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| 1 | Cytoplasmic expression of p27^(kip1) is associated with a favourable prognosis in colorectal cancer patients显示文摘AIM: To evaluate the prognostic significance of p27kip1 in colorectal cancer patients. METHODS: Cytoplasmic and nuclear p27kip1 expression was evaluated in 418 colorectal cancers using tissue microarrays. Data were associated with known patient and tumor variables and long-term patient outcomes, providing further insight into the mechanisms by which p27kip1 may influence tumor development. RESULTS: Nuclear and cytoplasmic p27Kip1 expressions were detected in 59% and 19% of tumors respectively. Cytoplasmic p27Kip1 was almost invariably associated with positive nuclear p27Kip1 expression. Neither case correlat- ed with known clinical or pathological variables, includ- ing tumor stage, grade or extramural vascular invasion. Furthermore, nuclear p27kip1 expression had no impact on survival. However, we identified a significant correla- tion between expression of cytoplasmic p27kip1 and longer disease-specific survival times. On multivariate analysis, TNM stage and extramural vascular invasion were highly significant independent prognostic factors, with positive cytoplasmic p27 expression showing a trend towards im- proved patient survival (P = 0.059).CONCLUSION: These findings support the recent evi- dence that cytoplasmic p27kip1 has a distinct and impor- tant biological role that can influence tumor outcome. | Nicholas FS Watson Lindy G Durrant John H Scholefield Zahra Madjd Duncan Scrimgeour Ian Spendlove Ian O Ellis Poulam M Patel | 2006 | World Journal of Gastroenterology2006，12，39： | 3 |
| 2 | Randomized, Placebo-Controlled Trial of Pioglitazone in Nondiabetic Subjects With Nonalcoholic Steatohepatitis显示文摘 | Guruprasad P. Aithal James A. Thomas Philip V. Kaye Adam Lawson Stephen D. Ryder Ian Spendlove Andrew S. Austin Jan G. Freeman Linda Morgan Jonathan Webber | 2008 | Gastroenterology2008，，4： | 2 |
| 3 | Expression of thestress-related MHC class I chain-related protein MICA is anindicator of good prognosis in colorectal cancer patients显示文摘 | Watson NF Spendlove I Madjd Z | 2006 | Int JCancer2006，118，14： | 1 |
| 4 | Expression of the stressrelated MHC class Ⅰ chain-related protein MICA is an indicator of good prognosis in colorectal cancer patients显示文摘 | Watson N Spendlove I Madjd Z | 2006 | Int J Cancer2006，118，： | 1 |
| 5 | The role of CD55 in protecting the tumour environment from complement attack显示文摘 | Morgan J Spendlove I Durrant L G | 2002 | Tissue Antigens2002，60，3： | 1 |
| 6 | CD55 is overexpressed in the tumour environment 显示文摘 | Li L Spendlove I Morgan J | 2001 | Br J Cancer2001，84，1： | 1 |
| 7 | Postmortem whole-body CT angiography: evaluation of two con- trast media solutions显示文摘 | Ross S Spendlove D Bolliger S | 2008 | AJR Am J Roentgenol2008，190，5： | 1 |
| 8 | Randomized, Placebo-Controlled Trial of Pioglitazone in Nondiabetic Subjects With Nonalcoholic Steatohepatitis显示文摘 | Guruprasad P. Aithal James A. Thomas Philip V. Kaye Adam Lawson Stephen D. Ryder Ian Spendlove Andrew S. Austin Jan G. Freeman Linda Morgan Jonathan Webber | 2008 | Gastroenterology2008，，4： | 1 |
| 9 | Expression of the stress-related MHC class Ⅰ chain-related protein MICA is an indicator of good prognosis in colorectal cancer patients 显示文摘 | WATSON N F SPENDLOVE I MADJD Z | 2006 | Int J Cancer2006，118，6： | 1 |
| 10 | ZNF652, a novel zinc finger protein, interacts with the putative breast tumor suppressor CBFA2T3 to repress transcription显示文摘 | Kumar R Manning J Spendlove HE | 2006 | Mol Cancer Res2006，4，： | 1 |
| 11 | The p53 positive Bcl-2 negative phenotype is an independent marker of prognosis in breast cancer显示文摘 | Rolland P Spendlove I Madjd Z | 2007 | Int J Caneer2007，120，6： | 1 |
| 12 | CD55 is over-expressed in the turnout environment显示文摘 | Li L Spendlove I Morgan J | 2001 | Br J Cancer2001，84，1： | 1 |
| 13 | The use of reverse immunology to identify HLA-A2 binding epitopes in Tie-2 显示文摘 | Ramage JM Spendlove I Rees R | 2006 | Cancer Immunol Immunother2006，55，8： | 1 |
| 14 | The role of CD97in regulating adap-tive T-cell responses显示文摘 | Spendlove I Sutavani R | 2010 | Adv Exp Med Biol2010，706，： | 1 |
| 15 | Production of high-titer bovine Rotavirus with trypsin 显示文摘 | Clark S M Barnett B B Spendlove R S | 1979 | Clin Microboil1979，9，3： | 1 |
| 16 | Effect of enzymes on Ro- tavirus infectivity 显示文摘 | Bamett B B Spendlove R S Clark M L | 1979 | J Clin Microboil1979，10，1： | 1 |
| 17 | Production of bacterial aerosols in an animal render- ing plant process 显示文摘 | Spendlove JC | 1957 | Public Health Rep1957，72，2： | 1 |
| 18 | Expression of the stress- related MHC class 1 chain-related protein MICA is an indcator of good prognosis in colorectal cancer patients 显示文摘 | Watson NF Spendlove I Madjd Z | 2006 | Int J Cancer2006，118，6： | 1 |
| 19 | Expression of the stress-related MHC class I chain--related protein MICA is an indi- cator of good prognosis in colorectal cancer patients显示文摘 | Watson NF Spendlove I Madjd Z | 2006 | IntJ Can- cer2006，118，6： | 1 |
| 20 | Expression of the stress-related MHC class I chaln-related protein MICA is an indicator of good prognosis in colorectal cancer patients 显示文摘 | Watson NF Spendlove I Madjd Z McGilvray R Green AR Ellis IO | 2006 | Int J Cancer2006，118，6： | 1 |
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