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| 1 | Protein tyrosine phosphatase non-receptor type 2 andinflammatory bowel disease显示文摘Genome wide association studies have associated single nucleotide polymorphisms within the gene locus encoding protein tyrosine phosphatase non-receptor type 2(PTPN2) with the onset of inflammatory bowel disease(IBD) and other inflammatory disorders. Expression of PTPN2 is enhanced in actively inflamed intestinal tissue featuring a marked up-regulation in intestinal epithelial cells. PTPN2 deficient mice suffer from severe intestinal and systemic inflammation and display aberrant innate and adaptive immune responses. In particular, PTPN2 is involved in the regulation of inflammatory signalling cascades, and critical for protecting intestinal epithelial barrier function, regulating innate and adaptive immune responses, and finally for maintaining intestinal homeostasis. On one hand, dysfunction of PTPN2 has drastic effects on innate host defence mechanisms, including increased secretion of pro-inflammatory cytokines, limited autophagosome formation in response to invading pathogens, and disruption of the intestinal epithelial barrier. On the other hand, PTPN2 function is crucial for controlling adaptive immune functions, by regulating T cell proliferation and differentiation as well as maintaining T cell tolerance. In this way, dysfunction of PTPN2 contributes to the manifestation of IBD. The aim of this review is to present an overview of recent findings on the role of PTPN2 in intestinal homeostasis and the impact of dysfunctional PTPN2 on intestinal inflammation. | Marianne R Spalinger Declan F McCole Gerhard Rogler Michael Scharl | 2016 | World Journal of Gastroenterology2016，22，3： | 4 |
| 2 | Analysis of the functional response in foraging in the Sitka black-tailed deer 显示文摘 | Spalinger D Hanley T Robbins C | 1988 | Ecology1988，69，4： | 1 |
| 3 | Assessing remedial effectiveness through the blood lead: soil/dust lead relationship at the Bunker Hill Superfund Site in the Silver Valley of Idaho 显示文摘 | Von Lindern I Spalinger S Petroysan V | 2003 | Sci Total Environ2003，303，： | 1 |
| 4 | Assessing remedial effectiveness through the blood lead: soil/dust lead relationship at the Bunker Hill Superfund Site in the Silver Valley of Idaho 显示文摘 | Von Lindern I Spalinger S Petroysan V | 2003 | Sci Total Environ2003，303，： | 1 |
| 5 | A Modified Method for Determining Tannin Protein Precipitation Capacity Using Accelerated Solvent Extraction (ASE) and Microplate Gel Filtration显示文摘 | Scott H McArt Donald E Spalinger John M Kennish | 2006 | J Chem Ecol2006，32，6： | 1 |
| 6 | Mechanisms of foraging in mammalian herbivores:new models of functional responses 显示文摘 | Spalinger D E Hoobs N T | 1992 | Animal Naturalist( S0003- 0031 )1992，140，： | 1 |
| 7 | Seasonal variations of lead concentration and loading rates in residential house dust in northern Idaho显示文摘 | Varduhi Petrosyan Margrit C. von Braun Susan M. Spalinger Ian H. von Lindern | 2005 | Journal of Hazardous Materials2005，，1： | 1 |
| 8 | The influence of soil remediation on lead in house dust 显示文摘 | von Lindem IH Spalinger SM Bero BN | 2003 | Sci Total Environ2003，303，12： | 1 |
| 9 | Assessing remedial effectiveness through the blood lead:soil/dust lead relationship at the Bunker Hill Superfund Site in the Silver Valley of Idaho显示文摘 | Ian von Lindern Susan Spalinger Varduhi Petroysan Margrit von Braun | 2002 | Science of the Total Environment2002，，1： | 1 |
| 10 | Seasonal variations of lead concentration and loading rates in residential house dust in northern Idaho 显示文摘 | Petrosyan V Braun M C V Spalinger S M | 2006 | Journal of Hazardous Materials2006，132，1： | 1 |
| 11 | Seasonal variations of lead concentration and loading rates in residential house dust in northern Idaho显示文摘 | Varduhi Petrosyan Margrit C yon Braun Susan M Spalinger | 2006 | Journal of Hazardous Materials2006，132，： | 1 |
| 12 | Assessing remedial effectiveness through the blood lead: soil/dust lead relationship at the Bunker Hill Superfund Site in the Silver Valley of Idaho 显示文摘 | von Lindern I Spalinger S Petroysan V | 2003 | Sci Total Environ2003，303，1： | 1 |
| 13 | Mechanisms of foraging in mammalian herbivores:new models of functional responses显示文摘 | Spalinger D E Hoobs N T | 1992 | Animal Naturalist1992，140，22： | 1 |
| 14 | Summer dietary nitrogen availability as a potential bottom-up constraint on moose in south-central Alaska显示文摘 | McArt S H Spalinger D E Collins W B | | 0，，05： | 1 |
| 15 | Seasonal variations of lead concentration and loading rates in residential house dust in northern Idaho显示文摘 | PETROSYAN V VONBRAUN M C SPALINGER S M | 2006 | Journal of Hazardous Materials2006，132，1： | 1 |
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