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| 1 | Restrictive model of compensated carbon tetrachloride-induced cirrhosis in rats显示文摘AIM: To develop a simplified and quick protocol to induce cirrhosis and standardize models of partial liver resection in rats.METHODS: In Fischer F344 rats two modified protocols of phenobarbital-carbon tetrachloride (CCl4) (dilution 50%) gavage to induce cirrhosis (frequency adjusted according to weight, but each subsequent dose was systematically administered) were tested, i.e. the rapid and slow protocols. Prothrombin time (PT) and total bili-rubin (TB) were also evaluated. Animals from the rapid group underwent 15% hepatectomy and animals from the slow group underwent 70% hepatectomy.RESULTS: Rapid protocol: This corresponded to 1 ga-vage/4 d over 6 wk (mortality 30%). Mean PT was 35.2 ± 2.8 s (normal: 14.5 s), and mean TB was 1.8 ± 0.2 mg/dL (normal: 0.1 mg/dL). Slow protocol: This cor-responded to 1 gavage/6 d over 9 wk (mortality 10%). Mean PT was 11.8 ± 0.2 s (normal: 14.5 s), and mean TB was 0.4 ± 0.04 mg/dL (normal: 0.1 mg/dL). Patho-logical analyses were performed in both protocols which showed persistent cirrhosis at 3 mo. Rat mortality in the rapid gavage group who underwent 15% hepatectomy and in the slow gavage group who underwent 70% hepatectomy was 50% and 70%, respectively.CONCLUSION: Our modified model is a simplified method to induce cirrhosis which is rapid (6 to 9 wk), efficient and stable up to 3 mo. Using this method, 'Child Pugh A' or 'Child Pugh BC' cirrhotic rats were obtained. Our models of cirrhosis and hepatectomy can be used in various situations focusing on postoperative survival. | Jean-Marc Regimbeau David Fuks Niaz Kohneh-Shahri Benot Terris Olivier Soubrane | 2008 | World Journal of Gastroenterology2008，14，45： | 8 |
| 2 | Laparoscopic liver resection for living donation: Where do we stand?显示文摘In Western countries, living donor liver transplantation(LDLT) may represent a valuable alternative to deceased donor liver transplantation. Yet, after an initial peak of enthusiasm, reports of high rates of complications and of fatalities have led to a certain degree of reluctance towards this procedure especially in Western countries. As for living donor kidney transplantation, the laparoscopic approach could improve patient's tolerance in order to rehabilitate this strategy and reverse the current trend. In this setting however, initial concerns regarding patient's safety and graft integrity, need for acquiring surgical expertise in both laparoscopic liver surgery and living donor transplantation and lack of evidence supporting the benefits of laparoscopy have delayed the development of this approach. Similarly to what is performed in classical resectional liver surgery, initial experiences of laparoscopy have therefore begunwith left lateral sectionectomy,which is performed for adult to child living donation.In this setting,the laparoscopic technique is now well standardized,is associated with decreased donor blood loss and hospital stays and provides graft of similar quality compared to the open approach.On the other hand laparoscopic major right or left hepatectomies for adult-adult LDLT currently lack standardization and various techniques such as the full laparoscopic approach,the hand assisted approach and the hybrid approach have been reported.Hence,even-though several reports highlight the feasibility of these procedures,the true benefits of laparoscopy over laparotomy remain to be fully assessed.This could be achieved through standardization of the procedures and creation of international registries especially in Eastern countries where LDLT keeps on flourishing. | Fran?ois Cauchy Lilian Schwarz Olivier Scatton Olivier Soubrane | 2014 | World Journal of Gastroenterology2014，20，42： | 4 |
| 3 | Liver Transplantation for Neuroendocrine Tumors in Europe—Results and Trends in Patient Selection: A 213-Case European Liver Transplant Registry Study显示文摘 | Yves Patrice Le Treut Emilie Grégoire Jürgen Klempnauer Jacques Belghiti Elisabeth Jouve Jan Lerut Denis Castaing Olivier Soubrane Olivier Boillot Georges Mantion Kia Homayounfar Manuel Bustamante Daniel Azoulay Philippe Wolf Marek Krawczyk Andreas Pasche | 2013 | Annals of Surgery2013，，5： | 3 |
| 4 | Cholecystocolonic fistula: facts and myths. A review of the 231 published cases显示文摘 | Renato Costi Bruto Randone Vincenzo Violi Olivier Scatton Leopoldo Sarli Olivier Soubrane Bertrand Dousset Thierry Montariol | 2009 | Journal of Hepato - Biliary - Pancreatic Surgery2009，，1： | 2 |
| 5 | Laparoscopic resection of hepatocellular carcinoma: a F rench survey in 351 patients显示文摘 | Olivier Soubrane Claire Goumard Alexis Laurent Hadrien Tranchart Stéphanie Truant Brice Gayet Chadi Salloum Guillaume Luc Safi Dokmak Tullio Piardi Daniel Cherqui Ibrahim Dagher Emmanuel Boleslawski Eric Vibert Antonio Sa Cunha Jacques Belghiti Patrick Pe | 2014 | HPB2014，，4： | 2 |
| 6 | A comparative study of Fas and Fas-ligand expression during melanoma progression显示文摘 | Soubrane C Mouawad R Antoine EC | | 0，，： | 2 |
| 7 | Choroidal neovascularization in pathologic myopia :recent developments in diagnosis and treatment 显示文摘 | Soubrane G | 2008 | Suw Oph- thalmol2008，53，2： | 1 |
| 8 | Graft saving management of hepatic artery thrombosis in pediatric liver transplantation显示文摘 | Massault PP Soubrane O Cardoso J | 1997 | Transplant Proc1997，29，12： | 1 |
| 9 | Influence of pregrancy on the evolution of diabetic retinopathy 显示文摘 | Soubrane G Coscas G | 1998 | Int ophthalmol Clin1998，38，： | 1 |
| 10 | Risk and prognostic factors of gut perforation after orthotopic liver transplantation for biliary atresia显示文摘 | Soubrane O Meteini M Devictor D | 1995 | Liver Transpl Surg1995，1，1： | 1 |
| 11 | Subretinal neovessels in degenerative myopia:results of photocoagulation显示文摘 | Soubrane G Pison J Bornert P | 1986 | Bull Soe Ophtalmol Fr1986，86，3： | 1 |
| 12 | Long-term visual outcome of choroidal neovascularization in pathologic myopia:natural history and laser treatment显示文摘 | Secretan M Kuhn D Soubrane G | 1997 | Eur J Ophthalmol1997，7，4： | 1 |
| 13 | Laparoscopic living donor hepatectomy for liver transplantation in children显示文摘 | Cherqui D Soubrane O Husson E | 2002 | Lancet2002，359，9304： | 1 |
| 14 | Laparoscopic living donor hepatectomy for liver transplantation in children 显示文摘 | Cherqui D Soubrane O Husson E | 2002 | Lancet2002，359，9304： | 1 |
| 15 | Basic fibroblast growth factor experimentally induced choroidal angiogenesis in the minipig显示文摘 | Soubrane G Cohen SY Delayre T | 1994 | Curr Eye Res1994，13，3： | 1 |
| 16 | Predicting high grade lesions of sinusoidal obstruction syndrome related to oxaliplatin - based chemotherapy for colorectal liver metastases correlation with post - hepatectomy outcome显示文摘 | Soubrane O Brouquet A Zalinski S | 2010 | Ann Surg2010，251，3： | 1 |
| 17 | Age-related macular degeneration and apoptosis显示文摘 | Haddad WM Coscas G Soubrane G | 2003 | J Fr Ophtalmol2003，26，3： | 1 |
| 18 | Laparoscopic living donor left lateral sectionectomy: a new standard practice for donor hepatectomy显示文摘 | Soubrane O de Rougemont O Kim KH | 2015 | Ann Surg2015，262，5： | 1 |
| 19 | Eligibility for treatment and angiographic features at the early stage of exudative age related macular degeneration显示文摘 | Haddad WM Coscas G Soubrane G | 2002 | Br J Ophthalmol2002，86，： | 1 |
| 20 | Laparoscopic living donor hepatectomy for liver transplantation in children显示文摘 | Cherqui D Soubrane O Husson E | 2002 | Lancet2002，359，9304： | 1 |
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