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| 1 | AKT and ERK1/2 signaling in intrahepatic cholangiocarcinoma显示文摘Intrahepatic cholangiocarcinomas (ICC) are neoplasms that originate from cholangiocytes and can occur at any level of the biliary tree. Surgical resection is the current therapy of choice for this highly aggressive cancer. However, the 5-year survival still is poor, with high recurrence rates. Due to the intrahepatic growth a signifi cant proportion of patients present with advanced disease and are not candidates for curative surgery or transplantation. The existing palliative options are of limited benefit and there is a great necessity for novel therapeutic options. In this article we review the role of the phosphoinositide 3-kinase(PI3K)/ AKT and extracellular regulated kinase (ERK) signaling pathways in ICC and present new data on the prognostic value of these protein kinases. Finally, we discuss future upcoming therapeutic options based on targeting these signaling pathways. | KJ Schmitz H Lang J Wohlschlaeger GC Sotiropoulos H Reis KW Schmid HA Baba | 2007 | World Journal of Gastroenterology2007，13，48： | 8 |
| 2 | Are acute exacerbations of chronic inflammatory appendicitis triggered by coprostasis and/or coproliths?显示文摘AIM: To examine the role of coprostasis and coproliths in recurrent appendicitis. METHODS: We evaluated four hundred and twenty seven consecutive pathology reports of all appende- ctomy specimens from January 2003 to December 2004. Findings were categorised as showing acute appen- dicitis, acute recurrent appendicitis, subacute recurrent appendicitis, chronic appendicitis, or appendices without inflammation. All patients had presented with acute right lower quadrant pain. In 94 instances, there was a history of recurrent similar episodes in the past. RESULTS: Of the 427 histology reports, 294 were inter- preted as showing acute appendicitis, 56 acute recurrent appendicitis, 34 subacute recurrent appen-dicitis, 28 chronic appendicitis, and 15 non-inflamed appendices. Coprostasis was observed in 58 patients (13.58%) and the presence of coprolith in 6 (1.4%). Coprostasis, and age, were among the predictors in the final model. CONCLUSION: Coprostasis but not coproliths seems to be a contributing factor to acute exacerbations of chronic inflammatory appendicitis. | George Sgourakis Georgios C Sotiropoulos Ernesto P Molmenti Charis Eibl Stylianous Bonticous Jurgen Moege Christoph Berchtold | 2008 | World Journal of Gastroenterology2008，14，20： | 5 |
| 3 | Totally laparoscopic left hepatectomy using the Torsional Ultrasonic Scalpel显示文摘Minimal invasive techniques have allowed for major surgical advances.We report our initial experience of performing total laparoscopic left hepatectomy(segmentsⅡ-Ⅳ)with the Lotus(laparoscopic operation by torsional ultrasound)Ultrasonic Scalpel.The perioperative and postoperative courses of the young female patient were uneventful and she is in a good general condition without complaints 18 mo after surgery.To the best of our knowledge,this is the first total laparoscopic hemihepatectomy to be performed in Greece,as well as the first laparoscopic liver resection using Lotus shears. | Georgios C Sotiropoulos Paraskevas Stamopoulos Petros Charalampoudis Ernesto P Molmenti Athanasios Voutsarakis Gregory Kouraklis | 2013 | World Journal of Gastroenterology2013，19，35： | 5 |
| 4 | Computer-Assisted Surgery Planning for Complex Liver Resections: When Is It Helpful? A Single-Center Experience Over an 8-Year Period显示文摘 | Arnold Radtke Georgios C. Sotiropoulos Ernesto P. Molmenti Tobias Schroeder Heinz O. Peitgen Andrea Frilling Dieter C. Broering Christoph E. Broelsch Massimo Malagó | 2010 | Annals of Surgery2010，，5： | 4 |
| 5 | Sorafenib Treatment for Recurrent Hepatocellular Carcinoma After Liver Transplantation显示文摘 | G.C. Sotiropoulos K.W. Nowak I. Fouzas S. Vernadakis S. Kykalos C.G. Klein A. Paul | 2012 | Transplantation Proceedings2012，，9： | 2 |
| 6 | Liver transplantation and neurological side effects显示文摘 | Fuat H. Saner Silvio Nadalin Arnold Radtke Georgios C. Sotiropoulos Gernot M. Kaiser Andreas Paul | 2009 | Metabolic Brain Disease2009，，1： | 2 |
| 7 | Prevalenceof thyroid dysfunction among Greek type 2 diabetic patients atten-ding an outpatient clinic显示文摘 | Papazafiropoulou A Sotiropoulos A Kokolaki A | 2010 | J Clin Med Res2010，2，2： | 1 |
| 8 | A new hybrid Genetic Algorithm for global optilnization显示文摘 | Sotiropoulos D G Stavropoulos E C | 1997 | Nonlinear Analysis Theory Methods and Applications1997，30，7： | 1 |
| 9 | Finite element collocation approximation of the characteristic exponent in BVPs with periodic coefficients显示文摘 | Saridakis Y G Sifniotopoulos C G Sotiropoulos D A | 1996 | Journal of Computational and Applied Math-ematics1996，70，： | 1 |
| 10 | Computer-assisted surgery planning for complex liver resections:when is it helpful? A single-center experience over an 8-year period显示文摘 | Radtke A Sotiropoulos GC Molmenti EP | 2010 | Ann Surg2010，252，5： | 1 |
| 11 | Experimental and computational investigation of local scour around bridge piers显示文摘 | Khosronejad A Kang S Sotiropoulos F | 2012 | Advances in Water Resources2012，37，： | 1 |
| 12 | Computer-assisted operative planning in adult living donor liver transplantation:a new way to resolve the dilemma of the middle hepatic vein显示文摘 | Radtke A Nadalin S Sotiropoulos GC | 2007 | World J Surg2007，31，1： | 1 |
| 13 | Three-dimensional numerical model of lateral-intake inflow 显示文摘 | Neary V S Sotiropoulos F Odgaard A J | 1996 | J Hydr Engrg ASCE1996，125，2： | 1 |
| 14 | Resectability of hepato- cellular carcinoma: evaluation of 333 consecutive cases at a single hepatobiliary specialty center and systematic review of the literature 显示文摘 | Sotiropoulos GC Lang H Frilling A | 2006 | Hepatogastroenterology2006，53，69： | 1 |
| 15 | Preoperative vol-- Lime prediction in adult live donor liver transplantation: 3 - D CT volumetry approach to prevent miscalculations 显示文摘 | Radtke A Sotiropoulos GC Nadalin S | 2008 | Eur J Med Res2008，13，7： | 1 |
| 16 | Resectability of hep-atocellular carcinoma:evaluation of 333 consecutive cases at a single hepatobiliary specialty center and systematic review of the literature显示文摘 | Sotiropoulos GC Lang H Frilling A | | 0，，69： | 1 |
| 17 | Numerical simulation of swirling flow in complex hydroturbine draft tube using unsteady statistical turbulence models显示文摘 | Paik Joongcheol Sotiropoulos Fotis Sale Michael J | 2005 | Journal of Hydraulic Engineering2005，131，6： | 1 |
| 18 | Computer-assisted operative planning in adult living donor liver transplantation : a new way to resolve the dilemma of the middle hepatic vein显示文摘 | Radtke A Nadalin S Sotiropoulos GC | 2007 | World J Surg2007，31，1： | 1 |
| 19 | 红海海相沉积物上大直径钻孔灌注后压浆桩(文摘)显示文摘介绍了在红海海相珊瑚层和碳酸盐沉积物上的大直径钻孔灌注混凝土后压浆桩的施工过程及桩的载荷试验结果。描述并讨论了在选择场地、钻孔、钢筋、混凝土浇注、以及压浆过程中的施工细节和所遇到的困难,以及场地条件和桩型选择的岩土工程依据。 | FOUAD M.GHAZALI ELIAS SOTIROPOULOS OSAMA A.MANSOUR 蒋秀玲 柴新夏 | 2012 | 土工基础2012，26，6： | 1 |
| 20 | Extended hepatectomy for intrahepatic cholangiocellular carcinoma (ICC):when is it worthwhile single center experience with 27 Resections in 50 patients over a 5-year period显示文摘 | Lang H Sotiropoulos R | 2005 | Ann Surg2005，241，1： | 1 |
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