflamation and Regeneration显示文摘 | Palana Martin-SSanz Sonsoles Hortelano NariaA | 2002 | Metabolic Brain Disease2002，17，4： | 1 |
| 4 | Role of Endothelial-Mesenchymal Transition (EndoMT) in the Pathogenesis of Fibrotic Disorders显示文摘 | Sonsoles Piera-Velazquez Zhaodong Li Sergio A. Jimenez | 2011 | The American Journal of Pathology2011，，3： | 1 |
| 5 | Ex- tensive neurite outgrowth and active synapse formation on self-assembling peptide scaffolds显示文摘 | Todd C Holmes Sonsoles de Lacalle Su Xing | 2000 | PNAS2000，97，12： | 1 |
| 6 | Vitamin D and incidence of diabetes: a prospective cohort study显示文摘 | Inmaeulada G M Gemma R M Sonsoles M | 2012 | Clin Nutr2012，31，4： | 1 |
| 7 | Mimicking chitin:chemical synthesis,conformational analysis,and molecular recognition of theβ (1 →3) N-Acetylchitopentaose analogue显示文摘 | Maria Morando Yanping Yao Sonsoles Martín-Santamaría | | 0，，： | 1 |
| 8 | Stokes Increased life span of human osteoarthritic chondrocytes by exogenous expression of telomerase显示文摘 | Sonsoles P Sergio A Jimenez | 2001 | Arthritis Rheum2001，23，： | 1 |
| 9 | Expression of bcl-2 but not Bax has a prognostic significance in tongue carcinoma 显示文摘 | Jnan CV Sonsoles O Palama LF | 2006 | J Oral pathol Med2006，35，： | 1 |
| 10 | Role of endothelial-mesenchymal transition (EndoMT) in the pathogenesis of fibrotic disordersv显示文摘 | Sonsoles Piera-Velazquez Zhaodong Li Sergio A Jimenez | | 0，，03： | 1 |
| 11 | The dependence of a halophilic malate dehydrogenase on Wo and surfactant concentration in reverse micelles显示文摘 | Sonsoles Piera-Velazaquez Frutos Maruenda-Egea Eduardo Cadenas | 2001 | Journal of Molecular Catalysis B: Enzymatic2001，13，13： | 1 |
| 12 | Role of Endothelial-Mesenchymal Transition (EndoMT) in the Pathogenesis of Fibrotic Disorders显示文摘 | Sonsoles Piera-Velazquez Zhaodong Li Sergio A. Jimenez | 2011 | The American Journal of Pathology2011，，3： | 1 |
| 13 | Fernando Val-Berna Purpuric Generalized Lichen nitidus:An Unusual Eruption Simulating Pigmented Purpuric Dermatosis显示文摘 | Sonsoles Yaeza J | 2004 | Dermatology2004，208，： | 1 |
| 14 | C‐reactive protein and incidence of type 2 diabetes in the Pizarra study显示文摘 | Elehazara Rubio‐Martín Federico Soriguer Carolina Gutiérrez‐Repiso Lourdes Garrido‐Sánchez Marisol S. Ruíz Adana Eduardo García‐Fuentes Sonsoles Morcillo Isabel Esteva Felipe J Chaves Gemma Rojo‐Martinez | 2012 | Eur J Clin Invest2012，，2： | 1 |
| 15 | Expression of Bcl-2 but not Bax has a prognostic significance in tongue carcinoma 显示文摘 | Jnan CV Sonsoles O Palama LF | 2006 | J Oral pathol Med2006，35，： | 1 |
| 16 | Dietary polyunsaturated fatty acids may increase plasma LDL-cholesterol and plasma cholesterol concentrations in carriers of an ABCG1 gene single nucleotide polymorphism: Study in two Spanish populations显示文摘 | Rosario Abellán María Luisa Mansego Sergio Martínez-Hervás Sonsoles Morcillo Mónica Pineda-Alonso Rafael Carmena José Tomás Real Josep Redon Gemma Rojo-Martínez Juan Carlos Martín-Escudero Felipe Javier Chaves | 2011 | Atherosclerosis2011，，2： | 1 |
| 17 | 2000, Extensive neurite out- growth and active synapseformation on self-assembling peptide scaffolds 显示文摘 | Todd CH Sonsoles de L Xing S | 2000 | Pnas2000，97，12： | 1 |
| 18 | Stokes Increased life span of human ostcoarthritic chondrocytes by exogenous expre~ion of telomerase 显示文摘 | Sonsoles Piera-Velazquez Sergio A Jimenez | 2001 | Arthritis Rheum2001，23，： | 1 |
| 19 | Phenylacetate : a novel nontoxic inducer of tumor cell differentiation 显示文摘 | Dvofit S Sonsoles S Lin TS | 1992 | Cancer Res1992，52，： | 1 |
| 20 | Extensive neurite out growth and active synapse formation on self-assembling peptide scaffolds显示文摘 | Todd C H Sonsoles L Xing S | 2000 | PNAS2000，97，12： | 1 |
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