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| 1 | Multiphase computed tomography radiomics of pancreatic intraductal papillary mucinous neoplasms to predict malignancy显示文摘BACKGROUND Intraductal papillary mucinous neoplasms(IPMNs)are non-invasive pancreatic precursor lesions that can potentially develop into invasive pancreatic ductal adenocarcinoma.Currently,the International Consensus Guidelines(ICG)for IPMNs provides the basis for evaluating suspected IPMNs on computed tomography(CT)imaging.Despite using the ICG,it remains challenging to accurately predict whether IPMNs harbor high grade or invasive disease which would warrant surgical resection.A supplementary quantitative radiological tool,radiomics,may improve diagnostic accuracy of radiological evaluation of IPMNs.We hypothesized that using CT whole lesion radiomics features in conjunction with the ICG could improve the diagnostic accuracy of predicting IPMN histology.AIM To evaluate whole lesion CT radiomic analysis of IPMNs for predicting malignant histology compared to International Consensus Guidelines.METHODS Fifty-one subjects who had pancreatic surgical resection at our institution with histology demonstrating IPMN and available preoperative CT imaging were included in this retrospective cohort.Whole lesion semi-automated segmentation was performed on each preoperative CT using Healthmyne software(Healthmyne,Madison,WI).Thirty-nine relevant radiomic features were extracted from each lesion on each available contrast phase.Univariate analysis of the 39 radiomics features was performed for each contrast phase and values were compared between malignant and benign IPMN groups using logistic regression.Conventional quantitative and qualitative CT measurements were also compared between groups,viaχ2(categorical)and Mann Whitney U(continuous)variables.RESULTS Twenty-nine subjects(15 males,age 71±9 years)with high grade or invasive tumor histology comprised the'malignant'cohort,while 22 subjects(11 males,age 70±7 years)with low grade tumor histology were included in the'benign'cohort.Radiomic analysis showed 18/39 precontrast,19/39 arterial phase,and 21/39 venous phase features differentiated malignant from benign IPMNs(P<0.05).Multivariate analysis including only ICG criteria yielded two significant variables:thickened and enhancing cyst wall and enhancing mural nodule<5 mm with an AUC(95%CI)of 0.817(0.709-0.926).Multivariable post contrast radiomics achieved an AUC(95%CI)of 0.87(0.767-0.974)for a model including arterial phase radiomics features and 0.834(0.716-0.953)for a model including venous phase radiomics features.Combined multivariable model including conventional variables and arterial phase radiomics features achieved an AUC(95%CI)of 0.93(0.85-1.0)with a 5-fold cross validation AUC of 0.90.CONCLUSION Multi-phase CT radiomics evaluation could play a role in improving predictive capability in diagnosing malignancy in IPMNs.Future larger studies may help determine the clinical significance of our findings. | Stuart L Polk Jung W Choi Melissa J McGettigan Trevor Rose Abraham Ahmed Jongphil Kim Kun Jiang Yoganand Balagurunathan Jin Qi Paola T Farah Alisha Rathi Jennifer B Permuth Daniel Jeong | 2020 | World Journal of Gastroenterology2020，26，24： | 5 |
| 2 | Complications and monitoring of OKT3 therapy 显示文摘 | Thistlethwaite J R Stuart J K Mayes J T | 1998 | AM J Kidney Dis1998，11，2： | 2 |
| 3 | Transgenic zebrafish as sentinels for aquatic pollution显示文摘 | Carvan M J Dalton T P Stuart G W | 2000 | Ann N Y Acad Sci2000，919，： | 1 |
| 4 | Emerging ap- plications of stimuli-response polymer materials 显示文摘 | Stuart M A C Huck W T S Genzer J | 2010 | Nat Mater2010，9，： | 1 |
| 5 | Aging, obsolescence and or- ganizational innovation 显示文摘 | Sorensen J B Stuart T E | 2000 | Administrative Science Quarterly2000，45，： | 1 |
| 6 | Maleated Coupling Agents for Natural Fiber Composites 显示文摘 | T J Keener R K Stuart T K Brown | 2004 | Cmnposites Part A: Applied Science and Manufacturing2004，35，3： | 1 |
| 7 | Local search and the evolution of technological capabilities显示文摘 | Stuart T E Podolny J M | 1996 | Strategic Management Journal1996，，： | 1 |
| 8 | Aging, obsolescence and organizational innovation显示文摘 | Srensen J B Stuart T E | 2000 | Administrative Science Quarterly2000，45，1： | 1 |
| 9 | Rival penalized competitive learning (RPCL) : a topology-determining algorithm for analyzing gene expression data 显示文摘 | NAIR T M ZHENG C L FINK J L STUART R O GRIBSKOV M | 2003 | Computational Biology and Chemistry2003，27，6： | 1 |
| 10 | An Evaluation of Cyber -bookshop s:the WebQual method显示文摘 | Stuart J Barnes Richard T Vidgen | | 0，，： | 1 |
| 11 | The Activity and Mechanism of Uranium Oxide Catalysts for the Oxidative Destruction of Volatile Organic Compounds显示文摘 | CATHERINE S H GRAHAM J H | 2000 | Catalysis Today2000，59，： | 1 |
| 12 | An Integrative App roach to the Assessment of E - commerce Quality显示文摘 | Stuart J Barnes Richard T Vidgen | | 0，，： | 1 |
| 13 | Prosity trends in the Skagerrak Formation, Central Graben, United Kingdom Continen- tal Shelf:The role of compaction and pore pressure history显示文摘 | Neil T Grant Alexander J Middleton Stuart Archer | 2014 | AAPG Bulletin2014，98，6： | 1 |
| 14 | Emerging applications of stimuli-responsive polymer materials显示文摘 | Stuart M A C Huck W T S Genzer J | 2010 | Nature Materials2010，9，： | 1 |
| 15 | Structure and receptor binding 显示文摘 | Jackson T Stuart D J Fry E | 2003 | Virus2003，，91： | 1 |
| 16 | Wormlike micellar and vesicular phases in aqueous solutions of single-tailed surfac- rants with aromatic counterions 显示文摘 | Buwalda T R Stuart M C A Engberts J B F N | 2000 | Langmuir2000，16，： | 1 |
| 17 | Zebra mussel invasion in a large, turbid river: Phytoplankton response to increased grazing 显示文摘 | Caraco N F Cole J J Raymond P A Strayer D L Pace M L Findlay Stuart E G Fischer D T | 1997 | Ecology1997，78，2： | 1 |
| 18 | Extraordinary-mode refractive-index change produced by the linear electro-optic effect in LiNbO3 and reverse-poled LiNbO3显示文摘 | Anyhony J Servizzi Joseph T Boyd S Sriram Stuart A Kingsley | 1995 | Applied Optics1995，21，34： | 1 |
| 19 | Networks,knowledge,and niches:Competition in the worldwide semiconductor industry,1984-1991显示文摘 | Podolny J M Stuart T E Hannan M T | 2002 | American Journal of Sociology2002，102，3： | 1 |
| 20 | Aging,obsolescence,and organizational innovation显示文摘 | Sorensen J B Stuart T E | 2000 | Administrative Science Quarterly2000，45，1： | 1 |
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