|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Interferon-a plus lamivudine vslamivudine reduces breakthroughs, but does not affect sustained response in HBeAg negative chronic hepatitis B显示文摘AIM: To investigate the efficacy of combination treatment of IFN-α and lamivudine compared to lamivudine monotherapy, after 24 mo of administration in HBeAg-negative hepatitis B patients.METHODS: Fifty consecutive patients were randomly assigned to receive IFN-α-2b (5 MU thrice per week, n = 24) plus lamivudine (100 mg daily) or lamivudine only (n = 26) for 24 mo. Patients were followed up for further 6 mo. The primary outcome was the proportion with sustained virological response (undetectable serum HBV DNA concentrations) and or sustained biochemical response (transaminase levels within normal range) at 30 mo (6 mo after the end of therapy). Secondary end-points were timed from initial virological (biochemical) response to VBR (BBR, respectively) and the emergence of YMDD mutants across the two arms.RESULTS: Five of twenty-four (21%) patients in the combination arm vs 3/26 (12%) in the lamivudine arm had sustained response (i.e., normal serum transaminase levels and undetectable HBV DNA by PCR assay) 6 mo after treatment discontinuation. A reduction in the emergence of YMDD mutants and in the development of virological breakthroughs was observed in patients receiving combination treatment (10% vs46%, P= 0.01 and 14% vs46%, P= 0.03,respectively).Time from initial virologic response to virologic breakthrough (VBR) was greater among initial responders receiving combination treatment compared to those receiving lamivudine (22.9 mo vs 15.9 mo, respectively; P = 0.005).CONCLUSION: Our results demonstrate that IFN-α plus lamivudine combination therapy does not increase the sustained response, compared to lamivudine. However,combination therapy reduces the likelihood of VBR due to YMDD mutants and prolongs the time period until the breakthrough development. | Michalis Economou Spilios Manolakopoulos Thomas A Trikalinos Spyros Filis Sotiris Bethanis Dimitrios Tzourmakliotis Alec Avgerinos Sotiris Raptis Epameinondas V Tsianos | 2005 | World Journal of Gastroenterology2005，11，37： | 6 |
| 2 | f(R) theories of gravity显示文摘 | Sotiriou T P Faraoni V | 2010 | Rev Mod Phys2010，82，： | 1 |
| 3 | A novel mutation in the mitochondrial DNA cytochrome b gene (MTCYB) in a patient with mitochondrial encephalomyopathy,lactic acidosis,and strokelike episodes syndrome显示文摘 | Emmanuele V Sotiriou E Rios PG | | 0，，： | 1 |
| 4 | Recurrent myoglobinuria in a sporadic patient with a novel mitochondrial DNA tRNA (Ile) mutation显示文摘 | Emmanuele V Sotiriou E Shirazi M | | 0，，1： | 1 |
| 5 | Peer pressure and productivity:the role of observing and being observed显示文摘 | Sotiris G Mirco T Michael V | 2015 | Journal of Economic Behavior Organization2015，117，3： | 1 |
| 6 | Cell-free DNA and RNA in plasma as a new molecular marker for prostate and breast cancer显示文摘 | Papadopoulou E Davilas E Sotiriou V | 2006 | Ann N Y Acad Sci2006，1075，： | 1 |
| 7 | Potential growth and biomass productivity of Miscanthus X giganteus as affected by plant density and N-fertilization in central Greece显示文摘 | Danalatos Nicholas G Archontoulis Sotiris V Mitsios Ioannis | 2007 | Biomass and Bioenergy2007，31，23： | 1 |
| 8 | Analysis of long-range transport influences on urban PM10 using two-stage atmospheric trajectory clusters 显示文摘 | RAFAEL B JULIO L SOTIRIS V | 2007 | Atmos Environ2007，41，： | 1 |
| 9 | Potential growth and biomaas productivity of Miscanthus ×giganteus as affected by plant density and N-fertilization in central Greece显示文摘 | Danalatos Nicholas G Archontonlis Sotiris V Mitsios Ioannis | 2007 | Biomass and Bioenergy2007，31，23： | 1 |
| 10 | Cell-free DNA and RNA in plasma as a new molecular maker for prostate cancer显示文摘 | Papadopoulou E Davilas E Sotirious V | 2004 | Oncol Res2004，14，9： | 1 |
| 11 | Potential growth and biomass productivity of Miscanthus×giganteus as affected by plant density and N-fertilization in central Greece 显示文摘 | Nicholas G Danalatos Sotiris V | 2007 | Biomass and Bioenergy2007，31，2： | 1 |
| 12 | Cell-free DNA and RNA in plasma as a new molecular maker for prostate cancer显示文摘 | Papadopoulou E Davilas E Sotiriou V | 2004 | Oncol Res2004，14，9： | 1 |
| 13 | Competition between TiCl4 hydrolysis and oxidation and its effection product TiO2 powder 显示文摘 | Kamal A M Srinnivas V Sotiris E P | 1994 | AICH E J1994，40，7： | 1 |
| 14 | Lipoprotein (a) in atherosclerotic plaques recruits inflammatory cells through interaction with Mac-1 integrin显示文摘 | SOTIRIOU S N ORLOVA V V AL-FAKHRI N | 2006 | Faseb J2006，20，： | 1 |
| 15 | Cell-free DNA and RNA in plasma as a new molecular marker for prostate and breast cancer显示文摘 | Papadopoulou E Davilas E Sotiriou V | 2006 | Ann N Y Acad Sci2006，1075，： | 1 |
| 16 | Analysis of long-range transport influences on urban PMlo using two-stage atmospheric trajectory clusters显示文摘 | RAFAEL B JULIO L SOTIRIS V | 2007 | Atmos Environ2007，41，21： | 1 |
| 17 | f(R) theory of gravity 显示文摘 | SOTIRIOU T P FARAONI V | 2010 | Rev Mod Phys2010，82，： | 1 |
| 18 | Lipoprotein(a) in atherosclerosie plaques recruits inflammatory cells through interaction with Mac-1 integrin 显示文摘 | Sotiriou S N Orlova V V A1-Fakhri N | 2006 | FASEB J2006，20，3： | 1 |
| 19 | Analysis of long-range transport influences on urban PMl0 using two-stage atmospheric trajectory clusters显示文摘 | RAFAEL B JULIO L SOTIRIS V | 2007 | Atmos Environ2007，41，： | 1 |
| 20 | Impact and uncertainty of a traffic management intervention: population exposure to polycyclic aromatic hydrocarbons显示文摘 | SOTIRIS V ZAID C TONY F | 2008 | Sei Total Environ2008，394，： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员