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| 1 | Advancing research diagnostic criteria for Alzheimer’s disease: the IWG-2 criteria显示文摘 | Bruno Dubois Howard H Feldman Claudia Jacova Harald Hampel José Luis Molinuevo Kaj Blennow Steven T DeKosky Serge Gauthier Dennis Selkoe Randall Bateman Stefano Cappa Sebastian Crutch Sebastiaan Engelborghs Giovanni B Frisoni Nick C Fox Douglas Galasko Ma | 2014 | Lancet Neurology2014，，6： | 7 |
| 2 | 帕博利珠单抗联合以铂类为基础的化疗治疗非小细胞肺癌合并稳定性脑转移患者的结局:KEYNOTE-021、-189和-407研究的汇总分析显示文摘背景与目的此项探索性分析回顾评价了晚期非小细胞肺癌(non-small cell lung cancer,NSCLC)患者的结局,旨在确定基线时合并脑转移是否会影响一线应用帕博利珠单抗联合化疗(pembrolizumab plus chemotherapy,PC)比对单用化疗的疗效。患者和方法对KEYNOTE-021队列G(非鳞癌)、KEYNOTE-189(非鳞癌)和KEYNOTE-407(鳞癌)三项研究晚期NSCLC患者的数据进行汇总分析。患者接受含铂两药化疗和/或35个周期帕博利珠单抗治疗(每3周200 mg)。所有研究均纳入了经治或初治的稳定性脑转移患者(KEYNOTE-189与KEYNOTE-407研究纳入初治脑转移患者)。经治的脑转移患者已处于病情稳定的状态≥2周(KEYNOTE-021队列G患者≥4周),无新发或脑转移病灶扩大的证据且入组前至少3天以上未使用激素。初治的无症状脑转移患者需定期接受脑部影像学检查。结果共纳入1298例患者,其中171例有基线脑转移,1127例无脑转移。两组的中位随访时间(范围)在数据截止时分别为10.9(0.1-35.1)个月和11.0(0.1-34.9)个月。合并脑转移和无脑转移患者的总生存期[0.48(95%CI:0.32-0.70)和0.63(95%CI:0.53-0.75)]和无进展生存期[0.44(95%CI:0.31-0.62)和0.55(95%CI:0.48-0.63)]的风险比(PC/化疗)相似。合并脑转移的患者中,PC组和单用化疗组患者的中位总生存期分别为18.8个月和7.6个月,中位无进展生存期分别为6.9个月和4.1个月。无论是否合并脑转移,PC组患者的客观缓解率都高于单用化疗组,且缓解持续时间有显著延长。合并脑转移的患者中,PC组与单用化疗组的治疗相关不良事件发生率分别为88.2%和82.8%;而无脑转移的患者中,两组治疗相关不良事件的发生率分别为94.5%和90.6%。结论无论是否合并脑转移,与单用化疗相比,帕博利珠单抗联合以铂类为基础的组织学特异性化疗可改善所有PD-L1亚组的临床结局,其中包括PD-L1肿瘤比例评分<1%的患者,并且在晚期NSCLC患者中安全性良好。该方案是晚期NSCLC初治患者的标准方案,并可用于合并稳定性脑转移的患者。 | 周清(翻译校对) Steven F Powell Delvys Rodríguez-Abreu Corey J Langer Ali Tafreshi Luis Paz-Ares Hans-Georg Kopp Jeronimo Rodríguez-Cid Dariusz M Kowalski Ying Cheng Takayasu Kurata Mark M Awad Jinaxin Lin Bin Zhao M Catherine Pietanza Bilal Piperdi Marina C Garassino | 2022 | 中国肺癌杂志2022，25，1： | 6 |
| 3 | Widespread use of gastric acid inhibitors in infants:Are they needed? Are they safe?显示文摘Gastroesophageal reflux is a common phenomenon in infants,but the differentiation between gastro-esophageal reflux and gastroesophageal reflux disease can be difficult.Symptoms are non-specific and there is increasing evidence that the majority of symptoms may not be acid-related.Despite this,gastric acid inhibitors such as proton pump inhibitors are widely and increasingly used,often without objective evidence or investigations to guide treatment.Several studies have shown that these medications are ineffective at treating symptoms associated with reflux in the absence of endoscopically proven oesophagitis.With a lack of evidence for efficacy,attention is now being turned to the potential risks of gastric acid suppression.Previously assumed safety of these medications is being challenged with evidence of potential side effects including GI and respiratory infections,bacterial overgrowth,adverse bone health,food allergy and drug interactions. | Mark Safe Wei H Chan Steven T Leach Lee Sutton Kei Lui Usha Krishnan | 2016 | World Journal of Gastrointestinal Pharmacology and Therapeutics2016，7，4： | 2 |
| 4 | Hepatic Resection for Metastatic Melanoma: Distinct Patterns of Recurrence and Prognosis for Ocular Versus Cutaneous Disease显示文摘 | Timothy M. Pawlik MD MPH Daria Zorzi MD Eddie K. Abdalla MD Bryan M. Clary MD Jeffrey E. Gershenwald MD Merrick I. Ross MD Thomas A. Aloia MD Steven A. Curley MD Luis H. Camacho MD MPH Lorenzo Capussotti MD Dominique Elias MD Jean-Nicolas Vauthey MD | 2006 | Annals of Surgical Oncology2006，，5： | 2 |
| 5 | The Effects of Business-to-Business E-Commerce on Transaction Costs显示文摘 | Luis Garicano Steven N Kaplan | 2001 | The journal of industrial economics2001，49，4： | 1 |
| 6 | Phylogeographic characteristics of vesicular stomatitis New Jersey viruses circulating in Mexico from 2005 to 2011 and their relationship to epidemics in the United States显示文摘 | Lauro Velazquez-Salinas Steven J. Pauszek Selene Zarate Francisco J. Basurto-Alcantara Antonio Verdugo-Rodriguez Andres M. Perez Luis L. Rodriguez | 2014 | Virology2014，，： | 1 |
| 7 | Low temperature H2S dry-desulfurization with zinc oxide 显示文摘 | Hector F G Hugo M G Luis J G Jennifer H Aimee M Steven L S | 2010 | Microporous and Mesoporous Materials2010，127，： | 1 |
| 8 | The Role of Trust and Contractual Safeguards on Cooperation in Non- equity Alliances 显示文摘 | Steven S Lui Hang-yue Ngo | 2004 | Journal of Management2004，30，4： | 1 |
| 9 | The Role of Trust and Con- tractual Safeguards on Cooperation in Non-equity Alliances显示文摘 | STEVEN S LUI H N | 2004 | Journal of Management2004，30，4： | 1 |
| 10 | Distinguishing costs of cooperation and control in alliances显示文摘 | STEVEN WHITE STEVEN SIU YUN LUI | 2005 | Strategic Management Journal2005，26，2005： | 1 |
| 11 | Inhibition of Pluripotency Networks by the Rb Tumor Suppressor Restricts Reprogramming and Tumorigenesis显示文摘 | Michael S. Kareta Laura L. Gorges Sana Hafeez Bérénice A. Benayoun Samuele Marro Anne-Flore Zmoos Matthew J. Cecchini Damek Spacek Luis F.Z. Batista Megan O’Brien Yi-Han Ng Cheen Euong Ang Dedeepya Vaka Steven E. Artandi Frederick A. Dick Anne Brunet Juli | 2014 | Cell Stem Cell2014，，： | 1 |
| 12 | The Role of Trust and Contractual Safeguards on Cooperation in Non-equity Alliances显示文摘 | Steven S. Lui | 2004 | Journal of Management2004，，4： | 1 |
| 13 | Coercive strategy in interfirm cooperation: Mediating roles of interpersonal and interorganizational trust显示文摘 | Steven S Lui H N Alice H Y | 2006 | Journal of Business Research2006，59，： | 1 |
| 14 | Reductive decomposition of calcium sulfate utilizing carbon monoxide and hydrogen显示文摘 | Luis M Diaz-Bossio Steven E | 1985 | Chemical Engineering1985，40，3： | 1 |
| 15 | Survey of data management and analysis in disaster situations显示文摘 | Vagelis Hristidis Shu-Ching Chen Tao Li Steven Luis Yi Deng | 2010 | The Journal of Systems & Software2010，，10： | 1 |
| 16 | The Energy Balance Experiment EBEX-2000. Part I: overview and energy balance显示文摘 | Steven P. Oncley Thomas Foken Roland Vogt Wim Kohsiek H. A. R. DeBruin Christian Bernhofer Andreas Christen Eva van Gorsel David Grantz Christian Feigenwinter Irene Lehner Claudia Liebethal Heping Liu Matthias Mauder Andrea Pitacco Luis Ribeiro Tamas Weid | 2007 | Boundary - Layer Meteorology2007，，1： | 1 |
| 17 | Short- and Long-Term Success of Substrate-Based Mapping and Ablation of Ventricular Tachycardia in Arrhythmogenic Right Ventricular Dysplasia显示文摘 | Atul Verma Fethi Kilicaslan Robert A. Schweikert Gery Tomassoni Antonio Rossillo Nassir F. Marrouche Volkan Ozduran Oussama M. Wazni Samy C. Elayi Luis C. Saenz Stephen Minor Jennifer E. Cummings J David Burkhardt Steven Hao Salwa Beheiry Patrick J. Tchou | 2005 | Circulation2005，，24： | 1 |
| 18 | Survey of data management and analysis in disaster situations显示文摘 | Vagelis Hristidis Shu-Ching Chen Tao Li Steven Luis Yi Deng | 2010 | The Journal of Systems & Software2010，，10： | 1 |
| 19 | Hepatic Resection for Metastatic Melanoma: Distinct Patterns of Recurrence and Prognosis for Ocular Versus Cutaneous Disease显示文摘 | Timothy M. Pawlik MD MPH Daria Zorzi MD Eddie K. Abdalla MD Bryan M. Clary MD Jeffrey E. Gershenwald MD Merrick I. Ross MD Thomas A. Aloia MD Steven A. Curley MD Luis H. Camacho MD MPH Lorenzo Capussotti MD Dominique Elias MD Jean-Nicolas Vauthey MD | 2006 | Annals of Surgical Oncology2006，，5： | 1 |
| 20 | TrkB Regulates Hippocampal Neurogenesis and Governs Sensitivity to Antidepressive Treatment显示文摘 | Yun Li Bryan W. Luikart Shari Birnbaum Jian Chen Chang-Hyuk Kwon Steven G. Kernie Rhonda Bassel-Duby Luis F. Parada | 2008 | Neuron2008，，3： | 1 |
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