|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | XPS and SEM studies of chromium oxide films chemically formed on stainless steel 316 L显示文摘 | P Stefanov D Stoychev M Stoycheva Ts Marinova | 2000 | Materials Chemistry and Physics2000，，2： | 4 |
| 2 | cytokine 的角色像受体的因素 1 在肝的星形的房间和纤维变性显示文摘 AIM:To elucidate the role of cytokine receptor-like factor 1(CRLF1) in hepatic stellate cells and liver fibrosis.METHODS:Rat hepatic stellate cells(HSCs) were isolated by Nykodenz gradient centrifugation and activated by culturing in vitro.Differentially expressed genes in quiescent and culture activated HSCs were identified using microarrays.Injections of carbon tetrachloride(CCl 4) for 4 wk were employed to induce liver fibrosis.The degree of fibrosis was assessed by Sirius red staining.Adenovirus expressing CRLF1 was injected through tail vein into mice to achieve overexpression of CRLF1 in the liver.The same adenovirus was used to overexpress CRLF1 in quiescent HSCs cultured in vitro.Expression of CRLF1,CLCF1 and ciliary neurotrophic factor receptor(CNTFR) in hepatic stellate cells and fibrotic livers was analyzed by semi-quantitative reverse transcription-polymerase chain reaction and Western blotting.Expression of profibrotic cytokines and collagens was analyzed by the same method.RESULTS:CRLF1 is a secreted cytokine with unknown function.Human mutations suggested a role in development of autonomous nervous system and a role of CRLF1 in immune response was implied by its similarity to interleukin(IL)-6.Here we show that expression of CRLF1 was undetectable in quiescent HSCs and was highly upregulated in activated HSCs.Likewise,expression of CRLF1 was very low in normal livers,but was highly upregulated in fibrotic livers,where its expression correlated with the degree of fibrosis.A cofactor of CLRF1,cardiotrophin-like cytokine factor 1(CLCF1),and the receptor which binds CRLF1/CLCF1 dimer,the CNTFR,were expressed to similar levels in quiescent and activated HSCs and in normal and fibrotic livers,indicating a constitutive expression.Overexpression of CLRF1 alone in the normal liver did not stimulate expression of profibrotic cytokines,suggesting that the factor itself is not pro-inflammatory.Ectopic expression in quiescent HSCs,however,retarded their activation into myofibroblasts and specifically decreased expression of type Ⅲ collagen.Inhibition of type Ⅲ collagen expression by CRLF1 was also seen in the whole liver.Our results suggest that CLRF1 is the only component of the CRLF1/CLCF1/CNTFR signaling system that is inducible by a profibrotic stimulus and that activation of this system by CLRF1 may regulate expression of type Ⅲ collagen in fibrosis.CONCLUSION:By regulating activation of HSCs and expression of type Ⅲ collagen,CRLF1 may have an ability to change the composition of extracellular matrix in fibrosis. | Lela Stefanovic Branko Stefanovic | 2012 | World Journal of Hepatology2012，4，12： | 3 |
| 3 | Nitric oxide mediates suppression of cartilage proteoglycan synthesis by interleukin- 1 显示文摘 | Taskirarv D Stefanovic M | 1994 | Biochem Biophy Res Comm1994，200，1： | 2 |
| 4 | Toward a biochemical understanding of human intervertebral disc degeneration and herniation显示文摘 | Kang JD Stefanovic -Racic M Melntyre LA | 1997 | Spine1997，22，： | 1 |
| 5 | No effect of fluticasone propionate on linear growth in preschool children with asthma 显示文摘 | Stefanovic IM Verona E Cicak B | 2011 | Pediatr Int2011，53，5： | 1 |
| 6 | The Influence of Nickel Ions and Triethylbenzy Lammoninm Chloride on the Electrowinning of Zinc from Sulphate Electrolytescontaining Manganes Ions显示文摘 | Stefanov Y Ivanov I | 2002 | Hydrometallurgy2002，64，3： | 1 |
| 7 | Generalized structure of a multilevel PWM inverter显示文摘 | Pradeep M Bhagwat V R Stefanovic | | 0，，06： | 1 |
| 8 | Butyrylcholines- temse activity in young men and women: association with cardiovas- cular risk factors显示文摘 | Stojanov M Stefanovic A Dzingalasevic G | 2011 | Clin Biochem2011，44，89： | 1 |
| 9 | Oxidative stress parameters as possible urine markers in patients with diabetic nephropathy 显示文摘 | Cvetkovic T Mitic B Lazarevic G Vlahovic P Antic S Stefanovic V | 2009 | J Diabetes Complications2009，23，： | 1 |
| 10 | Reversal of increased lymphocyte PC-1 activity in patients with type 2 diabetes treated with metformin显示文摘 | STEFANOVIC V ANTIC S MITIC-ZLATKOVIC M | 1999 | Diabetes Metab Res Rev1999，15，6： | 1 |
| 11 | The role of nitric oxide in proteglycan turnover by bovine articular cartilage organ cultures显示文摘 | Stefanovic RM Morales TI Taskiran D | 1996 | J Immunol1996，156，3： | 1 |
| 12 | Electron beam evaporation and welding:plasma formation and liquid pool in stabilities显示文摘 | Stefanov B Petrov P Pirgov P | 1988 | Vacuum1988，38，11： | 1 |
| 13 | Fresh and dry weight productivity of a Sorghum-Sudan grass hybrid compared with that of maize and Sudan grass显示文摘 | Stefanov D Dimitrov I Tanchev D | 1999 | Rasteniev dni-Nauki1999，36，2： | 1 |
| 14 | Evaluation and validation of two chromatographic methods (HPLC-Fluorescence and LC-MS/MS) for the determination and confirmation of ochratoxin a in pig tissues显示文摘 | MILICEVIC D JURIC V STEFANOVIC S | 2010 | Arch Environ Contam Toxicol2010，58，4： | 1 |
| 15 | Modeling of UPFC operation under unbalanced conditions with dynamic phasors显示文摘 | Stefanov P C Stankovic A M | 2002 | IEEE Trans on Power Systems2002，17，2： | 1 |
| 16 | The role of TGFbetal in initiating hepatic stellate cell activation in vivo 显示文摘 | Hellerbrand C Stefanovic B Giordano F | 1999 | J Hepatol1999，30，1： | 1 |
| 17 | Ceramics-based sealers as new al-ternative to currently used endodontic sealers 显示文摘 | Stefanov DKV Bulgaria | 2009 | Roots2009，1，： | 1 |
| 18 | Epithelial ovarian cancer with CD117 phenotype is highly aggressive and resistant to chemotherapy显示文摘 | Irena Conic Zorica Stanojevic Ljubinka Jankovic Velickovic Slavica Stojnev Ana Ristic Petrovic Miljan Krstic Marko Stanojevic Dragan Bogdanovi? Vladisav Stefanovic | 2015 | J. Obstet. Gynaecol. Res2015，，10： | 1 |
| 19 | A purified population of multipotent cardiovascular progenitors derived from primate pluripotent stem cells engrafts in postmyocardial infarcted nonhuman primates显示文摘 | Blin Guillaume Nury David Stefanovic Sonia Neri Tui Guillevic Oriane Brinon Benjamin Bellamy Valérie Rücker-Martin Catherine Barbry Pascal Bel Alain Bruneval Patrick Cowan Chad Pouly Julia Mitalipov Shoukhrat Gouadon Elodie Binder Patrice | 2010 | Journal of Clinical Investigation2010，，4： | 1 |
| 20 | Potentiodynamic and electron microscopy investigations of lead - cobalt alloy coated lead composite an- odes for zinc electro -winning显示文摘 | Stefanov Y Dobrev T | 2005 | Transactions of the Institute of Metal Finishing2005，83，6： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员