|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Liver tumor infiltrating lymphocytes: Comparison of hepatocellular and cholangiolar carcinoma显示文摘AIM: To investigate the role of tumor inf iltrating lym-phocytes (TIL) in primary hepatocellular and cholangio-lar carcinomas of the liver.METHODS: Immunohistochemical analysis was per-formed including antibodies to CD3, CD4, CD8, CD20, CD56 and TIA-1 in formalin-f ixed and paraff in-embed-ded tissue of 35 liver resection specimens of hepatocel-lular or cholangiocellular carcinomas. Semiquantitative evaluation was performed with emphasis on the area of the tumor itself and of the tumor/liver interface.RESULTS: All hepatocellular carcinomas showed in-filtration of lymphocytes predominantly around the tumor in the tumor/liver interface consisting mainly of CD3+ CD4+ T lymphocytes [164.3/10 high power f ields (HPF)] and in the tumor itself of CD8+ cells (54.9/10 HPF). Cholangiocarcinomas contained a heterogeneous amount of TIL, composed mainly of CD3+ T cells with a predominance of CD8+ cells in the tumor tissue (52.6/10 HPF) and of CD4+ cells in the interface region (223.1/10 HPF). CD56+ cells of the innate immune system were scarce. There was no significant difference between hepatocellular or cholangiolar carcinoma. No correlation with the clinicopathological data was seen. CONCLUSION: Liver TIL consists of intratumoral CD8+ T cells and peritumoral CD4+ T cells indepen-dent of histogenetic origin. Different functions of lym-phocytes in these regions seem possible. | Hans-Udo Kasper Uta Drebber Dirk Ludger Stippel Hans Peter Dienes Anton Gillessen | 2009 | World Journal of Gastroenterology2009，15，40： | 8 |
| 2 | Regional lymphadenectomy strongly recommended in T1b gallbladder cancer显示文摘This article discusses the adequate treatment of early gallbladder cancer(T1a,T1b) and is based on published studies extending over nearly 3 decades.Randomized studies and meta analyses comparing different surgical treatments do not exist.The literature shows that in up to 20% of patients lymph node metastasis are found in T1b gallbladder cancer.Due to high malignancy with early angiolymphatic spread and resistance to chemotherapy and radiation on the one hand,and the relative low operative risk of extended cholecystectomy(cholecystectomy and regional lymphadenectomy) on the other hand,we believe that this procedure is mandatory in early gallbladder cancer. | Ulrich Klaus Fetzner Arnulf H Hlscher Dirk L Stippel | 2011 | World Journal of Gastroenterology2011，17，38： | 8 |
| 3 | Simultaneous occurrence of a hepatocellular carcinoma and a hepatic non-Hodgkin's lymphoma infi ltration显示文摘To investigate the simultaneous occurrence of hepatocellular carcinoma and non-Hodgkin's lymphoma, we report the case of a 70 year old patient with a primary diagnosis of non-Hodgkin's lymphoma in 2002. In a routine follow up investigation of his chronic lymphocytic leukemia a newly detected mass in the Couinaud's segments 2 and 3 was found. No hepatitis C virus or hepatitis B virus infection or cirrhosis was evident. After laparoscopic segmentectomy the histological examination revealed a hepatocellular carcinoma. While the relation between liver parenchyma damages and hepatocellular carcinoma or non-Hodgkin's lymphoma is well known, only a few publications have focused on the coexistence of hepatocellular carcinoma and non-Hodgkin's lymphoma. With this case we demonstrate the coexistence of these diseases without having a pre- damaged liver parenchyma. | Sabine Heidecke Dirk L Stippel Arnulf H Hoelscher Inga Wedemeyer Hans-Peter Dienes Uta Drebber | 2010 | World Journal of Hepatology2010，2，6： | 2 |
| 4 | Variability of size and shape of necrosis induced by radiofrequency ablation in human livers: a volumetric evaluation 显示文摘 | Stippel DL Brochhagen HG Arenja M | 2004 | Ann Surg Oncol2004，11，4： | 1 |
| 5 | Successful treatment of radiofrequency-induced biliary lesions by interventional endoscopic retrograde cholangiography (ERC)显示文摘 | D. L. Stippel U. T?x A. Gossmann K. T. E. Beckurts A. H. H?lscher | 2003 | Surgical Endoscopy2003，，12： | 1 |
| 6 | Underestimation of nodules while staging hepatocellular carcinoma prior to neoadjuvant on waiting list for transplantation transplant显示文摘 | Stippel D L Kasper H U Schleimer K | 2003 | Proc2003，35，4： | 1 |
| 7 | Experimental bile duct protection by intraductal cooling during radiofrequency ablation 显示文摘 | Stippel DL Bangard C Kasper HU | 2005 | Br J Surg2005，92，7： | 1 |
| 8 | Transanal endoscopic microsurgery in large,sessile adenomas of the rectum:a 10-year experience显示文摘 | Said S Stippel D | 1995 | Surg Endosc1995，9，10： | 1 |
| 9 | Which parameters are needed for targeting a multitined radiofrequency device-an ap- proach to a simple algorithm 显示文摘 | Stippel DL Banqard C Prenzel K | 2009 | Langenbecks Arch Surg2009，394，4： | 1 |
| 10 | Portal vein arteri- alization increases hepatoceflular apoptosis and inhibits liver regeneration显示文摘 | Schleimer K Stippel DL Kasper HU | 2008 | J Surg Res2008，149，2： | 1 |
| 11 | Portal hyperperfusion causes disturbance of microcirculation and increased rate of hepatocellular apoptosis:investigations in heterotopic rat liver transplantation with portal vein arterialization显示文摘 | Schleimer K Stippel D Kasper HU | | 0，，03： | 1 |
| 12 | Portal hyperperfu- sion causes disturbance of microcirculation and increased rate of hepatocellular apoptosis: investigations in heterotopic rat liver transplantation with portal vein arterialization显示文摘 | Schleimer K Stippel D Kasper H | 2006 | Trans- plantat Proc2006，38，3： | 1 |
| 13 | Portal vein arterialization increases hepatocellular apoptosis and inhibits liver regeneration显示文摘 | Schleimer K Stippel DL Kasper HU | | 0，，02： | 1 |
| 14 | Postoperative recovery of microcirculation after gastric tube formation显示文摘 | Wolfgang Schr?der D. Stippel C. Gutschow J. Leers A. H. H?lscher | 2004 | Langenbeck’s Archives of Surgery2004，，4： | 1 |
| 15 | Intraoperative changes of mucosal pCO2 during gastric tube formation显示文摘 | W. Schr?der D. Stippel K. Beckurts M. Lacher C. Gutschow A. H?lscher | 2001 | Langenbeck’s Archives of Surgery2001，，5： | 1 |
| 16 | Primary cholangiocarcinoma in a case of Caroli's disease:case report and literature review显示文摘 | Kasper HU Stippel DL Tox U | 2006 | Der Pathol2006，27，4： | 1 |
| 17 | Successful treatment of radiofrequency-induced biliary lesions by interventional endoscopic retrograde cholangiography (ERC)显示文摘 | Stippel D L Tox U Gossmann A | 2003 | Surg Endosc2003，17，12： | 1 |
| 18 | A tissuespecific adaptive texture for medical ultrasound images显示文摘 | STIPPEL G PHILIPS W GOVAERT P | 2005 | Ultrasound in Med & Biol2005，31，9： | 1 |
| 19 | ALG versus OKT3 for treatment of steroid-resistant rejection in renal transplantation: ten-year follow-up results of a randomized trial显示文摘 | Stippel D L Arns W Pollok M | 2002 | Transplant Proc2002，34，6： | 1 |
| 20 | Underestimation of nodules while staging hepatocellular carcinoma prior to neoadjuvant treatment on waiting list for transplantation显示文摘 | Stippel DL Kasper HU Schleimer K | 2003 | Transplant Proc2003，35，4： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员