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| 1 | 在血压控制不良的高血压患者中使用数字化干预的家庭和在线血压管理:随机对照试验显示文摘HOME BP试验(The home and online management and evaluation of blood pressure)的目的是评估在初级预防中结合自我监测和自我管理的数字化干预在高血压管理中的作用。研究者纳入英国76个治疗中心经过治疗但血压控制不好(>140/90 mm Hg, 1 mm Hg=0.133 kPa)并能上网的患者622例,进行自动确定主要终点的公开随机对照试验。 | McMa-nus RJ Little P Stuart B Morton K Raftery J Kelly J Bradbury K Zhang J Zhu S Murray E May CR Mair FS Michie S Smith P Band R Ogburn E AllenJ Rice C Nut-tall J Williams B Yardley L 陈嘉睿(译) 叶鹏(审校) | 2021 | 中华高血压杂志2021，29，5： | 15 |
| 2 | Multiphase computed tomography radiomics of pancreatic intraductal papillary mucinous neoplasms to predict malignancy显示文摘BACKGROUND Intraductal papillary mucinous neoplasms(IPMNs)are non-invasive pancreatic precursor lesions that can potentially develop into invasive pancreatic ductal adenocarcinoma.Currently,the International Consensus Guidelines(ICG)for IPMNs provides the basis for evaluating suspected IPMNs on computed tomography(CT)imaging.Despite using the ICG,it remains challenging to accurately predict whether IPMNs harbor high grade or invasive disease which would warrant surgical resection.A supplementary quantitative radiological tool,radiomics,may improve diagnostic accuracy of radiological evaluation of IPMNs.We hypothesized that using CT whole lesion radiomics features in conjunction with the ICG could improve the diagnostic accuracy of predicting IPMN histology.AIM To evaluate whole lesion CT radiomic analysis of IPMNs for predicting malignant histology compared to International Consensus Guidelines.METHODS Fifty-one subjects who had pancreatic surgical resection at our institution with histology demonstrating IPMN and available preoperative CT imaging were included in this retrospective cohort.Whole lesion semi-automated segmentation was performed on each preoperative CT using Healthmyne software(Healthmyne,Madison,WI).Thirty-nine relevant radiomic features were extracted from each lesion on each available contrast phase.Univariate analysis of the 39 radiomics features was performed for each contrast phase and values were compared between malignant and benign IPMN groups using logistic regression.Conventional quantitative and qualitative CT measurements were also compared between groups,viaχ2(categorical)and Mann Whitney U(continuous)variables.RESULTS Twenty-nine subjects(15 males,age 71±9 years)with high grade or invasive tumor histology comprised the'malignant'cohort,while 22 subjects(11 males,age 70±7 years)with low grade tumor histology were included in the'benign'cohort.Radiomic analysis showed 18/39 precontrast,19/39 arterial phase,and 21/39 venous phase features differentiated malignant from benign IPMNs(P<0.05).Multivariate analysis including only ICG criteria yielded two significant variables:thickened and enhancing cyst wall and enhancing mural nodule<5 mm with an AUC(95%CI)of 0.817(0.709-0.926).Multivariable post contrast radiomics achieved an AUC(95%CI)of 0.87(0.767-0.974)for a model including arterial phase radiomics features and 0.834(0.716-0.953)for a model including venous phase radiomics features.Combined multivariable model including conventional variables and arterial phase radiomics features achieved an AUC(95%CI)of 0.93(0.85-1.0)with a 5-fold cross validation AUC of 0.90.CONCLUSION Multi-phase CT radiomics evaluation could play a role in improving predictive capability in diagnosing malignancy in IPMNs.Future larger studies may help determine the clinical significance of our findings. | Stuart L Polk Jung W Choi Melissa J McGettigan Trevor Rose Abraham Ahmed Jongphil Kim Kun Jiang Yoganand Balagurunathan Jin Qi Paola T Farah Alisha Rathi Jennifer B Permuth Daniel Jeong | 2020 | World Journal of Gastroenterology2020，26，24： | 5 |
| 3 | A randomized clinical trial of induction therapy with OKT3 in kidney transplantation 显示文摘 | Norman D J Kahana L Stuart F P | 1993 | Transplantation1993，55，1： | 2 |
| 4 | NEMO Satellite Sensor Imaging Payload 显示文摘 | Myers W A Smith R D Stuart J L | 1998 | Proceeding of SPIE1998，3437，： | 1 |
| 5 | Diagonally Scaled Permutations and Circulant Matrices 显示文摘 | STUART J L WEAVER J R | 1994 | Linear Algebra Appl1994，212，15： | 1 |
| 6 | Expression of the cyclin kinase inhibitor p27 in developing and mature human kidney显示文摘 | Combs Heidi L Stuart J | 1998 | Kidney International1998，53，4： | 1 |
| 7 | Rival penalized competitive learning (RPCL) : a topology-determining algorithm for analyzing gene expression data 显示文摘 | NAIR T M ZHENG C L FINK J L STUART R O GRIBSKOV M | 2003 | Computational Biology and Chemistry2003，27，6： | 1 |
| 8 | Zebra mussel invasion in a large, turbid river: Phytoplankton response to increased grazing 显示文摘 | Caraco N F Cole J J Raymond P A Strayer D L Pace M L Findlay Stuart E G Fischer D T | 1997 | Ecology1997，78，2： | 1 |
| 9 | Distributed fiber optic leak detection显示文摘 | Kurmer J P Stuart A K John S L | 1992 | Palo Alto CA :EPRI1992，1586，： | 1 |
| 10 | Effects of carbon additions on the high temperature mechanical properties of molybdenum disilicide 显示文摘 | STUART A M JOHN J L ARTHUR H H | 1992 | Mater Sci Eng1992，155，7： | 1 |
| 11 | Modeling Terrestrial Laser Scanner Data for Precise Structural Deformation Measurement显示文摘 | Stuart J G Derek D L | 2007 | Journal of Surveying Engineering2007，，5： | 1 |
| 12 | Use of intravenous contrast mateial duing in situ EWSL of ureteral calculi显示文摘 | Stuart wolf J R Willlam L Bub R | 1997 | J Urol1997，157，： | 1 |
| 13 | Diagonally Scaled Permutations and Girculant Matrices显示文摘 | Stuart J L | 1994 | Linear Algebra and Its Appl1994，，212213： | 1 |
| 14 | Matrices that commute with a permutation matrix 显示文摘 | Stuart J L Weaver J R | 1991 | Line Alge Appl1991，150，： | 1 |
| 15 | Estimated blood loss and transfusion ratesassociated with percutaneous nephrolithotomy显示文摘 | Marshall L Stoller J Stuart WJ | 1994 | J Urol1994，152，： | 1 |
| 16 | Sympathetic ophthalmia in Canada显示文摘 | Liddy L Stuart J | 1972 | Can J Ophthalmol1972，7，： | 1 |
| 17 | Multiple envi ronmental controls on phytoplankton growth strategies determine adaptive responses of the N : P ratio 显示文摘 | Stuart J D James R C Timothy M L | 2014 | E cology Letters2014，17，4： | 1 |
| 18 | Diagonally scaled permutetions and circulant matrices显示文摘 | Stuart J L Weaver J R | 1994 | Linear Algebra Appl1994，，： | 1 |
| 19 | Toxicity Screening by electrochemical detection of DNA damage by metabolites generated in situ in ultrathin DNA-enzyme Films显示文摘 | Zhou L P Estavillo C Stuart J D | 2003 | J Am Chem Soc2003，125，： | 1 |
| 20 | Diagonally scaled permutations and circulant matrices显示文摘 | STUART J L WEAVER J R | | 0，，： | 1 |
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