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	题名	作者	年代	出处	被引量
1	Favorable response to subcutaneous administration of infliximab in rats with experimental colitis显示文摘AIM: To investigate the influence of infliximab (Remicade)on experimental colitis produced by 2,4,6,trinitrobenzene sulfonic acid (TNBS) in rats.METHODS: Thirty-six Wistar rats were allocated into four groups (three groups of six animals each and a fourth of 12 animals). Six more healthy animals served as normal controls (Group 5). Group 1:colitis was induced by intracolonic installation of 25 mg of TNBS dissolved in 0.25 mL of 50% ethanol and infliximab was subcutaneously administered at a dose of 5 mg/kg BW; Group 2: colitis was induced and infliximab was subcutaneously administered at a dose of 10 mg/kg BW; Group 3: colitis was induced and infliximab was subcutaneously administered at a dose of 15 mg/kg BW; Group 4: colitis was induced without treatment with infliximab. Infliximab was administered on d 2-6. On the 7th d, all animals were killed. The colon was fixed in 10%buffered formalin and examined by light microscopy for the presence and activity of colitis and the extent of tissue damage. Tumor necrosis factor-alpha (TNF-α) and malondialdehyde (MDA) were also measured.RESULTS: Significant differences concerning the presence of reparable lesions and the extent of bowel mucosa without active inflammation in all groups of animals treated with infliximab compared with controls were found. Significant reduction of the tissue levels of TNF-α in all groups of treated animals as compared withthe untreated ones was found (0.47±0.44, 1.09±0.86,0.43±0.31 vs 18.73±10.53 respectively). Significant reduction in the tissue levels of MDA was noticed in group 1 as compared to group 4, as well as between groups 2 and 4.CONCLUSION: Subcutaneous administration of infliximab reduces the inflammatory activity as well as tissue TNF-α and MDA levels in chemical colitis in rats.Infliximab at a dose of 5 mg/kg BW achieves better histological results and produces higher reduction of the levels of TNF-α than at a dose of 10 mg/kg BW.Infliximab at a dose of 5 mg/kg BW produces higher reduction of tissue MDA levels than at a dose of 15 mg/kg BW.	John K Triantafillidis Apostolos E Papalois Aikaterini Parasi Emmanuel Anagnostakis Stavros Burnazos Aristofanis Gikas Emmanuel G Merikas Emmanuel Douzinas Maria Karagianni Helen Sotiriou	2005	World Journal of Gastroenterology2005，11，43：	5
2	REFILL: A lightweight programmable middleware platform for cost effective RFID application development显示文摘	Achilleas P Anagnostopoulos John K Soldatos Sotiris G Michalakos	2009	Pervasive and Mobile Computing2009，，：	1
3	查看详情显示文摘	Sotiriou G A Schneider M Pratsinis S E		0，，：	1
4	Photodynamic therapy for distal and lateral subungual toenail onychomycosis caused by Trichophyton rubrum:Preliminary results of a single-centre open trial显示文摘	Sotiriou E Koussidou-Eremonti T Chaidemenos G		0，，02：	1
5	Beneficial effects of statins in coronary artery disease-beyond lowering cholesterol 显示文摘	Sotiriou C G Cheng J W	2000	AnnPharmacother2000，34，12：	1
6	Chloride-induced corrosion of steel rein- forcement mechanical perlformance and pit depth a- nalysis显示文摘	Charis A Apostolopoulos Sotiris Demis Vagelis G Papadakis	2013	Construction and Building Materials2013，，38：	1
7	Kounis syndrome: a new twist on an old disease显示文摘	Nicholas G Kounis Andreas Mazarakis Grigorios Tsigkas Sotiris Giannopoulos John Goudevenos	2011	Future Cardiol2011，，6：	1
8	Antibacterial activity of nanosilver ions and particles显示文摘	Sotiriou G A Pratsinis S E	2010	Environmental Science&Technology2010，44，14：	1
9	Antibacterial activity of nanosil- vet ions and particles显示文摘	Sotiriou G A Pratsinis S E	2010	Environmental Science and Tech- nology2010，44，14：	1
10	A 3D face and hand biometric system for robust user-friendly authentication显示文摘	FILARETI T SOTIRIS M MICHAEL G S	2007	Pattern Recognition Letters2007，28，16：	1
11	Photothermal Killing of Cancer Cells by the Controlled Plasmonic Coupling of Silica-coated Au/ Fe203 Nanoaggregates显示文摘	SOTIRIOU G A STARSICH F DASARGYRI A	2014	Adv Funct Mater2014，，1：	1
12	Beneficial effects of statins in coronary artery disease-beyond lowering cholesterol显示文摘	Sotiriou C G Cheng J W	2000	Ann Pharmacother2000，34，12：	1
13	Peer pressure and productivity:the role of observing and being observed显示文摘	Sotiris G Mirco T Michael V	2015	Journal of Economic Behavior Organization2015，117，3：	1
14	Nanosilver on nanostructured silica: Antibacterial activity and Ag surface area显示文摘	Sotiriou G A Teleki A Camenzind A	2011	Chem Eng J2011，170，2：	1
15	Photody- namic therapy for distaland lateral subungual toenail onychomyco- sis caused byTrichophytonrubrum: preliminary results of a single- centreopen trial显示文摘	Sotiriou E Koussidou-Eremonti T Chaidemenos G	2010	Acta DermVenereol2010，90，2：	1
16	Potential growth and biomass productivity of Miscanthus X giganteus as affected by plant density and N-fertilization in central Greece显示文摘	Danalatos Nicholas G Archontoulis Sotiris V Mitsios Ioannis	2007	Biomass and Bioenergy2007，31，23：	1
17	Potential growth and biomaas productivity of Miscanthus ×giganteus as affected by plant density and N-fertilization in central Greece显示文摘	Danalatos Nicholas G Archontonlis Sotiris V Mitsios Ioannis	2007	Biomass and Bioenergy2007，31，23：	1
18	Antibacterial activity of nanosilver ions and particles显示文摘	Sotiriou G A Pratsinis S E	2010	Environmental Science and Technology2010，44，14：	1
19	Potential growth and biomass productivity of Miscanthus×giganteus as affected by plant density and N-fertilization in central Greece 显示文摘	Nicholas G Danalatos Sotiris V	2007	Biomass and Bioenergy2007，31，2：	1
20	Photodynamic therapy for distal and lateral subungual toenail onychomycosis caused by Trichophyton rubrum: preliminary results of a single-centre open trial 显示文摘	Sotiriou E Koussidou-Eremouti T Chaidemenos G	2010	Acta Derm Venereol2010，90，2：	1

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