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| 1 | Efficacy of boceprevir, an NS3 protease inhibitor, in combination with peginterferon alfa-2b and ribavirin in treatment-naive patients with genotype 1 hepatitis C infection (SPRINT-1): an open-label, randomised, multicentre phase 2 trial显示文摘 | Paul Y Kwo Eric J Lawitz Jonathan McCone Eugene R Schiff John M Vierling David Pound Mitchell N Davis Joseph S Galati Stuart C Gordon Natarajan Ravendhran Lorenzo Rossaro Frank H Anderson Ira M Jacobson Raymond Rubin Kenneth Koury Lisa D Pedicone Clifford | 2010 | The Lancet2010，，9742： | 3 |
| 2 | Ron receptor-dependent gene regulation in a mouse model of endotoxin-induced acute liver failure显示文摘BACKGROUND:Prior experimentation has shown that loss of the tyrosine kinase(TK) signaling domain of the Ron receptor leads to marked hepatocyte protection in a model of lipopolysaccharideinduced acute liver failure(ALF) in D-galactosamine(GalN)sensitized mice.The aim of this study was to identify the role of Ron in the regulation of hepatic gene expression.METHODS:Microarray analyses were performed on liver RNA isolated sequentially from wild-type(WT) and TK-/mice during the progression of ALF.Gene array data were validated using Western and immunohistochemistry analyses as well as with ex vivo culture systems.RESULTS:At baseline,101 genes were differentially expressed between WT and TK-/-livers,which regulate processes involved in hypoxia,proliferation,apoptosis and metabolism.One hour after ALF induction,WT livers exhibited increased cytokine expression compared to TK-/-livers,and after 4 hours,an induction of suppressor of cytokine signaling(SOCS) genes as well as JAK-STAT pathway activation were prominent in TK-/livers compared to controls.CONCLUSION:Our studies suggest a novel hepato-protective mechanism in Ron TK-/-mice wherein increased and sustained SOCS production and JAK-STAT activation in the hepatocyte may inhibit the destructive proinflammatory milieu and promote survival factors which blunt hepatic death and the ensuing development of ALF. | Rishikesh M Kulkarni Louis W Kutcher William D Stuart Daniel J Carson Mike A Leonis Susan E Waltz | 2012 | Hepatobiliary & Pancreatic Diseases International2012，11，4： | 3 |
| 3 | A randomized clinical trial of induction therapy with OKT3 in kidney transplantation 显示文摘 | Norman D J Kahana L Stuart F P | 1993 | Transplantation1993，55，1： | 2 |
| 4 | PHarmacokinetie Parameters and mechanisms of rat type 1 and 2 steroid 5 alpha-reduce-tases:determinants for differentiin vivo activities of c1198745 and finasfereride in the rat boil显示文摘 | Stuart J D Lee F W Simpson-Noel D | 2001 | Chen2001，162，： | 1 |
| 5 | NEMO Satellite Sensor Imaging Payload 显示文摘 | Myers W A Smith R D Stuart J L | 1998 | Proceeding of SPIE1998，3437，： | 1 |
| 6 | Regula- tion of leaf and fruit growth in plants growing in drying soil: ex ploitation of the plants' chemical signalling system and hydraulic architecture to increase the efficiency of water use in agriculture 显示文摘 | William J Davies Mark A Bacon D Stuart Thompson | 2000 | Journal of Experimental Botany2000，51，350： | 1 |
| 7 | An ex- perimental study of viscous flows in contractions显示文摘 | MCNEIL D A ADDLESEE J STUART A | 1999 | Journal of Loss Prevention in the Process Industries1999，12，4： | 1 |
| 8 | Exponential mean- square stability of numerical solutions to stochastic differ- ential equations 显示文摘 | Higham D J Mao X R Stuart A M | 2003 | LMS Journal of Computation and Mathematics2003，6，： | 1 |
| 9 | The structure of foot - and -mouth disease virus显示文摘 | FRY E E STUART D I ROWLANDS D J | 2005 | Curt Top Microbiol Immuno2005，288，： | 1 |
| 10 | Digital Models:An Introduction显示文摘 | Matthew J Peluso Stuart D | 2004 | Semin Orthod2004，10，3： | 1 |
| 11 | Valuing Customers 显示文摘 | Gupta S Lehmann D R Stuart J A | 2004 | Journal of Marketing Research2004，41，1： | 1 |
| 12 | Knowledge sharing: Context, confusion and controversy 显示文摘 | Scott F Stuart D Stephanie J W | 2003 | International Journal of Project Management2003，21，3： | 1 |
| 13 | Assessment of eccentric exercise-induced muscle damage of the elbow flexors by tensiomyography 显示文摘 | Angus M Hunter Stuart D R Galloway Iain J S | 2012 | Journal of Electromyography and Kinesiology2012，22，3： | 1 |
| 14 | A gene-coexpression network for global discovery of conserved genetic modules显示文摘 | STUART J M SEGAL E KOLLER D | 2003 | Science2003，302，： | 1 |
| 15 | Port System Simulation facility with an optimization capability显示文摘 | Keshav P D Stuart J G Gracme M B | 2003 | International Journal of Computational Intelligence and Applications2003，3，4： | 1 |
| 16 | T-cell division in human immunodeficiency virus (HIV)-1 infection is mainly due to immune activation:a longitudinal analysis in patients before and during highly active antiretroviral therapy (HAART)显示文摘 | Hazenberg M D Stuart J W Otto S A | 2000 | {H}Blood2000，，01： | 1 |
| 17 | Structure and receptor binding 显示文摘 | Jackson T Stuart D J Fry E | 2003 | Virus2003，，91： | 1 |
| 18 | Cycle training increased GLUT4 and activation of mammalian target of rapamycin in fast twitch muscle fibers 显示文摘 | Stuart C A Howell M E Baker J D | 2010 | Med Sci Sports Exerc2010，42，1： | 1 |
| 19 | Zebra mussel invasion in a large, turbid river: Phytoplankton response to increased grazing 显示文摘 | Caraco N F Cole J J Raymond P A Strayer D L Pace M L Findlay Stuart E G Fischer D T | 1997 | Ecology1997，78，2： | 1 |
| 20 | The structure of foot-and-mouth disease virus显示文摘 | Fry E E Stuart D 1 Rowlands D J | 2005 | Curr Top Microbiol Immunol2005，288，： | 1 |
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