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| 1 | Dual color optogenetic control of neural populations using low-noise,multishank optoelectrodes显示文摘Optogenetics allows for optical manipulation of neuronal activity and has been increasingly combined with intracellular and extracellular electrophysiological recordings.Genetically-identified classes of neurons are optically manipulated,though the versatility of optogenetics would be increased if independent control of distinct neural populations could be achieved on a sufficient spatial and temporal resolution.We report a scalable multisite optoelectrode design that allows simultaneous optogenetic control of two spatially intermingled neuronal populations in vivo.We describe the design,fabrication,and assembly of low-noise,multisite/multicolor optoelectrodes.Each shank of the four-shank assembly is monolithically integrated with 8 recording sites and a dualcolor waveguide mixer with a 7×30μm cross-section,coupled to 405 nm and 635 nm injection laser diodes(ILDs)via gradient-index(GRIN)lenses to meet optical and thermal design requirements.To better understand noise on the recording channels generated during diode-based activation,we developed a lumped-circuit modeling approach for EMI coupling mechanisms and used it to limit artifacts to amplitudes under 100μV upto an optical output power of 450μW.We implanted the packaged devices into the CA1 pyramidal layer of awake mice,expressing Channelrhodopsin-2 in pyramidal cells and ChrimsonR in paravalbumin-expressing interneurons,and achieved optical excitation of each cell type using sub-mW illumination.We highlight the potential use of this technology for functional dissection of neural circuits. | Komal Kampasi Daniel F.English John Seymour Eran Stark Sam McKenzie Mihály Vöröslakos György Buzsáki Kensall D.Wise Euisik Yoon | 2018 | Microsystems & Nanoengineering2018，4，1： | 8 |
| 2 | In situ product removel (ISPR) in whole cell biotechnology during the last twenty years 显示文摘 | Stark D Stockar U V | 2003 | Advances in Biochemical Engineering/Biotechnology2003，80，： | 1 |
| 3 | Histologic findings in axillary hydradeno- suction显示文摘 | Penna V Iblher N Stark BG | 2007 | Aesthetic Plast Surg2007，31，1： | 1 |
| 4 | The influence of Mn dispersoid content and stress state on ductile fracture of 2124 type Al alloys 显示文摘 | Walsh J A Jata K V Starke Jr E A | 1989 | Acta Metal1989，37，11： | 1 |
| 5 | On the nucleation and growth of AhCuMg (S1 in AI-Li-Cu-Mg and AI-Cu-Mg alloys显示文摘 | RADMILOVIC V THOMAS G SHIFLET G J STARKE E A | 1989 | Scripta Metall1989，23，7： | 1 |
| 6 | Early recogition ofneonatal hyperbiliru-binemia and its emergent management显示文摘 | Smitherman H Stark A R Bhutani V K | 2006 | Semin Fetal Neonatal Med2006，11，3： | 1 |
| 7 | Nanophase Cobalt oxyhydroxide mineral syn- thesized within the protein cage of ferritin显示文摘 | Douglas T Stark V T | 2000 | Inorganic Chemistry2000，39，8： | 1 |
| 8 | Case-based learning with worked examples in complex domains:Two experimental studies in under-graduate medical education 显示文摘 | Stark R Kopp V Fischer M | 2011 | Learning and Instruction2011，21，1： | 1 |
| 9 | Management of jaundice and prevention of severe neonatal hyperbilirubinemia in infants 35 weeks gestation显示文摘 | Bhutani V K Maisels M J Stark A R | 2008 | Neonatology2008，94，1： | 1 |
| 10 | Numerical lifting surface theoryproblems and progress显示文摘 | Landhal M T Stark V J E | 1977 | AIAA1977，6，11： | 1 |
| 11 | Monte- Carlo-type techniques for processing interval uncertainty, and their potential engineering applications显示文摘 | Kreinovich V Beck J Ferregut C Sanchez A Keller G R Avenll M Starks S A | 2007 | Reliable Computing2007，13，1： | 1 |
| 12 | Of tournament and temptation:an analysi of management incentive in the mutual fund industry 显示文摘 | Brown K C Harlow W V Laura T Starks | 1996 | The Journal of Finance1996，，51： | 1 |
| 13 | Adhesion of activated eosinophils to respiratory epithelial cells is enhanced by tumor necrosis factor-α and interleukin-1 /3显示文摘 | GODDING V STARK J M SEDGWICK J B | 1995 | Am J Respir Cell Mol Biol1995，13，5： | 1 |
| 14 | How closedloop PLM improves knowledge management over the complete product lifecycle and enables the factory of the future 显示文摘 | Kiritsis D Nguyen V K Stark J | 2008 | International Journal of Product Lifecycle Management2008，3，1： | 1 |
| 15 | Nanophase cobalt oxyhydroxide mineral synthesized within the protein cage of ferritin显示文摘 | DOUGLAS T STARK V T | 2000 | Inorganic Chemistry2000，39，8： | 1 |
| 16 | How closed-loop PLM improves knowledge management over the complete product life-cycle and enables the factory of the future 显示文摘 | KIRITSIS D NGUYEN V K STARK J | 2008 | International Journal of Product Lifecycle Management2008，3，1： | 1 |
| 17 | Aspirin-induced nuclear translocation of NFkB and apoptosis in colorectal cancer is independent of p53 status and DNA mismatch repair proficiency显示文摘 | Din F V Stark L A Dunlop M G | 2005 | Brit J Cancer2005，92，： | 1 |
| 18 | (ianuna-glutamyl transferast* : anovel cnrdiovasi-ular risk bionnnker显示文摘 | Mason JK Starke RD V an Kirk JK | 2010 | Prev (Cardiol2010，13，1： | 1 |
| 19 | A review of the safety and tolerance of propofol(‘Diprivan’)显示文摘 | Stark R D Binks S M Dutka V N | 1985 | Postgraduate Medical Journal1985，，3： | 1 |
| 20 | Nanoscalc metal oxide particles, Clllsters as chemical reagents: uni(tHe surface chemistry on magnesium oxide as shown by enhanced adsorption of acid gases显示文摘 | STARK J V KLABUNDE K J | 1996 | Chem Mater1996，8，8： | 1 |
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