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20篇 您的检索式：作者名="Staruch"

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	题名	作者	年代	出处	被引量
1	FK506, a potent novel immuno suppressive agent, binds to a cytosolic protein which is distinct from the cyclosporin A binding protein cyclophilin 显示文摘	Siekierka J Staruch MJ Hung SHY	1989	J Immunol1989，143，：	1
2	FK506, a potent novel immunosuppressive agent, binds to a cytosolic protein which is distinct from the cyclosporin a-binding protein, cyclophilin 显示文摘	Siekierka JJ Staruch MJO Hung SHY	1989	J Immunol1989，143，5：	1
3	Synthesis and char- acterization of iron-substituted hydroxyapatite via a simple ion- exchange procedure显示文摘	Kramer E R Morey A M Staruch M	2013	J Mater Sci2013，48，2：	1
4	FK-506,a potent novelimmunosuppressive agent, binds to a cytosolic protein which is dis-tinct from the cyclosporin A-binding protein,cyclophilin 显示文摘	Siekierka JJ Staruch MJ Hung S H	1989	J Im-munol1989，143，5：	1
5	Inhibition of T cell activation by pharmacologic disruption of the MEK1/ERK MAP Kinase of calcineurin signaling pathways results in differential modulation of cytokin eproduction显示文摘	Dumont FJ Staruch MJ Fischer P	1998	Journal Immunol1998，160，6：	1
6	FK-506, a potent novel immunosuppressive agent, binds to a cytosolic protein which is distinct from the cyclosporin A-binding protein cyclophihn 显示文摘	Siekierka JJ Staruch M J Hung SH	1989	J Immunol-1989，143，5：	1
7	Distinct mechanisms of suppression of murine T cell activation by the related macrolides FK-506 and rapamycin显示文摘	Dumont FJ Staruch MJ Koprak SL	1990	J Immunol1990，144，1：	1
8	FK506,a potent novel immunosuppressive agent,binds to a cytosolic protein which is distinct from the cyclosporin A-binding protein,cyclophilin 显示文摘	Siekierka J J Staruch M J Hung S H Y	1989	J Immunol1989，143，5：	1
9	The immunosuppressive macrolides FK-506 and rapamycin act as reciprocal antagonists in murine T cells显示文摘	DUMDUMONT F J MELINO M R STARUCH M J	1990	J lmmunol1990，144，4：	1
10	The immunosuppressive and toxic effects of FK-506 are mechanistically related: pharmacology of a novel antagonist of FK-506 and rapamycin显示文摘	Staruch MJ Kopark SL	1992	J Exp Med1992，176，3：	1
11	The adjuvanticity of interleukin 1 in vivo显示文摘	Staruch MJ Wood DD	1983	Int J Immunol1983，130，：	1
12	Inhibition of T cell activation by pharmacologic disruption of the MEK1/ERKMAP kinase or ealciueurin signaling pathways results in differential modulation of eytokine production 显示文摘	Dumont FJ Staruch M J Fischer P	1998	J Immunol1998，160，6：	1
13	Localised drug release using MRI-controlled focused ultrasound hyperthermia 显示文摘	Staruch R Chopra R Hynynen K	2010	International Journal of Hyperthermia2010，27，2：	1
14	Inhibition of T cell activation by pharmacologic disruption of the MEK1/ERK MAP kinase or caleineurin signaling pathways results in differential modulation of cytokine production显示文摘	Dumont FJ Staruch M J Fischer P		0，，06：	1
15	The immunosuppressive macrolides FK506 and rapamycin act as reciprocal antagonists in murine T cells显示文摘	Dumont FJ Staruch MJ Koprak SL	1990	J Immunol1990，144，：	1
16	The immunosuppressive and toxic effects of FK-506 are mechanistically related: pharmacology of a novel antagonist of FK-506 and rapamycin显示文摘	Dumont FJ Staruch MJ Koprak SL etal	1992	J Exp Med1992，176，3：	1
17	Non-invasive targeted peripheral nerve ablation using 3D MR neurography and MRI-guided high-intensity focused ultrasound (MR-HIFU):Pilot study in a swine model 显示文摘	Huisman M Staruch RM Ladouceur-wodzak M	2015	PLoS One2015，10，01：	1
18	FK-506, a potent novel immunosuppressive agent,binds to a cytosolic protein which is distinct from the cyclosporin A-binding protein, cyclophilin 显示文摘	Siekierka JJ Staruch M J Hung SH	1989	J Immunol1989，143，5：	1
19	Inhibition of T cell activation by pharmacologic disruption of the MEK1/ERK MAP klnase or calcineurin signaling pathways results in differential modulation of cytokine production显示文摘	DUMONT F J STARUCH M J FISCHER P	1998	J Immunol1998，160，6：	1
20	核磁共振成像控制的聚焦超声产生的骨骼高温:控制战略与给药技术显示文摘目的通过使用核磁共振(MR)成像控制的聚焦超声产生的高温以及温度敏感性脂质体,对成像引导的骨骼给药技术的可行性进行评估。材料与方法本文中实验均经动物保护制度委员会批准。研究人员通过使用核磁共振测温技术进行闭路温度控制,进而使用聚焦超声在9只兔子(受测对象)大腿骨骼与肌肉界面处直径10mm的区域内获取加温效果。热敏脂质体包裹的阿霉素受到加热过程的影响而得到系统地释放。在本实验中,4只受测对象(兔子)的核磁温控图像中心点定位于距离骨骼10mm处,另5只的图形则定位于骨骼上,对于所有的受测对象,研究人员均对加温过程的均一性和药物的定位载带进行了评估,并模拟计算骨骼的温度变化。通过测量从骨髓和肌肉中提取的阿霉素荧光强度,研究人员得以量化测量给药效果,并通过单侧Wileoxon符号秩次检验(WilcoxonSigned—RankTest)将处理过的与未经处理的对象部位进行对比。结果在超声聚焦一核磁共振温控面距离骨骼0mm和10mm的情况下,平均目标区域温度分别为43.1℃和43.3℃;估测骨骼温度分别为46.8℃和78.1℃。10mm测试组的对象体内观测到热烧蚀;估测骨骼肌肉界面的肌肉温度为66.1℃。阿霉素浓度在加热与未加热的骨髓(增加8.2倍,P=0.002)和肌肉(增加16.8倍,P=0.002)中均有显著差别,意味着骨骼局部给药可能伴随着高温和热烧蚀。结论通过使用核磁共振成像控制的聚焦超声和温度敏感型药物载体,可以通过骨骼局部高温而进行成像引导的定位给药。	Robert Staruch Rajiv Chopra Kullervo Hynynen	2012	中国医疗设备2012，27，8：	0

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