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| 1 | The clinical impact of bacterial biofilms显示文摘Bacteria survive in nature by forming biofilms on surfaces and probably most, if not all, bacteria (and fungi) are capable of forming biofilms. A biofilm is a structured consortium of bacteria embedded in a self-produced polymer matrix consisting of polysaccharide, protein and extracellular DNA. Bacterial biofilms are resistant to antibiotics, disinfectant chemicals and to phagocytosis and other components of the innate and adaptive inflammatory defense system of the body. It is known, for example, that persistence of staphylococcal infections related to foreign bodies is due to biofilm formation. Likewise, chronic Pseudomonas aeruginosa lung infections in cystic fibrosis patients are caused by biofilm growing mucoid strains. Gradients of nutrients and oxygen exist from the top to the bottom of biofilms and the bacterial cells located in nutrient poor areas have decreased metabolic activity and increased doubling times. These more or less dormant cells are therefore responsible for some of the tolerance to antibiotics. Biofilm growth is associated with an increased level of mutations. Bacteria in biofilms communicate by means of molecules, which activates certain genes responsible for production of virulence factors and, to some extent, biofilm structure. This phenomenon is called quorum sensing and depends upon the concentration of the quorum sensing molecules in a certain niche, which depends on the number of the bacteria. Biofilms can be prevented by antibiotic prophylaxis or early aggressive antibiotic therapy and they can be treated by chronic suppressive antibiotic therapy. Promising strategies may include the use of compounds which can dissolve the biofilm matrix and quorum sensing inhibitors, which increases biofilm susceptibility to antibiotics and phagocytosis. | Niels Hoiby Oana Ciofu Helle Krogh Johansen Zhi-jun Song Claus Moser Peter Ostrup Jenser Soren Molin Michael Givskov Tim Tolker-Nieisen Thomas Bjamsholt | 2011 | International Journal of Oral Science2011，3，2： | 48 |
| 2 | 板蓝根低极性流分的分离及其免疫活性显示文摘目的 :进行板蓝根低极性流分及其亚流分的分离 ,并研究其免疫活性。方法 :用快速低压干柱柱层析从板蓝根中分离出一个低极性流分及其一组亚流分 ;用化学发光法检测其对人多形核细胞化学发光的影响。结果 :板蓝根低极性流分具有双向免疫活性 ,在低浓度时具有激活作用 ,在高浓度时具有抑制作用 ;而亚流分的免疫活性并未因其纯度的提高而相应提高。结论 :板蓝根低极性流分及其亚流分含有抗炎成分。 | 秦箐 贺海平 Soren Brogger Christensen Hasse Bonde Rasmussen Arsalan Kharazmi 陈鸣 | 2001 | 中国临床药学杂志2001，10，1： | 30 |
| 3 | Clinically detected gastroenteropancreatic neuroendocrine tumors are on the rise: Epidemiological changes in Germany显示文摘AIM:To study the epidemiologic changes of gastroenteropancreatic neuroendocrine tumors(GEP-NET)in Germany,we analyzed two time periods 1976-1988 and1998-2006.METHODS:We evaluated epidemiological data of GEP-NET from the former East German National Cancer Registry(DDR Krebsregister,1976-1988)and its successor,the Joint Cancer Registry(GKR,1998-2006),which was founded after German reunification.Due to a particularly substantial database the epidemiological data from the federal states of Mecklenburg-Western Pomerania,Saxony,Brandenburg and Thuringia,covering a population of more than 10.8 million people,were analyzed.Survival probabilities were calculated using life table analysis.In addition,GEP-NET patients were evaluated for one or more second(non-GEP-NET)primary malignancies.RESULTS:A total of 2821 GEP neuroendocrine neoplasms were identified in the two registries.The overall incidence increased significantly between 1976 and2006 from 0.31(per 100.000 inhabitants per year)to2.27 for men and from 0.57 to 2.38 for women.In the later period studied(2004-2006),the small intestine was the most common site.Neuroendocrine(NE)neoplasms of the small intestine showed the largest absolute increase in incidence,while rectal NE neoplasms exhibited the greatest relative increase.Only the incidence of appendiceal NET in women showed little change between 1976 and 2006.Overall survival of patients varied for sex,tumor site and the two periods studied but improved significantly over time.Interestingly,about 20%of the GEP-NET patients developed one or more second malignancies.Their most common location was the gastrointestinal tract.GEP-NET patients without second malignancies fared better than those with one or more of them.CONCLUSION:The number of detected GEP-NET increased about 5-fold in Germany between 1976 and2006.At the same time,their anatomic distribution changed,and the survival of GEP-NET patients improved significantly.Second malignancies are common and influence the overall survival of GEP-NET patients.Thus,GEP-NET warrant our attention as well as intensive research on their tumorigenesis. | Hans Scherübl Brigitte Streller Roland Stabenow Hermann Herbst Michael Hopfner Christoph Schwertner Joachim Steinberg Jan Eick Wanda Ring Krishna Tiwari Soren M Zappe | 2013 | World Journal of Gastroenterology2013，19，47： | 16 |
| 4 | 一种新的黄芩类黄酮3',5,6',7-四羟基-2',8-二甲氧基黄酮的体外免疫药理作用显示文摘目的 :对新发现的一种黄芩类黄酮 ,3',5 ,6 ',7-四羟基 - 2 ',8-二甲氧基黄酮 ( TDF)的免疫药理作用进行研究。方法 :检测 TDF对人多形核细胞 ( PMN)、单个核细胞 ( MNC)化学发光反应、化学趋向性和 PHA诱导淋巴细胞增殖的影响。结果 :TDF本身不能激活 PMN和 MNC的氧呼吸爆发 ,TDF对 PMN和 MNC无毒性作用 ;当 TDF与 PMN或 MNC预先孵育后 ,明显的抑制 f ML P或 OZ激活 PMN以及 f ML P激活 MNC的氧呼吸爆发 ,抑制的强度与孵育的剂量成正比关系 ;对PMN的抑制能力大于 MNC。 TDF本身对 PMN和 MNC没有明显的化学趋化作用 ,但经与 TDF预先与细胞孵育后的 PMN或 MNC对 ZAS的化学趋向性明显增强 ,对 f ML P的化学趋向性作用不明显 ;TDF浓度在 ( 1.2 5× 10 - 4~ 5× 10 - 4 ) mol/ L 时 ,显著地抑制 PHA诱导的淋巴细胞增殖 ,抑制率达 31%~ 10 0 %。结论 | 贺海平 秦箐 陈明 Arsalan Kharazmi Soren Brogger Christensen | 2000 | 广西医科大学学报2000，17，3： | 14 |
| 5 | 黄芩提取物抗卵巢癌的体外活性研究显示文摘目的 :研究从黄芩中提取获得的化合物黄芩黄酮 A抑制卵巢癌 A2 780细胞生长及对常用抗肿瘤药的体外增效作用。方法 :MTT法测定黄芩黄酮 A的细胞毒作用及与多种抗癌药物作用后对卵巢癌 A2 780细胞的抑制作用 ,集落形成实验观察药物的诱导分化作用 ,PCR- EL ISA试剂盒测定细胞端粒酶活性。结果 :黄芩黄酮 A能抑制 A2 780细胞的增殖 ,其 IC5 0 为 2 0 0 mg/ L,同时黄芩黄酮 A与丝裂霉素 (MMC)、阿霉素 (ADM)、氟尿嘧啶(5 - Fu)、卡铂、羟基喜树碱合用具有相加或协同作用 ,可降低端粒酶活性的表达。结论 :黄芩黄酮 A具有体外抗肿瘤活性 ,对多种化疗药物具有增效作用。 | 秦箐 侯华新 黎丹戎 邱莉 吴华慧 梁永红 Soren Brogger Christensen Hasse Bonde Rasmussen | 2000 | 肿瘤研究与临床2000，12，3： | 13 |
| 6 | 板蓝根高级不饱和脂肪组酸的体外抗人肝癌BEL-7402细胞活性显示文摘目的 :研究板蓝根高级不饱和脂肪组酸体外抗人肝癌BEL 74 0 2细胞的活性。方法 :MTT法测定细胞毒作用 ,集落形成实验观察药物对肝癌细胞增殖的抑制作用 ,PCR ELISA试剂盒测定细胞的端粒酶活性。结果 :板蓝根高级不饱和脂肪组酸能抑制BEL 74 0 2细胞的增殖 ,其IC50 为 0 6mg·mL-1,有促使肿瘤细胞向正常细胞逆转的趋势 ,可降低端粒酶活性的表达。结论 | 侯华新 秦箐 黎丹戎 唐东平 邱莉 吴华慧 Soren BroggerChristensen Hasse Bonde Rasmussen | 2002 | 中国临床药学杂志2002，11，1： | 10 |
| 7 | Use of models in large-area forest surveys: comparing model-assisted, model-based and hybrid estimation显示文摘This paper focuses on the use of models for increasing the precision of estimators in large-area forest surveys.It is motivated by the increasing availability of remotely sensed data,which facilitates the development of models predicting the variables of interest in forest surveys.We present,review and compare three different estimation frameworks where models play a core role:model-assisted,model-based,and hybrid estimation.The first two are well known,whereas the third has only recently been introduced in forest surveys.Hybrid inference mixes designbased and model-based inference,since it relies on a probability sample of auxiliary data and a model predicting the target variable from the auxiliary data.We review studies on large-area forest surveys based on model-assisted,modelbased,and hybrid estimation,and discuss advantages and disadvantages of the approaches.We conclude that no general recommendations can be made about whether model-assisted,model-based,or hybrid estimation should be preferred.The choice depends on the objective of the survey and the possibilities to acquire appropriate field and remotely sensed data.We also conclude that modelling approaches can only be successfully applied for estimating target variables such as growing stock volume or biomass,which are adequately related to commonly available remotely sensed data,and thus purely field based surveys remain important for several important forest parameters. | Goran Stahl Svetlana Saarela Sebastian Schnell Soren Holm Johannes Breidenbach Sean P. Healey Paul L. Patterson Steen Magnussen Erik Naesset Ronald E. McRoberts Timothy G. Gregoire | 2016 | Forest Ecosystems2016，3，2： | 7 |
| 8 | Developmentally Regulated Glucosylation of Bitter Triterpenoid in Cucumber by the UDP-Glucosyltransferase UGT73AM3显示文摘 | Yang Zhong Xiaofeng Xue Zhiqiang Liu Yongshuo Ma Kewu Zeng Lida Han Jingjing Qi Dae-Kyun Ro Soren Bak Sanwen Huang Yuan Zhou Yi Shang | 2017 | Molecular Plant2017，10，7： | 7 |
| 9 | Current understanding of multi-species biofilms显示文摘Direct observation of a wide range of natural microorganisms has revealed the fact that the majority of microbes persist as surface-attached communities surrounded by matrix materials, called biofilms. Biofilms can be formed by a single bacterial strain. However, most natural biofilms are actually formed by multiple bacterial species. Conventional methods for bacterial cleaning, such as applications of antibiotics and/or disinfectants are often ineffective for biofilm populations due to their special physiology and physical matrix barrier. It has been estimated that billions of dollars are spent every year worldwide to deal with damage to equipment, contaminations of products, energy losses, and infections in human beings resulted from microbial biofilms. Microorganisms compete, cooperate, and communicate with each other in multi-species biofilms. Understanding the mechanisms of multi-species biofilm formation will facilitate the development of methods for combating bacterial biofilms in clinical, environmental, industrial, and agricultural areas. The most recent advances in the understanding of multi-species biofilms are summarized and discussed in the review. | Liang Yang Yang Liu Hong Wu Niels Hoiby Soren Molin Zhi-jun Song | 2011 | International Journal of Oral Science2011，3，2： | 6 |
| 10 | 河南地区婴幼儿把尿训练开始时间与排尿控制发育关系研究显示文摘目的了解婴幼儿把尿训练开始时间对排尿控制的影响。方法对7 415例6~12岁儿童进行无记名回顾性调查,按把尿训练开始时间将其分为6组(每3个月龄差分一组,第一组:0~3月龄,以此类推,第六组:16~18月龄)。统计每组获得白天排尿控制月龄。采用方差分析方法对各组及各组间的数据进行分析比较。结果把尿开始越早获得排尿控制的年龄越小(第1组和第6组控制月龄分别为:19.9±7.2,25.9±6.2)。其中,1、2、3组间(1~9个月龄开始把尿训练)白天获得排尿控制时间差异均无统计学意义(P>0.05),4~6组间的差异均有统计学意义(P<0.05)。结论婴幼儿出生后前9个月进行把尿训练,获得白天排尿控制的时间显著早于9个月后开始排尿训练。 | 马源 文一博 汪玺正 王庆伟 何翔飞 花朝阳 李杏 SOREN Rittig 文建国 | 2018 | 现代泌尿外科杂志2018，23，9： | 6 |
| 11 | Systematic mechanism-orientated approach to chronic pancreatitis pain显示文摘Pain in chronic pancreatitis(CP) shows similarities with other visceral pain syndromes(i.e.,inflammatory bowel disease and esophagitis),which should thus be managed in a similar fashion.Typical causes of CP pain include increased intrapancreatic pressure,pancreatic inflammation and pancreatic/extrapancreatic complications.Unfortunately,CP pain continues to be a major clinical challenge.It is recognized that ongoing pain may induce altered central pain processing,e.g.,central sensitization or pro-nociceptive pain modulation.When this is present conventional pain treatment targeting the nociceptive focus,e.g.,opioid analgesia or surgical/endoscopic intervention,often fails even if technically successful.If central nervous system pain processing is altered,specific treatment targeting these changes should be instituted(e.g.,gabapentinoids,ketamine or tricyclic antidepressants).Suitable tools are now available to make altered central processing visible,including quantitative sensory testing,electroencephalograpy and(functional) magnetic resonance imaging.These techniques are potentially clinically useful diagnostic tools to analyze central pain processing and thus define optimum management approaches for pain in CP and other visceral pain syndromes.The present review proposes a systematic mechanism-orientated approach to pain management in CP based on a holistic view of the mechanisms involved.Future research should address the circumstances under which central nervous system pain processing changes in CP,and how this is influenced by ongoing nociceptive input and therapies.Thus we hope to predict which patients are at risk for developing chronic pain or not responding to therapy,leading to improved treatment of chronic pain in CP and other visceral pain disorders. | Stefan AW Bouwense Marjan de Vries Luuk TW Schreuder Soren S Olesen Jens B Frokjær Asbjorn M Drewes Harry van Goor Oliver HG Wilder-Smith | 2015 | World Journal of Gastroenterology2015，21，1： | 6 |
| 12 | 低剂量环索奈德与固定剂量丙酸氟替卡松沙美特罗联合制剂对支气管哮喘长期控制效果的比较显示文摘研究背景:轻度持续性支气管哮喘(简称哮喘)约占哮喘患者的70%,对于轻度哮喘选择最好的一线治疗十分重要。我们比较了以环索奈德和丙酸氟替卡松/沙美特罗联合制剂作为轻度哮喘的一线治疗的效果。方法:纳入12~75岁轻度持续性哮喘患者1432例进行随机、 | Dirkje SP Paul MO Soren P. Chest 刘国梁 | 2011 | 中华结核和呼吸杂志2011，34，9： | 5 |
| 13 | Separating polydisperse particles using electrostatic precipitators with wire and spiked-wire discharge electrode design显示文摘 | Soren Sander Steffen Gawor Udo Fritsching | 2018 | Particuology2018，16，3： | 3 |
| 14 | Propeller Torque Load and Propeller Shaft Torque Response Correlation During Ice-propeller Interaction显示文摘轮船使用推进机械系统创造方向性的戳。当轮船壳进展,航行在盖住冰的水里包含碎冰片和他们的 submergence。有时,沉没了冰片与推进器交往并且引起转矩负担的不规则的变化。作为结果,推进器和引擎动力学,变得的 imbalanced,和能量通过推进机械系统宣传直到平衡被到达。处于如此的 imbalanced 状况,测量推进器柄转矩反应不等于推进器转矩。在这个工作,因此,全面系统反应用契约图模型在冰相关的转矩负担下面被模仿。推进器和推进器柄之间的能量差别被估计并且与他们的相应机械能量有关。另外,机械能量在模式之中被散布。基于分发,运动并且势能为在推进器转矩和推进器柄反应之间的关联是重要的。 | Drazen Polic Soren Ehlers Vilmar AEsoy | 2017 | Journal of Marine Science and Application2017，16，1： | 3 |
| 15 | Liver cirrhosis and arterial hypertension显示文摘在有肝硬化的病人的典型调查结果是有低全面全身的脉管的抵抗的血管舒张,高动脉的依从,增加的心输出量,柜台规章的系统的第二等的激活(renin-angiotensin-aldosterone 系统,交感神经系统,加压素的版本) ,并且抵抗到 vasopressors。vasodilatory 状态通过 adrenomedullin 被调停, calcitonin 基因相关的肽,氮的氧化物,和另外的血管扩张药,并且最在内脏的区域被读。这组成一有效(尽管亲戚) 抵销到增加的动脉的血压。这评论在与肾的起源的本质性高血压和高动脉压的关系与肝硬化在病人在全身的血液动力学考虑改变。有高动脉压的题目(必要,第二等) 可以在肝硬化的发展期间变得正常血压,并且高动脉压很少与肝硬化在病人被表明,甚至在有 renovascular 疾病和高传播高血压蛋白原酶活动的情况中。至于在有明白高动脉压的肝脏硬化症的病人的 homoeostatic 规定的理解有许多争论。这很可能在平行包括血管舒张和血管缩小的联合。 | Jens H Henriksen Soren Moller | 2006 | World Journal of Gastroenterology2006，12，5： | 3 |
| 16 | 中药板蓝根两个高极性流分的分离及其活性的研究显示文摘 | 秦箐 贺海平 Soren Brogger Christensen Hasse Bonde Rasmussen Arsalan Kharazmi 陈鸣 | 2001 | 中国药理学通报2001，17，6： | 3 |
| 17 | Comparison of Osteoprotegerin to Traditional Atherosclerotic Risk Factors and High-Sensitivity C-Reactive Protein for Diagnosis of Atherosclerosis显示文摘 | Rasmus Mogelvang Sune H. Pedersen Allan Flyvbjerg Mette Bjerre Allan Z. Iversen Soren Galatius Jan Frystyk Jan S. Jensen | 2012 | The American Journal of Cardiology2012，，4： | 3 |
| 18 | The role of forensic anthropology in disaster victim identification(DVI):recent developments and future prospects显示文摘Forensic anthropological knowledge has been used in disaster victim identification(DVI)for over a century,but over the past decades,there have been a number of disaster events which have seen an increasing role for the forensic anthropologist.The experiences gained from some of the latest DVI operations have provided valuable lessons that have had an effect on the role and perceived value of the forensic anthropologist as part of the team managing the DVI process.This paper provides an overview of the ways in which forensic anthropologists may contribute to DVI with emphasis on how recent experiences and developments in forensic anthropology have augmented these contributions.Consequently,this paper reviews the value of forensic anthropological expertise at the disaster scene and in the mortuary,and discusses the way in which forensic anthropologists may use imaging in DVI efforts.Tissue-sampling strategies for DNA analysis,especially in the case of disasters with a large amount of fragmented remains,are also discussed.Additionally,consideration is given to the identification of survivors;the statistical basis of identification;the challenges related to some specific disaster scenarios;and education and training.Although forensic anthropologists can play a valuable role in different phases of a DVI operation,they never practice in isolation.The DVI process requires a multidisciplinary approach and,therefore,has a close collaboration with a range of forensic specialists. | Hans H.de Boer Soren Blau Tania Delabarde Lucina Hackman | 2019 | Forensic Sciences Research2019，4，4： | 3 |
| 19 | Disaster victim identification operations with fragmented,burnt,or commingled remains:experience-based recommendations显示文摘Human-made and natural disasters can result in severely fragmented,compromised,and commingled human remains.The related disaster victim identification(DVI)operations are invariably challenging,with the state of the remains potentially precluding some identifications.Practitioners involved in these DVI operations will routinely face logistical,practical,and ethical challenges.This review provides information and guidance derived from firsthand experiences to individuals tasked with managing DVI operations with fragmented human remains.We outline several key issues that should be addressed during disaster preparedness planning and at the outset of an operation,when incident-specific strategies are developed.Specific challenges during recovery and examination of fragmented remains are addressed,highlighting the importance of experienced specialists at the scene and in the mortuary.DNA sample selection and sampling techniques are reviewed,as well as downstream effects of commingling and contamination,which can complicate reconciliation and emphasise the need for rigorous quality control.We also touch on issues that may arise during communication with families.While recommendations are provided,they are not intended as proscriptive policy but rather as an addition to the general recommendations given in the International Criminal Police Organization(INTERPOL)DVI Guide,to inform preparative discussions between government officials,judiciary,police,and forensic specialists. | Hans H.de Boer Julie Roberts Tania Delabarde Amy Z.Mundorff Soren Blau | 2020 | Forensic Sciences Research2020，5，3： | 3 |
| 20 | Evaluation of age, weaning weight, body condition score, and reproductive tract score in pre-selected beef heifers relative to reproductive potential显示文摘Background: Artificial insemination is a preferred breeding method for beef heifers as it advances the genetic background, produces a predictive and profitable calving season, and extends the heifer’s reproductive life span.As reproductive efficiency in heifers is key for the success of beef cattle production systems, following artificial insemination, heifers are exposed to a bull for the remainder of the breeding season. Altogether, up to 95% of heifers might become pregnant in their first breeding season. Heifers that do not become pregnant at the end of the breeding season represent an irreparable economical loss. Additionally, heifers conceiving late in the breeding season to natural service, although acceptable, poses serious losses to producers. To minimize losses due to reproductive failure, different phenotypic parameters can be assessed and utilized as selection tools. Here, we tested the hypothesis that in a group of pre-selected heifers, records of weaning weight, age at weaning, age at artificial insemination, and age of dam differ among heifers of varied reproductive outcomes during the first breeding season.Results: None of the parameters tested presented predictive ability to discriminate the heifers based on the response variable(‘pregnant to artificial insemination’, ‘pregnant to natural service’, ‘not pregnant’). Heifers categorized with body condition score = 6 and reproductive tract score ≥ 4 had the greatest proportion of pregnancy to artificial insemination(49% and 44%, respectively). Furthermore, it was notable that heifers presenting body condition score = 6 and reproductive tract score = 5 presented the greatest pregnancy rate at end of the breeding season(89%). Heifers younger than 368 d at the start of the breeding season did not become pregnant to artificial insemination. Those young heifers had 12.5% chance to become pregnant in their first breeding season,compared to 87.5% if the heifers were older than 368 days.Conclusion: Our results suggest that beef heifers with body condition score = 6 and reproductive tract score ≥ 4 are more likely to become pregnant to artificial insemination. Careful assessment should be undertaken when developing replacement heifers that will not reach 12 months of age by the beginning of the breeding season. | Sarah E.Dickinson Michelle F.Elmore Lisa Kriese-ANDerson Joshua B.Elmore Bailey N.Walker Paul W.Dyce Soren P.Rodning Fernando H.Biase | 2019 | Journal of Animal Science and Biotechnology2019，10，2： | 2 |
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