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| 1 | Iatrogenic esophago-tracheal fistula:Challenges in diagnosis and management显示文摘Esophageo-tracheal fistula is a rare condition,and in most cases such fistulas are caused by malignant disease or emergency endotracheal intubation.A case where a wrapped tablet produced a fistula between the esophagus and trachea is described.The patient is a male born in 1938 who swallowed a tablet without unwrapping it.The patient was treated with selfexpanding metal stents(SEMS),but closure of the fistula was not achieved.Different examinations and treatment options are discussed.Surgical treatment for this condition has demonstrated considerable mortality and morbidity.In some cases closure of the fistula can be achieved by use of SEMS.Although we advise treatment of such cases with SEMS,in some cases treatment with stents will prove troublesome and the risk/benefit analysis will have to be reevaluated. | istein Hovde yvind Haugen Lie Per Arthur Johansson ystein Stubhaug Egil Johnson Bjrn Hofstad Truls Hauge | 2013 | World Journal of Gastroenterology2013，19，4： | 5 |
| 2 | 饲料中大豆油替代鱼油对大西洋鲑肝细胞脂肪酸代谢的影响显示文摘为探讨大豆油替代鱼油对大西洋鲑(Salmo salar L.)肝细胞脂肪酸代谢的影响,本试验分别以鱼油和大豆油为脂肪源配制2种试验饲料,并分别饲喂大西洋鲑幼鲑5个月。饲养结束后,分离和培养大西洋鲑肝细胞,一方面将细胞与碳14标记油酸([1-14C]OA)共孵育,然后测定细胞和细胞内各脂质成分以及脂肪酸β-氧化产物的放射活性;另一方面提取肝细胞总RNA,采用实时荧光定量聚合酶链式反应(RT-qPCR)测定脂肪酸结合蛋白3(FABP3)、脂肪酸结合蛋白10(FABP10)、Δ5去饱和酶(D5D)、Δ6去饱和酶(D6D)及肉碱棕榈酰转移酶Ⅰ(CPT-Ⅰ)基因的相对表达量。结果表明:1)鱼油组与大豆油组肝细胞内游离脂肪酸(FFA)放射活性百分率分别为(62.7±13.0)%和(55.9±9.1)%,2组间无显著差异(P>0.05);鱼油组与大豆油组肝细胞内磷脂(PLs)放射活性百分率分别为(20.9±8.7)%和(17.9±5.4)%,2组间无显著差异(P>0.05);鱼油组肝细胞内三酰甘油(TAG)放射活性百分率为(2.0±0.9)%,显著高于大豆油组的(0.8±0.4)%(P<0.05);鱼油组与大豆油组肝细胞内β-氧化产物放射活性百分率分别为(1.0±0.3)%和(1.0±0.2)%,2组间无显著差异(P>0.05)。2)大豆油组肝细胞中FABP3、D6D、D5D基因的相对表达量均显著高于鱼油组(P<0.05),而FABP10和CPT-Ⅰ基因的相对表达量在2组间无显著差异(P>0.05)。由此可见,大豆油替代饲料中的鱼油对大西洋鲑肝细胞内FFA、PLs合成及脂肪酸β-氧化等脂肪酸代谢途径无显著影响,但显著降低了肝细胞内TAG的合成,促进了肝细胞内脂肪酸的去饱和,因此大豆油替代鱼油在一定程度上影响了肝细胞内脂肪酸代谢。 | 周继术 TORSTENSEN Bente Elisabeth STUBHAUG Ingunn 吉红 | 2013 | 动物营养学报2013，25，11： | 4 |
| 3 | 饲料中植物油替代鱼油对大西洋鲑肝细胞油酸跨膜吸收的影响显示文摘以[1-14C]油酸(oleic acid;18:1n-9,OA)为指示剂,研究了不同饲料油源饲喂下大西洋鲑肝细胞膜脂肪酸组成受到改变时该细胞对OA吸收的状况,以探讨植物油(Vegetable oil,VO)替代鱼油(Fish oil,FO)对大西洋鲑肝细胞脂肪酸跨膜吸收的影响,为大西洋鲑饲料中植物油替代鱼油的可行性提供理论依据。试验先以鱼油和大豆油为油源配制两种全价配合饲料,分别饲喂大西洋鲑幼鲑5个月,使其产生不同的脂肪酸组成。在饲养结束后,分离并培养试验鱼肝细胞,将细胞与[1-14C]OA及37.5μmol/L OA(1/30,mol/mol,0.3μCi/瓶)共孵育2h,收集并测定细胞内OA放射活性,再计算细胞内OA吸收量[nmol/(h·million cells)]。同时,试验采取RT-PCR方法测定了细胞脂肪酸运送蛋白(Fatty acid transport protein,FATP)、脂肪酸移位蛋白(Fatty acid translocase,FAT/CD36)的基因表达量。结果表明,FO和VO组肝细胞对OA吸收分别为(0.924±0.258)及(0.888±0.179)nmol/(h·million cells),两组间无显著差异(P>0.05)。RT-PCR的检测结果表明,FAT/CD36和FATP基因表达量在FO与VO两组间均无显著差异(P>0.05)。结果表明,从植物油替代鱼油不影响大西洋鲑肝细胞对长链脂肪酸的跨膜吸收方面来看,大西洋鲑饲料中以植物油替代鱼油具有可行性。 | 周继术 Bente E.Torstensen Ingunn Stubhaug | 2014 | 水生生物学报2014，38，1： | 4 |
| 4 | Effects of COX inhibition on experimental pain and hyperalgesia during and after remifentanil infusion in humans显示文摘 | Harald Lenz Johan Raeder Tomas Draegni Fridtjof Heyerdahl Martin Schmelz Audun Stubhaug | 2011 | Pain2011，，6： | 2 |
| 5 | Intra-articular morphine 5 mg after knee arthroscopy does not produce significant pain relief when administered to patients with moderate to severe pain via an intra-articular catheter显示文摘 | Solheim N Rosseland LA Stubhaug A | | 0，，06： | 1 |
| 6 | Mapping of punctuate hyperalgesia around a surgical incision demonstrates that ketamine is a powerful suppressor of central sensitization to pain following surgery显示文摘 | Stubhaug A Breivik H Eide PK | 1997 | Acta Anaesthesiol Scand1997，41，9： | 1 |
| 7 | Mapping of punctuate hyperalgesia around a surgical incision demonstrates that ketamime is a powerful suppressor of central sensitization to pain following surgery显示文摘 | Stubhaug A Breivik H Eide P K | 1997 | Acta Anaerthesiol Scand1997，41，： | 1 |
| 8 | Methylpred-nisolone and ketorolac rapidly reduce hyperalgesia around a skin burn injury and increase pressure pain thresholds显示文摘 | Stubhaug A Romundstad L Kaasa T | 2007 | Acta Anaesthesiol Scand2007，51，9： | 1 |
| 9 | Detecting Postoperative urinary retention with an ultrasound scanner 显示文摘 | Rosseland LA Stubhaug A Breivik H | 2002 | Acta Anaesthesiol scand2002，46，3： | 1 |
| 10 | Mapping of punctuate hyperalgesia around a surgical incision demonstrates that ketamine is a powerful suppressor of central sensitization to pain following surgery显示文摘 | Stubhaug A Breivik H Eide P K | 2006 | Acta Anaestheiol Scand2006，50，： | 1 |
| 11 | A Randomized and Blinded Single-Center Trial Comparing the Effect of Intracranial Pressure and Intracranial Pressure Wave Amplitude-Guided Intensive Care Management on Early Clinical State and 12-Month Outcome in Patients With Aneurysmal Subarachnoid Hemo显示文摘 | Per Kristian Eide Gunnar Bentsen Angelika G. Sorteberg P?l Bache Marthinsen Audun Stubhaug Wilhelm Sorteberg | 2011 | Neurosurgery2011，，5： | 1 |
| 12 | Haemodynamic effects of oxytocin in women with severe preeclampsia 显示文摘 | Langeszeter E Rosseland LA Stubhaug A | 2011 | Int J Obstet Anesth2011，20，1： | 1 |
| 13 | Relief of postherpetic neuralgia with the N-methy-D-aspartic acid receptor antagonist ketamine显示文摘 | Jorum E Stubhaug A | 1994 | Pain1994，58，： | 1 |
| 14 | Detecting postoperative urinary retention with an ultrasound scanner显示文摘 | Rosseland LA Stubhaug A Breivik H | 2002 | Acta Anaesthesiol Scand2002，46，3： | 1 |
| 15 | Relief of glossopharyngeal neural-gia by ketamine induced N-methyl-aspartate receptorblockade显示文摘 | Eide PK Stubhaug A | 1997 | Neurosurgery1997，41，2： | 1 |
| 16 | Haemodynamic effects of repeated doses of oxytocin during Caesarean delivery in healthy parturients 显示文摘 | LANGESAETER E ROSSELAND L A STUBHAUG A | 2009 | British Journal of Anaesthesia2009，103，2： | 1 |
| 17 | Comparison of intracranial pressure measured simultaneously within the brain parenchyma and cerebral ventricles显示文摘 | Brean A Eide PK Stubhaug A | 2006 | J Clin Monit Comput2006，20，6： | 1 |
| 18 | Detecting postoperative urinary retention with an ultrasound scanner显示文摘 | Rosseland L A Stubhaug A Breivik H | 2002 | Acta Anaesthesiol Scand2002，46，3： | 1 |
| 19 | β-oxidation capacity in liver increases during parr-smolt transformation of Atlantic salmon fed vegetable oil and fish oil显示文摘 | STUBHAUG I LIE O TORSTENSEN B E | 2006 | Journal of Fish Biology2006，69，2： | 1 |
| 20 | The incidence of de- lirium in Norwegian intensive care units: Deep sedation makes assessment difficult显示文摘 | Woien H Balsliemke S Stubhaug A | 2013 | Acta Anaesthesiol Scand2013，57，3： | 1 |
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