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| 1 | Axial strain enhances osteotomy repair with a concomitant increase in connexin43 expression显示文摘The mechanical environment is known to influence fracture healing. We speculated that connexin43(Cx43) gap junctions, which impact skeletal homeostasis, fracture healing and the osteogenic response to mechanical load,may play a role in mediating the response of the healing bone to mechanical strain. Here, we used an established rat fracture model, which uses a 2 mm osteotomy gap stabilized by an external fixator, to examine the impact of various cyclical axial loading protocols(2%, 10%, and 30% strain) on osteotomy healing. We examined the presence of Cx43 in the osteotomy-healing environment and assessed how mechanical strain modulates Cx43 expression patterns in the callus. We demonstrated that increased cyclical axial strain results in increased radiographic and histologic bone formation. In addition, we show by immunohistochemistry that Cx43 is abundantly expressed in the healing callus, with the expression most robust in samples exposed to increased cyclical axial strain. These data are consistent with the concept that an increase in Cx43 expression by mechanical load may be part of the mechanisms by which mechanical forces enhances fracture healing. | Rishi R Gupta Hyunchul Kim Yu-Kwan Chan Carla Hebert Leah Gitajn David J Yoo Robert V O’Toole Adam H Hsieh Joseph P Stains | 2015 | Bone Research2015，3，2： | 2 |
| 2 | Calculation of AC loss in an HTS wind turbine generator显示文摘 | FEE M STAINES M P BUCKLEY R G | 2003 | IEEE Trans on Applied Superconductivity2003，13，2： | 1 |
| 3 | Cell-to-cell interactions in bone 显示文摘 | Stains J P Civitelli R | 2005 | Bioehem Biophys Res Commun2005，328，： | 1 |
| 4 | New antimalarial targets: the example of glucose transport显示文摘 | Patel A P Staines H M Krishna S | 2008 | Travel Med Infect Dis2008，6，12： | 1 |
| 5 | Phosphyodiesterase-5 inhibition synergizes rho-kinase antagonism and enhance erectile response in male hypertensive rats显示文摘 | Wilkes N White S Stain P | 2004 | Int J Impot Res2004，16，2： | 1 |
| 6 | Characterization of a pollen-expressed gene encoding a putative pectin esterase of Petunia inflata显示文摘 | Mu J H Stains J P Kao T | 1994 | Plant Mol Siol1994，，3： | 1 |
| 7 | Beta-catenin and BM P-synergize to promote osteoblast differentiation and new hone formation 显示文摘 | MbMadele G Sheikh S Stains J P | 2005 | J Cell Biol Chem2005，94，2： | 1 |
| 8 | Analgesic response and plasma and brain extracellular fluid pharmacokinetics of morphine and morphine-6-β-D-glucuronide in the rat 显示文摘 | Stain F Barjavel MJ Sandouk P | 1995 | J Pharmacol Exp Ther1995，274，2： | 1 |
| 9 | Seasonality of birth of patients with childhooxd diabetes in Britain 显示文摘 | Staines A Smail P | 1998 | BMJ1998，312，： | 1 |
| 10 | Early replication in pulmonary B cells after infection with Marek’s disease herpesvirus by the respiratory route 显示文摘 | Baaten B J Staines K A Smith L P | 2009 | Viral Immunol2009，22，6： | 1 |
| 11 | Characterization of a pollenexpressed gene encoding a putative pectin esterase of petunia inflate显示文摘 | MU J H STAINS J P KAO T | | Plant Mol Biol0，25，3： | 1 |
| 12 | The devel- opment of a Robel cable based on 1 MVA HTS transformer 显示文摘 | STAINES M P GLASSON N D PANNU M | 2012 | Superconductor Science and Technololgy2012，25，01： | 1 |
| 13 | Ensembl Genomes: an integrative resource for genome-scale data from non- vertebrate species显示文摘 | Kersey P J Staines D M Lawson D | 2012 | Nucleic Acids Research2012，40，1： | 1 |
| 14 | Conflicts among work, leisure, and family roles显示文摘 | Staines G & OConnor P | 1980 | Monthly Labor Review1980，103，： | 1 |
| 15 | Beta-catenin and BMP2 synergize to promote osteoblast differentiation and new bone formation显示文摘 | Mbalaviele G Sheikh S Stains J P | 2005 | J Cell Biochem2005，94，2： | 1 |
| 16 | Heterogeneous nuclear ribonucleoprotein K represses transcription from a cytosine/thymidine-rich element in the osteocalcin promoter 显示文摘 | Stains J P Lecanda F Towler D A Civitelli R | 2005 | Biochem J2005，385，2： | 1 |
| 17 | Use of locus-specific AFLP markers to construct a high- density molecular map in barley 显示文摘 | Qi X Stain P Lindhout P | 1998 | Theor Appl Genet1998，96，： | 1 |
| 18 | Urban-rural variation in mortality and hospital admission rates for unintentional injury in Ireland显示文摘 | Boland M Staines A Fitzpatrick P | 2005 | Inj Prey2005，11，1： | 1 |
| 19 | Unintentional injury in Ireland: a comparison of mortality and morbidity data 显示文摘 | Scallan E Staines A Fitzpatrick P | 2004 | J Public Health2004，26，1： | 1 |
| 20 | Timing the radiations of leaf beetles:Hispines on gingers from latest Cretaceous to recent显示文摘 | Wilf P Labandeira CC Kress WJ Staines CL Windsor DM Allen AL Johnson KR | | 0，，： | 1 |
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