|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Helicobacter pylori and colorectal neoplasia:Is there acausal link?显示文摘Ever since Helicobacter pylori(H. pylori) was recognized as an infectious cause of gastric cancer, there has been increasing interest in examining its potential role in colorectal carcinogenesis. Data from casecontrol and cross-sectional studies, mostly relying on hospital-based samples, and several meta-analyses have shown a positive statistical relationship between H. pylori infection and colorectal neoplasia. However, the possibility exists that the results have been influenced by bias, including the improper selection of patients and disparities with respect to potential confounders. While the evidence falls short of a definitive causal link, it appears that infection with H. pylori /H. pylori-related gastritis is associated with an increased, although modest, risk of colorectal adenoma and cancer. The pathogenic mechanisms responsible for this association remain uncertain. H. pylori has been detected in colorectal malignant tissues; however, the possibility that H. pylori is a direct activator of colonic carcinogenesis remains purely hypothetical. On the other hand, experimental data have indicated a series of potential oncogenic interactions between these bacteria and colorectal mucosa, including induction and perpetuation of inflammatory responses, alteration of gut microflora and release of toxins and/or hormonal mediators, such as gastrin, which may contribute to tumor formation. | Vasilios Papastergiou Stylianos Karatapanis Sotirios D Georgopoulos | 2016 | World Journal of Gastroenterology2016，22，2： | 22 |
| 2 | Treatment of Helicobacter pylori infection:Meeting the challenge of antimicrobial resistance显示文摘Treatment of Helicobacter pylori(H.pylori)infection is paramount for the management of prevalent gastrointestinal disorders including peptic ulcer disease and gastric cancer.Due to the wide increase in prevalence of H.pylori resistance to antibiotics,clarithromycin-based triple therapies are not any more suitable for unconditional empiric use,and should not be recommended,unless local resistance to this antibiotic is low(<20%).Alternative strategies have been proposed to overcome the issue of increasing clarithromycin resistance,and some of them are already implemented in clinical practice.These comprise:(1)adoption of novel,more effective,empirical treatments:bismuth quadruple,sequential,non-bismuth quadruple(concomitant),dual-concomitant(hybrid),and levofloxacin-based regimens,the latter mainly designated as second-line/rescue options;(2)perspectives for a susceptibility-guided(tailored)therapeutic approach based on culture-free molecular testing methods;and(3)adjunct use of probiotics to improve eradication rates.The present article is aimed to provide a comprehensive overview of current and emerging strategies in the treatment of H.pylori infection,focusing on the challenge of antimicrobial resistance. | Vasilios Papastergiou Sotirios D Georgopoulos Stylianos Karatapanis | 2014 | World Journal of Gastroenterology2014，20，29： | 18 |
| 3 | Prediction of atrial fibrillation development and progression:current perspectives显示文摘Atrial fibrillation(AF) is the most common arrhythmia in clinical practice. Several conventional and novel predictors of AF development and progression(from paroxysmal to persistent and permanent types) have been reported. The most important predictor of AF progression is possibly the arrhythmia itself. The electrical, mechanical and structural remodeling determines the perpetuation of AF and the progression from paroxysmal to persistent and permanent forms. Common clinical scores such as the hypertension, age ≥ 75 years, transient ischemic attack or stroke, chronic obstructive pulmonary disease, and heart failure and the congestive heart failure, hypertension, age ≥ 75 years, diabetes mellitus, stroke/transient ischemic attack, vascular disease, age 65-74 years, sex category scores as well as biomarkers related to inflammation may also add important information on this topic. There is now increasing evidence that even in patients with so-called lone or idiopathic AF, the arrhythmia is the manifestation of a structural atrial disease which has recently been defined and described as fibrotic atrial cardiomyopathy. Fibrosis results from a broad range of factors related to AF inducing pathologies such as cell stretch, neurohumoral activation, and oxidative stress. The extent of fibrosis as detected either by late gadolinium enhancement-magnetic resonance imaging or electroanatomic voltage mapping may guide the therapeutic approach based on the arrhythmia substrate. The knowledge of these risk factors may not only delay arrhythmia progression, but also reduce the arrhythmia burden in patients with first detected AF. The present review highlights on the conventional and novel risk factors of development and progression of AF. | Konstantinos Vlachos Konstantinos P Letsas Panagiotis Korantzopoulos Tong Liu Stamatis Georgopoulos Athanasios Bakalakos Nikolaos Karamichalakis Sotirios Xydonas Michael Efremidis Antonios Sideris | 2016 | World Journal of Cardiology2016，8，3： | 16 |
| 4 | Treatment of Helicobacter pylori infection: Past, present and future显示文摘Helicobacter pylori(H. pylori) is a major human patho-gen associated with significant morbidity and mortal-ity. However, after decades of efforts, treatment of H. pylori remains a challenge for physicians, as there is no universally effective regimen. Due to the rising prevalence of antimicrobial resistance, mainly to clar-ithromycin, efficacy of standard triple therapies has declined to unacceptably low levels in most parts of the world. Novel regimens, specifically experimented to improve the therapeutic outcome against antibiotic-resistant H. pylori strains, are now recommended as first-line empirical treatment options providing high ef-ficacy(reportedly > 90% in intention to treat analysis) even in high clarithromycin resistance settings. These include the bismuth quadruple, concomitant, sequential and hybrid therapies. Due to the rapid development of quinolone resistance, levofloxacin-based regimens should be reserved as second-line/rescue options. Adjunct use of probiotics has been proposed in order to boost eradication rates and decrease occurrence of treatment-related side effects. Molecular testing meth-ods are currently available for the characterization of H. pylori therapeutic susceptibility, including genotypic detection of macrolide resistance and evaluation of the cytochrome P450 2C19 status known to affect the me-tabolism of proton pump inhibitors. In the future, use of these techniques may allow for culture-free, non-invasive tailoring of therapy for H. pylori infection. | Vasilios Papastergiou Sotirios D Georgopoulos Stylianos Karatapanis | 2014 | World Journal of Gastrointestinal Pathophysiology2014，5，4： | 11 |
| 5 | Investigation of proper modeling of very dense granular flows in the recirculation system of CFBs显示文摘The aim of this paper is the development of new models and/or the improvement of existing numerical models,used for simulating granular flow in CFB(circulating fluidized bed) recirculation systems.Most recent models follow the TFM(two-fluid model) methodology,but they cannot effectively simulate the inter-particle friction forces in the recirculation system,because the respective stress tensor does not incorporate compressibility of flow due to change of effective particle density.As a consequence,the induced normal and shear stresses are not modeled appropriately during the flow of the granular phase in the CFB recirculation system.The failure of conventional models,such as that of von Mises/Coulomb,is mainly caused by false approximation of the yield criterion which is not applicable to the CFB recirculation system.The present work adopts an alternative yield function,used for the first time in TFM Eulerian modeling.The proposed model is based on the Pitman-Schaeffer-Gray-Stiles yield criterion.Both the temporal deformation of the solid granular phase and the repose angle that the granular phase forms are more accurately simulated by this model.The numerical results of the proposed model agree well with experimental data,implying that frictional forces are efficiently simulated by the new model. | Aristeidis Nikolopoulos Nikos Nikolopoulos Nikos Varveris Sotirios Karellas Panagiotis Grammelis Emmanuel Kakaras | 2012 | Particuology2012，10，6： | 7 |
| 6 | Apolipoprotein J as a predictive biomarker for restenosis after carotid endarterectomy: a retrospective study显示文摘颈动脉 endarterectomy (CEA ) 是为在大多数病人的击预防的一种有效外科的选择。在 CEA 以后的狭窄能导致重新干预和不利事件,但是预言狭窄的因素糟糕被理解。Apolipoprotein J (ApoJ ) 被认为是脉管的狭窄的一个新奇预兆的因素并且与与动脉粥样硬化和房间周期阶段有关的很多过程被联系。这研究的目的是阐明在内部颈动脉动脉(集成通信适配器) 的 Apo J 的预兆的价值狭窄追随者 CEA。都检验的这回顾的研究有希望地为在一个 2 年的时期上在我们的外科的部门经历了 CEA 的病人收集了数据。100 个病人的浆液 ApoJ 层次被检验;经历了 CEA 的 56 个病人包括了脉管的组(VG ) ,并且经历了次要的外科的 44 个病人包括了控制组(CG ) 。ApoJ 样品外科手术前地被获得,在外科的过程以后并且在 1, 6 和 12 个月的 24 h 此后在后续期间。在在 CG 和 VG 之间的 ApoJ 层次的外科手术前的差别是统计上 signifcant;吝啬的价值是 39.11 并且每个方法的能力在正常之间区别吗?? | Anastasios MASKANAKIS Nikolaos PATELIS Georgios KARAOLANIS Spyridon DAVAKIS Dimitrios SCHIZAS Despina PERREA Chris KLONARIS Sotirios GEORGOPOULOS Theodoros LIAKAKOS Chris BAKOYIANNIS | 2018 | Acta Pharmacologica Sinica2018，39，7： | 6 |
| 7 | Serum leptin and ghrelin in chronic hepatitis C patients with steatosis显示文摘AIM:To determine the associations between leptin and ghrelin concentrations and sustained virological response(SVR)in chronic hepatitis C patients with ste-atosis.METHODS:We retrospectively assessed 56 patients infected with hepatitis C virus(HCV)genotype-1 and 40 with HCV genotype-3.Patients with decompensated cirrhosis,and those with other causes of chronic liver disease,were excluded.Serum HCV-RNA concentra-tions were measured before the initiation of treatment;at weeks 12(for genotype 1 patients),24 and 48 during treatment;and 24 wk after the end of treatment.Genotype was determined using INNO-LIPA HCV as-says,and serum leptin and ghrelin concentrations were measured using enzyme-linked immunosorbent assay.Biopsy specimens were scored according to the Ishak system and steatosis was graded as mild,moderate,or severe,according to the Brunt classif ication.RESULTS:Overall,SVR was positively related to the presence of genotype-3,to biopsy-determined lower histological stage of liver disease,and lower grade of steatosis.Patients ≥ 40 years old tended to be less responsive to therapy.In genotype-1 infected pa-tients,SVR was associated with a lower grade of liver steatosis,milder fibrosis,and an absence of insulin resistance.Genotype-1 infected patients who did not achieve SVR had significantly higher leptin concen-trations at baseline,with significant increases as the severity of steatosis worsened,whereas those who achieved SVR had higher ghrelin concentrations.In genotype-3 infected patients,SVR was associated only with fibrosis stage and lower homeostasis model as-sessment insulin resistance at baseline,but not with the degree of steatosis or leptin concentrations.Geno-type-3 infected patients who achieved SVR showed signif icant decreases in ghrelin concentration at end of treatment.Baseline ghrelin concentrations were elevat-ed in responders of both genotypes who had moderate and severe steatosis.CONCLUSION:Increased serum leptin before treat-ment may predict non-SVR,especially in HCV geno-type-1 infected patients,whereas increased ghrelin may predict SVR in genotype-1. | Christos Pavlidis Georgios I Panoutsopoulos Dina Tiniakos Sotirios Koutsounas John Vlachogiannakos Irini Zouboulis-Vafiadis | 2011 | World Journal of Gastroenterology2011，17，46： | 6 |
| 8 | Clinical Evaluation of a Ten‐Day Regimen with E someprazole, M etronidazole, A moxicillin, and C larithromycin for the Eradication of H elicobacter pylori in a High Clarithromycin Resistance Area显示文摘 | Sotirios D. Georgopoulos Elias Xirouchakis Beatriz Martinez‐Gonzalez Dionyssios N. Sgouras Charikleia Spiliadi Andreas F. Mentis Fotini Laoudi | 2013 | Helicobacter2013，，6： | 6 |
| 9 | Inferior mesenteric arteriovenous fistula: Case report and world-literature review显示文摘Arteriovenous fistulas between the inferior mesenteric artery and vein are rare, with only 26 primary and secondary cases described in the literature. Secondary fistulas occur following operations of the left hemicolon and manifest as abdominal pain, abdominal mass, gastrointestinal bleeding, colonic ischemia and portal hypertension. Symptom intensities are flow-dependent, and can range from minimal symptoms to severe heart failure due to left to right shunt. Diagnosis is usually established by radiological or intraoperative examination. Treatment options include embolization and/or surgical resection. Therapeutic decisions should be adapted to the unique characteristics of the fistula on an individual basis. A new case of a primary arteriovenous fistula is described and discussed along with a complete review of the literature. The patient in this report presented with signs and symptoms of colonic ischemia without portal hypertension. The optimal treatment for this pa-tient required a combination of embolization and surgical operation. The characteristics of these rare inferior mesenteric arteriovenous fistulas are examined and some considerations concerning diagnostic and therapeutic strategies that should be followed are presented. | Antonios Athanasiou Adamantios Michalinos reas Alexrou Sotirios Georgopoulos Evangelos Felekouras | 2014 | World Journal of Gastroenterology2014，20，25： | 5 |
| 10 | Fragility assessment of tunnels in soft soils using artificial neural networks显示文摘Recent earthquakes have shown that tunnels are prone to damage,posing a major threat to safety and having major cascading and socioeconomic impacts.Therefore,reliable models are needed for the seismic fragility assessment of underground structures and the quantitative evaluation of expected losses.Based on previous researches,this paper presented a probabilistic framework based on an artificial neural network(ANN),aiming at the development of fragility curves for circular tunnels in soft soils.Initially,a two-dimensional incremental dynamic analysis of the nonlinear soil-tunnel system was performed to estimate the response of the tunnel under ground shaking.The effects of soil-structure-interaction and the ground motion characteristics on the seismic response and the fragility of tunnels were adequately considered within the proposed framework.An ANN was employed to develop a probabilistic seismic demand model,and its results were compared with the traditional linear regression models.Fragility curves were generated for various damage states,accounting for the associated uncertainties.The results indicate that the proposed ANN-based probabilistic framework can results in reliable fragility models,having similar capabilities as the traditional approaches,and a lower computational cost is required.The proposed fragility models can be adopted for the risk analysis of typical circular tunnel in soft soils subjected to seismic loading,and they are expected to facilitate decision-making and risk management toward more resilient transport infrastructure. | Zhongkai Huang Sotirios A.Argyroudis Kyriazis Pitilakis Dongmei Zhang Grigorios Tsinidis | 2022 | Underground Space2022，7，2： | 4 |
| 11 | Use of demineralized bone matrix in spinal fusion显示文摘Spinal fusion remains the gold-standard treatment for several pathological spine conditions. Although, autologous Iliac Crest Bone Grafting is considered the goldstandard graft choice to promote spinal fusion; however, it is associated with significant donor site morbidity and a limited graft quantity. Therefore, several bone graft alternatives have been developed, to augment arthrodesis. The purpose of this review is to present the results of clinical studies concerning the use of demineralized bone matrix(DBM), alone or as a composite graft, in the spinal fusion. A critical review of the English-language literature was conducted on Pubmed, using key word 'demineralized bone matrix', 'DBM', 'spinal fusion', and 'scoliosis'. Results had been restricted to clinical studies. The majority of clinical trials demonstrate satisfactory fusion rates when DBM is employed as a graft extender or a graft enhancer.Limited number of prospective randomized controlled trials(4 studies), have been performed comparing DBM to autologous iliac crest bone graft in spine fusion. The majority of the clinical trials demonstrate comparable efficacy of DBM when it used as a graft extender in combination with autograft, but there is no clinical evidence to support its use as a standalone graft material. Additionally, high level of evidence studies are required, in order to optimize and clarify the indications of its use and the appropriate patient population that will benefit from DBM in spine arthrodesis. | Konstantinos Tilkeridis Panagiotis Touzopoulos Athanasios Ververidis Sotirios Christodoulou Konstantinos Kazakos Georgios I Drosos | 2014 | World Journal of Orthopedics2014，5，1： | 4 |
| 12 | 结肠的腺癌和麦芽淋巴瘤的同时的出现: 一系列三个盒子显示文摘 Simultaneous development of adenocarcinoma and primary B cell lymphoma of mucosa-associated lymphoid tissue(MALT) lymphoma of the colon is rare;only one case has so far been reported out of 13 cases with the coexistence of colonic adenocarcinoma with involvement of the colon by lymphoma.We hereby present three more cases,two females(aged 75 and 71 years) and a male(aged 72 years).All three underwent colectomy based on a preoperative biopsy revealing colonic carcinoma.Histological examination of the resection specimens disclosed a colonic adenocarcinoma in two cases,whereas a tubulovillous adenoma with superficial foci of intraepithelial adenocarcinoma was seen in the thirdcase.Moreover,in all three cases,a coexisting MALT lymphoma was diagnosed in the colon(1 case),in both colon and adjacent lymph nodes(1 case) or in colonic lymph nodes and omentum(1 case).In the last case,a post-operative bone marrow biopsy revealed extensive infiltration of the bone marrow,due to which the patient received postoperative chemotherapy.Diagnostic and treatment issues are briefly discussed. | Theodoros Argyropoulos Periklis Foukas Maria Kefala Panagiotis Xylardistos Sotirios Papageorgiou Nikolaos Machairas Evmorfia Boltetsou Anastasios Machairas Ioannis G Panayiotides | 2012 | World Journal of Gastrointestinal Oncology2012，4，4： | 4 |
| 13 | Nonbismuth Quadruple “Concomitant” Therapy Versus Standard Triple Therapy, Both of the Duration of 10 Days, for First-Line H. Pylori Eradication: A Randomized Trial显示文摘 | Sotirios Georgopoulos Vasilios Papastergiou Elias Xirouchakis Foteini Laoudi Philipos Lisgos Charikleia Spiliadi Nikitas Papantoniou Stylianos Karatapanis | 2013 | Journal of Clinical Gastroenterology2013，，3： | 3 |
| 14 | Multiple primary malignancies: a report of two cases显示文摘The diagnosis of multiple primary malignancies(MPMs) in a patient has been reported rather frequently during the past decade. Here we present two cases with three synchronous primary malignant tumors. The first patient is a 66-year-old male with synchronous colorectal cancer, renal cell carcinoma(RCC) and non-small cell lung cancer(NSCLC). The second patient is a 64-year-old female with breast cancer, transitional cell carcinoma of the ureter and endometrial cancer. MPMs seem to be diagnosed in a higher incidence than that predicted only by the influence of hazard and, whenever found, they raise questions regarding not only possible common etiologic factors or same pathogenetic mechanisms but also they cause a lot of troubles to both clinicians and patients because the therapeutic options usually become limited. | Minas Sakellakis Stavros Peroukides Gregoris Iconomou Sotirios Boumpoucheropoulos Haralabos Kalofonos | 2014 | Chinese Journal of Cancer Research2014，26，2： | 3 |
| 15 | Current options for the treatment of Helicobacter pylori显示文摘 | Sotirios D Georgopoulos Vasilios Papastergiou Stylianos Karatapanis | 2013 | Expert Opinion on Pharmacotherapy2013，，2： | 3 |
| 16 | Associations between serum relaxin 2, aneurysm formation/size and severity of atherosclerosis: a preliminary prospective analysis显示文摘(RL2 ) 浆液松弛激素 2 是对各种各样的机关和系统起作用的多种的荷尔蒙,特别地心血管的系统。尽管 RL2 似乎是氮的一氧化物的合成到 upregulate (没有) 并且它在动脉粥样硬化和动脉瘤形成的角色上的矩阵 metalloproteinase (MMP )-2 和 -9, 水流文学是少见的。这研究的目的是与一个动脉的动脉瘤以及在动脉粥样硬化患者病人在病人调查浆液 RL2 的层次,并且相关他们与他们的相关脉管的疾病的严厉。53 个题目的一个总数在这研究被注册:37 个病人被安排经历外科:为动脉粥样硬化患者疾病(ATH ) 的不同形式的 21 个病人,为一个动脉的动脉瘤(AA ) 的 16 个病人,为经历时间的动脉活体检视(标签) 的 6 个病人,和 10 个健康献血者(HBD ) 担任了控制组。RL2 用 enzymelinked immunosorbent 试金被测量。RL2 在与 ATH 相比的 AA 病人是显著地更高的(P < 0.01 ) ,标签(P < 0.001 ) 并且 HBD (P < 0.01 ) 。没有重要差别在 ATH 和标签组之间被发现(P > 0.05 ) 。另外, ATH 和 AA 病人进一步基于他们的疾病的严厉被细分。浆液 RL2 日益增多地与动脉的动脉瘤在病人被增加,显示出与 aneurysmatic 膨胀的尺寸的一种积极关系。由对比, RL2 水平是相反地与动脉粥样硬化患者疾病的严厉有关。有合并一张一致学习人口的一个更大的队的研究被保证验证我们的结果并且使这些过程的机械学的背景清楚些。 | Konstantinos PAPOUTSIS Alkistis KAPELOUZOU Diamantis I TSILIMIGRAS Nikolaos PATELIS Georgios KOUVELOS Dimitrios SCHIZAS Ioannis KARAVOKYROS Sotirios GEORGOPOULOS | 2018 | Acta Pharmacologica Sinica2018，39，7： | 2 |
| 17 | Nonbismuth Quadruple “Concomitant” Therapy Versus Standard Triple Therapy, Both of the Duration of 10 Days, for First-Line H. Pylori Eradication: A Randomized Trial显示文摘 | Sotirios Georgopoulos Vasilios Papastergiou Elias Xirouchakis Foteini Laoudi Philipos Lisgos Charikleia Spiliadi Nikitas Papantoniou Stylianos Karatapanis | 2013 | Journal of Clinical Gastroenterology2013，，3： | 2 |
| 18 | Is There a Nonbismuth Quadruple Therapy That Can Reliably Overcome Bacterial Resistance?显示文摘 | Sotirios D. Georgopoulos Elias Xirouchakis | 2013 | Gastroenterology2013，，6： | 2 |
| 19 | Unsedated transnasal endoscopy accurately detects Barrett’s metaplasia and dysplasia显示文摘 | Kia Saeian David M. Staff Sotirios Vasilopoulos William F. Townsend Urias A. Almagro Richard A. Komorowski Hongyung Choi Reza Shaker | 2002 | Gastrointestinal Endoscopy2002，，4： | 2 |
| 20 | Association of breastfeeding with tidal breathing analysis in infants with bronchiolitis显示文摘BACKGROUND Tidal breathing flow-volume(TBFV)analysis provides important information about lung mechanics in infants.AIM To assess the effects of breastfeeding on the TBFV measurements of infants who recover from acute bronchiolitis.METHODS In this cross-sectional study,TBFV analysis was performed in infants with bronchiolitis prior to hospital discharge.The ratio of time to peak expiratory flow to total expiratory time(tPEF/tE)at baseline and after the administration of 400 mcg salbutamol was evaluated.RESULTS A total of 56 infants(35 boys),aged 7.4±2.8 mo,were included.Of them,12.5%were exposed to tobacco smoke and 41.1%were breastfed less than 2 mo.There were no differences in baseline TBFV measurements between the breastfeeding groups;however,those who breastfed longer than 2 mo had a greater change in tPEF/tE after bronchodilation(12%±10.4%vs 0.9%±7.1%;P<0.001).Moreover,there was a clear dose-response relationship between tPEF/tE reversibility and duration of breastfeeding(P<0.001).In multivariate regression analysis,infants who breastfed less(regression coefficient-0.335,P=0.010)or were exposed to cigarette smoke(regression coefficient 0.353,P=0.007)showed a greater change in tPEF/tE after bronchodilation,independent of sex,prematurity,and family history of asthma or atopy.CONCLUSION Infants who recover from bronchiolitis and have a shorter duration of breastfeeding or are exposed to cigarette smoke,have TBFV measurements indicative of obstructive lung disease. | Evanthia Perikleous Sotirios Fouzas Athina Karageorgiou Paschalis Steiropoulos Evangelia Nena Athanasios Chatzimichael Aggelos Tsalkidis Emmanouil Paraskakis | 2021 | World Journal of Clinical Pediatrics2021，10，6： | 2 |
您所在的机构暂未开通此部分的功能，请联系管理员