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| 1 | Neuroretinal hypoxic signaling in a new preclinical murine model for proliferative diabetic retinopathy显示文摘Diabetic retinopathy(DR)affects approximately one-third of diabetic patients and,if left untreated,progresses to proliferative DR(PDR)with associated vitreous hemorrhage,retinal detachment,iris neovascularization,glaucoma and irreversible blindness.In vitreous samples of human patients with PDR,we found elevated levels of hypoxia inducible factor 1 alpha(HIF1α).HIFs are transcription factors that promote hypoxia adaptation and have important functional roles in a wide range of ischemic and inflammatory diseases.To recreate the human PDR phenotype for a preclinical animal model,we generated a mouse with neuroretinal-specific loss of the von Hippel Lindau tumor suppressor protein,a protein that targets HIF1αfor ubiquitination.We found that the neuroretinal cells in these mice overexpressed HIF1αand developed severe,irreversible ischemic retinopathy that has features of human PDR.Rapid progression of retinopathy in these mutant mice should facilitate the evaluation of therapeutic agents for ischemic and inflammatory blinding disorders.In addition,this model system can be used to manipulate the modulation of the hypoxia signaling pathways,for the treatment of non-ocular ischemic and inflammatory disorders. | Katherine J Wert Vinit B Mahajan Lijuan Zhang Yuanqing Yan Yao Li Joaquin Tosi Chun Wei Hsu Takayuki Nagasaki Kerstin M Janisch Maria B Grant MaryAnn Mahajan Alexander G Bassuk Stephen H Tsang | 2016 | Signal Transduction and Targeted Therapy2016，1，1： | 1 |
| 2 | Tranexamic acid for intracerebral haemorrhage within 2 hours of onset: protocol of a phase Ⅱ randomised placebo-controlled double-blind multicentre trial显示文摘Rationale Haematoma growth is common early after intracerebral haemorrhage(ICH),and is a key determinant of outcome.Tranexamic acid,a widely available antifibrinolytic agent with an excellent safety profile,may reduce haematoma growth.Methods and design Stopping intracerebral haemorrhage with tranexamic acid for hyperacute onset presentation including mobile stroke units(STOP-MSU)is a phase Ⅱ double-blind,randomised,placebo-controlled,multicentre,international investigator-led clinical trial,conducted within the estimand statistical framework.Hypothesis In patients with spontaneous ICH,treatment with tranexamic acid within 2 hours of onset will reduce haematoma expansion compared with placebo.Sample size estimates A sample size of 180 patients(90 in each arm)would be required to detect an absolute difference in the primary outcome of 20%(placebo 39%vs treatment 19%)under a two-tailed significance level of 0.05.An adaptive sample size re-estimation based on the outcomes of 144 patients will allow a possible increase to a prespecified maximum of 326 patients.Intervention Participants will receive 1 g intravenous tranexamic acid over 10 min,followed by 1 g intravenous tranexamic acid over 8 hours;or matching placebo.Primary efficacy measure The primary efficacy measure is the proportion of patients with haematoma growth by 24±6 hours,defined as either≥33%relative increase or≥6 mL absolute increase in haematoma volume between baseline and follow-up CT scan.Discussion We describe the rationale and protocol of STOP-MSU,a phase Ⅱ trial of tranexamic acid in patients with ICH within 2 hours from onset,based in participating mobile stroke units and emergency departments. | Nawaf Yassi Henry Zhao Leonid Churilov Bruce C V Campbell Teddy Wu Henry Ma Andrew Cheung Timothy Kleinig Helen Brown Philip Choi Jiann-Shing Jeng Annemarei Ranta Hao-Kuang Wang Geoffrey C Cloud Rohan Grimley Darshan Shah Neil Spratt Der-Yang Cho Karim Mahawish Lauren Sanders John Worthington Ben Clissold Atte Meretoja Vignan Yogendrakumar Mai Duy Ton Duc Phuc Dang Nguyen Thai My Phuong Huy-Thang Nguyen Chung Y Hsu Gagan Sharma Peter J Mitchell Bernard Yan Mark W Parsons Christopher Levi Geoffrey A Donnan Stephen M Davis | 2022 | Stroke & Vascular Neurology2022，7，2： | 1 |
| 3 | Moleculal Basis of Lubrication 显示文摘 | Stephen M Hsu | 2004 | Tri- bology International2004，37，： | 1 |
| 4 | Molecular basis of lubrication显示文摘 | Stephen M Hsu | 2004 | Tribology International2004，37，： | 1 |
| 5 | Wear and Wear Transition Modeling of Ceramic 显示文摘 | Yushu Wang Stephen M Hsu | 1996 | Wear1996，195，12： | 1 |
| 6 | Wear and Wear Transition Mechanisms of Ceramics显示文摘 | Yushu Wang Stephen M Hsu | 1996 | Wear1996，195，12： | 1 |
| 7 | Single Wedge Sliding Test to Investigate the Mechanism of UH- MWPE Particle Generation with Microfahricated Surface Textures显示文摘 | Hsu-Wei Fang Stephen M Hsu Jan V Sengers | 2006 | Polymer Testing2006，25，3： | 1 |
| 8 | Wear and Wear Transition Mechanisms of Ceramics 显示文摘 | Stephen M Hsu | 1996 | Wear1996，195，： | 1 |
| 9 | Wear and wear transition mechanisms of ceramics 显示文摘 | Wang Y S Hsu Stephen M | 1996 | Wear1996，195，： | 1 |
| 10 | Molecular basis of lubrication显示文摘 | Stephen M Hsu | 2004 | Tribology International2004，37，： | 1 |
| 11 | Nano-lubrication:concept and design显示文摘 | Stephen M Hsu | 2004 | Tribology International2004，37，： | 1 |
| 12 | Nano-lubrication:concept and design显示文摘 | Stephen M Hsu | 2004 | Tribology International2004，37，： | 1 |
| 13 | Molecular basis of lubrication显示文摘 | Stephen M Hsu | 2004 | Tribology International2004，37，7： | 1 |
| 14 | The effects of operating parameters and environment on the wear and wear transition of alumina显示文摘 | Yushu Wang Stephen M Hsu | 1996 | Wear1996，195，： | 1 |
| 15 | Chemical regulation of carotenoid biosynthesis, Part lO:Chemical induction of β carotene biosynthesis显示文摘 | Poling Stephen M Hsu Wan-Jean Koehrn Fred J | 1977 | Phytochemistry1977，16，5： | 1 |
| 16 | Molecular basis of lubrication显示文摘 | Stephen M Hsu | 2004 | Tribology International2004，37，： | 1 |
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