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| 1 | Mesenchymal stem cells: Molecular characteristics and clinical applications显示文摘Mesenchymal stem cells (MSCs) are non-hematopoietic stem cells with the capacity to differentiate into tissues of both mesenchymal and non-mesenchymal origin. MSCs can differentiate into osteoblastic, chondrogenic, and adipogenic lineages, although recent studies have demonstrated that MSCs are also able to differentiate into other lineages, including neuronal and cardiomyogenic lineages. Since their original isolation from the bone marrow, MSCs have been successfully harvested from many other tissues. Their ease of isolation and ex vivo expansion combined with their immunoprivileged nature has made these cells popular candidates for stem cell therapies. These cells have the potential to alter disease pathophysiology through many modalities including cytokine secretion, capacity to differentiate along various lineages, immune modulation and direct cell-cell interaction with diseased tissue. Here we first review basic features of MSC biology including MSC characteristics in culture, homing mechanisms, differentiation capabilities and immune modulation. We then highlight some in vivo and clinical evidence supporting the therapeutic roles of MSCs and their uses in orthopedic, autoimmune, and ischemic disorders. | Farbod Rastegar Deana Shenaq Eric R Wagner Stephanie H Kim Russell R Reid Hue H Luu Rex C Haydon | 2010 | World Journal of Stem Cells2010，2，4： | 35 |
| 2 | Global and regional mortality from 235 causes of death for 20 age groups in 1990 and 2010: a systematic analysis for the Global Burden of Disease Study 2010显示文摘 | Rafael Lozano Mohsen Naghavi Kyle Foreman Stephen Lim Kenji Shibuya Victor Aboyans Jerry Abraham Timothy Adair Rakesh Aggarwal Stephanie Y Ahn Mohammad A AlMazroa Miriam Alvarado H Ross Anderson Laurie M Anderson Kathryn G Andrews Charles Atkinson Larry M | 2012 | The Lancet . 2012 (9859)2012，，9859： | 7 |
| 3 | PAHs in the Fraser River basin: a critical appraisal of PAH ratios as indicators of PAH source and composition显示文摘 | Mark B Yunker Robie W Macdonald Roxanne Vingarzan Reginald H Mitchell Darcy Goyette Stephanie Sylvestre | 2002 | Organic Geochemistry2002，，4： | 5 |
| 4 | 脑部磁共振白质高信号的临床重要性:系统性综述和荟萃分析(摘要)显示文摘目的 回顾与卒中、认知功能衰退、痴呆和死亡风险相关的脑白质高信号的证据。
设计 系统性回顾和荟苇分析。
数据来源 从1966年至2009年11月23日PubMed数据库。 | Stephanie Debette H S Markus 廖怡(译) 李飞(译) 龚启勇(校) 付诗琴(校) | 2010 | 英国医学杂志中文版2010，13，6： | 5 |
| 5 | Global and regional mortality from 235 causes of death for 20 age groups in 1990 and 2010: a systematic analysis for the Global Burden of Disease Study 2010显示文摘 | Rafael Lozano Mohsen Naghavi Kyle Foreman Stephen Lim Kenji Shibuya Victor Aboyans Jerry Abraham Timothy Adair Rakesh Aggarwal Stephanie Y Ahn Mohammad A AlMazroa Miriam Alvarado H Ross Anderson Laurie M Anderson Kathryn G Andrews Charles Atkinson Larry M | 2012 | The Lancet2012，，9859： | 5 |
| 6 | DNA damage induced by chronic inflammation contributes to colon carcinogenesis in mice显示文摘 | Meira Lisiane B Bugni James M Green Stephanie L Lee Chung-Wei Pang Bo Borenshtein Diana Rickman Barry H Rogers Arlin B Moroski-Erkul Catherine A McFaline Jose L Schauer David B Dedon Peter C Fox James G Samson Leona D | 2008 | Journal of Clinical Investigation2008，，7： | 2 |
| 7 | Global and regional mortality from 235 causes of death for 20 age groups in 1990 and 2010: a systematic analysis for the Global Burden of Disease Study 2010显示文摘 | Rafael Lozano Mohsen Naghavi Kyle Foreman Stephen Lim Kenji Shibuya Victor Aboyans Jerry Abraham Timothy Adair Rakesh Aggarwal Stephanie Y Ahn Mohammad A AlMazroa Miriam Alvarado H Ross Anderson Laurie M Anderson Kathryn G Andrews Charles Atkinson Larry M | 2012 | 2012 (9859)2012，，9859： | 2 |
| 8 | Physical activity and nutrition attitudes in obese Hispanic children with non-alcoholic steatohepatitis显示文摘AIM:To assess nutrition,physical activity and health-ful knowledge in obese children with biopsy-proven nonalcoholic steatohepatitis(NASH or NA)compared to children without liver disease.METHODS:Children with biopsy-proven NASH comprised the NASH group.Age,sex and ethnicity matched control groups consisted of obese(OB)and lean(CO) children with no liver disease.Subjects were adminis-tered the School Physical Activity and Nutrition Survey and one blood draw was obtained.RESULTS:Fifty-seven patients were enrolled with a mean age of 12.1±2.1 years,and all were Hispanic.Even though the OB and NA had a similar increased body mass index(%),35%of the NA group always read nutrition labels compared to none in the OB(P<0.05),and more NA children felt their diet is'less healthy'.NA consumed the least amount of fruits with only 25%having≥1 fruit/d vs 45%in OB and 64.7% in CO(P<0.05 NA vs CO).Only 15%of NA subjects performed light exercise vs 35%and 59%of OB and CO groups,respectively(P=0.02).The mean physical activity score was lowest in the NA group(P<0.05).Amongst the subjects with NASH,we found that 100% of patients with grade 2 or 3 fibrosis had a sedentary score>2 compared to only 63.6%of those with grade 1 or no fibrosis(P<0.05).CONCLUSION:Children with NASH had increased sedentary behavior,decreased activity,and fruit intake.Larger studies may determine the benefit of changing these behaviors as treatment for NASH. | Lana N Hattar Theresa A Wilson Leanel A Tabotabo E O'Brian Smith Stephanie H Abrams | 2011 | World Journal of Gastroenterology2011，17，39： | 2 |
| 9 | Interarch tooth size relationships of 3 populations:does Bolton's analysis apply显示文摘 | Stephanie S Peter H Etasuko W | 2000 | Am J Orthod Dentofac Orthop2000，117，2： | 1 |
| 10 | Hydrogen peroxide plays a critical role in the defence response of tomato to Cladosporium fulvum显示文摘 | Stephanie B Verna J H | 2002 | Physiological and Molecular Plant Pathology2002，6，： | 1 |
| 11 | Bacterial RNA chaperones confer abiotic stress tolerance in plants and improved grain yield in maize under water-limited condition 显示文摘 | Paolo C Dave W Robert J B Don C A Jay H Martin S Mark A Ganesh K Sara S Robert D Santiago N Stephanie B Mary F Jayaprakash T Santanu D Christopher B Michael H L Jacqueline E H | 2008 | Plant Physiology2008，147，2： | 1 |
| 12 | Development of an enzyme immuno assay for the determination of porcine haptoglobin in various body fluids:testing the significance of meat juice measurements for quality monitoring programs显示文摘 | Stephanie H Susanne K D Gertraud R | 2003 | Vet Immunol Immunopathol2003，96，： | 1 |
| 13 | Stable genetic transformation of tomato plastids and expression of a foreign protein in fruit 显示文摘 | STEPHANIE R MARITA H IRVING J B | 2001 | NatBiotechnol2001，19，： | 1 |
| 14 | Enhanced binding of Aspergillus fumigatus spores to A549 epithelial ceils and extraeellular matrix proteins by a component from the spore surface and inhibition by rat lung lavage fluid 显示文摘 | ZHAN Y STEPHANIE M H COLIN G M | 2000 | Thorax2000，55，10： | 1 |
| 15 | Loneliness, attachment, and the perception and use of social support in university students 显示文摘 | Stephanie B Kimberley A Julie H | 2011 | Can Behav Sci2011，43，1： | 1 |
| 16 | Measurement,analysis,and display of haptic signals during surgical cutting 显示文摘 | Stephanie G V H Vanessa C A O Thomas S | 2002 | Presence2002，11，6： | 1 |
| 17 | Interarch tooth size relationships of 3 populations:“does Bolton's analysis apply?” 显示文摘 | Stephanie S Peter H Etasuko W | 2000 | Am J Orthod Dentofac Orthop2000，117，2： | 1 |
| 18 | Showing results for preservation of cardiac function and energy reserve by the angiotensin converting enzyme inhibitor quinapril during post myocardial infarction remodeling in the rat显示文摘 | Stephanie H | 2001 | Cardiovasc Magn Reson2001，3，3： | 1 |
| 19 | Euro- pean brown hare syndrome virus: molecular cloning and se- quencing of the genome显示文摘 | GHISLAINE L G STEPHANIE H PATRICE V | 1996 | J Gen Virol1996，77，8： | 1 |
| 20 | Evaluation the reinforcing effects of choice in comparison to reinforcement rate 显示文摘 | Rachel H T Wayne W F Stephanie A C | 1998 | Research in Developmental Disabilities1998，19，2： | 1 |
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