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| 1 | Nationwide trends and predictors of inpatient mortality in 83884 transjugular intrahepatic portosystemic shunt显示文摘AIM: To evaluate and validate the national trends and predictors of in-patient mortality of transjugular intrahepatic portosystemic shunt(TIPS) in 15 years.METHODS: Using the National Inpatient Sample which is a part of Health Cost and Utilization Project, we identified a discharge-weighted national estimate of 83884 TIPS procedures performed in the United States from 1998 to 2012 using international classification of diseases-9 procedural code 39.1. The demographic, hospital and co-morbility data were analyzed using a multivariant analysis. Using multi-nominal logistic regression analysis, we determined predictive factors related to increases in-hospital mortality. Comorbidity measures are in accordance to the Comorbidity Software designed by the Agency for Healthcare Research and Quality.RESULTS: Overall, 12.3% of patients died during hospitalization with downward trend in-hospitalmortality with the mean length of stay of 10.8 ± 13.1 d. Notable, African American patients(OR = 1.809 vs Caucasian patients, P < 0.001), transferred patients(OR = 1.347 vs non-transferred, P < 0.001), emergency admissions(OR = 3.032 vs elective cases, P < 0.001), patients in the Northeast region(OR = 1.449 vs West, P < 0.001) had significantly higher odds of inhospital mortality. Number of diagnoses and number of procedures showed positive correlations with in-hospital death(OR = 1.249 per one increase in number of procedures). Patients diagnosed with acute respiratory failure(OR = 8.246), acute kidney failure(OR = 4.359), hepatic encephalopathy(OR = 2.217) and esophageal variceal bleeding(OR = 2.187) were at considerably higher odds of in-hospital death compared with ascites(OR = 0.136, P < 0.001). Comorbidity measures with the highest odds of in-hospital death were fluid and electrolyte disorders(OR = 2.823), coagulopathy(OR = 2.016), and lymphoma(OR = 1.842).CONCLUSION: The overall mortality of the TIPS procedure is steadily decreasing, though the length of stay has remained relatively constant. Specific patient ethnicity, location, transfer status, primary diagnosis and comorbidities correlate with increased odds of TIPS in-hospital death. | Edward Wolfgang Lee Andrew Kuei Sammy Saab Ronald W Busuttil Francisco Durazo Steven-Huy Han Mohamed M El-Kabany Justin P Mc Williams Stephen T Kee | 2016 | World Journal of Gastroenterology2016，22，25： | 7 |
| 2 | Cancer Genome Scanning in Plasma: Detection of Tumor-Associated Copy Number Aberrations, Single-Nucleotide Variants, and Tumoral Heterogeneity by Massively Parallel Sequencing显示文摘 | Chan K C Allen Jiang Peiyong Zheng Yama W L Liao Gary J W Sun Hao Wong John Siu Shing Shun N Chan Wing C Chan Stephen L Chan Anthony T C Lai Paul B S Chiu Rossa W K Lo Y M D | 2013 | Clinical Chemistry2013，，1： | 2 |
| 3 | Biomarker-guided sequential targeted therapies to overcome therapy resistance in rapidly evolving highly aggressive mammary tumors显示文摘组合指向的治疗在由堵住治疗癌症是更有效的绕过机制或导致的合成致命性。然而,他们的临床的申请被抵抗和毒性妨碍。遇见这重要挑战,我们用 ErbB2-overexpressing/PTEN-low 开发了并且测试各种各样的指向的治疗的指导 biomarker 的顺序的应用程序的一个新奇概念,高度好攻击的乳癌作为我们的模型。惊人地,从遗传上设计的鼠标与 intratumoral 异质从病人和乳房的肿瘤在两 PTEN-low/trastuzumab-resistant 乳癌支撑了 ErbB2 和下游的小径驱动器 trastuzumab 抵抗的激活。尽管 lapatinib 开始禁止了 trastuzumab 抵抗的鼠标肿瘤,肿瘤由激活表明由量的蛋白质数组出现的网络的 PI3K/mTOR 绕过抑制。有趣地,小径也是的 mTOR 的激活在 neoadjuvant 观察了表明 lapatinib 抵抗的对待 lapatinib 的病人。Trastuzumab + lapatinib 抵抗被一个 PI3K/mTOR 双 kinase 禁止者(BEZ235 ) 的顺序的申请有效地没有重要毒性克服。然而,我们的 p-RTK 数组分析证明 BEZ235 治疗在遗传上设计的老鼠肿瘤导致了增加的 ErbB2 表示和 phosphorylation,导致 BEZ235 抵抗并且在 3-D,然而并非 2-D,文化。机械学地,我们作为 BEZ235 抵抗的新奇机制识别了 ErbB2 蛋白质稳定和激活,它被随后的治疗与 lapatinib + BEZ235 联合颠倒。显著地, biomarker 指导的指向的治疗的这个顺序的应用程序在很快发展加倍的抵抗的肿瘤改变忍受极其好攻击的肿瘤的鼠标的寿命。使用的这条根本上新奇的途径有效地在一个顺序的顺序罐头指向了治疗目标和改编在在治疗期间发展抵抗的癌症的发信号的网络。 | Ozgur Sahin Qingfei Wang Samuel W Brady Kenneth Ellis Hai Wang Chia-Chi Chang Qingling Zhang Preety Priya Rui Zhu Stephen T Wong Melissa D Landis William J Muller Francisco J Esteva Jenny Chang Dihua Yu | 2014 | Cell Research2014，24，5： | 2 |
| 4 | Release of Vasoactive substances during Cardiopulmonary Bypass 显示文摘 | Stephen W Haak T Bacattik M | 1992 | Ann Thorac Surg1992，54，： | 1 |
| 5 | Application of fractal mathematics to soil water retention estimation显示文摘 | Scott W T Stephen W W | 1989 | Soil Science Society of America Journal1989，53，： | 1 |
| 6 | In situ investigation of the calcium-induced proteolytic and salting-in mechanisms causing tenderization in calcium-enhanced muscle显示文摘 | Lawrance T E Dikeman M E Stephens J W | 2003 | Meat Sci2003，66，： | 1 |
| 7 | Fractal scaling of soil particle-size distributions: Analysis and limitation显示文摘 | Scott W T Stephen W W | 1992 | Soil Science Society of America Journal1992，56，： | 1 |
| 8 | Gradient projection for sparse reconstruction: application to compressed sensing and other inverse problems 显示文摘 | Figueiredo M T Nowak R D Stephen J W | 2007 | IEEE Journal of Selected Topics in Signal Processing2007，1，4： | 1 |
| 9 | DAVID gene ID conversion tool 显示文摘 | Huang D W Sherman B T Stephens R | 2008 | Bioinformation2008，2，10： | 1 |
| 10 | Investigation of benzene oxide in bone marrow and other tissues of F344 rats following metabolism of benzene in vitro and in vivo 显示文摘 | Andrew B L Karen YO C Suramya W Thomas A M Bernard T G Stephen M R | 1998 | Chemical Research in Toxicology1998，11，4： | 1 |
| 11 | Tidal energy dissipation at the sill of Sechelt Inlet, British Columbia 显示文摘 | SCOTT W T STEPHEN P | 2001 | Journal of Physical Oceanog- raphy2001，31，12： | 1 |
| 12 | Optical fibre long-period grating sensors: characteristics and application显示文摘 | Stephen W J Ralph P T | 2003 | Measurement Science and Technology2003，15，5： | 1 |
| 13 | The role of neuropeptide Y in the antiobesity action of the obese gene product显示文摘 | Stephens T W Basinski M Bristow P K | 1995 | Nature1995，377，6549： | 1 |
| 14 | Nanoscale Atoms in Solid- State Chemistry 显示文摘 | Roy X Lee C H Crowther A C Schenck C L Besara T Lalancette R A Siegrist T Stephens P W Brus L E Kim P Steigerwald M L Nuckolls C | 2013 | Science2013，，341： | 1 |
| 15 | Specific genomic fingerprints of phytopathogenic Xanttzomonas and Pseudomonas pathovars and strains generated with repeti tive sequences and PCR显示文摘 | Louws F J Fulbright D W Stephens C T | 1994 | Applied and Environmental Microbiology1994，60，7： | 1 |
| 16 | A longitudinal study oral ulcerative mucositis in bone marrow transplant recipients显示文摘 | Sook-Bin W Stephen T Michael M | 1993 | Cacer1993，72，5： | 1 |
| 17 | Performance analysis of a feasible air-cycle refrigeration system for road transport 显示文摘 | Stephen W T Spence W John Doran David Wart | 2005 | International Journal of Refrigeration2005，，28： | 1 |
| 18 | In situ investigation of the calpain-induced proteolytic and salting-in mechanisms causing tenderization in calcium-enhanced muscle 显示文摘 | Lawrence T E Dikeman M E Stephens J W | 2003 | Meat Sci2003，66，： | 1 |
| 19 | The role of neu ropeptide Y in the antiobesity action of the obese gene product显示文摘 | Stephens T W Basinski Bristow P K | 1995 | Nature (Lond)1995，377，： | 1 |
| 20 | A longitudinal study of oral uralulcerative mucositis in bone marrow transplant recipi- ents 显示文摘 | Sook-Bin W Stephen T Michael M | 1993 | Caneer1993，72，5： | 1 |
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