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| 1 | Risk factors and outcome of bacterial infections in cirrhosis显示文摘Viable and non-viable pathological bacterial translocation promote a self-perpetuating circle of dysfunctional immune activation and systemic inflammation facilitating infections and organ failure in advanced cirrhosis.Bacterial infections and sepsis are now recognized as a distinct stage in the natural progression of chronic liver disease as they accelerate organ failure and contribute to the high mortality observed in decompensated cirrhosis.The increasing knowledge of structural,immunological and hemodynamic pathophysiology in advanced cirrhosis has not yet translated into significantly improved outcomes of bacterial infections over the last decades.Therefore,early identification of patients at the highest risk for developing infections and infectionrelated complications is required to tailor the currently available measures of surveillance,prophylaxis and therapy to the patients in need in order to improve the detrimental outcome of bacterial infections in cirrhosis. | Tony Bruns Henning W Zimmermann Andreas Stallmach | 2014 | World Journal of Gastroenterology2014，20，10： | 24 |
| 2 | Dual-sugar tests of small intestinal permeability are poor predictors of bacterial infections and mortality in cirrhosis: a prospective study显示文摘AIM: To prospectively analyze the impact of increased intestinal permeability(IP) on mortality and the occurrence of infections in patients with cirrhosis.METHODS: IP was quantified using the lactulose/mannitol(L/M) test in 46 hospitalized patients with cirrhosis(25 Child-Pugh A/B, 21 Child-Pugh C) and in 16 healthy controls. Markers of inflammation [LPSbinding protein, Interleukin-6(IL-6)] and enterocyte death [intestinal fatty-acid binding protein(I-FABP)] were determined in serum using enzyme-linked immunosorbent assays. Patients were followed for one year and assessed for survival, liver transplantation, the necessity of hospitalization and the occurrence of bacterial infections. The primary endpoint of the study was defined as differences in survival between patients with pathological and without pathological lactulose/mannitol test.RESULTS: Thirty-nine(85%) patients with cirrhosis had a pathologically increased IP index(L/M ratio > 0.07) compared to 4(25%) healthy controls(P < 0.0001). The IP index correlated with the ChildPugh score(r = 0.484, P = 0.001) and with serum IL-6(r = 0.342, P = 0.02). Within one year, nineteen(41%) patients developed a total of 33 episodes of hospitalization with bacterial or fungal infections. Although patients who developed spontaneous bacterial peritonitis(SBP)(n = 7) had a higher IP index than patients who did not(0.27 vs 0.14, P = 0.018), the baseline IP index did not predict time to infection, infection-free survival or overall survival, neither when assessed as linear variable, as tertiles, nor dichotomized using an established cut-off. In contrast, model for end-stage liver disease score, Child-Pugh score, the presence of ascites, serum IL-6 and I-FABP were univariate predictors of infection-free survival.CONCLUSION: Although increased IP is a frequent phenomenon in advanced cirrhosis and may predispose to SBP, it failed to predict infection-free and overall survival in this prospective cohort study. | Anika Vogt Philipp A Reuken Sven Stengel Andreas Stallmach Tony Bruns | 2016 | World Journal of Gastroenterology2016，22，11： | 8 |
| 3 | Parameters of a severe disease course in ulcerative colitis显示文摘AIM:To detect high risk patients with a progressive disease course of ulcerative colitis(UC) requiring immunosuppressive therapy(IT).METHODS:A retrospective,multicenter analysis of 262 UC patients from eight German tertiary inflammatory bowel disease centres was performed.Patients were divided into two groups depending on the patients need to initiate immunosuppressive therapy in the disease course.A comparison between the two groups was made with regard to demographics,clinical and laboratory parameters obtained within three months after UC diagnosis and the response to first medical therapy.Using this data,a prognostic model was established to predict the individual patients probability of requiring an immunosuppressive therapy.RESULTS:In 104(39.7%) out of 262 patients,UC therapy required an immunosuppressive treatment.Patients in this group were significantly younger at time of diagnosis(HR = 0.981 ± 0.014 per year,P = 0.009),and required significantly more often a hospitalisation(HR = 2.5 ± 1.0,P < 0.001) and a systemic corticosteroid therapy at disease onset(HR = 2.4 ± 0.8,P < 0.001),respectively.Response to steroid treatment was significantly different between the two groups of patients(HR = 5.2 ± 3.9 to 50.8 ± 35.6 compared to no steroids,P = 0.016 to P < 0.001).Furthermore,in the IT group an extended disease(HR = 3.5 ± 2.4 to 6.1 ± 4.0 compared to proctitis,P = 0.007 to P = 0.001),anemia(HR = 2.2 ± 0.8,P < 0.001),thrombocytosis(HR = 1.9 ± 1.8,P = 0.009),elevated C-reactive protein(CRP)(HR = 2.1 ± 0.9,P < 0.001),and extraintestinal manifestations in the course of disease(HR = 2.6 ± 1.1,P = 0.004) were observed.Six simple clinical items were used to establish a prognostic model to predict the individual risk requiring an IT.This probability ranges from less than 2% up to 100% after 5 years.Using this,the necessity of an immunosuppressive therapy can be predicted in 60% of patients.Our model can determine the need for an immunosuppressive drug therapy or if a 'watch and wait' approach is reasonable already early in the treatment course of UC.CONCLUSION:Using six simple clinical parameters,we can estimate the patients individual risk of developing a progressive disease course. | Andreas Stallmach Luisa Nickel Thomas Lehmann Bernd Bokemeyer Martin Bürger Dietrich Hüppe Wolfgang Kruis Susanna Nikolaus Jan C Preiss Andreas Sturm Niels Teich Carsten Schmidt | 2014 | World Journal of Gastroenterology2014，20，35： | 2 |
| 4 | Aber-rant positioning of trophoblast and lymphocytes in the feto-maternal interface with pre-eclampsia显示文摘 | STALLMACH T HEBISCH G ORBAN P | 1999 | Virchows Arch1999，434，3： | 1 |
| 5 | Cytokine/chemokine transcript profiles reflect mucosal inflammation in Crohn's disease显示文摘 | Giese T Schmidt C | 2004 | Int J Colorectal Dis2004，19，4： | 1 |
| 6 | Malignant trans-formation in inflammatory bowel disease-surveillanceguide显示文摘 | Stallmach A Bielecki C Schmidt C | 2009 | Dig Dis2009，27，4： | 1 |
| 7 | Constitutively overexpressed erythropoietin reduces infarct size in a mouse model of permanent coronary artery ligation显示文摘 | Camici G G Stallmach T Hermann M | 2007 | Methods Enzymol2007，435，： | 1 |
| 8 | Abortion in mice with excessive erythrocytosis is due to impaired arteriogenesis of the U- terine Arcade显示文摘 | Gassmann M Manini A Stallmach T | 2008 | Biol Reprod2008，78，6： | 1 |
| 9 | Cystic nephroma: a rare benign renal tumor显示文摘 | P. Sacher U. V. Willi F. Niggli T. Stallmach | 1998 | Pediatric Surgery International (-)1998，，2： | 1 |
| 10 | Carboxylates and sulfates of polysaccharides for controlled internal water release during cement hydration显示文摘 | Karen Friedemann Frank Stallmach Jorg Karger | 2009 | Cement Concrete Compos2009，31，4： | 1 |
| 11 | Drug delivery strategies for targeted treatment of inflammatory bowel disease显示文摘 | C. Lautenschl?ger C. Schmidt K. Lange A. Stallmach | 2015 | Z Gastroenterol2015，，： | 1 |
| 12 | Abortion in mice with excessive erythrocytosis is due to impaired arteriogenesis of the Uterine Arcade显示文摘 | Gassmann M Manini A Stallmach T | 2008 | Biol Reprod2008，78，6： | 1 |
| 13 | Low toxic neoadjuvant cisplatin, 5-fluorouracil and folinic acid in locally advanced gastric cancer yields high R-0 resection rate显示文摘 | Markus Menges Carsten Schmidt Werner Lindemann Karsten Ridwelski Werner Pueschel Bernhard Jüngling Gernot Feifel Martin Schilling Andreas Stallmach Martin Zeitz | 2003 | Journal of Cancer Research and Clinical Oncology2003，，7： | 1 |
| 14 | A boy with congenital analbu-minemia and steroid-sensitive idiopathic nephrotic syndrome: an experiment of nature 显示文摘 | Neuhaus TJ Stallmach T Genewein A | 2008 | Eur Pediatr2008，167，9： | 1 |
| 15 | Acute appendicitis in neonates:complication or morbus sui generic?显示文摘 | Stallmach T Sacher P | 1998 | Pediatr Surg Int1998，14，12： | 1 |
| 16 | Image cytometric DNA analysis of adrenocortical neoplasms as a prognostic parameter:a clinico-pathologic study of 13 patients显示文摘 | LU X STALLMACH T GEBBERS JO | 1996 | Anal Cell Pathol1996，12，1： | 1 |
| 17 | Altered glycosylation of inte- grin adhesion molecules in colorectal cancer cells and decreased adhe- sion to the extracellular matrix 显示文摘 | von Lampe B Stallmach A Riecken EO | 1993 | Gut1993，34，6： | 1 |
| 18 | Contrast-enhanced endoscopic ultrasound in discrimination between benign and malignant mediastinal and abdominal lymph nodes显示文摘 | Michael Hocke Markus Menges Theodor Topalidis Christoph F. Dietrich Andreas Stallmach | 2008 | Journal of Cancer Research and Clinical Oncology2008，，4： | 1 |
| 19 | Ueo pouch-anal anastomosis显示文摘 | STALLMACH A SCHMIDT C | 2007 | Internist (Berl)2007，48，6： | 1 |
| 20 | Role of infections in the manifestation on reactivation of inflammatory bowel disease显示文摘 | Stallmach A Carstan S | 2002 | Inflammatory bowel disease2002，8，3： | 1 |
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